CN1228066C - Oral liquid for tonifying-kidney and qi contg. eighteen herb medicines, and prepn. method thereof - Google Patents

Oral liquid for tonifying-kidney and qi contg. eighteen herb medicines, and prepn. method thereof Download PDF

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CN1228066C
CN1228066C CN 02139823 CN02139823A CN1228066C CN 1228066 C CN1228066 C CN 1228066C CN 02139823 CN02139823 CN 02139823 CN 02139823 A CN02139823 A CN 02139823A CN 1228066 C CN1228066 C CN 1228066C
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parts
radix
concentrated
fructus
kidney
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CN1513483A (en
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姚曙康
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Hunan Star Sword Pharmaceutical Group Co Ltd
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Abstract

The present invention relates to oral liquid for tonifying kidneys and qi with eighteen herb medicines, which is a traditional Chinese medicine preparation and has the main components of 5 to 8 parts of antler, 5 to 8 parts of American ginseng, 30 to 50 parts of ginseng, 20 to 30 parts of geckoes, 50 to 80 parts of cynomorium, 80 to 120 parts of broomrape, 60 to 90 parts of common curculigo rhizome, 60 to 90 parts of milk vetch, 80 to 100 parts of psoralea, 60 to 90 parts of morinda root, 60 to 90 parts of barrenwort, 80 to 120 parts of dogwood, 60 to 80 parts of dodder, etc. The processing method of the oral liquid comprises: the antler, the ginseng, the geckoes and the American ginseng are taken; alcohol is added as a solvent for soaking the materials for 49 days; the materials are filtered; filtration liquid is concentrated; the rest sixteen Chinese medicines in the recipe of medicine dregs are decocted twice by adding water, and are filtered; after being combined twice, the filtration liquid is concentrated; the alcohol is added for extraction; the liquid first concentrated and the liquid second concentrated are combined and uniformly stirred; sucrose or honey is added for adjusting a total amount; the concentrated liquid is uniformly stirred, filled and sterilized for obtaining a finished product. The product obtains approval registered numbers of national medicine on September 30th, 2002. The present invention has the efficacy of nourishing kidneys, strengthening yang, supplying semen, filling marrow, supplementing qi, nourishing yin, etc., and can treat leukopenia due to senile body weakness, hypaphrodisia, impotence, prospermia and deficiency of the kidneys and the qi.

Description

18 flavor tonify Qi of the kidney oral liquid and preparation methoies
Technical field
The present invention relates to a kind of Chinese medicine oral liquid of tonifying Qi of the kidney, relate to the preparation method of this medicine simultaneously.
Background technology
Along with the progress and development of society, the improvement of people's sanitary condition, middle-aged and elderly people accounts for the population ratio to be increased year by year.Antidotal research has become demands of social development.In addition, development of modern industry pollutes to environment, waste gas as the generation of chemical industry such as chemical fertilizer, pesticide, the electronic game machine in the mobile phone that the computer of the CT scan of hospital, x-ray fluoroscopy, office, communication are used, the colour TV of family, street corner or the like, human body is all produced radiation, affect the intravital leukocyte of people to some extent.Especially the radiotherapy of malignant tumor is that responsive hematopoietic cell is directly killed in radiation, produces apparent myelosuppression, makes leukopenia.Also have some cancer therapy drugs to cause human leukocytes to reduce in a large number, immune function of human body is descended, infectious disease or the like takes place easily.
Over past ten years, the medicine of relevant kidney invigorating and YANG supporting progressively increases, and wherein applies for a patent quite a few.The retrieval Chinese patent literature as can be known, application number is 94,110,398 1 kinds of kidney tonifying oral liquid medicines and preparation method, this medicine is made up of 24 flavor Chinese medicines such as Cornu Cervi Pantotrichum, Gecko, Radix Ginseng, the Radix Astragali, Cortex Cinnamomi, Fructus Psoraleae, Radix Achyranthis Bidentatae, Herba Epimedii, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Corni, Radix Morindae Officinalis, contains three kinds of animal kidneys in the side.Its effect is kidney invigorating and YANG supporting, defying age.Application number is 95110175 " Hushengbaoyuanye (medicinal solution for male body promoting) formula and preparation method thereof ", this medicine is made up of 16 flavor Chinese medicines such as Radix Ginseng, Cornu Cervi Pantotrichum, Fructus Lycii, Semen Cuscutae, Herba Epimedii, Radix Morindae Officinalis, Fructus Corni, sucrose, also have male Bombycis mori, Formica fusca, Aspongopus etc. in the side, function is a kidney invigorating and YANG supporting, life essence-filling, marrow-benefitting cures mainly deficiency of kidney-YANG syndrome.Application number is that 97112883 " Tianjing Busuiye medicinal liquid and manufacture methods " are authorized, this medicine mainly is made up of 25 kinds of Chinese and western drugses such as calf thymus, spleen, Radix Ginseng, Hippocampus, Herba Epimedii, Fructus Psoraleae, Radix Scutellariae, Radix Et Caulis Acanthopanacis Senticosi, procaine and animal thymus etc., and main effect is kidney invigorating and YANG supporting, slow down aging, raising immune function of human body.In addition, also having application number is 93,100,397 1 kinds of Yin-nourishing and Yang-strengthening health Chinese medicines.The prescription of 93,111,064 1 kinds of Chinese medicine health-care oral liquids and preparation method etc.Popular kidney-reinforcing drug has " converge with core renal aid " etc. on the market, and as for the medicine that the treatment human leukocytes reduces, curative effect is not high, not lasting mostly at present.
Summary of the invention
The purpose of this invention is to provide a kind of medicine of tonifying Qi of the kidney, be used for kidney invigorating and YANG supporting, old asthenia and the thanks to empty leukopenia that causes of treatment kidney qi.Another object of the present invention provides the preparation method of this medicine.
The object of the present invention is achieved like this, because human leukocytes all is from bone marrow, the variation of its quantity and quality all can reflect the functional status of bone marrow hematogenesis tissue.A little less than leukopenia and kidney are insufficiency of the spleen substantial connection is arranged, the kidney being the origin of congenital constitution, kidney governing bones, kidney are given birth to marrow, the then marrow deficiency of suffering from a deficiency of the kidney.By warming and recuperating the kidney-YANG, kidney and spleen invigorating, the conditioning kidney qi is lost empty, rises white purpose thereby reach hemopoietic.The medicine that the present invention's 18 flavors are tonified Qi of the kidney is made by the following weight proportion raw material:
Cornu Cervi Pantotrichum 5-8 part Radix Panacis Quinquefolii 5-8 part Radix Ginseng 30-50 part
Gecko 20-30 part Herba Cynomorii 50-80 part Herba Cistanches 80-120 part
Rhizoma Curculiginis 60-90 part Radix Astragali 60-90 part Fructus Psoraleae 80-100 part
Radix Morindae Officinalis 60-90 part Herba Epimedii 60-90 part Fructus Corni 80-120 part
Semen Cuscutae 60-80 part Fructus Alpiniae Oxyphyllae 50-80 part Fructus Lycii 80-120 part
Cortex Cinnamomi 20-30 part Radix Scutellariae 20-30 part Pericarpium Citri Reticulatae 20-30 part
Radix Achyranthis Bidentatae 50-80 part Radix Rehmanniae Preparata 60-80 part.
The above-mentioned 18 flavor medicines of tonifying Qi of the kidney, each material medicine optimum weight proportioning is:
30 parts of 5 parts of Radix Ginsengs of 5 parts of Radix Panacis Quinquefoliis of Cornu Cervi Pantotrichum
120 parts of 50 parts of Herba Cistanches of 20 parts of Herba Cynomoriis of Gecko
100 parts of 60 parts of Fructus Psoraleaes of 60 parts of Radixs Astragali of Rhizoma Curculiginis
100 parts of 60 parts of Fructus Corni of 60 parts of Herba Epimedii of Radix Morindae Officinalis
120 parts of 80 portions of Fructus Lyciis of 60 parts of Fructus Alpiniae Oxyphyllae of Semen Cuscutae
20 parts of 20 parts of Pericarpium Citri Reticulataes of 20 parts of Radix Scutellariaes of Cortex Cinnamomi
60 parts in 50 parts of Radix Rehmanniaes Preparata of Radix Achyranthis Bidentatae.
Said medicine has 20 flavors, wherein plant medicine 18 flavors.The dosage form of said medicine can be capsule or electuary or tablet, is best with the oral liquid.
The preparation method of said medicine oral liquid is: 1) get Cornu Cervi Pantotrichum, Radix Ginseng, Gecko, Radix Panacis Quinquefolii, 50% ethanol that adds 7 times of amounts is made solvent, soaks 49 days, filters filtrate recycling ethanol; 2) it is standby that filtrate is concentrated into the pulpous state concentrated solution; 3) decocting that all the other 16 flavor Chinese medicines add 8 times of amounts in medicinal residues and the prescription boiled 1.5 hours, collected decocting liquid, and the decocting that filtering residue adds 6 times of amounts again boiled 1 hour, filtered; 4) be concentrated into pulpous state after twice filtrate of merging, adding ethanol is 65% to containing the alcohol amount, stirs, and leaves standstill 48 hours, filters; Filtrate recycling ethanol with its concentrated solutions such as Radix Ginseng merging with aforementioned gained, stirs evenly to there not being the alcohol flavor again; Left standstill 48 hours, and filtered; 5) with sucrose or Mel, adjust total amount to 1000ml, stir evenly, fill, sterilization is promptly.
Medicine of the present invention is examined the side through the famous old docter of TCM Ou Yangqi academician in the whole nation, Hunan Province, and evaluates several times by medical professor expert of educational circles, all speaks highly of.Nineteen ninety-five begins, bear pharmacology, toxicological study work by the Hunan Inst of Traditional Chinese Medicine, the drug effect by three big effects and ten indexs detects and shows: this product has obvious rising effect, face nourishing antidebilitation, kidney invigorating and YANG supporting to leukopenia, effect significantly is better than like product.Particularly, fill up the blank in China's medical insurance to the rising of leukopenia.This product is passed through through the evaluation of national drug evaluation committee, through health ministry clinical pharmacology base---hospitals such as Hunan Chinese medicine institute, attached one, two hospitals of the Hunan Province college of traditional Chinese medicine, the attached Second Academy of Hunan Medical University have done routine clinical verification surplus in the of 300: lose the empty leukopenia that causes for the men and women because of kidney qi, particularly malignant tumor put, the leukopenia patient after the chemotherapy, obvious effective rate is 46.7%, and effective percentage is 80%; Old old and feeble disease effective percentage 92% Neo-Confucianism such as lazy speech, aversion to cold and cold limbs, hoariness and alopecia, senile plaque pitch, lose heart tinnitus, tooth; Sexual impotence, sexual hypofunction, waist soreness, insomnia health, nocturia, blurred vision, hypomnesis etc. are all had obvious effects, and effective percentage reaches more than 95%.This product is safe in utilization, has no side effect.On JIUYUE 30th, 2002, and this product obtains the accurate font size certification of National Drug Administration: the accurate word B20020473 of traditional Chinese medicines, standard numbering: WS-5452 (B-0452)-2002.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Example 1: medicine of the present invention is write out a prescription by following crude drug weight ratio:
30 parts of 5 parts of Radix Ginsengs of 5 parts of Radix Panacis Quinquefoliis of Cornu Cervi Pantotrichum
120 parts of 50 parts of Herba Cistanches of 20 parts of Herba Cynomoriis of Gecko
100 parts of 60 parts of Fructus Psoraleaes of 60 parts of Radixs Astragali of Rhizoma Curculiginis
100 parts of 60 parts of Fructus Corni of 60 parts of Herba Epimedii of Radix Morindae Officinalis
120 parts of 80 portions of Fructus Lyciis of 60 parts of Fructus Alpiniae Oxyphyllae of Semen Cuscutae
20 parts of 20 parts of Pericarpium Citri Reticulataes of 20 parts of Radix Scutellariaes of Cortex Cinnamomi
60 parts in 50 parts of Radix Rehmanniaes Preparata of Radix Achyranthis Bidentatae.
Be that unit takes by weighing raw material according to the above ratio with the gram, give as one thinks fit cataclasm, according to the following steps processing:
1) get Cornu Cervi Pantotrichum, Radix Ginseng, Gecko, Radix Panacis Quinquefolii, 50% ethanol that adds 7 times of amounts is done the solvent sealing, soaks 49 days, constantly stirs, and filters, and filtrate recycling ethanol is to there not being the alcohol flavor;
2) it is standby that filtrate is concentrated into the pulpous state concentrated solution;
3) decocting that all the other 16 flavor Chinese medicines add 8 times of amounts in medicinal residues and the prescription boiled 1.5 hours, filtered and collected decocting liquid, and the decocting that filtering residue adds 6 times of amounts again boiled 1 hour, filtered;
4) be concentrated into pulpous state after twice filtrate of merging, relative density is about 1.15, and adding ethanol again is 65% to containing the alcohol amount, stirs, and leaves standstill 48 hours, filters; Filtrate recycling ethanol is not to there being the alcohol flavor, and concentrated solutions such as the Radix Ginseng merging with concentrated solution and aforementioned gained stirs evenly; Left standstill 48 hours, and filtered;
5) filtrate is adjusted total amount to 1000ml with sucrose or Mel, stir evenly, and fill, sterilization got product in 30 minutes under 70 ℃.
Example 2: medicine of the present invention also can be made by following materials of weight proportions:
40 parts of 6 parts of Radix Ginsengs of 6 parts of Radix Panacis Quinquefoliis of Cornu Cervi Pantotrichum
100 parts of 60 parts of Herba Cistanches of 30 parts of Herba Cynomoriis of Gecko
80 parts of 80 parts of Fructus Psoraleaes of 80 parts of Radixs Astragali of Rhizoma Curculiginis
90 parts of 80 parts of Fructus Corni of 80 parts of Herba Epimedii of Radix Morindae Officinalis
90 parts of 60 portions of Fructus Lyciis of 80 parts of Fructus Alpiniae Oxyphyllae of Semen Cuscutae
30 parts of 20 parts of Pericarpium Citri Reticulataes of 20 parts of Radix Scutellariaes of Cortex Cinnamomi
70 parts in 60 parts of Radix Rehmanniaes Preparata of Radix Achyranthis Bidentatae.
Its technological process is the same.
This product is brownish red or brown liquid, and it is sweet to distinguish the flavor of, little hardship.Relative density 〉=1.08, pH value are 3.5-5.5, and specification is every 10ml.This product contains Fructus Psoraleae with psoralen (C 11H 6O 3) and isopsoralen (C 11H 6O 3) summation meter, every milliliter is no less than 0.03mg.
Medicine of the present invention is studied for many years by inventor Yao Shu health succession secret prescription handed down in the family from generation to generation and is formed, and entrusts the processing of Hengyang Yan Heng pharmaceutical factory.On November 19th, 1993 was agreed trial production by Hunan Province bureau of drug administration reply (No. 187 literary composition of medicine marking-up defended in Hunan), and commodity were called " sea God's oral liquid " at that time, authentication code: strong word (1993) 101-018 of medicine is defended in Hunan.Nineteen ninety-five JIUYUE 5 days, Hunan Province bureau of drug administration reply (No. 107 literary composition of medicine marking-up defended in Hunan), agree to revise sea God's oral liquid effect purposes and be: " kidney invigorating and YANG supporting, beneficial essence are filled out marrow, supplementing QI and nourishing YIN.Be used for old asthenia, hyposexuality, impotence and premature ejaculation, waist soreness, aversion to cold and cold limbs, nocturia, spiritlessness and weakness and kidney qi and lose the empty leukopenia that causes." on JIUYUE obtained the national drug authentication code in 30 2002: the accurate word B20020473 of traditional Chinese medicines.And former " sea God's oral liquid " renamed as " 18 flavors tonify Qi of the kidney oral liquid ".
The clinical verification report of relevant medicine of the present invention is finished by specified hospital of national Bureau of Drugs Supervision, submits to when proposing examination as to substances, and encloses relevant documentary evidence.

Claims (3)

1, the 18 flavor oral liquids of tonifying Qi of the kidney is characterized in that it is the medicament of being made by the following weight proportion raw material:
Cornu Cervi Pantotrichum 5-8 part Radix Panacis Quinquefolii 5-8 part Radix Ginseng 30-50 part
Gecko 20-30 part Herba Cynomorii 50-80 part Herba Cistanches 80-120 part
Rhizoma Curculiginis 60-90 part Radix Astragali 60-90 part Fructus Psoraleae 80-100 part
Radix Morindae Officinalis 60-90 part Herba Epimedii 60-90 part Fructus Corni 80-120 part
Semen Cuscutae 60-80 part Fructus Alpiniae Oxyphyllae 50-80 part Fructus Lycii 80-120 part
Cortex Cinnamomi 20-30 part Radix Scutellariae 20-30 part Pericarpium Citri Reticulatae 20-30 part
Radix Achyranthis Bidentatae 50-80 part Radix Rehmanniae Preparata 60-80 part.
2, the 18 flavor oral liquids of tonifying Qi of the kidney according to claim 1, wherein the weight proportion of each raw material is:
30 parts of 5 parts of Radix Ginsengs of 5 parts of Radix Panacis Quinquefoliis of Cornu Cervi Pantotrichum
120 parts of 50 parts of Herba Cistanches of 20 parts of Herba Cynomoriis of Gecko
100 parts of 60 parts of Fructus Psoraleaes of 60 parts of Radixs Astragali of Rhizoma Curculiginis
100 parts of 60 parts of Fructus Corni of 60 parts of Herba Epimedii of Radix Morindae Officinalis
120 parts of 80 portions of Fructus Lyciis of 60 parts of Fructus Alpiniae Oxyphyllae of Semen Cuscutae
20 parts of 20 parts of Pericarpium Citri Reticulataes of 20 parts of Radix Scutellariaes of Cortex Cinnamomi
60 parts in 50 parts of Radix Rehmanniaes Preparata of Radix Achyranthis Bidentatae.
3, the preparation method of the described oral liquid of tonifying Qi of the kidney of claim 2 is characterized in that: take by weighing raw material in described ratio, and cataclasm, processing according to the following steps:
1) get Cornu Cervi Pantotrichum, Radix Ginseng, Gecko, Radix Panacis Quinquefolii, 50% ethanol that adds 7 times of amounts is made solvent, soaks 49 days, filters filtrate recycling ethanol;
2) it is standby that filtrate is concentrated into the pulpous state concentrated solution;
3) decocting that all the other 16 flavor Chinese medicines add 8 times of amounts in medicinal residues and the prescription boiled 1.5 hours, collected decocting liquid, and the decocting that filtering residue adds 6 times of amounts again boiled 1 hour, filtered;
4) be concentrated into pulpous state after twice filtrate of merging, adding ethanol is 65% to containing the alcohol amount, stirs, and leaves standstill 48 hours, filters; Filtrate recycling ethanol with its concentrated solutions such as Radix Ginseng merging with aforementioned gained, stirs evenly to there not being the alcohol flavor again; Left standstill 48 hours, and filtered;
5) with sucrose or Mel, adjust total amount to 1000ml, stir evenly, fill, sterilization is promptly.
CN 02139823 2002-12-11 2002-12-11 Oral liquid for tonifying-kidney and qi contg. eighteen herb medicines, and prepn. method thereof Expired - Fee Related CN1228066C (en)

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