CN1220506C - 治疗脂肪肝的中药制剂及制作方法 - Google Patents
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Abstract
一种治疗脂肪肝的中药制剂及制作方法，它的原料及重量百分比含量是，泽泻12-30%，丹参10-25%，山楂12-30%，决明子10-25%，制何首乌5-20%，柴胡5-20%。其制作方法是：首先按比例将泽泻、丹参、山楂分别加乙醇回流提取2次，每次2小时；将泽泻、丹参、山楂的提取液合并，过滤，减压回收乙醇至无醇味时，浓缩成清膏；将泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子、制何首乌、柴胡加水浸泡2小时，浸泡后煎煮两次，将上述清膏与滤液合并浓缩成清膏，将清膏真空干燥，成为干浸膏粉备用；往膏粉内加入淀粉，混匀，然后加入乙醇适量泛丸，制成成品。本发明经临床使用证明，治疗效果显著，无毒副作用。
Description
技术领域
本发明涉及一种治疗肝病的中药，特别是治疗脂肪肝的中药制剂及制作方法。
背景技术
随着生活水平的不断提高，脂肪肝的发病率也越来越高，治疗脂肪肝的中药药品一般选用丹参降脂，单一的丹参降脂治疗效果不显著，复发率高。制止目前还没有单纯治疗脂肪肝的中药复方药品出现。
发明内容
本发明的目的在于提供一种由六种中药原料组成，按照一定的生产工艺生产制作的治疗脂肪肝的中药制剂及制作方法。
本发明的目的是这样实现的：它的原料及重量百分比含量是，泽泻12-30％，丹参10-25％，山楂12-30％，决明子10-25％，制何首乌5-20％，柴胡5-20％。
它的制作方法按下述步骤进行，
a、首先按比例将泽泻12-30％、丹参10-25％、山楂12-30％分别加浓度为60-80％的乙醇回流提取2次，每次2小时；
b、将泽泻、丹参、山楂的提取液合并，过滤，减压回收乙醇至无醇味时，浓缩成一定相对密度的清膏，清膏备用；
c、将泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子10-25％、制何首乌5-20％、柴胡5-20％加水浸泡2小时，浸泡后煎煮两次，合并煎液，并将其过滤，滤液备用；
d、将上述清膏与滤液合并浓缩至一定相对密度的清膏，将清膏真空干燥，成为干浸膏粉备用；
e、往膏粉内加入淀粉，混匀，然后加入乙醇适量泛丸，制成成品。
本发明的各种药物的药理作用是：泽泻具有利小便，清湿热的功能。用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高血脂。丹参祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭闭经，病瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠，肝脾肿大，心绞痛。山楂消食建胃，行气散瘀。用于肉食积滞，胃脘疼痛，泻痢腹痛，瘀血经闭，疝气疼痛，高脂血症。柴胡和解表里，疏肝升阳。用于感冒发热，寒热往来，胸肋胀痛，月经不调，子宫脱垂，脱肛。决明子清热明目，润肠通便。用于目赤涩痛，羞明多泪，头痛眩晕，目暗不明，大便秘结。制何首乌补肝肾，益精血，乌须发强筋骨。用于血虚萎黄，眩晕耳鸣，须发早白，腰膝酸软，肢体麻木，崩漏带下，久疟体虚，高脂血。
本发明经临床使用证明，以上述药物为原料，经精湛的加工工艺制得的中药制剂，治疗效果显著，无毒副作用。它的原料易得，生产工艺简单，操作容易。尤其是服用本发明可彻底地根治脂肪肝，加快代谢，复发率几乎为零。
具体实施方式
本发明原料的重量百分比含量实施例如下表：
表1
| 原料名称 | 重量百分比含量(％) | |||||
| 泽泻 | 15 | 20 | 25 | 12 | 30 | 18 |
| 丹参 | 10 | 20 | 25 | 15 | 18 | 10 |
| 山楂 | 20 | 20 | 12 | 23 | 15 | 30 |
| 决明子 | 15 | 25 | 10 | 20 | 22 | 18 |
| 制何首乌 | 20 | 5 | 18 | 15 | 10 | 12 |
| 柴胡 | 20 | 10 | 10 | 15 | 5 | 12 |
| 合计 | 100 | 100 | 100 | 100 | 100 | 100 |
本发明的制作方法实施例：
1、按上述比例称取泽泻、丹参、山楂、分别将泽泻、丹参、山楂，加浓度为60-85％的乙醇在多功能提取罐内回流2次，每次2小时。
2、然后将三种药物的回流提取液合并在一起，用60目的筛网过滤，将过滤后的药液放入乙醇回收罐内减压回流至无醇味止，然后放入真空浓缩罐内浓缩成相对密度为0.8-1.5的清膏备用。
3、将泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子、制何首乌、柴胡混合加水(每1kg加水8kg)浸泡2小时，浸泡后煎煮2小时后过滤，滤液备用。然后再次加水煎煮泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子、制何首乌、柴胡1.5小时，并将煎液过滤，滤液备用；将两次煎煮的滤液合并，再次过滤，滤液备用。
4、将上述清膏与滤液合并浓缩至相对密度为0.8-1.5的清膏，将相对密度的清膏放入喷雾干燥机真空干燥，成为干浸膏粉备用；
5、往膏粉内加入淀粉，每42g的细粉加入淀粉8g，混和均匀后加入浓度为60-85％的乙醇，每公斤混合细粉加入适量乙醇泛丸，乙醇泛丸的加入量依季节和膏粉的性质盯，如果膏粉潮，则少加，反之亦反。制成成品固体制剂装袋，每袋5克。
本发明的服用方法：口服每日三次，每次5克。
本发明作为治疗脂肪肝和高血脂症的制剂在临床上已应用多年，有较好的疗效。临床观察肥胖性脂肪肝30例，疗程3个月，结果表明总显效率为70％，总有效率93.3％。对湿浊内停，肝郁血瘀症的总显效率为73.5％，总有效率为96.7％。本发明可明显改善患者胁肋痛胀，脘腹胀满，食欲不振，大便不爽及肝肿大等主要症状体征，对血脂ACT的异常亦有较为显著的改善效果。观察过程中没有发现明显不良反应。
Claims (4)
1、一种治疗脂肪肝的中药制剂，其特征在于，它的原料及重量百分比含量是，泽泻12-30％，丹参10-25％，山楂12-30％，决明子10-25％，制何首乌5-20％，柴胡5-20％。
2一种治疗脂肪肝的中药制剂的制作方法，其特征在于，它按下述步骤进行，
a、首先按比例将泽泻12-30％、丹参10-25％、山楂12-30％分别加浓度为60-80％的乙醇回流提取2次，每次2小时；
b、将泽泻、丹参、山楂的提取液合并，过滤，减压回收乙醇至无醇味时，浓缩成一定相对密度的清膏，清膏备用；
c、将泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子10-25％、制何首乌5-20％、柴胡5-20％加水浸泡2小时，浸泡后煎煮两次，合并煎液，并将其过滤，滤液备用；
d、将上述清膏与滤液合并浓缩至一定相对密度的清膏，将清膏真空干燥，成为干浸膏粉备用；
e、往膏粉内加入淀粉，混匀，然后加入乙醇适量泛丸，制成成品。
3、根据权利要求2所述的治疗脂肪肝的中药制剂的制作方法，其特征在于，泽泻、丹参、山楂过滤后的药渣与按比例称取的决明子、制何首乌、柴胡加水浸泡后第一次煎煮2小时，第二次煎煮1.5小时。
4、根据权利要求1或2所述的治疗脂肪肝的中药制剂及制作方法，其特征在于所述清膏的相对密度为0.8-1.5，泛丸用乙醇的浓度为70-90％。
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| CN1330346C (zh) * | 2005-05-22 | 2007-08-08 | 崔秀芝 | 治疗高血压、高血脂的中成药及其制备方法 |
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| CN103230486B (zh) * | 2013-04-17 | 2014-11-05 | 苏州深久医药生物技术有限公司 | 一种中药组合物及其制备方法以及在制备治疗脂肪肝药物中的应用 |
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