CN1985902B - Chinese medicine for treating chronic hepatopathy - Google Patents

Abstract

The Chinese medicine for treating chronic hepatopathy is prepared with 12 kinds of Chinese medicinal materials, including white atractylodes rhizome, Americal ginseng, agaric, tuckahoe, astragalus root, etc in certain weight proportion. It is prepared into capsule or tablet through extraction, concentration, mix, stoving, crushing, sterilizing and other steps.

Description

A kind of Chinese medicine for the treatment of chronic hepatopathy

Technical field

The present invention relates to a kind of Chinese medicine, especially relate to a kind of Chinese medicine for the treatment of chronic hepatopathy.

Background technology

Chronic hepatopathy is commonly encountered diseases, the frequently-occurring disease in the internal disease, and its serious consequence can cause malignant diseases such as liver cirrhosis, hepatocarcinoma, hepatic ascites, and Therapeutic Method is many based on comprehensive therapy at present.China is the chronic hepatopathy district occurred frequently, and the average year sickness rate is 120-140/10 ten thousand.Be outstanding with hepatitis B (HB) especially wherein.China's hepatitis B virus (HBV) infection rate is up to 57.63%, and promptly the whole nation has at least 600,000,000 people to infect HBV.HBsAg positive rate 9.75% has 1.2 hundred million people approximately, accounts for 1/3 of the whole world; Wherein about 1/4 will develop into chronic hepatopathy, and part patient can develop into liver cirrhosis, even develop into hepatocarcinoma.These diseases are serious harm China people's health not only, but also bring serious social economic burden for country.The treatment time of chronic hepatopathy is long, and medical expense is higher, adds inappropriate Drug abuse again, has more increased the weight of country and the extra financial burden of individual.The direct medical treatment that China is used for the treatment of chronic hepatitis, liver cirrhosis, hepatocarcinoma every year expends about 30,000,000,000 yuans.Therefore, strengthen the prevention of chronic hepatopathy, seek effective Therapeutic Method of chronic hepatopathy, very important social meaning is arranged.

Summary of the invention

The object of the present invention is to provide a kind of cheaply, have hepatoprotective, fall enzyme, correct white/ball ratio, fibrosis, improve the Chinese medicine preparation of liver function effect, another object of the present invention provides the preparation method of this Chinese medicine finished product.

Above-mentioned purpose of the present invention mainly is achieved by following technical proposals:

A: prescription: the weight proportion of each component is---Rhizoma Atractylodis Macrocephalae 5%～18%, Radix Panacis Quinquefolii 1%～105, Polyporus 1%～15%, Poria 0%～15%, Radix Astragali 5%～20%, Herba Sedi 10%～50%, Herba Hedyotidis Diffusae 5%～30%, Herba Artemisiae Scopariae 1%～15%, Grilled chicken Endothelium corneum 1%～10%, Radix Salviae Miltiorrhizae 0%～15%, Radix Paeoniae Rubra 1%～10%, the Radix Paeoniae Alba 1%～10%, each component summation is 100%.

B: processing technique---get Herba Sedi, Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae extracting solution earlier and be concentrated into proportion between 1.10～1.15, adding Polyporus, Poria, Radix Astragali decocted 20 minutes, mix with surplus medicine again, stir, through 55 ℃～80 ℃ constant temperature oven oven dry, be ground into 100 order fine powders, sterilization treatment is 10～30 minutes under 100～110 ℃ of temperature, be inserted in capsule set, make capsule; Also can after sterilization, add auxiliary type agent, use the tablet machine compression molding, make tablet.

The present invention is according to Traditional Chinese medical theory, think that the pathogenesis of chronic hepatitis is positive QI-insufficiency, epidemic disease (damp and hot) poison is outer invades, and stops in interior, touching deadlocked, sick position is mainly at liver and gall, taste, pathological product is long struggle between vital QI and pathogen for wet, heat, the stasis of blood, poison, due to the vital QI cannot conquer pathogen, therefore the course of disease of chronic hepatitis can be summarized with " touching deadlocked " four words.Because the chronic hepatitis course of disease " touching deadlocked ", deficiency and excess is staggered, and the syndrome complexity is in the state of struggle between vital QI and pathogen for a long time,, correctly handles the relation of " setting upright " and " eliminating evil " well for this reason, and is very necessary.

The present invention's prescription is by " setting upright " (replenishing QI to invigorate the spleen class), and " eliminating evil " (antipyretic and antidotal type, blood-activating stasis-removing kind) drug regimen forms; Because the sick position of chronic hepatopathy is mainly at liver and gall, taste, pathological product mainly be wet, heat, the stasis of blood, poison, resistance during its being attacked by dampness, heat are the easiest again, " disease of seeing liver is tonifying the spleen in the ban ", so in medicine for treatment, very pay attention to turning round and look at protecting taste, replenishing QI to invigorate the spleen class medicine in the prescription is a monarch-minister drug, and benefiting qi and raising yang is mended and do not hindered heresy; The antipyretic and antidotal type medicine is an adjuvant drug, heat-clearing and toxic substances removing, eliminating evil just the wound; Again because damp and hot bridle of a specified duration, change that to give birth to expectorant turbid, the turbid resistance network of expectorant, hematogenous blockage is satisfied into blood stasis, so select for use medicine that blood-activating stasis-removing kind do not injure one's stomach again as adjuvant; Full side is the treatment rule with " deficiency syndrome should be treated by tonifying method; sthenia syndrome requiring purgation " selecting on the medicine, pay attention to " a moving " word, on consumption, pay attention to " degree " word, degree of keeping and moving, make prescription " mend and do not hinder heresy, eliminating evilly just do not hindering, blood circulation promoting and blood stasis dispelling do not injure one's stomach ", in the guiding patient state of struggle between vital QI and pathogen to helping the development of healthy energy aspect, thereby reach desirable curative effect.

Each component pharmacology:

Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature, tool invigorating the spleen and benefiting QI, dampness diuretic, the Rhizoma Atractylodis Macrocephalae mainly contains volatile oil, lactone compound and polysaccharide, and wherein the volatile oil main component is atractylone, atractylol etc., the Rhizoma Atractylodis Macrocephalae has the function of opening big peritoneum hole significantly, and the open number in peritoneum hole is increased, distribution density obviously increases, and significant treating ascites effect is promptly arranged; The Rhizoma Atractylodis Macrocephalae also has the rate of increase that reduces oncocyte, reduces the aggressive of tumor tissue, and raising body antitumor respond reaches the cytotoxicity to oncocyte.

The main active of Radix Panacis Quinquefolii is the saponin of Radix Ginseng, and saponin can reduce the activity of alanine aminotransferase in the serum, and malonaldehyde (MDA) content is descended, and increases the activity of hepatic glycogen content and glutathione peroxidase, to alleviate hepatic injury; Saponin itself also has active anticancer, and hepatoma carcinoma cell is had tangible tumor-inhibiting action, and suppresses the differentiation again of inducing of tumor, and its antitumaous effect is because due to the immune stimulatory function; In addition, Radix Panacis Quinquefolii polysaccharide is commonly used for immunostimulant, by regulating lotus cancer and T lymphocyte, promotes lymphocyte transformation, to improve immunologic function.

The chemical constituent of Polyporus mainly contains ergosterol, biotin, protein, polyporusum bellatus B etc., and polyporusum bellatus has significant protective effect to liver, and clinical practice is used for the treatment of chronic viral hepatitis more.

The Poria property of medicine relaxes, can heart-spleen boosting, diuretic is wet, mend and not high, sharp and wet, can set upright and can be eliminating evil, mainly contain su-fuling, phytosterin compound, chitin, protein, lecithin, adenine etc., wherein su-fuling has obvious irreversible inhibitory action to the DNA of cancerous cell, and anticarcinogen is had potentiation, also there is obvious enhancing macrophage to produce the ability that induces tumor necrosis factor, hepatoma carcinoma cell is also had the cytotoxin effect; In addition, pachyman has the effect of enhance immunity systemic-function, both strengthened cellular immunization, strengthen humoral immunization again, and gpt activity is obviously reduced, prevent hepatic necrosis, the function that has the swelling of liver cell of making to disappear, liver weight is obviously increased, quicken liver cell regeneration, reach the effect of the liver protecting and ALT lowering.

The Grilled chicken Endothelium corneum, sweet, flat.Return taste, small intestinal, urinary bladder channel.Be longer than the spleen invigorating removing food stagnancy, treating stranguria fossil has the soothing the liver effect that helps spleen behind the processed with vinegar, " key medicine is divided agent " said: " Endothelium Corneum Gigeriae Galli can be gone into liver and be removed liver-heat, go into spleen and diabetes with polyphagia as the prominent symptom is long-pending ", Ginseng west Recording in the Ju 《 Medical Learn inner feelings " record: " the Endothelium Corneum Gigeriae Galli effect is that spleen invigorating is to help the source of vital function; it is vigorous that QI and blood is generated, on annotate in lung the convergence of vessels in the lung; the defeated cloth whole body vital organs of the human body, the sea of blood of making a bet completely is full of and does not overflow; no matter where the internal organs meridians have long-pendingly, and Endothelium Corneum Gigeriae Galli can disappear it to the greatest extent, Endothelium Corneum Gigeriae Galli is with the Rhizoma Atractylodis Macrocephalae and use in addition; be the key medicine of digestion alluvial; the more magical effect of spleen invigorating benefit stomach, the taste stalwartness more can be transported chemical medicine power ... " above theoretical; be used for chronic hepatopathy; just right, chronic hepatitis patients, how impaired the liver spleen is; qi stagnation blood stasis; poly-ly form long-pendingly, and that Endothelium Corneum Gigeriae Galli is gone into liver spleen two is dirty, strengthening the spleen and stomach; change alluvial, giving consideration to both the incidental and fundamental.

Herba Sedi, sweet in the mouth, light, cool in nature has the effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, evacuation of pus granulation promoting, cures mainly erysipelas ulcer, acute, chronic hepatitis etc.; Herba Sedi mainly contains protein, aminoacid, saccharide, flavonoid, triterpenes and Herba Sedi glycoside, and sarmentosin has the inhibition inflammatory exudation, reduces the effect of hepatocyte injury, and serum glutamic pyruvic transminase is reduced.

The Radix Astragali, warm in nature, sweet in the mouth.Be the Chinese medicine resistance and supplementing qi medicine, contain multiple compositions such as polysaccharide, glycoside, flavone and trace element.Experiment shows, astragalus decoction can promote the function that healthy human lymphocyte transforms, enhance immunity and fibrosis all are beneficial to, clinical research shows, Radix Astragali injection can be used for various types of hepatitis patients, especially be applicable to the chronic persistent hepatitis (cph) of cellular immune function reduction and the patient of chronic active hepatitis (cah), but appetite stimulator, improve liver function, its liver glycogen is increased, and lysosome and organize dehydrogenase active strengthens cellular immunization, improve leukocyte and multinuclear leucocyte quantity, reduce hbs antigen (hbsag) titre or make it to turn out cloudy.

Herba Hedyotidis Diffusae has heat-clearing and toxic substances removing, and effects such as inducing diuresis to remove edema, promoting blood circulation and stopping pain for oral administration are used for the treatment of diseases such as malignant tumor, appendicitis, hepatitis, urinary system infection, tonsillitis more, and external can be treated venom, carbuncle furuncle or the like.

Herba Artemisiae Scopariae has the effect of clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice, and its chemical constituent comprises coumarin, flavone, chromone, organic acid, eneyne, triterpene, steroidal and aldehyde ketone; Wherein multiple composition has the function of gallbladder promoting liver-protecting activity; contained choline is a kind of lipotropic vitamin; Herba Artemisiae Scopariae can be protected liver plasma membrane, prevent hepatic necrosis; promote liver cell regeneration and improve liver microcirculation; be widely used in diseases such as treatment jaundice, hepatitis clinically; along with Herba Artemisiae Scopariae effective ingredient function of gallbladder promoting, protect the liver illustrating of mechanism; find that also wherein multiple composition has pharmacological actions such as antitumor, antiinflammatory and antianginal; its antitumor action shows the propagation of direct obstruction tumor cell, and the effect that strengthens cellular immune function.

The Radix Paeoniae Alba, cold nature, bitter in the mouth acid have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing to receive the function of antiperspirant, and the Radix Paeoniae Alba contains paeoniflorin, paeonol, paeoniflorin also contains the peony lactone glycoside, and in addition, the Radix Paeoniae Alba also contains volatile oil, fatty oil, resin, sugar, starch, phlegmatic temperament, protein and triterpenes components; Radix Paeoniae Alba water decoction has obvious facilitation to macrophage function, and the pair cell immunologic function has certain regulating action; But because of Radix Paeoniae Alba decocting liquid antagonism cyclophosphamide to the lymphocytic inhibitory action of peripheral blood T, make it to recover normal level, show that the Radix Paeoniae Alba can make the cellular immune function that is in low state recover normal; The Radix Paeoniae Alba is the Chinese medicine that a class has multiple physiology and pharmacologically active, has that antibacterial action is strong, the characteristics of has a broad antifungal spectrum, and paeoniflorin is brought into play drug effect as main component clinically, is used for the treatment of chronic diseases such as rheumatoid arthritis, hepatitis etc.

The chemical constituent of Radix Paeoniae Rubra mainly is peoniflorin and the former glycosides of paeonol, in addition, also contains benzoic acid, volatile oil, fatty oil, resin, tannin, amylose, phlegmatic temperament, protein etc.; Radix Paeoniae Rubra has the blood circulation promoting and blood stasis dispelling effect of promoting blood circulation preferably, and clinical manifestation improves myocardial ischemia for promoting disappearing of arteriosclerosis focus; Radix Paeoniae Rubra has obvious facilitation to hepatocellular DNA is synthetic, and liver cell regeneration and liver function recovery are had good influence; In addition, Radix Paeoniae Rubra also has the effect of antitumor, increase immunologic function.

As preferably, the medicine of described treatment chronic hepatopathy, the weight proportion that it is characterized in that each component is: Rhizoma Atractylodis Macrocephalae 12%, Radix Panacis Quinquefolii 4%, Polyporus 5%, Poria 5%, Radix Astragali 10%, Herba Sedi 25%, Herba Hedyotidis Diffusae 15%, Herba Artemisiae Scopariae 5%, Grilled chicken Endothelium corneum 5%, Radix Salviae Miltiorrhizae 6%, Radix Paeoniae Rubra 4%, the Radix Paeoniae Alba 4%, each component summation is 100%.

Characteristics such as therefore, the present invention has reasonable recipe, and technology is simple, it has hepatoprotective, falls enzyme, corrects white/ball ratio, fibrosis, improves the effect of liver function chronic hepatopathy, and toxicity evident in efficacy, no, taking convenience, having is a kind of ideal medicament for the treatment of chronic hepatopathy.

The specific embodiment

Below by embodiment, and in conjunction with the accompanying drawings, technical scheme of the present invention is described in further detail.

Embodiment: the Chinese medicine with every production 100Kg treatment chronic hepatopathy is example, get earlier after 25Kg Herba Sedi, 15Kg Herba Hedyotidis Diffusae, 5Kg Herba Artemisiae Scopariae extracting solution be concentrated into proportion and be 1.10～1.15 according to prescription, adding 5Kg Polyporus, 5Kg Poria, 10Kg Radix Astragali decocted 20 minutes, mix with 12Kg Rhizoma Atractylodis Macrocephalae, 4Kg Radix Panacis Quinquefolii, 5Kg Grilled chicken Endothelium corneum, 6Kg Radix Salviae Miltiorrhizae, 4Kg Radix Paeoniae Rubra, the 4Kg Radix Paeoniae Alba again, stir, through 70 ℃ of constant temperature oven oven dry, be ground into 100 order fine powders, sterilization treatment is 20 minutes under 110 ℃ of temperature, be inserted in capsule set, make capsule, promptly can be made into.

At last, should be pointed out that above embodiment only is the more representational example of the present invention.Obviously, technical scheme of the present invention is not limited to the foregoing description, and many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.

Claims (3)

1. a Chinese medicine for the treatment of chronic hepatopathy according to " monarch " formulation principle compatibility, is characterized in that monarch drug is a Rhizoma Atractylodis Macrocephalae; Ministerial drug is Radix Panacis Quinquefolii, Polyporus, Poria, Radix Astragali; Adjuvant drug is Herba Sedi, Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae; Messenger drug is Grilled chicken Endothelium corneum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba; The percentage by weight of each component is: Rhizoma Atractylodis Macrocephalae 5%～18%, Radix Panacis Quinquefolii 1%～10%, Polyporus 1%～15%, Poria 0%～15%, Radix Astragali 5%～20%, Herba Sedi 10%～50%, Herba Hedyotidis Diffusae 5%～30%, Herba Artemisiae Scopariae 1%～15%, Grilled chicken Endothelium corneum 1%～10%, Radix Salviae Miltiorrhizae 0%～15%, Radix Paeoniae Rubra 1%～10%, the Radix Paeoniae Alba 1%～10%, each component summation is 100%.

2. a kind of Chinese medicine for the treatment of chronic hepatopathy according to claim 1, it is characterized in that its processing technique comprises following steps: get Herba Sedi, Herba Hedyotidis Diffusae, Herba Artemisiae Scopariae extracting solution earlier and be concentrated into proportion between 1.10～1.15, adding Polyporus, Poria, Radix Astragali decocted 20 minutes, mix with surplus medicine again, stir, through 55 ℃～80 ℃ constant temperature oven oven dry, be ground into 100 order fine powders, sterilization treatment is 10～30 minutes under 100～110 ℃ of temperature, is inserted in capsule set, makes capsule; Also can after sterilization, add excipient, use the tablet machine compression molding, make tablet.

3. a kind of Chinese medicine for the treatment of chronic hepatopathy according to claim 1 and 2, the weight proportion that it is characterized in that each component is: Rhizoma Atractylodis Macrocephalae 12%, Radix Panacis Quinquefolii 4%, Polyporus 5%, Poria 5%, Radix Astragali 10%, Herba Sedi 25%, Herba Hedyotidis Diffusae 15%, Herba Artemisiae Scopariae 5%, Grilled chicken Endothelium corneum 5%, Radix Salviae Miltiorrhizae 6%, Radix Paeoniae Rubra 4%, the Radix Paeoniae Alba 4%, each component summation is 100%.