CN121057812A - 人诱导性调节性t细胞及其制作方法以及用于治疗或预防t细胞相关疾病的药物组合物 - Google Patents

人诱导性调节性t细胞及其制作方法以及用于治疗或预防t细胞相关疾病的药物组合物

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Publication number
CN121057812A
CN121057812A CN202480023635.5A CN202480023635A CN121057812A CN 121057812 A CN121057812 A CN 121057812A CN 202480023635 A CN202480023635 A CN 202480023635A CN 121057812 A CN121057812 A CN 121057812A
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CN
China
Prior art keywords
cells
positive
cell
cell population
human
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480023635.5A
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English (en)
Chinese (zh)
Inventor
三上统久
坂口志文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reg Cell Co ltd
University of Osaka NUC
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Reg Cell Co ltd
Osaka University NUC
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Publication date
Application filed by Reg Cell Co ltd, Osaka University NUC filed Critical Reg Cell Co ltd
Publication of CN121057812A publication Critical patent/CN121057812A/zh
Pending legal-status Critical Current

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CN202480023635.5A 2023-03-29 2024-03-28 人诱导性调节性t细胞及其制作方法以及用于治疗或预防t细胞相关疾病的药物组合物 Pending CN121057812A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2023053538 2023-03-29
JP2023-053538 2023-03-29
PCT/JP2024/012680 WO2024204553A1 (ja) 2023-03-29 2024-03-28 ヒト誘導性制御性ｔ細胞およびその作製方法、およびｔ細胞関連疾患を治療または予防するための医薬組成物

Publications (1)

Publication Number Publication Date
CN121057812A true CN121057812A (zh) 2025-12-02

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CN202480023635.5A Pending CN121057812A (zh) 2023-03-29 2024-03-28 人诱导性调节性t细胞及其制作方法以及用于治疗或预防t细胞相关疾病的药物组合物

Country Status (7)

Country Link
EP (1) EP4692327A1 (https=)
JP (1) JPWO2024204553A1 (https=)
KR (1) KR20250166296A (https=)
CN (1) CN121057812A (https=)
MX (1) MX2025011478A (https=)
TW (1) TW202506995A (https=)
WO (1) WO2024204553A1 (https=)

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8598344B2 (en) 2009-11-30 2013-12-03 Senex Biotechnology CDKI pathway inhibitors and uses thereof
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
EA027531B1 (ru) 2011-09-13 2017-08-31 Игорь Ронинсон ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κB
KR20150023223A (ko) 2012-02-02 2015-03-05 세넥스 바이오테크놀러지 인코포레이티드 Ｃｄｋ8/ｃｄｋ19 선택성 억제제 및 암에 대한 항-전이 및 화학예방 방법에서 이들의 용도
RU2015107550A (ru) 2012-08-23 2016-10-10 Ф. Хоффманн-Ля Рош Аг Новые фенилпиридин/пиразинамиды для лечения рака
WO2014063778A1 (en) 2012-10-08 2014-05-01 Merck Patent Gmbh 2-aminopyridine compounds
GB201220157D0 (en) 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
HK1213544A1 (zh) 2012-12-10 2016-07-08 霍夫曼-拉罗奇有限公司 新型二环苯基-吡啶/吡嗪用於治疗癌症
WO2014106606A1 (en) 2013-01-05 2014-07-10 F. Hoffmann-La Roche Ag Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer
WO2014123900A1 (en) 2013-02-05 2014-08-14 Sirenas Marine Discovery Anti-cancer and anti-hiv compounds
WO2014154723A1 (en) 2013-03-29 2014-10-02 F. Hoffmann-La Roche Ag Novel pyrrole derivatives for the treatment of cancer
WO2014194245A2 (en) 2013-05-31 2014-12-04 Nimbus Iris, Inc. Cdk8 inhibitors and uses thereof
TW201605857A (zh) 2013-10-03 2016-02-16 赫孚孟拉羅股份公司 Ｃｄｋ８之醫療性抑制劑及其用途
AU2014369834B2 (en) 2013-12-24 2018-12-20 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
WO2015144290A1 (en) 2014-03-27 2015-10-01 Merck Patent Gmbh Pyridyl piperidines
JP6521387B2 (ja) 2014-04-18 2019-05-29 武田薬品工業株式会社 縮合複素環化合物
JP6529085B2 (ja) 2014-04-18 2019-06-12 武田薬品工業株式会社 複素環化合物
JP2017522324A (ja) 2014-07-17 2017-08-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 新規ナフチリジン及びイソキノリンならびにｃｄｋ８／１９阻害剤としてのその使用
CN114921468A (zh) * 2017-01-30 2022-08-19 国立大学法人京都大学 新型化合物以及调节性t细胞的制造方法
US20210238551A1 (en) * 2018-08-22 2021-08-05 Osaka University Method for Generating Regulatory T Cells
JP2023053538A (ja) 2021-10-01 2023-04-13 セイコーエプソン株式会社 繊維体の製造方法
MX2024006370A (es) * 2021-11-24 2024-08-19 Regcell Co Ltd Composicion farmaceutica para tratar o prevenir trastornos relacionados con celulas t.
US20250018033A1 (en) * 2021-11-24 2025-01-16 Regcell Co., Ltd. Human inducibility controllable t-cell and method for preparing same

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KR20250166296A (ko) 2025-11-27
MX2025011478A (es) 2025-11-03
WO2024204553A1 (ja) 2024-10-03
JPWO2024204553A1 (https=) 2024-10-03
EP4692327A1 (en) 2026-02-11
TW202506995A (zh) 2025-02-16

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