CN1215874C - 一种止咳平喘化痰药及其制备工艺 - Google Patents
一种止咳平喘化痰药及其制备工艺 Download PDFInfo
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- CN1215874C CN1215874C CN 03152998 CN03152998A CN1215874C CN 1215874 C CN1215874 C CN 1215874C CN 03152998 CN03152998 CN 03152998 CN 03152998 A CN03152998 A CN 03152998A CN 1215874 C CN1215874 C CN 1215874C
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 剂量(g/kg) | EDT50(秒) | R值 |
对照组 | 同容量 | 15.5 | |
本发明组 | 0.99 | 32.3 | 208% |
咳喘宁片组 | 1.07 | 23.44 | 151% |
组别 | 剂量(g/kg) | 气管分泌物引流量(mm/100g) | 相对百分率 |
对照组 | 同容量 | 7.35±1.02 | 100 |
本发明组 | 0.69 | 15.73±4.91 | 214 |
咳喘宁片组 | 0.75 | 17.53+6.56 | 239 |
组别 | 剂 量(g/kg) | 引喘潜伏期(秒)( x±SE) | 延长时间(秒) | 延长率(%) | P | |
给药前 | 给药后 |
对照组 | 同容量 | 90.55±15.1 | 117.82±21.53 | 27.27 | 30.2 | |
本发明组 | 0.61 | 71.57±24.07 | 151.55±31.38 | 79.98 | 111.5 | <0.05 |
咳喘宁片组 | 0.67 | 79.75+31.64 | 113.75±32.27 | 34.0 | 42.7 | >0.05 |
组别 | 剂 量(g/kg) | 组织胺反应高度(mm)( x±SE) | 药物加组织胺反应高度(mm)( x±SE) | 抑制率(%) |
本发明组 | 10-4 | 11.92±2.83 | 11.53±2.50 | 5.2 |
咳喘宁片组 | 5×10-3 | 12.10±3.12 | 11.83±2.80 | 2.4 |
药物 | 剂量(g/kg) | 观察项目 | 给药前 | 给药后(分) x±SE | ||||
20 | 30 | 40 | 60 | 90 | ||||
生理 | 同容积 | 呼吸(次/分) | 46±2.83 | 48±0 | 44±1.41 | 40±1.41 | 39±1.41 | 43±0 |
盐水组 | 心率(次/分) | 177.5±148.5 | 177.5±14.85 | 177.5±148.5 | 177.5±14.85 | 177.5±14.85 | 177.5±14.85 | |
血压(mmHg) | 155+7.07 | 152.5±3.54 | 148±0 | 145±0 | 137.5±3.54 | 127.5±10.60 | ||
血压下降(%) | -1.6 | -4.5 | -6.5 | -11.3 | -17.7 | |||
本发明组 | 0.30 | 呼吸(次/分) | 35.5±3.54 | 43±25.46 | 34±31.18 | 39.5±14.85 | 44±19.80 | 33±11.31 |
心率(次/分) | 151.5±21.92 | 177.5±14.85 | 177.5±148.5 | 177.5±14.85 | 130.5±7.78 | 130.5±7.78 | ||
血压(mmHg) | 142.5±45.96 | 155±21.21 | 151.5±23.33 | 147.5±17.68 | 129±1.41 | 121.5±4.95 | ||
血压下降(%) | 8.7 | 6.3 | 3.5 | -9.4 | -14.7 | |||
咳喘宁片组 | 0.32 | 呼吸(次/分) | 37±8.49 | 30±7.07 | 31±2.83 | 28.5±2.12 | 29.5±3.54 | 28.5±2.12 |
心率(次/分) | 155±16.97 | 155±26.87 | 165±9.90 | 164±0 | 164±0 | 164±0 | ||
血压(mmHg) | 139±29.70 | 129.5±26.16 | 128.4±15.56 | 124.4±15.56 | 120.5±4.95 | 119±15.56 | ||
血压下降(%) | -6.8 | -7.6 | -10.5 | -13.3 | -14.3 |
Claims (5)
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CN 03152998 CN1215874C (zh) | 2003-09-12 | 2003-09-12 | 一种止咳平喘化痰药及其制备工艺 |
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CN 03152998 CN1215874C (zh) | 2003-09-12 | 2003-09-12 | 一种止咳平喘化痰药及其制备工艺 |
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CN1490043A CN1490043A (zh) | 2004-04-21 |
CN1215874C true CN1215874C (zh) | 2005-08-24 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101979066B (zh) * | 2010-11-19 | 2012-06-06 | 孙丽 | 定喘祛痰雾化液及其制备方法 |
CN102716400B (zh) * | 2012-07-02 | 2014-11-05 | 罗碧 | 小儿清肺止咳汤 |
CN105497712A (zh) * | 2015-12-21 | 2016-04-20 | 贵州瑞和制药有限公司龙里药厂 | 一种咳喘宁制剂的制作方法 |
CN113244346A (zh) * | 2016-08-30 | 2021-08-13 | 北京盈科瑞创新医药股份有限公司 | 一种咳喘宁雾化吸入用溶液制剂及其制备方法 |
CN112569322A (zh) * | 2020-12-30 | 2021-03-30 | 成都正中医疗投资管理有限公司 | 一种具有止咳平喘作用的药物组合物 |
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- 2003-09-12 CN CN 03152998 patent/CN1215874C/zh not_active Expired - Lifetime
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