CN1237965C - 盐酸班布特罗口腔崩解片及其制备方法 - Google Patents
盐酸班布特罗口腔崩解片及其制备方法 Download PDFInfo
- Publication number
- CN1237965C CN1237965C CN 200310111140 CN200310111140A CN1237965C CN 1237965 C CN1237965 C CN 1237965C CN 200310111140 CN200310111140 CN 200310111140 CN 200310111140 A CN200310111140 A CN 200310111140A CN 1237965 C CN1237965 C CN 1237965C
- Authority
- CN
- China
- Prior art keywords
- kwd
- oral cavity
- cavity disintegration
- disintegration tablet
- weighing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 18
- HWAXMFYECKQLDX-UHFFFAOYSA-N 5-[[(4-chlorobenzoyl)amino]methyl]thiophene-2-sulfonyl chloride Chemical compound C1=CC(Cl)=CC=C1C(=O)NCC1=CC=C(S(Cl)(=O)=O)S1 HWAXMFYECKQLDX-UHFFFAOYSA-N 0.000 title abstract description 5
- 229960003416 bambuterol hydrochloride Drugs 0.000 title abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 42
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 26
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 14
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims abstract description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 14
- 108010011485 Aspartame Proteins 0.000 claims abstract description 13
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 13
- 229930195725 Mannitol Natural products 0.000 claims abstract description 13
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 13
- 235000010357 aspartame Nutrition 0.000 claims abstract description 13
- 239000000605 aspartame Substances 0.000 claims abstract description 13
- 229960003438 aspartame Drugs 0.000 claims abstract description 13
- 239000008101 lactose Substances 0.000 claims abstract description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- 239000000594 mannitol Substances 0.000 claims abstract description 13
- 235000010355 mannitol Nutrition 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 4
- 239000000686 essence Substances 0.000 claims abstract 4
- 235000015165 citric acid Nutrition 0.000 claims abstract 2
- 229960001375 lactose Drugs 0.000 claims abstract 2
- 229960001855 mannitol Drugs 0.000 claims abstract 2
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims description 39
- 210000000214 mouth Anatomy 0.000 claims description 31
- 239000002671 adjuvant Substances 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 20
- 238000005303 weighing Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 7
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000007907 direct compression Methods 0.000 claims description 3
- DAYVUSIHRXCXPE-UHFFFAOYSA-N C(CCC)C(C)(O)NCC Chemical group C(CCC)C(C)(O)NCC DAYVUSIHRXCXPE-UHFFFAOYSA-N 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 238000005550 wet granulation Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 8
- 208000006673 asthma Diseases 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 208000009079 Bronchial Spasm Diseases 0.000 abstract description 3
- 208000014181 Bronchial disease Diseases 0.000 abstract description 3
- 206010006458 Bronchitis chronic Diseases 0.000 abstract description 3
- 206010006482 Bronchospasm Diseases 0.000 abstract description 3
- 208000019505 Deglutition disease Diseases 0.000 abstract description 3
- 206010006451 bronchitis Diseases 0.000 abstract description 3
- 208000007451 chronic bronchitis Diseases 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract description 3
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 241000167854 Bourreria succulenta Species 0.000 description 4
- 235000019693 cherries Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 235000019615 sensations Nutrition 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 229940126701 oral medication Drugs 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- 206010014561 Emphysema Diseases 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000009748 deglutition Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200310111140 CN1237965C (zh) | 2003-12-09 | 2003-12-09 | 盐酸班布特罗口腔崩解片及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200310111140 CN1237965C (zh) | 2003-12-09 | 2003-12-09 | 盐酸班布特罗口腔崩解片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1546010A CN1546010A (zh) | 2004-11-17 |
CN1237965C true CN1237965C (zh) | 2006-01-25 |
Family
ID=34335948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200310111140 Expired - Lifetime CN1237965C (zh) | 2003-12-09 | 2003-12-09 | 盐酸班布特罗口腔崩解片及其制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN1237965C (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101920018B (zh) * | 2009-06-09 | 2012-11-28 | 苏州迪星生物医药科技有限公司 | 一种药用辅料及其制备方法 |
CN104784131B (zh) * | 2014-01-17 | 2018-09-21 | 南京瑞尔医药有限公司 | 一种盐酸班布特罗片剂的制备方法 |
CN104784128B (zh) * | 2014-01-17 | 2018-09-21 | 南京瑞尔医药有限公司 | 一种盐酸班布特罗片剂组合物 |
CN113750061B (zh) * | 2021-08-18 | 2022-12-23 | 河南省人民医院 | 一种班布特罗口崩片及其制备方法 |
-
2003
- 2003-12-09 CN CN 200310111140 patent/CN1237965C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1546010A (zh) | 2004-11-17 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Chengdu Kaijie bio Pharmaceutical Technology Development Co Ltd Assignor: CHENGDU SHENGNUO TECH Co.,Ltd. Contract fulfillment period: 2008.11.6 to 2013.11.6 Contract record no.: 2009510000042 Denomination of invention: Oral disintegrating tablet of bambuterol hydrochloride and its preparation method Granted publication date: 20060125 License type: Exclusive license Record date: 20090917 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.11.6 TO 2013.11.6; CHANGE OF CONTRACT Name of requester: CHENGDU KAIJIE BIOLOGICAL MEDICINE SCIENCE AND TEC Effective date: 20090917 |
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C56 | Change in the name or address of the patentee |
Owner name: CHENGDU SHENGNUO BIOTEC CO., LTD. Free format text: FORMER NAME: SHENGNUO SCIENCE AND TECHNOLOGY DEVELOPMENT CO LTD, CHENGDU |
|
CP01 | Change in the name or title of a patent holder |
Address after: 610041 No. 111, Xiaojiahe street, hi tech Zone, Sichuan, Chengdu Patentee after: Chengdu Shengnuo BioTec Co.,Ltd. Address before: 610041 No. 111, Xiaojiahe street, hi tech Zone, Sichuan, Chengdu Patentee before: CHENGDU SHENGNUO TECH Co.,Ltd. |
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CX01 | Expiry of patent term |
Granted publication date: 20060125 |
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CX01 | Expiry of patent term |