CN1233323C - 美洛昔康口腔崩解片及其制备方法 - Google Patents
美洛昔康口腔崩解片及其制备方法 Download PDFInfo
- Publication number
- CN1233323C CN1233323C CN 200310111142 CN200310111142A CN1233323C CN 1233323 C CN1233323 C CN 1233323C CN 200310111142 CN200310111142 CN 200310111142 CN 200310111142 A CN200310111142 A CN 200310111142A CN 1233323 C CN1233323 C CN 1233323C
- Authority
- CN
- China
- Prior art keywords
- meloxicam
- weighing
- orally disintegrating
- adjuvant
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 229960001929 meloxicam Drugs 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims description 21
- 239000006191 orally-disintegrating tablet Substances 0.000 title claims description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 37
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 24
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 21
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims abstract description 13
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 12
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 12
- 229930195725 Mannitol Natural products 0.000 claims abstract description 12
- 239000008101 lactose Substances 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 12
- 239000000594 mannitol Substances 0.000 claims abstract description 12
- 235000010355 mannitol Nutrition 0.000 claims abstract description 12
- 108010011485 Aspartame Proteins 0.000 claims abstract description 11
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 11
- 235000010357 aspartame Nutrition 0.000 claims abstract description 11
- 239000000605 aspartame Substances 0.000 claims abstract description 11
- 229960003438 aspartame Drugs 0.000 claims abstract description 11
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 11
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 7
- 239000002671 adjuvant Substances 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 239000003826 tablet Substances 0.000 claims description 22
- 238000005303 weighing Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 17
- 210000000214 mouth Anatomy 0.000 claims description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 238000010298 pulverizing process Methods 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000314 lubricant Substances 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000007907 direct compression Methods 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 201000008482 osteoarthritis Diseases 0.000 abstract description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract 2
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 239000000686 essence Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000019640 taste Nutrition 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 235000019615 sensations Nutrition 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000001647 drug administration Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229940126701 oral medication Drugs 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000019505 Deglutition disease Diseases 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 230000009748 deglutition Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200310111142 CN1233323C (zh) | 2003-12-09 | 2003-12-09 | 美洛昔康口腔崩解片及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200310111142 CN1233323C (zh) | 2003-12-09 | 2003-12-09 | 美洛昔康口腔崩解片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1546033A CN1546033A (zh) | 2004-11-17 |
CN1233323C true CN1233323C (zh) | 2005-12-28 |
Family
ID=34335950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200310111142 Expired - Lifetime CN1233323C (zh) | 2003-12-09 | 2003-12-09 | 美洛昔康口腔崩解片及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1233323C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020262618A1 (en) * | 2019-06-28 | 2020-12-30 | Ssp Co., Ltd. | Meloxicam-containing granulated product |
WO2022097024A1 (en) * | 2020-11-06 | 2022-05-12 | Mylan Laboratories Ltd | Pharmaceutical composition comprising meloxicam |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
MXPA05008575A (es) * | 2005-08-12 | 2007-02-12 | Leopoldo Espinosa Abdala | Formulaciones farmaceuticas solidas sublinguales conteniendo meloxicam. |
EP1870102A1 (en) | 2006-06-15 | 2007-12-26 | Alpex Pharma SA | Solid forms containing meloxicam with improved taste and process for their preparation |
CN101618026B (zh) * | 2009-07-06 | 2011-03-16 | 江苏飞马药业有限公司 | 美洛昔康片及其生产工艺和用途 |
US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
CN102525974A (zh) * | 2011-08-31 | 2012-07-04 | 南京仕必得生物技术有限公司 | 犬猫用美洛昔康片以及其制备方法 |
CN103054872B (zh) * | 2013-01-24 | 2014-06-04 | 宁夏康亚药业有限公司 | 美洛昔康药物组合物及其制备方法 |
CN107970219A (zh) * | 2017-12-27 | 2018-05-01 | 佛山市南海东方澳龙制药有限公司 | 宠物用美洛昔康片及其制备方法和应用 |
-
2003
- 2003-12-09 CN CN 200310111142 patent/CN1233323C/zh not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020262618A1 (en) * | 2019-06-28 | 2020-12-30 | Ssp Co., Ltd. | Meloxicam-containing granulated product |
JP7348703B2 (ja) | 2019-06-28 | 2023-09-21 | エスエス製薬株式会社 | メロキシカム含有造粒物 |
WO2022097024A1 (en) * | 2020-11-06 | 2022-05-12 | Mylan Laboratories Ltd | Pharmaceutical composition comprising meloxicam |
Also Published As
Publication number | Publication date |
---|---|
CN1546033A (zh) | 2004-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20041117 Assignee: Chengdu Shengnuo Biopharm Co.,Ltd. Assignor: CHENGDU SHENGNUO TECH Co.,Ltd. Contract record no.: 2010510000012 Denomination of invention: Orally disintegrating tablet of meloxicam and its preparation Granted publication date: 20051228 License type: Exclusive License Record date: 20100412 |
|
C56 | Change in the name or address of the patentee |
Owner name: CHENGDU SHENGNUO BIOTEC CO., LTD. Free format text: FORMER NAME: SHENGNUO SCIENCE AND TECHNOLOGY DEVELOPMENT CO LTD, CHENGDU |
|
CP01 | Change in the name or title of a patent holder |
Address after: 610041 No. 111, Xiaojiahe street, hi tech Zone, Sichuan, Chengdu Patentee after: Chengdu Shengnuo BioTec Co.,Ltd. Address before: 610041 No. 111, Xiaojiahe street, hi tech Zone, Sichuan, Chengdu Patentee before: CHENGDU SHENGNUO TECH Co.,Ltd. |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20051228 |