CN1179662C - Health food composition for liver - Google Patents
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- CN1179662C CN1179662C CNB01132662XA CN01132662A CN1179662C CN 1179662 C CN1179662 C CN 1179662C CN B01132662X A CNB01132662X A CN B01132662XA CN 01132662 A CN01132662 A CN 01132662A CN 1179662 C CN1179662 C CN 1179662C
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Abstract
The present invention discloses a health food composition for livers, which is prepared from medicinal herbs. The health food composition for livers is prepared from wormwood, phellinus linteus teng, ganoderma lucidum, northern crataegus, polygala root, common dayflower herb, aloe, sachalin raspberry leaf, ligusticum jeholense, zanthoxyli, matrimony vine, japanese artactylodes rhizome, common macrocarpium fruit, wrinkled gianthyssop herb, plum blossom, acanthopanax root, heart bamboo leaf, indian buead, tuber fleeceflower root, houttuynia and mongolian dandelion herb. The health food composition for livers is safe to human bodies; the health food composition for livers has excellent effect on promoting liver function.
Description
Technical field
The present invention relates generally to the health food composition to liver, more specifically, relate to compositions with the medicinal herbs preparation, comprise that wormwood sand draws careless mutation (Artemisia Messerschmidtiana Besser), phellinus linteus (Phellinus linteus), Ganoderma (Ganoderma lucidum), Fructus Crataegi (Cratageguspinnatifida Bge.), Radix Polygalae (Polygola tenuifolia Willd), Herba Commelinae (Commelinacommunis L.), Aloe (Aloe.sp.), Caulis et Folium Rubi sachalinensis (Rubus sachalinensis Lev.), Ligusticum jeholense Nakai et kitag (Ligusticum jeholense Kitag.), Fructus Zanthoxyli (Zanthoxylum piperitum (L.) DC.), Fructus Lycii (Lycium chinense Miller), atractylodes japonica (Atractylodes japonica (Koidz.) Kitag.), Fructus Corni (Macrocarpium officinale Sieb.et Zucc.), Herba Pogostemonis (Agastacherugosa (Fischer et Meyer) O.Kuntze), prunus mume (sieb.) sieb.et zucc. (Prunus mume S.et Z.), Radix Et Caulis Acanthopanacis Senticosi (Acanthopanax sessiliflorum Seeman), XINXINGZHUYEZI (Streptolirioncordifolium (GRIFF.) O.KUNITZE), Poria (Poria cocos (Schw.) Wolf), the root of Radix Polygoni Multiflori (Polygonum multiflorum Thunb.), Herba Houttuyniae (Hottuynia cordata Thunb.) and T. platycarpum Dahlst (Taraxacum Platycarpum H.dahlsi) are used for the effective health food of liver.
Background technology
Liver is the intravital trunk gland of people, and the continuous essence that is covered by tunicle constitutes, and the various functions of known realization, comprises bile secretion, makes some blood protease and removes toxin from systemic circulation.The about 2.5-3% of liver percentage of liveweight is a body of gland maximum in the body.In the adult, liver weight is about the 1-1.5 kilogram.Liver is positioned at diaphragm below, and the epigastrium right side is divided into lobus dexter and lobus sinister by caval vein internally to the plane of fossa for gallbladder (along middle hepatic veins).
In vivo, the function of liver can be divided into three classes usually.The first, liver secretes 550-1 every day as digestive gland, and 000cc bile is helped digestion and absorption fatty in the small intestinal.In addition, liver has played important function in various nutrient metabolism, comprise chemical change, storage and utilization.At last, liver is responsible for detoxifcation in the body to a great extent.Many toxin (no matter being external source or inner the generation) are handled neutralization by the oxidation in the liver, reduction, gathering etc., discharge together with bile then or are delivered to kidney, discharge by urine.Say that simply liver has played decomposition, synthesizes and stored the nutrient of carrying by portal vein, contratoxin detoxifcation and drainage, and play a key effect in the metabolism in vivo.
80% blood flow is crossed hepatic portal vein in about liver, and hepatic portal vein is collected blood from digestive tract and spleen, and makes it pass through blood capillary in the liver, and remaining blood is brought oxygen and nutrient into liver from Hepatic artery.When liver hardens, the circulation that blood is can not be in liver good, thus cause portal hypertension, make esophagus, stomach, intestinal and spleen hyperemia.
Liver has shown remarkable compensatory and regeneration function.For example, even people removes the liver of cumulative volume 4/5, his or her life also is safe from danger.Blood flow in the liver is always not constant, influences blood storage in the liver and the control of measuring.The nutrient that is transported to liver from portal vein finally decomposes, as hepatocellular energy.In addition, but their also synthetic polymers are stored in the liver or are discharged in the blood.
Except nutraceutical absorption, metabolism and storage and biliary secretion, liver plays the effect of a part of urinary system, osmotic pressure control, metabolite transhipment and blood coagulation at least.
For example, monosaccharide such as glucose aggregate into glycogen, and it is the energy storages molecule in the liver.This polymerization storage molecule can resolve into glucose when needed, from the hepatic secretion to blood in, come glucose level control.Glucose produces the chemical energy of ATP form further being decomposed through the TCA circulation in mitochondrion.
Fatty acid through beta oxidation, becomes S-acetyl-coenzyme-A in hepatocellular mitochondrion, produce ATP simultaneously.S-acetyl-coenzyme-A by further oxidation, discharges ATP in the TCA circulation.Fatty acid also is used to synthetic cholesterol.When combining with glycerol, fatty acid is synthesized neutral lipid and phospholipid.Be stored at the active metabolism of fat quilt in the liver, do not increase, and because anti--fatty liver factor maintains constant level (3-5%) as methionine, choline, lecithin etc., these factors eliminated the fat that accumulates in the liver above certain level.
Aminoacid is orgotein by biosynthesis, as albumin, globulin, Fibrinogen, thrombinogen, lipoprotein etc., is stored at liver (protein library) or is discharged in the blood.In hepatocyte, aminoacid is by amino deaminizating or transamination metabolism.Oxidized in the Krebs circulation when the keto acid that aminoacid produces during by deaminizating, come produce power.Another kind of approach is synthetic ketoboidies or saccharide.The ammonia that the aminoacid deaminizating produces is converted to urea in ornithine cycle, be discharged in the urine then.
In addition, as mentioned above, liver has played gluconeogenesis, promptly from non-sugar precursor, produces sugar as lactic acid, glycerol or aminoacid.
Various vitamin, especially vitamin A, D, B
1, B
2, B
12Be stored within the hepatocyte with folic acid, and be activated.A kind of critical function of liver is the secretion cholic acid, and it is that the small intestinal lipid metabolism is essential.In addition, in liver, blood toxicity is detoxified.After bonded glucuronic acid was removed, the antibacterial in the intestinal had formed urobilinogen with bilirubin.The sub-fraction urobilinogen is heavily absorbed, and is extracted from circulation by hepatocyte, and is discharged by kidney.If formed excessive bilirubin, as when the haemolysis, can occur urobilinogen in urine increases, and is converted to xanchromatic Urobilin.
Because many nutritional factorss, comprise the metabolism of sugar, lipid, protein, aminoacid, vitamin etc., receive the control of liver between at least, if liver becomes unusually, they just can not effectively be used in vivo.In addition, hepatic disease such as hepatitis, fatty liver, liver cirrhosis etc. also can cause fatal result.
Hepatic disease, as acute and chronic hepatitis, liver cirrhosis etc., mainly because drug dependence, excessively potable spirit, stress cause with viral infection, cause not energy metabolism and synthetic of various nutrients.
Usually, with rest cure, dietotherapy and pharmacotherapy treatment hepatic disease.For pharmacotherapy, use aminoacid such as arginine, methionine, sulfur proline, glycine, peptide, thioctic acid, glutathion, liver or pancreas extract, glucuronic acid derivant and from the glycyrrhizin of Radix Glycyrrhizae (Glycyrrhiza glabra).Particularly, known glycyrrhizin is useful to the recovery of the liver function of chronic hepatitis.Yet if Orally administered, this extract of Radix Glycyrrhizae can not be kept its pharmacological effect.
Yet except that virus and alcoholic hepatitis, the pathology mechanism of hepatic disease is unclear as yet to be illustrated.The treatment hepatic disease mainly relies on rest cure or dietetic therapy.Recently, many Europe and Japanese firm have researched and developed new medicine, are used for the treatment of hepatic disease.For example, find Nippon Nohyaku, the Malotilate of Japan exploitation can suppress hepatic fibrosis by recovering hepatocellular RNA and protein synthesis.Yet this chemical compound only is used for the treatment of liver cirrhosis.
Another example of medicine newly developed is cianidanol (cyanidanol), is used for the treatment of the Type B viral hepatitis.Yet the pharmacological Mechanism of this chemical compound it be unclear that.In addition, some patients that used this chemical compound are in Italy and Portugal's death.At present, the use of cianidanol is forbidden in Japan.
Therefore, need a kind of safe drugs, be used for prevention and treatment broad-spectrum hepatic disease.
Summary of the invention
The inventor is in order to overcome the problem that runs in the prior art, thereby liver health food has been carried out extensive research obtained the present invention, found that some wild medical herbs can improve liver function, and for the treatment hepatic disease medically be effective.
Therefore, an object of the present invention is to provide a kind of health food composition to liver, it is safe for human body, and improves liver function.
According to the present invention, a kind of health food composition to liver can be provided, finish above-mentioned purpose, said composition contains: the wormwood sand of 5-10% weight draws careless mutation, the phellinus linteus of 5-10% weight, the Ganoderma of 5-10% weight, the Fructus Crataegi of 2-8% weight, the Radix Polygalae of 2-8% weight, the Herba Commelinae of 2-8% weight, the Aloe of 2-8% weight, the Caulis et Folium Rubi sachalinensis of 2-8% weight, the Ligusticum jeholense Nakai et kitag of 2-8% weight, the Fructus Zanthoxyli of 2-8% weight, the Fructus Lycii of 2-8% weight, the atractylodes japonica of 2-8% weight, the Fructus Corni of 2-8% weight, the Herba Pogostemonis of 2-8% weight, the prunus mume (sieb.) sieb.et zucc. of 2-8% weight, the Radix Et Caulis Acanthopanacis Senticosi of 2-8% weight, the XINXINGZHUYEZI of 2-8% weight, the Poria of 2-8% weight, the Radix Polygoni Multiflori of 2-8% weight, the T. platycarpum Dahlst of the Herba Houttuyniae of 2-8% weight and 2-8% weight.
The specific embodiment
The present invention relates to a kind of compositions from the medicinal herbs preparation, the health food that is used for liver, comprise that wormwood sand draws careless mutation, phellinus linteus, Ganoderma, Fructus Crataegi, Radix Polygalae, Herba Commelinae, Aloe, Caulis et Folium Rubi sachalinensis, Ligusticum jeholense Nakai et kitag, Fructus Zanthoxyli, Fructus Lycii, atractylodes japonica, Fructus Corni, Herba Pogostemonis, prunus mume (sieb.) sieb.et zucc., Radix Et Caulis Acanthopanacis Senticosi, XINXINGZHUYEZI, Poria, Radix Polygoni Multiflori, Herba Houttuyniae and T. platycarpum Dahlst.
Wormwood sand draws the herbaceos perennial that careless mutation is a kind of high 1-1.5 rice.Find that this herbaceous plant contains quintessence oil, as pinene, terpinene, limonene, terpinol and citronellol, aromatic hydroxycarboxylic acids, as chlorogenic acid and caffeic acid, flavonoid, hydroxycoumarin etc.Recently, drawn the careless mutation from wormwood sand and be separated to umbelliferone.In the medical science, this herbaceos perennial is used as antibiotic, antipyretic, diuretic and sweating medicine in the Orient, is used for the treatment of febrile icterus disease, hepatitis and cholecystitis.
(Chaenomeles sinensis) is the same with Fructus Chaenomelis, and the fruit of Fructus Crataegi shows the medical science function that promotion is urinated, because they contain quercetin and oleanolic acid.The fruit of also finding Fructus Crataegi contains vitamin B, C, carotene and chlorogenic acid.In the Orient in the medical science, fruit be used for the treatment of suffer from puerperal abdonimal pain, be still drank after a night, dyspepsia or diarrheal patient.Particularly this fruit is used as stomachic.
Radix Polygalae belongs to Polygalaceae, is a kind of herbaceos perennial, has thick and long root.A branch of main root is long to about 30 centimeter length, and the root hair seldom.Its flower is a purple, opens racemose flower in summer.Every flower has five sepals, and wherein lower two sepals and a sepal are strips, and in addition two sepals as a slice petal.Every flower separates at an upper portion thereof, forms petal, and the bottom is integrated.The end of each petal separates, as Folium Pini.Its capsule is flat, is divided into two parts.
Herba Commelinae, formal name used at school are Commelina communis L., are a kind of annual herb plants, high 15-50 centimetre.Its spire and stem are as medicine.
Aloe contains the aloin (C of 16-20% weight
20H
18O
9), emodin, nataloin (nataloin), isoemodin and the resin of 12% weight.Because its bitterness, Aloe are used to appetizing.In the medical science, Aloe is used for the treatment of baby's anemia and constipation with the dosage of 1-2 gram in the Orient.
The fruit of Caulis et Folium Rubi sachalinensis is rich in organic acid, as citric acid, salicylic acid, caproic acid, formic acid and salt thereof.Find that also this fruit contains pectin, carotene (0.3 milligram of %), vitamin B, 4.3% glucose, 8% fructose, 6.5% sucrose, 0.3% tannin, cyanidin chloride (C
27H
31O
6), acetoin (C
4H
8O
2), alpha, beta-lonone, benzaldehyde etc.In animal experiment, the decoct that identifies Caulis et Folium Rubi sachalinensis can alleviate heating, and as cardiac tonic and diuretic.In the medical science, this fruit is suffered from the patient of fever, flu, pneumonia or cough by open in the Orient.
The root of Ligusticum jeholense Nakai et kitag contains quintessence oil and coumarin, is used as tranquilizer in the medical science in the Orient.
Fruit or the peel of Fructus Zanthoxyli contain quintessence oil, and its amount is a 2-4% weight, mainly by dipentene (C
10H
16, 54%), citronellal (C
10H
18, 8%), 1-β-phellandrene (C
10H
16), geraniol and citronellol form.In addition, the characteristic pungent of this fruit is owing to Fructus Zanthoxyli alcohol Zanthol I and II, and their amount is respectively 5-8%.Known these components show the local anesthesia effect.It is ripe more that fruit becomes, and shows strong more anesthetic action.In addition, find that fruit is inhibited to various pathogenic bacterias.In the medical science, as fragrant stomachic, treat gastroenteritis, flatulence and gastroptosis in the Orient with this fruit.It is also as diuretic, local irritant and vermicide.
Phellinus linteus is a kind of white saprophytic fungus, belongs to rust leather (Hymenochaetaceae) section.In some nearest researchs, the extract of finding its sporophore shows the antitumor action up to 96.7%.In addition, the extract that also identifies its haploid mycelium also has anti-tumor activity and can enhance immunity.
The fruit of Fructus Lycii contains vitamin and zeaxanthine.Recently, identify scopoletin (scopletin) from this fruit, this is a kind of biological active agents.Also isolate carotenoid and sterol, be accredited as physalin and cupreol respectively.In the medical science, Chinese wolfberry fruit is used as depressor in the Orient.Have the function that reduces blood cholesterol levels owing to be found, this fruit is used to prevention and treatment arteriosclerosis.In some ancient medical books, describe this fruit and can be used for the treatment of lumbago, weak, dizzy, headache and diabetes.The people who has also described this fruit of chronic administration will enjoy medicinal effectiveness, comprise the bone density of increase, strong health, clearly vision, to cold and hot insensitive, and long-lived.
Atractylodes japonica is a kind of 80 centimetres of high herbaceos perennials.In the medical science, its root is useful in the Orient.For as medical material,, remove radicula, then sun cured at the root of spring and autumn collection atractylodes japonica.Known drying, root thick and that removed the peel show stronger medicinal effectiveness.This root contains quintessence oil and carotene, inulin and the alkaloid of 1.5% weight of having an appointment.Discovery shows calmness, nervus centralis paralysis, blood pressure lowering and diuresis from the quintessence oil that the root extracting goes out, and is used as fragrant stomachic treatment dyspepsia.In the medical science, the velamen of atractylodes japonica is described as and water can be excreted in the Orient.Therefore, it is used as the diuretic and the sweating medicine for the treatment of renal failure.It also by open suffer from diarrhoea, feel sick, diabetes, pulmonary tuberculosis, cough, rheumatoid arthritis, gout, heating, flu, hepatic disease, the splenopathy and malignant tumor.
The fruit of Fructus Corni contains crystalline organic acid, gallic acid, malic acid, tartaric acid etc.Morroniside (morroniside), Semen Strychni glycosides and sweroside in peel, have been found.In the medical science, help to recover renal function and be used for usually perspiring or oliguria with this fruit, or suffer from the patient of lumbago or menoxenia in the Orient.
Herba Pogostemonis is a kind of perennial plant of high 1-1.5 rice.Isolate and account for herb about 0.3%, the quintessence oil of 5% and stem 0.1% of about 0.2-2.3% of leaf, flower is by methyl chavicol, anisaldehyde, methoxybenzene (anethol), d-limonene, sesquiterpene, australene, nopinene, α-limonene, oxane ketone, form P-cymene (P-cymol) and coriandrol.Also isolate flavonoid, comprise acacetin, tiliadin (tiliacin), Lignum cinnamomi camphorae element (linalin) and agastachoside.In the medical science, this herbaceous plant is used as stomachic, carminative, digestive pharmaceutical or antipyretic in the Orient, and is applied to by hot weather and influences, and has dyspepsia, flu, and headache, or suffer from vomiting and diarrheal patient.In addition, this herbaceous plant also is usually used in treating cortex disease and tumor.Particularly, it is mainly used in treatment spleen and gastric disease.
Radix Achyranthis Bidentatae (Achyranthes bidentata B1) is a kind of about 90 centimetres of high perennial plants.The root that it dries in the sun is useful on materia medica in the medical science in the Orient.When velamen is under water, saponin (as oleanolic acid and glucuronic acid) can with alkaloid, as achyranthine (C
6H
11O
2NH
2O) etc. discharge together.In addition, be separated to a large amount of mucus from root.Water extract contains have an appointment 6% ash and about 24.5% potassium.In animal experiment, find that the water and the pure extract of root has uterotonic pharmic function.In addition, identify extract and can promote the glomerular filtration effect, and suppress the heavily absorption of renal tubules, thereby show the diuretic pharmic function.
In the medical science, the fruit of prunus mume (sieb.) sieb.et zucc. is used to promote the function of liver and gallbladder and relaxes heating and pain in the Orient.In addition, this fruit is used to quench one's thirst.They also are used to treat leucorrhea and diarrhoea.Other disease example with the treatment of the fruit of prunus mume (sieb.) sieb.et zucc. comprises menoxenia, constipation, has blood in stool, hematuria, paralysis and infantile spasm.
Used the bark of Radix Et Caulis Acanthopanacis Senticosi among the present invention.Acanthoside, tannin, quintessence oil and vitamin A and C have been separated to from bark.Bark also contains water soluble polysaccharide, helps drug component water-soluble and be absorbed into health.In the Orient in the medical science, with the short restorative of bark conduct, diuretic, stomachic or analgesic.In addition, they also are used to treatment of arthritis, neuralgia, nervous dyspepsia, vitamin B1 deficiency, flu and lumbago.
XINXINGZHUYEZI is a kind of annual herb plant, and is grown in humidity at the foot of the hill.A branch of softish stem diverges to branch, and total length is to about 80 centimetres.It is lobate that leaf grows up to list, and be heart-shaped, has the handle of coming into leaves.Summer, stem or the branch end have spending in vain of diameter 5-6 millimeter.Long 4 millimeters of calyx have arteries and veins in 1-3, and stamen has curling fine hair.Its fruit is avette, and long 8-11 millimeter has three crestal lines, does not have hair, contains 2-6 grain seed.Children's stem and leaf are as food.
Poria is rich in the polysaccharide pachyman.This herbaceous plant also contains triterpene, sugar, inorganic matter and ergosterol.In the medical science, as diuretic or tranquilizer, be used for the treatment of edema, gastroptosis, cardiopalmus, insomnia, clonism and dizzy in the Orient with this herbaceous plant.In addition, this herbaceous plant is used to stimulate appetite.
The root of analyzing the discovery Radix Polygoni Multiflori has about 1.8% hydroxymethyl anthraquinone derivative, about 45% starch, about 3% lecithin and about 26% water-soluble substances.In the medical science, treat puerperal or senile constipation in the Orient with radical cure, and dermatosis, as pruritus and eczema.The nourishing of known Radix Polygoni Multiflori root and blood tonification effect are stronger than Radix Rehmanniae (Rehmanniaglutinosa (GAERTNER) LIBOSCHITZ) or Radix Asparagi (Asparagus cochinchinensis (Lour.) Merr).
Herba Houttuyniae is a kind of herbaceos perennial, high 15-30 centimetre.This medical herbs plays the effect of anti-inflammatory, diuretic and antidote, is used for the treatment of gonorrhea, urethritis, cystitis, metritis, pneumonia, bronchitis, edema, tinea pedis, anal fistula, proctoptosis and abscess.Drink the tea that steeps with Herba Houttuyniae every day if in famous ancient medical book, described a people, can avoid suffering from arteriosclerosis.
Ganoderma is a kind of mushroom of basidiomycetes, belongs to Polyporaceae, and Aphyllophorales is long at the deciduous tree root.Mushroom has a cap, and the hard glossy top layer of one deck is arranged above.This mushroom plays the effect of tonic, antitussive, anticarcinogen, is used for the treatment of neurasthenia, heart disease, hypertension and cancer in the Orient in the medical science.
T. platycarpum Dahlst is used for the treatment of biliary tract.This herbaceous plant also can be used for urinary system.In addition, stomach is the position that this medical herbs is brought into play its drug effect.Therefore, it is used to treat dyspepsia, gastritis and stomachache.Particularly it is used as convalescent appetite stimulant.Example with other disease of this herbtherapy has dyschesia, flu, laryngalgia and eyes to ache.
As mentioned above, the material that uses among the present invention is to obtain from the medical herbs of spontaneous growth, is safe to human body.In order to be used for the compositions of liver health food, wormwood sand is drawn fruit, Radix Polygalae, Herba Commelinae, Aloe, the fruit of Caulis et Folium Rubi sachalinensis, Ligusticum jeholense Nakai et kitag root, the fruit of Fructus Zanthoxyli, the fruit of Fructus Lycii, atractylodes japonica, the fruit of Fructus Corni, Herba Pogostemonis, prunus mume (sieb.) sieb.et zucc., Radix Et Caulis Acanthopanacis Senticosi bark, XINXINGZHUYEZI, the Poria of careless mutation, phellinus linteus, Ganoderma, Fructus Crataegi, and the root of Radix Polygoni Multiflori, Herba Houttuyniae and T. platycarpum Dahlst are dry and pulverize.Mixture of powders can be mixed with tablet, pill or capsule form, or be used as the material of beverage or decoction.In addition, available hot water or organic solvent extracting medical herbs.
Can obtain better understanding of the present invention according to the following example, to list these embodiment and be in order to illustrate, rather than in order to limit the present invention.
Embodiment 1
Health food composition to liver
The compositions that has prepared liver health food from following component:
| Wormwood sand draws careless mutation | 8% weight |
| Phellinus linteus | 6% weight |
| Ganoderma | 6% weight |
| The fruit of Fructus Crataegi | 4% weight |
| Radix Polygalae | 4% weight |
| Herba Commelinae | 4% weight |
| Aloe | 4% weight |
| The fruit of Caulis et Folium Rubi sachalinensis | 4% weight |
| The root of Ligusticum jeholense Nakai et kitag | 4% weight |
| The fruit of Fructus Zanthoxyli | 4% weight |
| The fruit of Fructus Lycii | 4% weight |
| Atractylodes japonica | 4% weight |
| The fruit of Fructus Corni | 4% weight |
| Herba Pogostemonis | 4% weight |
| Prunus mume (sieb.) sieb.et zucc. (fruit) | 4% weight |
| The bark of Radix Et Caulis Acanthopanacis Senticosi | 4% weight |
| XINXINGZHUYEZI | 4% weight |
| Poria | 4% weight |
| The root of Radix Polygoni Multiflori | 4% weight |
| Herba Houttuyniae | 4% weight |
| T. platycarpum Dahlst | 4% weight |
In following animal experiment, tested the promotion of compositions to liver function:
Experimental embodiment 1: health food is to the effect of acute insufficiency
Before test, the Sprague-Dawley rat of heavily about 200 grams was cultivated for 1 week or longer in keeping the animal testing chamber of steady temperature and humidity.Selection thinks that healthy rat is used for test.
50 rats selecting are divided into 5 groups, 10 every group, administration then.For the test group, intravenous is suspended in compositions 4 days in 9% saline with 1 milligram/kilogram/day, 20 milligrams/kilogram/days and 100 milligrams/kilogram/days injections.After injecting the dusk last day, be 0.2 milliliter of carbon tetrachloride (CCl that the Orally administered ratio of per kilogram of body weight is 1: 4 (v/v) with dosage to the test group
4) and the mixture of Semen Maydis oil.For two matched groups, in the injection phase, only use 0.9% saline.Inject last day at dusk after, feed to one of matched group Semen Maydis oil and another organizes the mixture of oral carbon tetrachloride and Semen Maydis oil.Hereinafter table 1 has been summed up the administration timetable of each group.
Table 1
The administration timetable
| Group | The administration timetable | ||||
| The 1st day | The 2nd day | The 3rd day | Evenings 6 on the 4th point | Evenings 9 on the 4th point | |
| A | Saline | Saline | Saline | Saline | Semen Maydis oil |
| B | Saline | Saline | Saline | Saline | CCl 4 |
| C | 1 milligram/kilogram/day of compositions | 1 milligram/kilogram/day of compositions | 1 milligram/kilogram/day of compositions | 1 milligram/kilogram/day of compositions | CCl 4 |
| D | 20 milligrams/kilogram/days of compositionss | 20 milligrams/kilogram/days of compositionss | 20 milligrams/kilogram/days of compositionss | 20 milligrams/kilogram/days of compositionss | CCl 4 |
| E | 100 milligrams/kilogram/days of compositionss | 100 milligrams/kilogram/days of compositionss | 100 milligrams/kilogram/days of compositionss | 100 milligrams/kilogram/days of compositionss | CCl 4 |
Annotate: 0.9% saline
CCl
42.5 milliliter/kilogram/day
CCl
4With with the mixture oral administration of Semen Maydis oil.
Composition suspendedly float in 0.9% the saline oral administration.
After administration the 5th day, hungry 12 hours of all rats, the anesthesia back is from the heart extracting blood sample.Measured the sero-enzyme activity, hereinafter table 2 has been listed the result.
Table 2
The activity value of sero-enzyme S-AST and S-ALT
| Group | S-AST | S-ALT |
| Value (U/L) | Ratio | Value (U/L) | Ratio | |
| A | 85±5 | - | 46±3 | - |
| B | 4879±652 | 100.0 | 1381±386 | 100.0 |
| C | 2613±989 | 53.6 | 564±169 | 408 |
| D | 352±52 | 7.2 | 115±22 | 8.3 |
| E | 161±27 | 3.2 | 67±12 | 4.8 |
Show that as the data of table 1 composition dosage of liver health food is big more, the improvement of liver function is big more.
Experimental embodiment 2
The comparison in promoting liver function of compositions and alpha-tocopherol
The known alpha-tocopherol of liver function and the compositions of the present invention of promoting compared.To this, compositions of the present invention and alpha-tocopherol respectively with 20 milligrams/kilogram/days and 350 milligrams/kilogram/days, are applied to rat with method identical among the embodiment 1.Measure the S-AST and the S-ALT activity of the blood sample that each test group obtains.Hereinafter table 3 has provided the result.
Table 3
| Group | S-AST | S-ALT | ||
| Value (U/L) | Ratio | Value (U/L) | Ratio | |
| Contrast | 100±4 | 4.1 | 38±1 | 2.6 |
| Use the contrast of CCl4 | 2439±148 | 100.0 | 1482±44 | 100.0 |
| Use compositions | 1251±117 | 50.9 | 276±19 | 18.6 |
As seen in Table 3, with alpha-tocopherol relatively, when using the health food composition to liver of the present invention, the improvement of liver function is bigger.
As described earlier in this article,, provide a kind of health food composition, be used to improve liver function according to the present invention.Said composition is made with medicinal herbaceous plant, is safe to liver, and has shown pharmacotoxicological effect.
Described the present invention with illustrative approach, it is descriptive rather than restrictive should understanding used term.According to top spirit, the present invention can have many modifications and change.Therefore, should understand the present invention can use the mode except the mode of top special description to implement within the scope of the claims.
Claims (1)
1. health food composition to liver is characterized in that said composition contains:
The wormwood sand of 5-10% weight draws careless mutation,
The phellinus linteus of 5-10% weight,
The Ganoderma of 5-10% weight,
The Fructus Crataegi of 2-8% weight,
The Radix Polygalae of 2-8% weight,
The Herba Commelinae of 2-8% weight,
The Aloe of 2-8% weight,
The Caulis et Folium Rubi sachalinensis of 2-8% weight,
The Ligusticum jeholense Nakai et kitag of 2-8% weight,
The Fructus Zanthoxyli of 2-8% weight,
The Fructus Lycii of 2-8% weight,
The atractylodes japonica of 2-8% weight,
The Fructus Corni of 2-8% weight,
The Herba Pogostemonis of 2-8% weight,
The prunus mume (sieb.) sieb.et zucc. of 2-8% weight,
The Radix Et Caulis Acanthopanacis Senticosi of 2-8% weight,
The XINXINGZHUYEZI of 2-8% weight,
The Poria of 2-8% weight,
The Radix Polygoni Multiflori of 2-8% weight,
The Herba Houttuyniae of 2-8% weight and
The T. platycarpum Dahlst of 2-8% weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01132662XA CN1179662C (en) | 2001-09-05 | 2001-09-05 | Health food composition for liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01132662XA CN1179662C (en) | 2001-09-05 | 2001-09-05 | Health food composition for liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403021A CN1403021A (en) | 2003-03-19 |
| CN1179662C true CN1179662C (en) | 2004-12-15 |
Family
ID=4671503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB01132662XA Expired - Fee Related CN1179662C (en) | 2001-09-05 | 2001-09-05 | Health food composition for liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1179662C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100509649B1 (en) * | 2003-07-04 | 2005-08-24 | 진주상황버섯영농조합법인 | Method for producing noodle and Chinese noodle(Ramyon) containing an extract of Phellinus Linteus Teng |
| CN1308014C (en) * | 2004-06-28 | 2007-04-04 | 张克 | Medicine for treating hepatitis B hepatitis C, hepatitis cirrhosis |
| CN101912456B (en) * | 2010-07-28 | 2012-09-19 | 福建中医药大学 | Novel application of rubus alceaefolius poir total alkaloid |
| CN108853470A (en) * | 2017-05-08 | 2018-11-23 | 谢勇 | A kind of composition of the Chinese medicine that can promote liver function recovery and nutrient |
-
2001
- 2001-09-05 CN CNB01132662XA patent/CN1179662C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1403021A (en) | 2003-03-19 |
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