CN119979504A - 含用于纯化芳基硫酸酯酶a的方法 - Google Patents

含用于纯化芳基硫酸酯酶a的方法 Download PDF

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Publication number
CN119979504A
CN119979504A CN202510351647.7A CN202510351647A CN119979504A CN 119979504 A CN119979504 A CN 119979504A CN 202510351647 A CN202510351647 A CN 202510351647A CN 119979504 A CN119979504 A CN 119979504A
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China
Prior art keywords
chromatography
asa
column
protein
buffer
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Pending
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CN202510351647.7A
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English (en)
Chinese (zh)
Inventor
D·尼科尔斯
I·基农尼斯·加西亚
B·L·郑
M·H·蒋
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of CN119979504A publication Critical patent/CN119979504A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001—Arylsulfatase (3.1.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06008—Cerebroside-sulfatase (3.1.6.8)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202510351647.7A 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法 Pending CN119979504A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361750693P 2013-01-09 2013-01-09
US61/750,693 2013-01-09
CN201480003307.5A CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
PCT/US2014/010856 WO2014110246A1 (en) 2013-01-09 2014-01-09 Methods for purification of arylsulfatase a

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480003307.5A Division CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Publications (1)

Publication Number Publication Date
CN119979504A true CN119979504A (zh) 2025-05-13

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN202510351647.7A Pending CN119979504A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN201480003307.5A Pending CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202011058581.6A Pending CN112126634A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202510851520.1A Pending CN120665836A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201480003307.5A Pending CN104903442A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202011058581.6A Pending CN112126634A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法
CN202510851520.1A Pending CN120665836A (zh) 2013-01-09 2014-01-09 含用于纯化芳基硫酸酯酶a的方法

Country Status (12)

Country Link
US (3) US11407984B2 (enExample)
EP (1) EP2943568B1 (enExample)
JP (5) JP6427502B2 (enExample)
CN (4) CN119979504A (enExample)
AU (3) AU2014205441B2 (enExample)
BR (1) BR112015015948B1 (enExample)
CA (1) CA2896979C (enExample)
EA (1) EA030551B1 (enExample)
ES (1) ES2768261T3 (enExample)
HK (1) HK1214622A1 (enExample)
MX (2) MX372711B (enExample)
WO (1) WO2014110246A1 (enExample)

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JP6985282B2 (ja) * 2016-03-16 2021-12-22 フェニックス ティシュー リペア インコーポレイテッドPhoenix Tissue Repair, Inc. ７型コラーゲンの精製方法
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
KR20200107984A (ko) * 2017-12-19 2020-09-16 샤이어 휴먼 지네틱 테라피즈 인크. 정제된 아릴설파타아제 a 및 이의 조성물
KR20250016468A (ko) * 2018-02-02 2025-02-03 엔지반트 테라퓨틱스 게엠베하 파버병을 치료하는 방법
WO2019199476A1 (en) * 2018-04-12 2019-10-17 Amgen Inc. Methods for making stable protein compositions
CN112082832B (zh) * 2019-06-12 2022-03-29 华南理工大学 一种保存城市污水中硫酸酯结合体和葡萄糖苷醛酸结合体的方法
KR102286892B1 (ko) * 2019-07-08 2021-08-06 삼천당제약주식회사 안과용 단백질 제제의 정제방법
CN110632052A (zh) * 2019-10-25 2019-12-31 山西师范大学 土壤芳基硫酸酯酶活性的荧光光谱检测法
WO2021118900A1 (en) * 2019-12-12 2021-06-17 Eli Lilly And Company Methods for viral inactivation by environmentally compatible detergents
CN112759643B (zh) * 2021-03-17 2023-05-30 华兰生物工程股份有限公司 一种血清白蛋白的脱脂方法
CN116693659B (zh) * 2023-07-11 2025-03-28 浙江大学 一种分离重组人血白蛋白的两步混合模式层析方法

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JP2016504040A (ja) 2016-02-12
MX2015008875A (es) 2015-10-22
BR112015015948A2 (enExample) 2017-08-15
US20150353904A1 (en) 2015-12-10
AU2014205441A1 (en) 2015-06-25
CA2896979A1 (en) 2014-07-17
EA201590826A1 (ru) 2015-11-30
MX372711B (es) 2020-04-21
US12319940B2 (en) 2025-06-03
CA2896979C (en) 2023-05-02
JP2020015750A (ja) 2020-01-30
JP2024001160A (ja) 2024-01-09
US11884945B2 (en) 2024-01-30
AU2014205441B2 (en) 2019-12-12
JP2018171067A (ja) 2018-11-08
US20230235303A1 (en) 2023-07-27
EP2943568B1 (en) 2019-11-20
JP7663649B2 (ja) 2025-04-16
CN104903442A (zh) 2015-09-09
AU2020201079B2 (en) 2022-05-26
HK1214622A1 (zh) 2016-07-29
ES2768261T3 (es) 2020-06-22
EP2943568A1 (en) 2015-11-18
EA030551B1 (ru) 2018-08-31
JP2022023225A (ja) 2022-02-07
US20240392268A1 (en) 2024-11-28
BR112015015948B1 (pt) 2022-05-17
JP6427502B2 (ja) 2018-11-21
CN120665836A (zh) 2025-09-19
JP7407161B2 (ja) 2023-12-28
MX2020003798A (es) 2020-08-03
CN112126634A (zh) 2020-12-25
HK1216429A1 (en) 2016-11-11
WO2014110246A1 (en) 2014-07-17
AU2022221475B2 (en) 2025-05-22
AU2022221475A1 (en) 2022-09-22
AU2020201079A1 (en) 2020-03-05
US11407984B2 (en) 2022-08-09

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