CN120757601A - 肠道细菌胆汁酸代谢的小分子调节剂 - Google Patents

肠道细菌胆汁酸代谢的小分子调节剂

Info

Publication number
CN120757601A
CN120757601A CN202510563299.XA CN202510563299A CN120757601A CN 120757601 A CN120757601 A CN 120757601A CN 202510563299 A CN202510563299 A CN 202510563299A CN 120757601 A CN120757601 A CN 120757601A
Authority
CN
China
Prior art keywords
substituted
disease
cancer
certain embodiments
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510563299.XA
Other languages
English (en)
Chinese (zh)
Inventor
A·S·德夫林
A·阿德希卡里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of CN120757601A publication Critical patent/CN120757601A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN202510563299.XA 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂 Pending CN120757601A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962846457P 2019-05-10 2019-05-10
US62/846,457 2019-05-10
US202062962048P 2020-01-16 2020-01-16
US62/962,048 2020-01-16
PCT/US2020/032016 WO2020231776A1 (en) 2019-05-10 2020-05-08 Small molecule modulators of gut bacterial bile acid metabolism
CN202080050183.1A CN114641280B (zh) 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080050183.1A Division CN114641280B (zh) 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂

Publications (1)

Publication Number Publication Date
CN120757601A true CN120757601A (zh) 2025-10-10

Family

ID=73289482

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202510563299.XA Pending CN120757601A (zh) 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂
CN202080050183.1A Active CN114641280B (zh) 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080050183.1A Active CN114641280B (zh) 2019-05-10 2020-05-08 肠道细菌胆汁酸代谢的小分子调节剂

Country Status (9)

Country Link
US (1) US12577273B2 (https=)
EP (1) EP3965748A4 (https=)
JP (2) JP7769176B2 (https=)
KR (2) KR20250171471A (https=)
CN (2) CN120757601A (https=)
AU (1) AU2020274319B2 (https=)
BR (1) BR112021022431A2 (https=)
CA (1) CA3137308A1 (https=)
WO (1) WO2020231776A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
EP3890745B1 (en) 2018-12-04 2025-11-19 President and Fellows of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
IT202200008861A1 (it) * 2022-05-03 2023-11-03 Chemelectiva S R L Processo per la preparazione di derivati dell’acido colico.
CN115337312B (zh) * 2022-08-19 2025-06-03 金熊药业(珠海横琴)有限公司 胆酸复合物及其制备方法和应用
CN117801047B (zh) * 2023-01-19 2024-12-20 北京华睿鼎信科技有限公司 神经甾体衍生物及其用途
CN118021751A (zh) * 2024-01-15 2024-05-14 中国人民解放军总医院第五医学中心 一种免疫调节的口服微球、制备方法及应用
US20250299939A1 (en) * 2024-03-25 2025-09-25 Thermo Finnigan Llc Calibration of an Image Current-based Mass Analyzer Included in a Mass Spectrometer
WO2025235593A1 (en) * 2024-05-09 2025-11-13 The Regents Of The University Of California Treatment for obstructive sleep apnea-associated atherosclerosis
CN119565571B (zh) * 2024-10-17 2025-11-21 湖北省食品质量安全监督检验研究院(湖北食品、保健食品、化妆品质量安全检测中心) 一种不溶性吸附除氟复合材料颗粒及其制备方法、应用和除氟包
CN119950519B (zh) * 2025-01-07 2025-11-21 山东省海洋科学研究院(青岛国家海洋科学研究中心) 奥贝胆酸在对虾急性肝胰腺坏死病防治中的应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1360354A (en) 1972-01-20 1974-07-17 Union International Co Ltd Chenodeoxycholic acid
JPS5826360B2 (ja) 1974-08-23 1983-06-02 エ−ザイ カブシキガイシヤ グリコケノデオキシコ−ルサンノ セイホウ
IT1221734B (it) 1983-02-24 1990-07-12 Schiena Michele Giuseppe Di Ursodesossicolico solfato acido sale sodico
US5210272A (en) 1990-02-16 1993-05-11 Prototek, Inc. Process for forming a fluoromethyl ketone
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
NZ245504A (en) 1991-12-20 1995-08-28 Hoechst Ag Bile acid derivatives containing an ethylenically unsaturated grouping
IT1255450B (it) 1992-06-30 1995-10-31 Montefarmaco Spa Uso di acidi biliari come agenti antivirali
EP0624593A3 (de) 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
IT1270853B (it) 1993-05-20 1997-05-13 Sanofi Elf Procedimento per la preparazione di derivati taurocolanici
EP0717631B1 (en) 1993-09-09 2003-07-09 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US5695738A (en) 1995-06-15 1997-12-09 Glycomed Incorporated Steroidal C-glycosides
US5763435A (en) 1995-11-21 1998-06-09 Children's Hospital Medical Center Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders
CA2206047A1 (en) 1997-05-23 1998-11-23 Romeo Rang (Deceased) Immunomodulating compositions for the treatment of viral disorders
DE19849722A1 (de) 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN1187364C (zh) 1999-04-30 2005-02-02 亚其发展公司 类固醇衍生物
DE19941764A1 (de) 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
SK3862002A3 (en) 1999-09-22 2003-01-09 Aventis Pharma Gmbh 4-Benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use
US6451355B1 (en) 2000-07-17 2002-09-17 Howard M. Reisner Composition to treat diabetes
ITTO20020102A1 (it) 2002-02-06 2003-08-06 Abc Ist Biolog Chem Spa Procedimento per la preparazione dell'acido ursodesossicolico disolfato e suoi sali farmaceuticamente accettabili.
ITMI20030822A1 (it) 2003-04-18 2004-10-19 Erregierre Spa Processo per la preparazione dell'acido ursodesossicolico
US20070032464A1 (en) 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
CA2608052A1 (en) 2005-05-10 2006-11-16 Laboratoires Fournier S.A. Novel use of liver x receptor agonists
US9295677B2 (en) 2008-02-26 2016-03-29 Qing Bile Therapeutics Inc. Polyhydroxylated bile acids for treatment of biliary disorders
CA2758023A1 (en) 2008-04-09 2009-10-15 Cornell University Commensal bacteria as signal mediators within a mammalian host
CA2744697C (en) 2008-11-26 2016-06-21 Satiogen Pharmaceuticals, Inc. Use of compositions comprising bile acids, salts, and mimics thereof for the treatment of obesity or diabetes
WO2012151252A2 (en) 2011-05-02 2012-11-08 Biokier, Inc. Composition and method for treatment of diabetes
IT1393095B1 (it) 2009-02-19 2012-04-11 Prodotti Chimici Alimentari Processo per la sintesi del sale disodico dell'acido ursodesossicolico 3,7-disolfato.
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
EP2470553B1 (en) 2009-08-25 2024-06-19 Qing Bile Therapeutics Inc. Polyhydroxylated bile acids for treatment of biliary disorders
CA2859965A1 (en) 2011-12-21 2013-06-27 Ardelyx, Inc. Non-systemic tgr5 agonists
WO2013113680A1 (en) 2012-02-03 2013-08-08 Aarhus Universitet Radiolabeled bile acids and bile acid derivatives
US20140206657A1 (en) 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
US9580459B2 (en) 2013-04-26 2017-02-28 Metselex, Inc. Water-soluble ursodeoxycholic acid prodrugs
US10538550B2 (en) 2014-11-19 2020-01-21 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators
US20190125745A1 (en) 2014-12-17 2019-05-02 Rgenix, Inc. Treatment and diagnosis of cancer
AR103260A1 (es) * 2014-12-23 2017-04-26 4D Pharma Res Ltd Modulación inmunitaria
TW201704251A (zh) * 2015-04-29 2017-02-01 正大天晴藥業集團股份有限公司 鵝去氧膽酸衍生物
EP3310801B1 (en) 2015-06-19 2021-04-07 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
TWI618714B (zh) * 2015-08-27 2018-03-21 中央研究院 涎酸轉移酶抑制劑及其用途
CN106478759A (zh) 2015-08-31 2017-03-08 陕西合成药业股份有限公司 奥贝胆酸衍生物及其制备方法和用途
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
US20170233431A1 (en) 2016-02-17 2017-08-17 City Of Hope Bile acid derivatives and methods for synthesis and use
RU2665685C1 (ru) 2017-09-18 2018-09-04 Общество с ограниченной ответственностью "МДК Медика" Способ получения алкиламмонийных солей алкилсерных кислот
JP2020536566A (ja) * 2017-10-13 2020-12-17 バッテル メモリアル インスティチュート 胆汁酸塩ヒドロラーゼプローブならびにその製造方法および使用方法
US20210122780A1 (en) 2018-03-29 2021-04-29 Metselex, Inc. Compositions for the prevention and treatment of parkinson's disease
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
EP3890745B1 (en) 2018-12-04 2025-11-19 President and Fellows of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
WO2021226447A1 (en) 2020-05-08 2021-11-11 President And Fellows Of Harvard College Methods for inducing bile acid sulfotransferase sult2a for treating metabolic disorders

Also Published As

Publication number Publication date
US20220204548A1 (en) 2022-06-30
EP3965748A4 (en) 2023-02-01
CN114641280A (zh) 2022-06-17
WO2020231776A8 (en) 2021-05-14
US12577273B2 (en) 2026-03-17
BR112021022431A2 (pt) 2022-05-24
WO2020231776A1 (en) 2020-11-19
CN114641280B (zh) 2025-05-27
KR20250171471A (ko) 2025-12-08
JP2022533069A (ja) 2022-07-21
AU2020274319A1 (en) 2021-12-02
EP3965748A1 (en) 2022-03-16
CA3137308A1 (en) 2020-11-19
KR102893599B1 (ko) 2025-12-01
JP2026000925A (ja) 2026-01-06
KR20220007112A (ko) 2022-01-18
AU2020274319B2 (en) 2026-02-12
JP7769176B2 (ja) 2025-11-13

Similar Documents

Publication Publication Date Title
CN114641280B (zh) 肠道细菌胆汁酸代谢的小分子调节剂
EP3609888B1 (en) Farnesoid x receptor agonists and uses thereof
AU2021218228B2 (en) Oxysterols and methods of use thereof
US10745405B2 (en) Glucuronide prodrugs of Janus kinase inhibitors
CA3069181A1 (en) Compounds for tau protein degradation
EP3592755A1 (en) Glucuronide prodrugs of tofacitinib
EP3890745B1 (en) Synthetic derivatives of cholic acid 7-sulfate and uses thereof
CA3000709A1 (en) Inhibitors of menaquinone biosynthesis
WO2020114307A1 (zh) 异噁唑衍生物及其制备方法和用途
KR20230061505A (ko) 알킬-옥사사이클로알킬 모이어티를 함유하는 설파모일 우레아 유도체 및 이의 용도
BR112019017003A2 (pt) antibióticos macrocíclicos de amplo espectro
US10961231B2 (en) NTCP inhibitors
JP2020500907A (ja) 細胞外クエン酸の取込みの阻害剤としてのスルホンアミド
BR122025012723A2 (pt) Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, respectivos usos, método para inibir hidrolase do sal biliar (bsh) e kit
US20210238225A1 (en) Peptidomimetic inhibitors of the peptidyl-prolyl cis/trans isomerase (pin1)
CN108276354B (zh) Tlr4/md2抑制剂及其在抗炎药物中的应用
US20260076966A1 (en) Method of inhibiting trem-1
US20260035340A1 (en) Inhibitors of akr1c3 and methods of use
CN116143744A (zh) 一种芳香酯类化合物及其用途
TW201544494A (zh) 胰高血糖素樣肽第一型（ｇｌｐ－１）受體調控子及其於調節血糖濃度之用途
EA040704B1 (ru) Агонисты фарнезоидного x-рецептора и их применение

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination