CN1222529C - 水溶性雷怕霉素酯类 - Google Patents

水溶性雷怕霉素酯类 Download PDF

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Publication number
CN1222529C
CN1222529C CNB018159117A CN01815911A CN1222529C CN 1222529 C CN1222529 C CN 1222529C CN B018159117 A CNB018159117 A CN B018159117A CN 01815911 A CN01815911 A CN 01815911A CN 1222529 C CN1222529 C CN 1222529C
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CN
China
Prior art keywords
compound
contain
carbon atom
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018159117A
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English (en)
Chinese (zh)
Other versions
CN1460108A (zh
Inventor
朱天民
M·B·福兹
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Wyeth LLC
Wyeth Inc
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CN1460108A publication Critical patent/CN1460108A/zh
Application granted granted Critical
Publication of CN1222529C publication Critical patent/CN1222529C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
CNB018159117A 2000-09-19 2001-09-13 水溶性雷怕霉素酯类 Expired - Fee Related CN1222529C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23377600P 2000-09-19 2000-09-19
US60/233,776 2000-09-19

Publications (2)

Publication Number Publication Date
CN1460108A CN1460108A (zh) 2003-12-03
CN1222529C true CN1222529C (zh) 2005-10-12

Family

ID=22878646

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018159117A Expired - Fee Related CN1222529C (zh) 2000-09-19 2001-09-13 水溶性雷怕霉素酯类

Country Status (13)

Country Link
US (1) US6432973B1 (US06432973-20020813-C00004.png)
EP (1) EP1319008B1 (US06432973-20020813-C00004.png)
JP (1) JP2004509898A (US06432973-20020813-C00004.png)
CN (1) CN1222529C (US06432973-20020813-C00004.png)
AT (1) ATE411321T1 (US06432973-20020813-C00004.png)
AU (1) AU2001290841A1 (US06432973-20020813-C00004.png)
BR (1) BR0113975A (US06432973-20020813-C00004.png)
CA (1) CA2421485A1 (US06432973-20020813-C00004.png)
DE (1) DE60136200D1 (US06432973-20020813-C00004.png)
DK (1) DK1319008T3 (US06432973-20020813-C00004.png)
ES (1) ES2313983T3 (US06432973-20020813-C00004.png)
MX (1) MXPA03002258A (US06432973-20020813-C00004.png)
WO (1) WO2002024706A2 (US06432973-20020813-C00004.png)

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ATE426414T1 (de) * 2002-05-15 2009-04-15 Endocyte Inc Vitamin-mitomycin-konjugate
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WO2004014222A2 (en) * 2002-08-12 2004-02-19 The Regents Of The University Of Michigan Diagnosis and treatment of tuberous sclerosis
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AU2004232308A1 (en) * 2003-04-23 2004-11-04 Wyeth Holdings Corporation PEG-wortmannin conjugates
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WO2006012527A1 (en) * 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
JP2008533007A (ja) * 2005-03-07 2008-08-21 ワイス ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
US20080280937A1 (en) * 2005-08-19 2008-11-13 Christopher Paul Leamon Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
KR20130113543A (ko) * 2005-08-19 2013-10-15 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
CN101351702A (zh) * 2005-12-07 2009-01-21 惠氏公司 结晶雷帕霉素的制备方法以及使用差示扫描量热法测量雷帕霉素化合物结晶度的方法
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CN101321769A (zh) 2005-12-07 2008-12-10 惠氏公司 制备纯化的晶体cci-779的方法
US7605257B2 (en) * 2006-03-07 2009-10-20 Wyeth Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
US20080207671A1 (en) * 2006-07-31 2008-08-28 The Regents Of The University Of Michigan Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
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US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
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RU2523909C2 (ru) * 2007-06-25 2014-07-27 Эндосайт, Инк. Конъюгаты, содержащие гидрофильные спейсеры линкеров
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Also Published As

Publication number Publication date
DK1319008T3 (da) 2009-02-09
US20020055518A1 (en) 2002-05-09
US6432973B1 (en) 2002-08-13
WO2002024706A3 (en) 2002-10-10
EP1319008A2 (en) 2003-06-18
BR0113975A (pt) 2003-07-29
MXPA03002258A (es) 2003-06-24
CA2421485A1 (en) 2002-03-28
ATE411321T1 (de) 2008-10-15
JP2004509898A (ja) 2004-04-02
ES2313983T3 (es) 2009-03-16
WO2002024706A2 (en) 2002-03-28
DE60136200D1 (de) 2008-11-27
AU2001290841A1 (en) 2002-04-02
EP1319008B1 (en) 2008-10-15
CN1460108A (zh) 2003-12-03

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