CN1242993C - 杂环衍生物和药物 - Google Patents

杂环衍生物和药物 Download PDF

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Publication number
CN1242993C
CN1242993C CNB018075347A CN01807534A CN1242993C CN 1242993 C CN1242993 C CN 1242993C CN B018075347 A CNB018075347 A CN B018075347A CN 01807534 A CN01807534 A CN 01807534A CN 1242993 C CN1242993 C CN 1242993C
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CN
China
Prior art keywords
compound
group
alkyl
alkoxy
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018075347A
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English (en)
Chinese (zh)
Other versions
CN1422255A (zh
Inventor
冈野昌彦
森和哉
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Nippon Shinyaku Co Ltd
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Nippon Shinyaku Co Ltd
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Publication of CN1422255A publication Critical patent/CN1422255A/zh
Application granted granted Critical
Publication of CN1242993C publication Critical patent/CN1242993C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018075347A 2000-03-31 2001-03-30 杂环衍生物和药物 Expired - Fee Related CN1242993C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2000098874 2000-03-31
JP98874/00 2000-03-31
JP98874/2000 2000-03-31
JP336464/2000 2000-11-02
JP2000336464 2000-11-02
JP336464/00 2000-11-02

Publications (2)

Publication Number Publication Date
CN1422255A CN1422255A (zh) 2003-06-04
CN1242993C true CN1242993C (zh) 2006-02-22

Family

ID=26589216

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018075347A Expired - Fee Related CN1242993C (zh) 2000-03-31 2001-03-30 杂环衍生物和药物

Country Status (10)

Country Link
US (1) US6794389B2 (enExample)
EP (1) EP1306372B1 (enExample)
KR (1) KR20020083533A (enExample)
CN (1) CN1242993C (enExample)
AT (1) ATE449084T1 (enExample)
AU (1) AU2001244688A1 (enExample)
CA (1) CA2403605A1 (enExample)
DE (1) DE60140545D1 (enExample)
RU (1) RU2268260C2 (enExample)
WO (1) WO2001072710A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024666A2 (en) * 2000-09-20 2002-03-28 Merck Patent Gmbh 4-amino-quinazolines
ATE383860T1 (de) * 2000-11-02 2008-02-15 Nippon Shinyaku Co Ltd Chinazolinderivate und -arzneimittel
RU2003130752A (ru) * 2001-03-19 2005-03-10 Ниппон Синяку Ко., Лтд. (Jp) Противозудные средства
US6907295B2 (en) * 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
JP4513566B2 (ja) * 2002-04-26 2010-07-28 日本新薬株式会社 キナゾリン誘導体及び医薬
JP4805234B2 (ja) * 2002-12-16 2011-11-02 キッセイ薬品工業株式会社 経口固形医薬
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
JP5129957B2 (ja) 2003-07-03 2013-01-30 ミリアド ジェネティクス， インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘発因子としての４−アリールアミノ−キナゾリン
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US20050165032A1 (en) * 2004-01-23 2005-07-28 Norman Mark H. Vanilloid receptor ligands and their use in treatments
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
WO2007040231A1 (ja) 2005-10-03 2007-04-12 Nippon Shinyaku Co., Ltd. キナゾリン誘導体及び医薬
RU2314295C2 (ru) * 2006-03-01 2008-01-10 Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Южный Федеральный Университет" 2-гетарилзамещенные 1,3-трополона, способ их получения (варианты) и фармацевтическая композиция антимикробного действия
MX2009012117A (es) * 2007-05-09 2009-11-23 Pfizer Composiciones y derivados heterociclicos sustituidos y su uso farmaceutico como antibacterianos.
EP2017294A1 (de) 2007-07-16 2009-01-21 Sika Technology AG Hitzehärtender Schaum
BRPI0923786C8 (pt) 2008-12-30 2021-05-25 Arqule Inc compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostos
WO2012027495A1 (en) 2010-08-27 2012-03-01 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
SG11201403744YA (en) 2011-12-28 2014-09-26 Fujifilm Corp Novel nicotinamide derivative or salt thereof
WO2024258849A2 (en) * 2023-06-13 2024-12-19 The Trustees Of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753981A (en) 1970-07-15 1973-08-21 Squibb & Sons Inc 4-amino-2-styrylquinazoline compounds
PT100905A (pt) 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
WO1997020821A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Heteroaryl derivatives
EP0973513A4 (en) 1996-10-23 2003-03-19 Zymogenetics Inc COMPILATIONS AND METHOD FOR TREATING BONE DEFICIENCY
CA2226058C (en) 1997-01-30 2008-01-29 F. Hoffmann-La Roche Ag 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives
AR012634A1 (es) 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
DE69826278T2 (de) 1997-05-30 2005-11-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazol-derivate
AU8748798A (en) 1997-08-22 1999-03-16 Kyowa Hakko Kogyo Co. Ltd. 4-aminoquinazoline derivatives
RU2202344C2 (ru) * 1998-03-26 2003-04-20 Джапан Тобакко Инк. Антагонисты ноцицептина, производные амида, аналгетик, способ инициирования антагонистического действия к ноцицептину, способ лечения боли, фармацевтические композиции
RU2003130752A (ru) 2001-03-19 2005-03-10 Ниппон Синяку Ко., Лтд. (Jp) Противозудные средства

Also Published As

Publication number Publication date
KR20020083533A (ko) 2002-11-02
AU2001244688A1 (en) 2001-10-08
RU2002129100A (ru) 2004-02-27
CA2403605A1 (en) 2002-09-18
US6794389B2 (en) 2004-09-21
ATE449084T1 (de) 2009-12-15
RU2268260C2 (ru) 2006-01-20
CN1422255A (zh) 2003-06-04
EP1306372A1 (en) 2003-05-02
US20030119855A1 (en) 2003-06-26
WO2001072710A1 (en) 2001-10-04
EP1306372B1 (en) 2009-11-18
EP1306372A4 (en) 2004-03-17
DE60140545D1 (enExample) 2009-12-31

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee