CN1244203A - 抗原 - Google Patents
抗原 Download PDFInfo
- Publication number
- CN1244203A CN1244203A CN98801973A CN98801973A CN1244203A CN 1244203 A CN1244203 A CN 1244203A CN 98801973 A CN98801973 A CN 98801973A CN 98801973 A CN98801973 A CN 98801973A CN 1244203 A CN1244203 A CN 1244203A
- Authority
- CN
- China
- Prior art keywords
- definition
- protein
- pseudomonas aeruginosa
- composition
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000036639 antigens Human genes 0.000 title claims abstract description 38
- 108091007433 antigens Proteins 0.000 title claims abstract description 38
- 239000000427 antigen Substances 0.000 title claims abstract description 31
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims abstract description 50
- 238000003745 diagnosis Methods 0.000 claims abstract description 10
- 238000001514 detection method Methods 0.000 claims abstract description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 40
- 108090000623 proteins and genes Proteins 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 38
- 239000012634 fragment Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 14
- 239000000523 sample Substances 0.000 claims description 13
- 229960005486 vaccine Drugs 0.000 claims description 11
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 9
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 4
- 101710116435 Outer membrane protein Proteins 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 description 15
- 210000004072 lung Anatomy 0.000 description 12
- 238000002649 immunization Methods 0.000 description 11
- 230000003053 immunization Effects 0.000 description 11
- 150000001413 amino acids Chemical group 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- SJUXYGVRSGTPMC-IMJSIDKUSA-N Asn-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CC(N)=O SJUXYGVRSGTPMC-IMJSIDKUSA-N 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 239000004141 Sodium laurylsulphate Substances 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- LGYZYFFDELZWRS-DCAQKATOSA-N Glu-Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(O)=O LGYZYFFDELZWRS-DCAQKATOSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 238000013016 damping Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 210000001539 phagocyte Anatomy 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- YHBDGLZYNIARKJ-GUBZILKMSA-N Ala-Pro-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N YHBDGLZYNIARKJ-GUBZILKMSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DEGCBBCMYWNJNA-RHYQMDGZSA-N Thr-Pro-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O DEGCBBCMYWNJNA-RHYQMDGZSA-N 0.000 description 2
- NDZYTIMDOZMECO-SHGPDSBTSA-N Thr-Thr-Ala Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O NDZYTIMDOZMECO-SHGPDSBTSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000566150 Pandion haliaetus Species 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- BHATUINFZWUDIX-UHFFFAOYSA-N Zwittergent 3-14 Chemical compound CCCCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O BHATUINFZWUDIX-UHFFFAOYSA-N 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- NIFKBBMCXCMCAO-UHFFFAOYSA-N methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-4-(methanesulfonamidomethyl)benzoate Chemical compound COC(=O)C1=CC=C(CNS(C)(=O)=O)C=C1S(=O)(=O)NC(=O)NC1=NC(OC)=CC(OC)=N1 NIFKBBMCXCMCAO-UHFFFAOYSA-N 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
大鼠组 | nb | 攻击后4小时回收的铜绿色假单胞菌(log10CFU)aBAL 肺匀浆 | |
非免疫组 | 5 | 7.63±0.11 | 8.66±0.18 |
10μg Pa60 | 6 | 6.95±0.07 | 8.43±0.09 |
40μg Pa60 | 4 | 7.19±0.07 | 8.37±0.19 |
动物组 | BAL中的总吞噬细胞数 |
非免疫组 | 1.2(±0.3)×106 |
10μg Pa60 | 4.3(±1.2)×106 |
40μg Pa60 | 7.4(±1.7)×106 |
患者 | 血清a | BALa | ||||
IgG | IgA | IgM | IgG | IgA | IgM | |
组1 | 1.74 | 0.11 | 0.67 | 0.03 | 0.05 | 0.02 |
组2 | 1.40 | 2.34 | 2.10 | 0.03 | 0 | 0.02 |
组3 | 7.08±8.4 | 10.9±18 | 2.03±2.5 | 0.03±0.01 | 0.21±0.13 | 0.03±0.01 |
组4 | 18.9±21.9 | 0.56±0.6 | 1.46±2.07 | 0.02±0.01 | 0.12±0.04 | 0.01±0.01 |
组5 | 54.5±76 | 7.5±12.5 | 6.2±0.5 | 0.03±0.01 | 0.81±0.30 | 0.03±0.01 |
细菌回收log10(FU)* | |||
组别 | n+ | BAL | 肺 |
非免疫组10μgPa60 | 55 | 7.92±0.116.34±0.08 | 9.01±0.157.58±0.08 |
BAL中的白细胞数 | ||
组别 | n | 白细胞数*(×106) |
非免疫组 | 5 | 6.8±14 |
10μg Pa60 | 5 | 36.0±5.0 |
组别 | n | IgG* | IgA* | IgM* |
非免疫组10μg Pa60 | 55 | 01310±119 | 010±2 | 14.8±0.56100±59 |
组别 | n | IgG* | IgA* | IgM* |
非免疫组10μg Pa60 | 55 | 1.5±0.221.3±2.6 | 07.8±4.2 | 0.5±0.020.8±0.3 |
Claims (25)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9701489.8A GB9701489D0 (en) | 1997-01-24 | 1997-01-24 | Antigen |
GB9701489.8 | 1997-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1244203A true CN1244203A (zh) | 2000-02-09 |
Family
ID=10806544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98801973A Pending CN1244203A (zh) | 1997-01-24 | 1998-01-26 | 抗原 |
Country Status (10)
Country | Link |
---|---|
US (2) | US7029684B1 (zh) |
EP (1) | EP0980389B1 (zh) |
JP (2) | JP2001511125A (zh) |
CN (1) | CN1244203A (zh) |
AT (1) | ATE420104T1 (zh) |
AU (1) | AU5771798A (zh) |
DE (1) | DE69840438D1 (zh) |
GB (1) | GB9701489D0 (zh) |
WO (1) | WO1998032769A1 (zh) |
ZA (1) | ZA98587B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9915419D0 (en) * | 1999-07-01 | 1999-09-01 | Cortecs Uk Ltd | Antigens |
GB9928676D0 (en) * | 1999-12-03 | 2000-02-02 | Provalis Uk Ltd | Pseudomonas aeruginosa antigens |
JP4978637B2 (ja) | 2009-02-12 | 2012-07-18 | 株式会社デンソー | 炭化珪素単結晶の製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5237053A (en) | 1986-06-24 | 1993-08-17 | Immuno Aktiengesellschaft | Preparation active against Pseudomonas aeruginosa infections and methods of producing them |
AT391080B (de) | 1986-06-24 | 1990-08-10 | Immuno Ag | Verfahren zur herstellung von gegen pseudomonas aeruginosa infektionen wirksamen praeparationen |
ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
US6100380A (en) * | 1991-10-28 | 2000-08-08 | Cytran, Inc. | Immunomodulating peptides and methods of use |
WO1993024636A1 (en) * | 1992-05-29 | 1993-12-09 | The University Of British Columbia | Use of protein oprf for bacterial cell surface expression of oligopeptides |
EP0717106B1 (en) * | 1994-12-16 | 2000-03-15 | Chiron Behring Gmbh & Co. | Immunogenic hybrid protein OprF-Oprl derived from Pseudomonas aeruginosa membrane proteins |
CA2175435A1 (en) * | 1996-04-30 | 1997-10-31 | Joseph Lam | Proteins involved in the synthesis and assembly of o-antigen in pseudomonas aeruginosa |
US6436391B1 (en) * | 1997-01-31 | 2002-08-20 | Imperial College Of Science, Technology & Medicine | Use of interferon (IFN)-α8 and -α14 as vaccine adjuvants |
-
1997
- 1997-01-24 GB GBGB9701489.8A patent/GB9701489D0/en active Pending
-
1998
- 1998-01-23 ZA ZA9800587A patent/ZA98587B/xx unknown
- 1998-01-26 WO PCT/GB1998/000217 patent/WO1998032769A1/en active Application Filing
- 1998-01-26 AT AT98901378T patent/ATE420104T1/de not_active IP Right Cessation
- 1998-01-26 JP JP53174198A patent/JP2001511125A/ja not_active Withdrawn
- 1998-01-26 DE DE69840438T patent/DE69840438D1/de not_active Expired - Fee Related
- 1998-01-26 AU AU57717/98A patent/AU5771798A/en not_active Abandoned
- 1998-01-26 EP EP98901378A patent/EP0980389B1/en not_active Expired - Lifetime
- 1998-01-26 CN CN98801973A patent/CN1244203A/zh active Pending
-
1999
- 1999-07-22 US US09/359,426 patent/US7029684B1/en not_active Expired - Fee Related
-
2005
- 2005-06-22 US US11/158,599 patent/US7371394B2/en not_active Expired - Fee Related
-
2008
- 2008-09-24 JP JP2008243780A patent/JP2009029825A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2001511125A (ja) | 2001-08-07 |
EP0980389B1 (en) | 2009-01-07 |
WO1998032769A1 (en) | 1998-07-30 |
US20050232943A1 (en) | 2005-10-20 |
GB9701489D0 (en) | 1997-03-12 |
DE69840438D1 (en) | 2009-02-26 |
US7371394B2 (en) | 2008-05-13 |
AU5771798A (en) | 1998-08-18 |
JP2009029825A (ja) | 2009-02-12 |
US7029684B1 (en) | 2006-04-18 |
EP0980389A1 (en) | 2000-02-23 |
ZA98587B (en) | 1999-07-23 |
ATE420104T1 (de) | 2009-01-15 |
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