CN1205880A

CN1205880A - Immune anticancer medicine

Info

Publication number: CN1205880A
Application number: CN 96117419
Authority: CN
Inventors: 陈明
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-01-23
Filing date: 1996-01-23
Publication date: 1999-01-27

Abstract

The immune anticancer medicine has in its components ginseng, Codonopsis Pilosulae, Astragalus membranaceus, licorice,Atractylodis Macrocephalae and other 29 Chinese medicinal materials. It contains plant hemagglutinin and plant polysaccharide components capable of activating limphocyte and complement system and activated limphocyte and complement becomes immunity anticancer cell or medium. The plant hemagglutinin and plant polysaccharide components can promote and regulate body's immunity and body's physiological function and thus strengthen anticancer ability.

Description

Immune anticancer medicine

What the present invention relates to is a kind of medicine, particularly be a kind of immune anticancer medicine.

Decoction of ten powerful tonics comes from " formulary of peaceful benevolent dispensary ", is made up of Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae (moxibustion), the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Chinese date etc., forms for the eight delicacies Tonga Radix Astragali, Cortex Cinnamomi actually.This BAZHEN TANG vigorate qi and replenish the blood is joined the merit of the Radix Astragali with gain gas, and the assistant Cortex Cinnamomi is more strengthened the power of tonification with the supporing yang inspiration QI and blood of opening, and is mainly seen in the toxic and side effects of treatment cancer and control radiotherapy, chemotherapy clinically.1. decoction of ten powerful tonics can improve patient's ordinary circumstance in the auxiliary treatment of cancer, be outstanding with the effect of improving to appetite and the idle volume sense of whole body; 2. alleviating the untoward reaction of body due to anticancer chemotherapeutic agent and the radiotherapy, is good with the prevention effect to leukopenia especially; 3. with operation, radiotherapy and chemotherapy and usefulness, can prolong patient's life.Decoction of ten powerful tonics is used for clinically curing the disease with regard to disease, is not the principle of assisting from putting prevention first, treat more, has in mind from prevention minimizing tumor.

In view of above reason, the objective of the invention is for provide a kind of and put prevention first, treat be assist, immune anticancer medicine that immune anti-cancer effect is good.

Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Polyporus, Pericarpium Citri Reticulatae, Radix Rehmanniae, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Fructus Lycii, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), Rhizoma Cyperi, Rhizoma Cimicifugae, Fructus Psoraleae, Cortex Cinnamomi, Radix Morindae Officinalis, the Radix Paeoniae Alba, Herba Epimedii, Fructus Ligustri Lucidi, Fructus Chaenomelis, Fructus Corni, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Testa arachidis hypogaeae, Herba Hedyotidis Diffusae, Herba Selaginellae Doederleinii, Pheretima, Bombyx Batryticatus, Herba Cistanches are arranged in the immune anticancer medicine of the present invention.

Each set of dispense is as follows than (weight portion) in the said medicine:

Radix Ginseng 5-15 Radix Codonopsis 8-25

Radix Astragali 8-20 Radix Glycyrrhizae 5-10

Rhizoma Atractylodis Macrocephalae 6-25 Rhizoma Dioscoreae 6-20

Seem Lablab Album 6-100 Poria 8-25

Polyporus 8-25 Pericarpium Citri Reticulatae 4-10

Radix Rehmanniae 9-30 Radix Angelicae Sinensis 6-30

Radix Polygoni Multiflori 9-30 Fructus Lycii 9-30

Rhizoma Polygonati 8-20 Radix Adenophorae (Radix Glehniae) 6-20

Rhizoma Cyperi 6-15 Rhizoma Cimicifugae 3-8

Fructus Psoraleae 8-30 Cortex Cinnamomi 1-4

Radix Morindae Officinalis 8-25 Radix Paeoniae Alba 6-20

Herba Epimedii 6-35 Fructus Ligustri Lucidi 6-25

Fructus Chaenomelis 6-20 Fructus Corni 6-25

Rhizoma Chuanxiong 6-30 Radix Salviae Miltiorrhizae 6-25

Testa arachidis hypogaeae 2-10 Herba Hedyotidis Diffusae 6-20

Herba Selaginellae Doederleinii 6-20 Pheretima 6-20

Bombyx Batryticatus 6-20 Herba Cistanches 8-30

Radix Glycyrrhizae the most handy (moxibustion) Radix Glycyrrhizae, Radix Polygoni Multiflori is used (living, ripe) Radix Rehmanniae with (system) Radix Polygoni Multiflori, Radix Rehmanniae.

Also have in the said medicine seasoning Mel, crystal sugar or white sugar, can be made into oral liquid.

Also has pure grain wine in the above-mentioned medicine.

This medicine is mixed with food such as oral liquid or the medicated wine that people be willing to accept, can exempts people and take medicine to have an injection and detest psychology, making drinks becomes enjoyment, and can reach the purpose that the immunity of taking medicine is kept fit.

" Cecil Textbook of Medicine " pointed out: be that cellular immunization or liquid immunity lymphocyte and complement obviously all are the crux roles.Lymphocyte and complement are activated under the stimulation of antigen or some mitogen such as phytohaemagglutinin, vegetable polysaccharides, produce immune protective effect on cancer risk.Lymphocyte is divided into B cell and T cell, is divided into the main cell that plasma cell-be produces antibody behind the B cell-stimulating.T cell troop is numerous and jumbled, and after the activation, some T cell can increase and is germinal cell, produces the multiple factor and medium, and immunologic process is produced important function.Wherein a kind of differentiation of assistant's factor pair B cell plays regulating action.The T cellular products that another kind has critical function is a cytotoxic cell, and target cell (oncocyte) is had special adhering to and destruction.The transfer factor that disengages behind the lymphocyte activation, can make the delayed hypersensitivity reaction that specific antigen takes place become feminine gender by the positive, to tuberculin, diphtherin and coccidioides immitis have the sensitivity effect, other also produce migration inhibition factor, promptly suppress the migration of macrophage and produce phagocytosis.Also produce interferon, lymphotoxin, chemotactic factor, skin reactive factor etc.The above-mentioned medium and the factor much can both influence and strengthen macrophage to antibacterial and the usefulness of other effects to it.Also produce a kind of lethal K cell in addition, this cell antagonist has high affinity, acts on target cell with antibody combined, and promptly antibody-mediated sexual cell dissolving produces the effect that cellular immunization plays cancer-resisting therefrom.

Complement is promoting or is mediating in the immune system to play key effect, after complement is activated by vegetable polysaccharides, be that effect, the chemotactic factor cell guiding that classical path or bypass C3a-C5a have intensive anaphylatoxin and chemotactic factor enters infection and inflammation part, anaphylatoxin then can make local capillary permeability improve, and makes more complement and antibody enter this place and reaches immune effect.Complement after the activation can promote cytophagous function, improves macrophage and phagocyte to antigenic processing.Complement C5-C9 after the activation makes target cell (oncocyte) that osmotic lysis takes place attached to causing hole on the target cell membrane eventually.Thereby reach the effect of liquid immunity cancer-resisting.

Often there is tumor cell to take place in the human body, handle or eliminate the people of immunologic function difference because of normal immunity function, unablely low drive the erosion of tumor cell and produce canceration, endanger people's life security at last, the normal equilibrium that this just needs the immunologic function of constant adjusting human body strengthens its defence capability.Immunity cancer-resisting wine or oral liquid utilize effective natural vegetable Chinese herbal medicine composition exactly, stimulate lymphocyte and complement to be converted into killing cancer cell, promote and regulate the normal equilibrium of immunologic function, reach the effect of immune functions of resisting cancer and delaying senility.

Immunopharmacology studies show that, immune traditional tonic medicine, not forked rubbing and QI and blood, the effect of regulating immunologic function is all arranged, be not the dosage and the differing property of tiring in ordinary circumstance, minimum effective dose differs 10-50 doubly with the highest effective dose, produce effects no longer just when surpassing the best effective amount.This dose-effect relationship may reflect body cell immunologic function self adjusting and intrinsic stability.When especially being in immunologic hypofunction, this class medicine human body immunity improving power is then more remarkable.These phenomenons show the key that improves immunity not at drug dose, and in immunity tense level.Adjusting lower body at hemagglutinin and polysaccharide can be got back to normal level in autoimmune vigor scope.Surpass height and add no longer produce effects of dosage in limited time.Therefore, immunopharmacological property is the same with other physiological functions, and the homeostasis of himself is all arranged.These Chinese medicine immunity have dual regulation.Can make to hang down and be returned to normal level with height.The cell of immunity sensitization can be kept the effect of several months in vivo.

Polysaccharide Chinese medicine is regulated the mechanism of body's immunity by integral coordination function, to keep the dynamic equilibrium of body, equilibrium between yin and yang, QI and blood balance.Its means all are by the QI and blood of regulating whole body and the level of negative and positive, control the vigor of cell and cytokine by mass action, mainly realize by nerve-endocrine-immunomodulating network.

It is about 4% that Radix Ginseng in the medicine of the present invention contains Saponin, volatile oil, polysaccharide, vitamin, aminoacid.Experiment showed, that Radix Ginseng has inhibitory action to tumor, to sarcoma 180, adenocarcinoma 755, pulmonary carcinoma, gastric cancer all have inhibitory action.Radix Ginseng has the recovery hemopoietic function of bone marrow, and the effect of rising hemoglobin has the improvement effect to cardiac muscle and cardiovascular; There is specific effect at senior position to nervus centralis; Can improve the mental and physical function of human body; Increase the defence capability of body to various destructive stimuluses.Ginsenoside and polysaccharide are not only immunostimulant to body, and are immunomodulators, and the breeder reaction of immunocyte is had facilitation, make the reticuloendothelial system phagocytic increased functionality, and enhancing antibody forms.Hormonal system is also exerted an influence, nerve-hypophysis-interrenal system is had certain effect.

Radix Codonopsis: Radix Codonopsis contains polysaccharide, 17 seed amino acids, and 14 kinds of no base elements, Saponin, volatile oil and alkaloids have the material base that anti-tumor is controlled tumor.Experiment showed, that Radix Codonopsis has enhancing body and supports ability, raise immunity can obviously improve the phagocytic rate of macrophage.Strengthen lymphocytic conversion ratio, thereby run into the generation and the development of swollen sulfur, clinical compound recipe is used multiple cancers such as the esophageal carcinoma, pulmonary carcinoma evident in efficacy.

The Radix Astragali: the Radix Astragali contains tens of kinds of Saponins, polysaccharide, aminoacid and trace element, experimental results show that, in external XGVHR test, show that cancer patient's lymphatic function is had the completeness restitution, can improve the cellular immunization and the liquid immunologic function of body, and dual regulation is arranged.It is reported: with astragalus membranaceus powder treatment advanced liver cancer 60 examples, total effective rate 87.5%.

Radix Glycyrrhizae: contain glycyrrhizin, glycyrrhizic acid, multiple flavoneization contains thing etc., experimental results show that, Radix Glycyrrhizae can make phagocytic activity of leukocytes improve, thereby can improve body defense function, can stimulate the mononuclear phagocyte effect, trigger the performance of " antigen recognition processing ", make antigen be discerned by lymphocyte easily and utilize.Radix Glycyrrhizae has resistance attitude and antiinflammatory action, and the hepatic injury that chemical substance is caused has protective effect, and glycyrrhizin can suppress growth of tumor.

Fructus Chaenomelis: contain Fructus Chaenomelis alkali, papain, saccharide etc.Fructus Chaenomelis alkali has active anticancer and antiangiogenic property leukemia.P388, L1210, the effect of EA tumor cell has certain curative effect to ehrlich carcinoma, and papain is used for the proteopepsis medicine.

The Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae contains volatile oil, believes half ketenes, vitamin A etc.Experiment showed, that Rhizoma Atractylodis Macrocephalae volatile oil has obvious inhibitory action to the esophageal carcinoma, ehrlich carcinoma, sarcoma 180.The Rhizoma Atractylodis Macrocephalae has the rate of increase that reduces tumor tissues, lowers the aggressive of tumor tissues, improves the reactive ability of body antitumor, and to the toxic action of tumor cell.Use anti-startup effect of Rhizoma Atractylodis Macrocephalae back mutation, stop recurrence, the transfer of tumor.

Radix Angelicae Sinensis: contain volatile oil, water soluble compound, polysaccharide, aminoacid and trace element etc.Experiment showed, Radix Angelicae Sinensis and extract ferulic acid and polysaccharide, there is the obvious stimulation effect in the monokaryon system, immune system is had regulate and restitution.Radix Angelicae Sinensis has facilitation to healthy people's lymphocytic conversion, and the water soluble ingredient of Radix Angelicae Sinensis and polysaccharide have fairly obvious facilitation to the liquid immunologic function, and polysaccharide has antitumor and antiinflammatory action.

Radix Rehmanniae: contain iridoid, polysaccharide etc.Experiment showed, that Dihuang polysaccharide RPS has the enhancing human body immunity function, suppress tumor growth, promote hemopoietic function.Clinically be used for anti-curing cancers and play positive inhibition growth of tumor, improve body resistance against diseases.

Fructus Lycii: contain alkaloid, phytosterin compound, aminoacid polysaccharide, vitamin etc.Experiment showed, that Fructus Lycii polysaccharide LBP can play the effect of antibiotic, antiviral, antitumor, defying age, anti-chemotherapy side effect and autoimmune disease.The LBP polysaccharide mainly is that selection increases in thymus T cell quantity, and strengthens " emptying " function, thymocyte cell is moved to outer planet increase, the effect of performance thymus immunity center adjustment strengthens disease-resistant and function in delaying senility.

Herba Epimedii: mainly contain EPS, EPS and contain polysaccharide, flavone and icariine etc.Experiment showed, that Herba Epimedii EPS can activate the immunologic function of thymocyte cell, thymic weight is obviously increased, help raise immunity and slow down aging, the enhancing body resistance against diseases, Fructus Lycii and Herba Epimedii share then tire higher.

Radix Polygoni Multiflori: Radix Polygoni Multiflori extract PM-2 experimental results show that, can human body immunity improving function, strengthen thymus and spleen lymphocyte proliferation vigor, have the red system of obvious enhancing bone marrow, be CFU-GM quantity, promote hemopoietic function, the granulocytopenia that causes because of chemotherapy is recovered ahead of time.Radix Polygoni Multiflori has defying age, can promote cellular immunization, can promote the effect of hemopoietic function again.

Radix Adenophorae (Radix Glehniae): contain soap and starch etc.Experiment showed, that Radix Adenophorae (Radix Glehniae) ginseng obviously strengthens tip blood lymphocyte amount and T cell, thereby improve cellular immunization and nonspecific immunity, regulate the immunity of organism balance, pulmonary carcinoma, hepatocarcinoma, nasopharyngeal carcinoma are had curative effect preferably.

Rhizoma Polygonati: contain Yan acid, polysaccharide etc.Experiment showed, Rhizoma Polygonati have the arteries of preventing atherosis, stimulate the lymphocyte transformation of body meat for killing oncocyte, strengthen the immunity of anti-malignant tumor.

Seem Lablab Album: contain protein, hemagglutinin, polysaccharide, contain anti-SK virus composition etc.Hemagglutinin and polysaccharide energy human activin lymphocyte and complement system, the immunocompetence of enhancing body has the effect of separating the organic substance poison.

Poria: contain β-(1-3) glucose polysaccharide, straight-chain polysaccharide etc.Pharmacological evaluation: straight-chain polysaccharide has that significant anti-cancer activity β-(1-3) the glucose polysaccharide can reach 96.88% to the sarcoma 180 suppression ratio, and the influence of anti-immunosuppressant to monocyte function arranged, and increases spleen and thymic weight, impels the raising of immunologic function.The clinical spleen damp disease that is used for esophageal carcinoma and various tumors, effect is better.

Polyporus: contain polysaccharide, crude protein, biotin, ergosterol etc.Experimental results show that: polyporusum bellatus can improve the T cellular immune function, and immunity has regulating action to liquid.It can make the empty child of body of immunologic hypofunction energetic.To murine sarcoma 180 suppression ratio is 62%, and the hepatocarcinoma suppression ratio is 37-54%.Clinical report is obvious with Polyporus treatment pulmonary carcinoma and esophageal carcinoma effect.

Fructus Psoraleae: contain volatile oil 20%, psoralen, Corylifolinin (chalcone derivative).Experimental results show that: Corylifolinin is in the external effect that inhibition Hela cell and S180 sarcoma are arranged, and Fructus Psoraleae volatile oil has antitumaous effect, and Fructus Psoraleae has better function of increasing leukocyte, reduces chemotherapy toxic side effect.Chalcone derivative has the effect of coronary artery dilator, makes blood flow increase more than 80%.Fructus Psoraleae side regulates the various functions of body from aspects such as immune system, hormonal system and second message,second messengers, make it to run well, and reaches therapeutic purposes.

Radix Morindae Officinalis: contain cupreol, oligosaccharide etc.Experimental results show that: oligosaccharide mixture can strengthen the propagation of thymus T cell, and immunologic enhancement and antidepressant effect are arranged.

Fructus Ligustri Lucidi: contain triterpenes components, saccharide etc.Experimental results show that: the Fructus Ligustri Lucidi immersion has inhibitory action to cervical cancer 14, and effective percentage is 49.20%.

Fructus Corni: contain Saponin, fruit acid, vitamin A etc.Experiment showed, diuresis and the effect of bringing high blood pressure down, had antibioticly that leukocyte that anti-chemotherapy radiotherapy causes descends, and the leukocytic effect of rising is arranged, immunity that can the enhancing body anti-malignant tumor.

Radix Salviae Miltiorrhizae: contain multiple ketone, methyl ester, vitamin E etc.Radix Salviae Miltiorrhizae does not have mass formed by blood stasis Accommodation is arranged the high fibrin in-fibrinolytic-platelet system disorder of coagulating of tumor host.The S180 oncocyte there is lethal effect.Radix Salviae Miltiorrhizae can obviously prolong the life span of mice ehrlich carcinoma.The short molten effect of Radix Salviae Miltiorrhizae is one of important mechanisms of antitumaous effect.

Herba Selaginellae Doederleinii: contain alkaloid, Saponin etc.Experimental results show that: Herba Selaginellae Doederleinii has inhibitory action to S180U14, L16, can prolong the existence of liver cancer mouse, the metabolism that can also enhancing body and the function of reticuloendothelial system.Clinical report has definite curative effect to nourishing the leaf tumor.With other drug partner treatment pulmonary carcinoma, nasopharyngeal carcinoma, breast carcinoma, skin carcinoma have curative effect preferably.Herba Hedyotidis Diffusae: contain Herba Hedyotidis Diffusae element, polysaccharide, alkaloid etc.Experiment showed, has inhibitory action to leukemia, can make all death of ascites hepatoma carcinoma cell, a watt gram cancer 256, cervical cancer 14, sarcoma 180 are all had inhibitory action.The mitosis of energy anticancer, the immunity of polysaccharide and energy enhancing body.

Testa arachidis hypogaeae: have the bone marrow of promotion to make hematoblastic function and shorten the bleeding time and reach hemostasis.The treatment hemophilia has good effect.Testa arachidis hypogaeae has the hematoblastic matter of improvement, strengthens the contraction function of blood capillary, improves the defective of thrombin.

Pheretima: contain lumbrifebrine, locust earthworm element etc.Clinical and experiment showed, that Pheretima and Rhizoma Chuanxiong compound recipe can improve cancer patient's blood clotting high viscosity and high coagulant state.The back mutation effect is arranged, have anticancer, the blood pressure lowering of relievining asthma, calmness, convulsion and good refrigeration function.

Bombyx Batryticatus: contain protein, fat, oxamide, calcium oxalate, silkworm excrement contains chlorophyll, vitamin A B etc., experimental results show that, Bombyx Batryticatus has inhibitory action to sarcoma 180, and the cortex effect has anticonvulsant action on the proteolipin stimulation of renal, clinically be used for multiple treatment for cancer and dispel the wind, reduce phlegm, the function of eliminating stagnation, it is remarkable that the silkworm excrement chlorophyll is controlled the malignant tumor effect.

Immune anticancer medicine of the present invention has adopted tens kinds of natural vegetable Chinese herbal medicines with immunity anti-cancer anti-cancer and kill cancer action, contain can activated lymphocyte and the phytohaemagglutinin of complement system and vegetable polysaccharides be converted into the ingredient of cancer effect extremely.This ingredient not only can promote immunologic function to keep its normal equilibrium, and can also promote and regulate human physiological functions, keeps its normal equilibrium, plays immunity anti-cancer and keeps fit anticancer effect.The immunity anti-cancer effect is good.Available biochemical method is produced immune cancer-resisting medicine slurry, and the wine of selecting quality better then is carrier, with the medicine slurry add inject this wine immune cancer-resisting medicated wine; Also but the medication slurry is produced immune cancer-resisting oral liquid or beverage and non-staple food, popularizes wide.

Introduce embodiments of the invention (seeing Table 1) below:

Table 1.

By above prescription: make the process of medicated wine with tradition, with an amount of pure grain wine (as 5 times to above-mentioned formulation weight) immersion sealing about 15 days, the taking-up medicine juice blent into 18 ° with medicine, and 28 °, 38 °, 45 ° serial wine.Also available modern biochemical method extracts ingredient, then, is filled in the wine and forms; Also available this medicine juice is filled into the health food that becomes immune cancer-resisting in other non-staple food.Also can be made into immune cancer-resisting oral liquid and fruit juice and tea.

Claims

1, immune anticancer medicine is characterized in that Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Polyporus, Pericarpium Citri Reticulatae, Radix Rehmanniae, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, Fructus Lycii, Rhizoma Polygonati, Radix Adenophorae (Radix Glehniae), Rhizoma Cyperi, Rhizoma Cimicifugae, Fructus Psoraleae, Cortex Cinnamomi, Radix Morindae Officinalis, the Radix Paeoniae Alba, Herba Epimedii, Fructus Ligustri Lucidi, Fructus Chaenomelis, Fructus Corni, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Testa arachidis hypogaeae, Herba Hedyotidis Diffusae, Herba Selaginellae Doederleinii, Pheretima, Bombyx Batryticatus, Herba Cistanches are arranged in the described medicine.

2, immune anticancer medicine as claimed in claim 1 is characterized in that each set of dispense of described medicine is as follows than (weight portion):