CN1403073A - 口腔消毒液 - Google Patents

口腔消毒液 Download PDF

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CN1403073A
CN1403073A CN 02133883 CN02133883A CN1403073A CN 1403073 A CN1403073 A CN 1403073A CN 02133883 CN02133883 CN 02133883 CN 02133883 A CN02133883 A CN 02133883A CN 1403073 A CN1403073 A CN 1403073A
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natural
oral
glucin
ethanol
propylene glycol
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CN1208043C (zh
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余京儒
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Chengdu Rosun Disinfection Pharmaceutical Co ltd
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Abstract

本发明提供了一种口腔消毒液。按重量百分比包括三氯新0.1～0.3％、天然多酚类化合物0.15～0.35％、天然甜素0.01～0.1％、丙二醇3～15％、丙三醇1～5％、乙醇1～10％、蒸馏水余量。本发明口腔消毒液口感好，杀菌效果佳。

Description

口腔消毒液
技术领域：
本发明涉及的是用于口腔的消毒液，特别涉及的是一种口腔消毒液。
背景技术：
人们常用洗必泰作口腔消毒液，其口感、杀菌效果均差。
发明内容：
本发明的目的是为了提供一种口感好，杀菌效果佳的口腔消毒液。
本发明口腔消毒液按重量百分比包括如下组分：
    三氯新                           0.1～0.3％
    天然多酚类化合物                 0.15～0.35％
    天然甜素                         0.01～0.1％
    丙二醇                           3～15％
    丙三醇                           1～5％
    乙  醇                           1～10％
    蒸馏水                           余量。
上述的口腔消毒液，按重量百分比包括如下组分：
    三氯新                           0.1～0.3％
    天然多酚类化合物                 0.15～0.35％
    天然甜素                         0.01～0.1％
    丙二醇                           3～15％
    丙三醇                           1～5％
    乙  醇                           1～10％
    薄荷油                           0.001～0.01％
    蒸馏水                           余量，治疗效果佳。
上述的口腔消毒液，按重量百分比包括如下组分：
    三氯新                           0.2％
    天然多酚类化合物                 0.25％
    天然甜素                         0.05％
    丙二醇                           8％
    丙三醇                           3％
    乙  醇                           6％
    薄荷油                           005％
    蒸馏水                           余量，治疗效果更佳。
上述的天然多酚类化合物采用茶多酚，天然甜素采用甘草甜素。
本发明消毒液中三氯新杀菌、茶多酚清除自由基，甘草甜素防止牙垢形成，并起甜味剂作用，丙二醇、丙三醇起调合及保湿作用，乙醇起溶剂作用，薄荷油起调味作用，蒸馏水为稀释剂。
本发明经四川省卫生防疫站检测，对金黄色萄葡球菌，白色念珠菌有较强的抑制作用(见表1、2)，稳定性好，杀菌效果佳，口感好，无毒无刺激性，(见表3)，安全，使用方便。
表1：口腔消毒液对金黄色萄葡球菌的抑菌结果药物浓度                 作用不同时间(min)的平均抑菌率及范围(％)(％)            1                 3                5             10
          87.19             90.84            92.95          93.764         (84.21-88.92)      (89.53-92.32)   (92.10-94.14)   (92.23-95.42)
          68.01             75.94            78.62          80.912         (67.54-68.35)      (72.80-77.63)   (74.12-81.42)   (75.00-84.28)
          42.33             54.03            62.63          65.991         (40.35-44.29)      (53.94-54.28)   (57.01-66.78)   (58.77-73.21)
阳性对照组平均菌数为：2.48×104(2.28×104～2.8×104)cfu/片。
阴性对照组无菌生长。
结论：
在20±2℃温度下采用载体法，2％浓度作用金黄色萄葡球菌1min，抑菌率为68.01％(67.54％～68.35％)；1％浓度作用3min，抑菌率为54.03％(53.94％～54.28％)。表2：口腔消毒液对白色念珠菌的抑菌结果药物浓度               作用不同时间(min)的平均抑菌率及范围(％)(％)           1              3                5               10
         74.18          83.33            85.60            87.5150        (71.53-78.91)  (80.93-84.56)    (85.19-86.04)    (86.97-88.26)
         62.48          68.93            74.54            78.442         (60.19-65.86)  (67.67-71.08)    (71.92-78.13)    (75.96-82.55)
         41.27          52.05            59.00            63.6812.5      (36.34-47.39)  (47.30-57.82)    (56.15-64.13)    (60.23-68.04)
阳性对照组平均菌数为：4.7×104(4.3×104～5.2×104)cfu/片。
阴性对照组无菌生长。
结论：
在20±2℃温度下采用载体法，25％浓度作用白色念珠菌1min，抑菌率为62.48％(60.19％～65.86％)；12.5％浓度作用5min，抑菌率为59.00％(56.15％～64.13％)。
表3：口腔消毒液急性经口毒性试验结果性  别        剂量(mg/kg)      动物(只)       死亡数(只)      死亡率(％)
             1000             5               0              0
             2150             5               0              0♂               4640             5               0              0
             10000            5               0              0
             1000             5               0              0
             2150             5               0              0♀               4640             5               0              0
             10000            5               0              0
结论：
口腔消毒液对小鼠急性经口LD50＞10000mg/kg，按化学物质急性毒性分级，属实际无毒级。
具体实施方式：
本发明实施例见表4。表4：
Figure A0213388300061
上述各实施例生产工艺如下：①，配料；②，丙二醇、丙三醇、乙醇加入三氯新、茶多酚充分搅拌均匀；③，加甘草甜素、薄荷油搅拌均匀；④，加蒸馏水混合均匀；⑤，净置、过滤、灌装、包装、成品入库。

Claims (4)

1、口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新                          0.1～0.3％
   天然多酚类化合物                0.15～0.35％
   天然甜素                        0.01～0.1％
   丙二醇                          3～15％
   丙三醇                          1～5％
   乙  醇                          1～10％
   蒸馏水                         余量。
2、根据权利要求1所述的口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新                          0.1～0.3％
   天然多酚类化合物                0.15～0.35％
   天然甜素                        0.01～0.1％
   丙二醇                          3～15％
   丙三醇                          1～5％
   乙  醇                          1～10％
   薄荷油                          0.001～0.01％
   蒸馏水                          余量。
3、根据权利要求1所述的口腔消毒液，其特征在于按重量百分比包括如下组分：
   三氯新                          0.2％
   天然多酚类化合物                0.25％
   天然甜素                        0.05％
   丙二醇                          8％
   丙三醇                          3％
   乙  醇                          6％
   薄荷油                          005％
   蒸馏水                          余量。
4、根据权利要求1或2或3所述的口腔消毒液，其特征在于天然多酚类化合物采用茶多酚，天然甜素采用甘草甜素。
CN 02133883 2002-10-10 2002-10-10 口腔消毒液 Expired - Lifetime CN1208043C (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100508944C (zh) * 2005-12-06 2009-07-08 中国科学院沈阳应用生态研究所 一种玫瑰口腔消毒液及其制备方法
CN1943625B (zh) * 2006-10-30 2010-06-09 中国人民解放军第三军医大学第一附属医院 一种口腔消毒液
CN109125176A (zh) * 2018-09-28 2019-01-04 江苏瑾辉生物科技有限公司 一种含茶多酚漱口液及其制备方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100508944C (zh) * 2005-12-06 2009-07-08 中国科学院沈阳应用生态研究所 一种玫瑰口腔消毒液及其制备方法
CN1943625B (zh) * 2006-10-30 2010-06-09 中国人民解放军第三军医大学第一附属医院 一种口腔消毒液
CN109125176A (zh) * 2018-09-28 2019-01-04 江苏瑾辉生物科技有限公司 一种含茶多酚漱口液及其制备方法

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