CN1205468C - 用氟nmr定量表示固相反应的方法和含氟固相反应组分 - Google Patents

用氟nmr定量表示固相反应的方法和含氟固相反应组分 Download PDF

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Publication number
CN1205468C
CN1205468C CNB988133334A CN98813333A CN1205468C CN 1205468 C CN1205468 C CN 1205468C CN B988133334 A CNB988133334 A CN B988133334A CN 98813333 A CN98813333 A CN 98813333A CN 1205468 C CN1205468 C CN 1205468C
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China
Prior art keywords
fluorine
polystyrene resin
resin
phase reaction
solid phase
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Expired - Fee Related
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CNB988133334A
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English (en)
Chinese (zh)
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CN1284165A (zh
Inventor
V·K·纳古拉帕里
E·奥顿
J·E·艾雷
P·H·克罗里科斯基
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Aventis Pharmaceuticals Inc
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Aventis Pharmaceuticals Inc
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Priority claimed from PCT/US1997/023920 external-priority patent/WO1998029376A1/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of CN1284165A publication Critical patent/CN1284165A/zh
Application granted granted Critical
Publication of CN1205468C publication Critical patent/CN1205468C/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/14—Esterification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C08F8/20—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/26—Removing halogen atoms or halogen-containing groups from the molecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
CNB988133334A 1997-12-17 1998-12-14 用氟nmr定量表示固相反应的方法和含氟固相反应组分 Expired - Fee Related CN1205468C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/US1997/023920 WO1998029376A1 (en) 1996-12-19 1997-12-17 Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds
USPCT/US97/23920 1997-12-17
US9056398P 1998-06-24 1998-06-24
US9055898P 1998-06-24 1998-06-24
US60/090,563 1998-06-24
US60/090,558 1998-06-24

Publications (2)

Publication Number Publication Date
CN1284165A CN1284165A (zh) 2001-02-14
CN1205468C true CN1205468C (zh) 2005-06-08

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ID=27376603

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988133334A Expired - Fee Related CN1205468C (zh) 1997-12-17 1998-12-14 用氟nmr定量表示固相反应的方法和含氟固相反应组分

Country Status (16)

Country Link
EP (1) EP1044364B8 (enExample)
JP (1) JP2003522934A (enExample)
CN (1) CN1205468C (enExample)
AT (1) ATE364837T1 (enExample)
AU (1) AU748529C (enExample)
BG (1) BG65184B1 (enExample)
BR (1) BR9813701A (enExample)
CA (1) CA2315152A1 (enExample)
DE (1) DE69837936T2 (enExample)
DK (1) DK1044364T3 (enExample)
ES (1) ES2288310T3 (enExample)
HU (1) HUP0200726A2 (enExample)
IL (1) IL136718A0 (enExample)
MX (1) MXPA00006050A (enExample)
PL (1) PL197620B1 (enExample)
WO (1) WO1999031491A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280272A1 (en) * 2000-09-27 2011-02-02 Universiteit Leiden Method for applying NMR for ligand discovery or as a drug screening tool
FR2955862B1 (fr) * 2010-02-02 2012-07-13 Commissariat Energie Atomique Materiau polymere fluorocarbone et procede de synthese
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN108593696B (zh) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 一种利用定量核磁测定多肽中三氟乙酸残留的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5566324A (en) * 1992-12-24 1996-10-15 Ncr Corporation Computer apparatus including a main memory prefetch cache and method of operation thereof
GB9515070D0 (en) * 1995-07-22 1995-09-20 Zeneca Ltd Label
US6355490B1 (en) * 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis

Also Published As

Publication number Publication date
PL197620B1 (pl) 2008-04-30
EP1044364A1 (en) 2000-10-18
PL341357A1 (en) 2001-04-09
BG104614A (en) 2001-10-31
WO1999031491A1 (en) 1999-06-24
DE69837936D1 (de) 2007-07-26
AU748529C (en) 2002-10-17
MXPA00006050A (es) 2004-05-21
DK1044364T3 (da) 2007-09-24
BR9813701A (pt) 2000-12-12
EP1044364B1 (en) 2007-06-13
CN1284165A (zh) 2001-02-14
ES2288310T3 (es) 2008-01-01
DE69837936T2 (de) 2008-02-28
IL136718A0 (en) 2001-06-14
AU748529B2 (en) 2002-06-06
ATE364837T1 (de) 2007-07-15
HUP0200726A2 (en) 2002-06-29
BG65184B1 (bg) 2007-05-31
AU2556999A (en) 1999-07-05
EP1044364B8 (en) 2008-01-02
JP2003522934A (ja) 2003-07-29
EP1044364A4 (en) 2004-10-06
CA2315152A1 (en) 1999-06-24

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Granted publication date: 20050608

Termination date: 20100114