CN121159628A - Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途 - Google Patents

Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

Info

Publication number
CN121159628A
CN121159628A CN202510609954.0A CN202510609954A CN121159628A CN 121159628 A CN121159628 A CN 121159628A CN 202510609954 A CN202510609954 A CN 202510609954A CN 121159628 A CN121159628 A CN 121159628A
Authority
CN
China
Prior art keywords
peptide
amino acid
lung
seq
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510609954.0A
Other languages
English (en)
Chinese (zh)
Inventor
D·克里斯滕森
J·J·科冷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ryan Treatment Co
Original Assignee
Ryan Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ryan Treatment Co filed Critical Ryan Treatment Co
Publication of CN121159628A publication Critical patent/CN121159628A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202510609954.0A 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途 Pending CN121159628A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862728997P 2018-09-10 2018-09-10
US62/728997 2018-09-10
CN201980059209.6A CN112739367B (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途
PCT/US2019/050332 WO2020055812A1 (en) 2018-09-10 2019-09-10 Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980059209.6A Division CN112739367B (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

Publications (1)

Publication Number Publication Date
CN121159628A true CN121159628A (zh) 2025-12-19

Family

ID=69778115

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202510609954.0A Pending CN121159628A (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途
CN201980059209.6A Active CN112739367B (zh) 2018-09-10 2019-09-10 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途

Family Applications After (1)

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Country Status (9)

Country Link
US (4) US11905336B2 (enExample)
EP (1) EP3849580A4 (enExample)
JP (3) JP7496826B2 (enExample)
KR (2) KR102958241B1 (enExample)
CN (2) CN121159628A (enExample)
AU (2) AU2019339260B2 (enExample)
BR (1) BR112021004404A2 (enExample)
CA (2) CA3111563A1 (enExample)
WO (1) WO2020055812A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230148263A (ko) 2013-03-15 2023-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 누트린-3a 및 펩티드에 의한 폐 섬유증의 저해
KR102958241B1 (ko) 2018-09-10 2026-04-30 레인 테라퓨틱스, 인크. Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도
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WO2021216659A1 (en) * 2020-04-21 2021-10-28 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and uses thereof
EP4168031A4 (en) * 2020-06-19 2024-07-10 Lung Therapeutics, LLC MODIFIED CAVEOLIN-1 PEPTIDES FOR THE TREATMENT OF PATHOGEN-INDUCED LUNG LESION
EP4297768A4 (en) 2021-02-25 2025-01-15 Lung Therapeutics, LLC Biomarkers for the treatment of interstitial lung disease
US20250041383A1 (en) * 2021-06-17 2025-02-06 Lung Therapeutics, Inc. Modified caveolin-1 peptides for the treatment of post-acute covid-19
JP2024539242A (ja) * 2021-10-22 2024-10-28 ラング セラピューティクス，エルエルシー 慢性腎疾患の治療のための改変カベオリン－１ペプチド
EP4554605A4 (en) * 2022-07-12 2026-06-17 Rein Therapeutics Inc MODIFIED CAVELOIN-1 PEPTIDE FORMULATIONS AND THEIR METHODS OF MANUFACTURING AND USING
CN119661656B (zh) * 2024-11-20 2026-05-15 华中科技大学同济医学院附属梨园医院 一种靶向拮抗pCAV1的多肽及其应用

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US20230212223A1 (en) 2023-07-06
JP2022500078A (ja) 2022-01-04
CN112739367B (zh) 2025-06-06
US20210347820A1 (en) 2021-11-11
WO2020055812A1 (en) 2020-03-19
US11905336B2 (en) 2024-02-20
JP2025184877A (ja) 2025-12-18
AU2019339260B2 (en) 2025-06-26
US20260062444A1 (en) 2026-03-05
US11787838B2 (en) 2023-10-17
EP3849580A4 (en) 2022-06-15
KR20210084453A (ko) 2021-07-07
AU2019339260A1 (en) 2021-03-25
JP7737492B2 (ja) 2025-09-10
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