CN1208043C - 口腔消毒液 - Google Patents

口腔消毒液 Download PDF

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CN1208043C
CN1208043C CN 02133883 CN02133883A CN1208043C CN 1208043 C CN1208043 C CN 1208043C CN 02133883 CN02133883 CN 02133883 CN 02133883 A CN02133883 A CN 02133883A CN 1208043 C CN1208043 C CN 1208043C
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oral
cavity disinfectant
oral cavity
triclosan
glycerol
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CN1403073A (zh
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余京儒
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Chengdu Rosun Disinfection Pharmaceutical Co ltd
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Abstract

本发明提供了一种口腔消毒液。按重量百分比包括三氯新0.1～0.3%、茶多酚0.15～0.35%、甘草甜素0.01～0.1%、丙二醇3～15%、丙三醇1～5%、乙醇1～10%、蒸馏水余量。本发明口腔消毒液口感好，杀菌效果佳。

Description

口腔消毒液
技术领域：
本发明涉及的是用于口腔的消毒液，特别涉及的是一种口腔消毒液。
背景技术：
人们常用洗必泰作口腔消毒液，其口感、杀菌效果均差。
发明内容：
本发明的目的是为了提供一种口感好，杀菌效果佳的口腔消毒液。
本发明口腔消毒液按重量百分比包括如下组分：
三氯新                      0.1～0.3％
茶多酚                      0.15～0.35％
甘草甜素                    0.01～0.1％
丙二醇                      3～15％
丙三醇                      1～5％
乙  醇                      1～10％
蒸馏水                      余量。
上述的口腔消毒液，按重量百分比包括如下组分：
三氯新                      0.1～0.3％
茶多酚                      0.15～0.35％
甘草甜素                    0.01～0.1％
丙二醇                      3～15％
丙三醇                      1～5％
乙  醇                      1～10％
薄荷油                      0.001～0.01％
蒸馏水                      余量，治疗效果佳。
上述的口腔消毒液，按重量百分比包括如下组分：
三氯新                      0.2％
茶多酚                      0.25％
甘草甜素                     0.05％
丙二醇                       8％
丙三醇                       3％
乙  醇                       6％
薄荷油                       0.005％
蒸馏水                       余量，治疗效果更佳。
本发明消毒液中三氯新杀菌、茶多酚清除自由基，甘草甜素防止牙垢形成，并起甜味剂作用，丙二醇、丙三醇起调合及保湿作用，乙醇起溶剂作用，薄荷油起调味作用，蒸馏水为稀释剂。
本发明经四川省卫生防疫站检测，对金黄色萄葡球菌，白色念珠菌有较强的抑制作用(见表1、2)，稳定性好，杀菌效果佳，口感好，无毒无剌激性，(见表3)，安全，使用方便。
表1：口腔消毒液对金黄色萄葡球菌的抑菌结果
药物浓度    作用不同时间(min)的平均抑菌率及范围(％)             
(％)        1              3              5              10
          87.19          90.84          92.95          93.76
4     (84.21-88.92)  (89.53-92.32)  (92.10-94.14)  (92.23-95.42)
          68.01          75.94          78.62          80.91
2     (67.54-68.35)  (72.80-77.63)  (74.12-81.42)  (75.00-84.28)
          42.33          54.03          62.63          65.99
1     (40.35-44.29)  (53.94-54.28)  (57.01-66.78)  (58.77-73.21)
阳性对照组平均菌数为：2.48×104(2.28×104～2.8×104)cfu/片。
阴性对照组无菌生长。
结论：
在20±2℃温度下采用载体法，2％浓度作用金黄色萄葡球菌1min，抑菌率为68.01％(67.54％～68.35％)；1％浓度作用3min，抑菌率为54.03％(53.94％～54.28％)。
表2：口腔消毒液对白色念珠菌的抑菌结果
药物浓度    作用不同时间(min)的平均抑菌率及范围(％)              
(％)        1               3              5             10
          74.18           83.33          85.60          87.51
50    (71.53-78.91)   (80.93-84.56)  (85.19-86.04)  (86.97-88.26)
          62.48           68.93          74.54          78.44
2     (60.19-65.86)   (67.67-71.08)  (71.92-78.13)  (75.96-82.55)
          41.27           52.05          59.00           63.68
12.5  (36.34-47.39)   (47.30-57.82)  (56.15-64.13)  (60.23-68.04)
阳性对照组平均菌数为：4.7×104(4.3×104～5.2×104)cfu/片。
阴性对照组无菌生长。
结论：
在20±2℃温度下采用载体法，25％浓度作用白色念珠菌1min，抑菌率为62.48％(60.19％～65.86％)；12.5％浓度作用5min，抑菌率为59.00％(56.15％～64.13％)。
表3：口腔消毒液急性经口毒性试验结果
性  别    剂量(mg/kg)    动物(只)    死亡数(只)    死亡率(％)
             1000           5           0             0
             2150           5           0             0
♂           4640           5           0             0
             10000          5           0             0
             1000           5           0             0
             2150           5           0             0
♀           4640           5           0             0
             10000          5           0             0
结论：
口腔消毒液对小鼠急性经口LD50＞10000mg/kg，按化学物质急性毒性分级，属实际无毒级。
具体实施方式：
本发明实施见表4：
Figure C0213388300051
上述各实施例生产工艺如下：
①，配料；
②，丙二醇、丙三醇、乙醇加入三氯新、茶多酚充分搅拌均匀；
③，加甘草甜素、薄荷油搅拌均匀；
④，加蒸馏水混合均匀；
⑤，净置、过滤、灌装、包装、成品入库。

Claims (3)

1、口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新             0.1～0.3％
   茶多酚             0.15～0.35％
   甘草甜素           0.01～0.1％
   丙二醇             3～15％
   丙三醇             1～5％
   乙  醇             1～10％
   蒸馏水             余量。
2、根据权利要求1所述的口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新             0.1～0.3％
   茶多酚             0.15～0.35％
   甘草甜素           0.01～0.1％
   丙二醇             3～15％
   丙三醇             1～5％
   乙  醇             1～10％
   薄荷油             0.001～0.01％
   蒸馏水             余量。
3、根据权利要求2所述的口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新             0.2％
   茶多酚             0.25％
   甘草甜素           0.05％
   丙二醇             8％
   丙三醇             3％
   乙  醇             6％
   薄荷油             0.005％
   蒸馏水             余量。
CN 02133883 2002-10-10 2002-10-10 口腔消毒液 Expired - Lifetime CN1208043C (zh)

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CN1208043C true CN1208043C (zh) 2005-06-29

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100508944C (zh) * 2005-12-06 2009-07-08 中国科学院沈阳应用生态研究所 一种玫瑰口腔消毒液及其制备方法
CN1943625B (zh) * 2006-10-30 2010-06-09 中国人民解放军第三军医大学第一附属医院 一种口腔消毒液
CN109125176A (zh) * 2018-09-28 2019-01-04 江苏瑾辉生物科技有限公司 一种含茶多酚漱口液及其制备方法

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