CN1296825A - Capsule or tablet for treating viral hepatitis - Google Patents

Abstract

A Chinese medicine in the form of capsule or tablet for treating viral hepatitis, recovering liver function and relieving liver or spleen swelling is prepared from 12 Chinese-medicinal materials including turtle shell, ground beetle, ginseng, belamcanda rhizome, peach kernel, etc through preparing raw materials, purifying and capsulizing or tabletting. Its advantages are high curative effect on viral hepatitis, fatty liver and hepatitises A, B, C and E.

Description

A kind of capsule or tablet for the treatment of viral hepatitis

The present invention relates to a kind of capsule and tablet for the treatment of viral hepatitis, original name GANLIKANG JIAONANG, GANLIKANG PIAN.

In background technology, sell tablet medicines such as ZANGYINCHEN sheet, liver-protecting tablet on the market, all based on the treatment hepatopathy; In " Chinese invention patent communique ", " Chinese medicine " Margarita Huibiedan " of treatment hepatitis B " was disclosed on November 26th, 1997, purpose is to kill hepatitis B virus, promote that liver function recovery is normal, medicine has 16 flavor medicines such as Margarita, Aloe, Semen Momordicae frost, Carapax Trionycis, pyrolusitum, golden Radix Bupleuri, through infusion technology, make capsule preparations.Above-mentioned treatment hepatopathy all has their own characteristics each.

The objective of the invention is to develop a kind of capsule or tablet for the treatment of viral hepatitis, eliminate hepatosplenomegaly, removing blood stasis is attacked the stasis of blood, softening hardness and resolving stasis, the toxin expelling of invigorating blood circulation, reinforcement and elimination in combination, regulate body immunity, the control virus replication improves the liver detoxification ability, promote hepatic tissue to recover and regeneration, reach the treatment viral hepatitis, recover liver function, remove hepatosplenomegaly, hepatitis B virus serum thing is turned out cloudy and can make the purpose of hepatitis A, hepatitis C, hepatitis D, the clear antibody male rotary the moon of the eleventh of the twelve Earthly Branches liver blood.

Technical solution of the present invention is as follows:

Medicine source, side: component of the present invention is the classical prescription " Carapax Trionycis ball " of Treatise on Febrile and Miscellaneous Disease, cures mainly malaria with the passing of time, and fullness and rigidity in the hypochondrium has piece, becomes malaria with splenomegaly; Form and contain Carapax Trionycis, Rhizoma Belamcandae, Radix Scutellariae, Radix Bupleuri, Armadillidium, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, Radix Paeoniae, Cortex cinnamomi japonici (Ramulus Cinnamomi), booth power seed, Folium Pyrrosiae, Cortex Magnoliae Officinalis, Paeonia suffruticosa, Dianthus superbus L., purple prestige, the Rhizoma Pinelliae, Radix Ginseng, eupolyphaga, Colla Corii Asini, beehive, red nitre, Catharsii molossi, Semen Persicae, 23 flavor Chinese herbal medicine, reinforcement and elimination in combination in the side, generous for the removing mass blood stasis dispelling.

The present invention is the change sanction side of above-mentioned " Carapax Trionycis ball ", gets wherein Carapax Trionycis, eupolyphaga, Rhizoma Belamcandae, Semen Persicae, Radix Paeoniae, Radix Ginseng, Radix Scutellariae, Cortex Moutan 8 flavors and adds the Rhizoma Atractylodis Macrocephalaes, my art, pool a kind of reed mentioned in ancient books, Radix Gentianae 4 flavors and form 12 flavors.

Medicine material weight percent content: Carapax Trionycis processed with vinegar 6-14%, eupolyphaga 10-15%, Radix Ginseng 4-6%, Rhizoma Belamcandae 6-10%, Semen Persicae 6-10%, Radix Paeoniae Alba 6-10%, Radix Scutellariae 8-12%, Radix Gentianae 8-12%, unpeeled CORTEX MOUTAN 8-12%, my art 10-15%, pool Siberian cocklebur 10-15%, Rhizoma Atractylodis Macrocephalae 10-15%, getting each component sum is 100%;

Preparation method: raw material is prepared: get above-mentioned eupolyphaga, Rhizoma Belamcandae, Semen Persicae, the Radix Paeoniae Alba, Radix Scutellariae, Radix Gentianae, unpeeled CORTEX MOUTAN, my art, pool Siberian cocklebur, Rhizoma Atractylodis Macrocephalae raw material, and stand-by after processing purifies; Purify:, purify, filter, reduce pressure, be concentrated into relative density 1.3 grams～1.5 gram per centimeters through refluxing above-mentioned material precentagewise weight proportion ³Thick paste, add Carapax Trionycis processed with vinegar and Radix Ginseng powder's mix homogeneously of weight percent; Make:, make a capsules preparation or a tablet preparation by 0.5 gram medicine through vacuum drying.

Advantage of the present invention and effect: 1, good through clinical therapeutic efficacy.Matched group 106 examples, 105 examples are organized in treatment; The treatment standard: glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, alkali phosphatase, total bilirubin, the high value of bilirubin direct, all the arm's length standard scope of formulating with Ministry of Public Health is as the criterion.Through clinical treatment 3 months was a course of treatment, total inspection 6 months; The medication process: matched group adopts anti-hepatitis B immune ribonucleic acid; Each 4mg, the next day once, intramuscular injection, three months is a course of treatment; Oral vitamin B6 measures 0.2g simultaneously, vitamin C amount 0.3g, and inosine 0.4g, every day three times, every month chemical examination liver function is once; Capsule 0.5 gram that the treatment group is made with the present invention, three times every month, each 6,3 months is a course of treatment, every month chemical examination liver function is once.Serological testing: for the anti-source HBSAg in surface, the anti-source HBEAg of E, the anti-source HBCAg of core turns out cloudy simultaneously, and 11 examples are organized in treatment, matched group 2 examples; Turn out cloudy for anti-HBE, 34 examples are organized in treatment, matched group 4 examples; Turn out cloudy for HBEAg, HBCAg, 6 examples are organized in treatment, matched group 2 examples; HBSAg turns out cloudy, and 5 examples are organized in treatment, matched group 1 example; HBSAg, anti--HBE, anti-HBC turn out cloudy, and 6 examples are organized in treatment, matched group 1 example; Total effectively negative conversion rate treatment group 58.4%, matched group 9.4%.

Curative effect: treatment group: after 6 months, liver function is cured 84 examples, produce effects 17 examples, effective 2 examples, invalid 3 examples.Total effectively negative conversion rate 58.4%.

Matched group: after 6 months, liver function is cured 39 examples, produce effects 23 examples, and effective 24 examples, invalid 19, total effectively negative conversion rate 9.4%.

2, through clinical treatment, treatment group cure rate is greater than 79%, total effective rate 98%, matched group cure rate 37%, total effective rate 81.9%; In the treatment group, total bilirubin TB, bilirubin direct DB, glutamate pyruvate transaminase ALT, glutamic oxaloacetic transaminase, GOT, alkali phosphatase ALP have notable difference, liver function to recover obviously excellent and matched group of normal person more than 4 weeks fully before and after the treatment.It is weak to cure mainly the patient, uncomfortable liver area or pain, and dyspepsia, liver is painful, and the matched group hepatosplenomegaly does not have effect substantially.

3, the present invention all has curative effect preferably to viral hepatitis, hepatitis A, hepatitis B, hepatitis C, hepatitis E and fatty liver, and clinical practice has no side effect, and the hepatosplenomegaly that can bounce back can make hepatosplenomegaly with obvious elimination or bounce back to normal.To the high value of albumen, albumen value has tangible balanced action.

4, the elimination clinical symptoms is obvious, can regulate body immunity, the control virus replication recovers liver function, improves the liver detoxification ability, promote hepatic tissue to recover and regeneration, can antiinflammatory, function of gallbladder promoting, jaundice eliminating, improve organism metabolism, can the anti-hepatitis B fibrosis, the effect that suppresses liver cirrhosis and hepatocarcinoma is arranged, the serum virus thing is turned out cloudy.To the clinical symptom that produces: weak, dyspepsia, sodium error, hepatalgia, gallbladder merges the secondary inflammation that the obvious treatment effect is arranged, to surface antigen HBSAg, anti-source HBEAg of E or E antibody HBEAb and the anti-source HBSAg of core or core antibody HBCAb can turn out cloudy fully, thoroughly remove hepatitis B virus, three more than the course of treatment, negative conversion rate is higher, three months each courses of treatment.

The embodiment of the invention: get following weight percent: Carapax Trionycis processed with vinegar 6-14%, eupolyphaga 10-15%, Radix Ginseng 4-6%, Rhizoma Belamcandae, Semen Persicae, the Radix Paeoniae Alba respectively are 6-10%, Radix Scutellariae, Radix Gentianae, each 8-12% of unpeeled CORTEX MOUTAN, my art 10-15%, pool Siberian cocklebur 10-15%, Rhizoma Atractylodis Macrocephalae 10-15% gets the each component sum and is a hundred per cent.Be monarch with Carapax Trionycis, eupolyphaga in the side, eliminate hepatosplenomegaly, Semen Persicae, my art, Radix Paeoniae are minister, removing blood stasis is attacked silt, softening hardness and resolving stasis, the toxin expelling of invigorating blood circulation, treating the liver must be invigorated blood circulation, and the toxin expelling of invigorating blood circulation is the main outline of treatment viral hepatitis, removing blood stasis counteracting toxic substances, remove the knot of blood poisoning heresy, liver is a blood bank, is the major organs of blood digestion, assistant is with pool Siberian cocklebur, the Rhizoma Atractylodis Macrocephalae, invigorating spleen and reinforcing stomach, and toxin expelling is gone out, Radix Scutellariae, Radix Gentianae, Rhizoma Belamcandae are the main medicine of heat clearing away toxin expelling, unpeeled CORTEX MOUTAN, Radix Ginseng, the removing heat from blood that purifies the blood, enhance immunity for making.

Preparation method: 1, raw material is prepared: choose clean fresh raw material, and after the processing section purifies, stand-by.2, purify: the above-mentioned raw materials after will purifying is formed proportioning by weight percentage, wherein Carapax Trionycis routinely infusion become the Carapax Trionycis processed with vinegar, it is stand-by that Radix Ginseng was all made 110 mesh sieve powder.With the said medicine mix homogeneously, place to be equipped with still, adding concentration is 60% ethanol, temperature is controlled at 60 ± 5 degree, reflux, extract, 2 times wherein adds for the first time ten to 20 times of amount alcoholic solution backflow secondaries, and the alcoholic solution that adds 6～10 times of amounts for the second time refluxed 1 hour, merging secondary raffinate filters, filtrate decompression is concentrated into the thick paste that relative density 1.3 restrains～1.5 grams per cubic centimters (60 ℃), adds the Carapax Trionycis processed with vinegar, the Radix Ginseng powder mixes, through disinfection by ultraviolet light; Behind the vacuum drying, be prepared into capsule or tablet by 0.5 gram/capsule or 0.5 gram/sheet, once more through disinfection by ultraviolet light, bottling or making sheet.One capsule or a tablet are equivalent to former medicine 2.5～2.6 grams.Above-mentioned technology all can be produced preparation capsule or tablet routinely.

Claims (1)

1, a kind of capsule or tablet for the treatment of viral hepatitis, it is characterized in that: make by following weight percentages, Carapax Trionycis processed with vinegar 6-14%, eupolyphaga 10-15%, Radix Ginseng 4-6%, Rhizoma Belamcandae 6-10%, Semen Persicae 6-10%, Radix Paeoniae Alba 6-10%, Radix Scutellariae 8-12%, Radix Gentianae 8-12%, unpeeled CORTEX MOUTAN 8-12%, my art 10-15%, pool Siberian cocklebur 10-15%, Rhizoma Atractylodis Macrocephalae 10-15%, getting each component sum is 100%;

Preparation method: raw material is prepared: get above-mentioned eupolyphaga, Rhizoma Belamcandae, Semen Persicae, the Radix Paeoniae Alba, Radix Scutellariae, Radix Gentianae, unpeeled CORTEX MOUTAN, my art, pool Siberian cocklebur, Rhizoma Atractylodis Macrocephalae raw material, usefulness such as after processing purifies; Purify: with above-mentioned material precentagewise weight proportion, purify, filter, reduce pressure, be concentrated into the thick paste of relative density 1.3 grams～1.5 grams per cubic centimters through refluxing, add Carapax Trionycis processed with vinegar and Radix Ginseng powder's mix homogeneously of weight percent; Make:, make a capsules preparation or a tablet preparation by 0.5 gram medicine through vacuum drying.