CN1197867C - 蛇床子总香豆素在制备治疗银屑病药物中的应用 - Google Patents
蛇床子总香豆素在制备治疗银屑病药物中的应用 Download PDFInfo
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- CN1197867C CN1197867C CNB021149038A CN02114903A CN1197867C CN 1197867 C CN1197867 C CN 1197867C CN B021149038 A CNB021149038 A CN B021149038A CN 02114903 A CN02114903 A CN 02114903A CN 1197867 C CN1197867 C CN 1197867C
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- fructus cnidii
- total coumarins
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Biotechnology (AREA)
- Mycology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
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- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
Abstract
Description
组别 | 给药量(ml/kg) | 动物数(只) | 有丝分裂指数 |
蛇床子总香豆素 | 150 | 15 | 11.3±2.0* |
蛇床子总香豆素 | 75 | 15 | 19.8±2.8** |
蒽啉 | 15 | 15 | 13.4±2.1* |
生理盐水 | 15ml | 15 | 22.2±2.4 |
组别 | 给药量(g/鼠) | 动物数(只) | 每100个鳞片中有颗粒层形成的鳞片数(X±SD) |
蛇床子总香豆素软膏 | 0.3 | 10 | 25.36±9.28* |
蛇床子总香豆素软膏*** | 0.3 | 10 | 18.45±8.78** |
蒽啉 | 0.3 | 10 | 21.76±8.51* |
蛇床子总香豆素软膏空白基质 | 0.3 | 10 | 10.87±5.64 |
组别 | 给药量(ml/kg) | 动物数(只) | 光密度(O.D) | 抑制率(%) |
蛇床子总香豆素 | 150 | 15 | 0.029±0.018* | 67.42 |
蛇床子总香豆素 | 75 | 15 | 0.045±0.027** | 49.44 |
蒽啉 | 15 | 15 | 0.043±0.25* | 51.69 |
生理盐水 | 15ml | 15 | 0.089±0.41 |
组别 | 给药量(g/耳) | 动物数(只) | 耳片重量差(mg) |
蛇床子总香豆素软膏 | 0.3 | 20 | 1.52±0.76* |
蛇床子总香豆素软膏 | 0.15 | 20 | 0.93±0.68** |
蒽啉 | 0.3 | 20 | 0.95±0.71** |
蛇床子总香豆素软膏空白基质 | 0.3 | 20 | 0.49±0.25 |
组别 | 给药量(g/耳) | 动物数(只) | 肿 胀 度1h 2h 4h 6h |
蛇床子总香豆素软膏 | 0.15 | 10 | 0.401±0.210* 0.386±0.183* 0.371±0.167* 0.354±0.152* |
蛇床子总香豆素软膏 | 0.3 | 10 | 0.324±0.181** 0.308±0.168** 0.290±0.146** 0.290±0.146** |
蒽啉 | 0.3 | 10 | 0.408±0.210* 0.391±0.209* 0.375±0.189** 0.351±0.165 |
蛇床子总香豆素软膏基质 | 0.3 | 10 | 0.584±0.205 0.579±0.198 0.554±0.186 0.528±0.181 |
对照 | / | 10 | 0.612±0.207 0.608±0.214 0.591±0.195 0.486±0.104 |
组别 | 给药量(g/足) | 动物数(只) | 致痒阈 |
蛇床子总香豆素软膏 | 0.15 | 10 | 142.75±120.15* |
蛇床子总香豆素软膏 | 0.3 | 10 | 206.25±111.60** |
蒽啉软膏 | 0.3 | 10 | 158.50±131.48* |
蛇床子总香豆素软膏基质 | 0.3 | 10 | 38.75±20.14 |
对照 | / | 10 | 37.50±25.00 |
药物 | 病例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效率 |
蛇床子总香豆素软膏 | 30 | 18 | 9 | 2 | 1 | 96.7% |
蒽啉软膏 | 30 | 12 | 16 | 2 | 0 | 100% |
Claims (3)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021149038A CN1197867C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素在制备治疗银屑病药物中的应用 |
CNB2004100792505A CN1327837C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素作为制备治疗过敏性皮肤病或变态反应性皮肤病药物中的应用 |
KR1020107018912A KR101207479B1 (ko) | 2002-02-27 | 2003-02-26 | 건선 치료용 약제 제조를 위한 벌사상자 열매의 전체 쿠마린의 용도 |
US10/505,015 US8124133B2 (en) | 2002-02-27 | 2003-02-26 | Use of the total coumarins of Cnidium monnieri in preparation of the medicament for treating psoriasis |
RU2004128461/15A RU2311188C2 (ru) | 2002-02-27 | 2003-02-26 | Применение суммарных кумаринов плода cnidium в приготовлении лекарственных средств для лечения псориаза |
JP2003570865A JP4613012B2 (ja) | 2002-02-27 | 2003-02-26 | 乾癬を治療するための医薬の調製におけるジャショウシの全クマリン類の使用 |
CA002477019A CA2477019C (en) | 2002-02-27 | 2003-02-26 | Use of total coumarins of cnidium fruit in preparing medicaments for treating psoriasis |
PCT/CN2003/000150 WO2003072120A1 (fr) | 2002-02-27 | 2003-02-26 | Utilisation de coumarines totales de cnidium monnieri dans la preparation d'un medicament contre le psoriasis |
AT03709569T ATE541579T1 (de) | 2002-02-27 | 2003-02-26 | Verwendung der gesamten cumarine von cnidium monnieri bei der herstellung eines medikaments zur behandlung von psoriasis |
AU2003221280A AU2003221280B2 (en) | 2002-02-27 | 2003-02-26 | The use of the total coumarins of cnidium monnieri in preparation of the medicament for treating psoriasis |
KR1020047013365A KR101016680B1 (ko) | 2002-02-27 | 2003-02-26 | 건선 치료용 약제 제조를 위한 벌사상자 열매의 전체 쿠마린의 용도 |
DK03709569.2T DK1486213T3 (da) | 2002-02-27 | 2003-02-26 | Cnidium totale cumarin anvendelse i behandlingen af psoriasis lægemidler |
EP03709569A EP1486213B1 (en) | 2002-02-27 | 2003-02-26 | The use of the total coumarins of cnidium monnieri in preparation of the medicament for treating psoriasis |
US13/355,532 US8518460B2 (en) | 2002-02-27 | 2012-01-21 | Use of total coumarins of cnidium fruit in preparing medicaments for treating psoriasis |
US13/956,378 US10383843B2 (en) | 2002-02-27 | 2013-08-01 | Use of total coumarins of cnidium fruit in preparing medicaments for treating psoriasis |
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CNB021149038A CN1197867C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素在制备治疗银屑病药物中的应用 |
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CNB2004100792505A Division CN1327837C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素作为制备治疗过敏性皮肤病或变态反应性皮肤病药物中的应用 |
Publications (2)
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CN1374309A CN1374309A (zh) | 2002-10-16 |
CN1197867C true CN1197867C (zh) | 2005-04-20 |
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CNB021149038A Expired - Lifetime CN1197867C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素在制备治疗银屑病药物中的应用 |
CNB2004100792505A Expired - Lifetime CN1327837C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素作为制备治疗过敏性皮肤病或变态反应性皮肤病药物中的应用 |
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CNB2004100792505A Expired - Lifetime CN1327837C (zh) | 2002-02-27 | 2002-02-27 | 蛇床子总香豆素作为制备治疗过敏性皮肤病或变态反应性皮肤病药物中的应用 |
Country Status (11)
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US (3) | US8124133B2 (zh) |
EP (1) | EP1486213B1 (zh) |
JP (1) | JP4613012B2 (zh) |
KR (2) | KR101016680B1 (zh) |
CN (2) | CN1197867C (zh) |
AT (1) | ATE541579T1 (zh) |
AU (1) | AU2003221280B2 (zh) |
CA (1) | CA2477019C (zh) |
DK (1) | DK1486213T3 (zh) |
RU (1) | RU2311188C2 (zh) |
WO (1) | WO2003072120A1 (zh) |
Cited By (1)
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CN100404524C (zh) * | 2005-07-22 | 2008-07-23 | 中国医学科学院放射医学研究所 | 高纯度蛇床子素及其制备方法和以该化合物为活性成分的药物组合物 |
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US6596125B2 (en) | 2001-09-21 | 2003-07-22 | Philip Morris Incorporated | Method and apparatus for applying a material to a web |
CN1197867C (zh) * | 2002-02-27 | 2005-04-20 | 杨利平 | 蛇床子总香豆素在制备治疗银屑病药物中的应用 |
JP4129475B2 (ja) * | 2003-10-17 | 2008-08-06 | エルジー ハウスホールド アンド ヘルス ケア エルティーディー. | コラーゲン合成促進剤及びこれを含む皮膚外用剤組成物 |
JP2009137889A (ja) * | 2007-12-06 | 2009-06-25 | Lion Corp | 育毛養毛剤、育毛養毛用組成物および育毛養毛方法 |
KR101698830B1 (ko) * | 2015-04-08 | 2017-01-23 | 주식회사 오비엠랩 | 피지 과다분비 또는 지루성 피부염의 억제 또는 개선용 조성물 |
KR20190046241A (ko) | 2017-10-25 | 2019-05-07 | (주)예스킨 | 건선 개선 식품조성물 |
CN108030903A (zh) * | 2017-12-14 | 2018-05-15 | 珠海横琴新区德群中医药科学研究院有限公司 | 一种用于治疗牛皮癣的中药 |
RU2743848C1 (ru) * | 2020-06-25 | 2021-02-26 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ коррекции гиперкоагуляционного состояния при введении противоопухолевого препарата цисплатина |
CN111728968A (zh) * | 2020-07-08 | 2020-10-02 | 桂林医学院 | 瑞香素在制备治疗银屑病的药物中的应用 |
CN112426413A (zh) * | 2020-11-13 | 2021-03-02 | 川北医学院附属医院 | 一种花椒毒酚水溶性纳米新剂型的制备方法及应用 |
CN115969891A (zh) * | 2022-10-13 | 2023-04-18 | 杨利平 | 一种蛇床子总提取物及其应用和图谱构建方法 |
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JPS5953477A (ja) * | 1982-09-20 | 1984-03-28 | Res Inst For Prod Dev | クマリン誘導体 |
JPS5953476A (ja) * | 1982-09-20 | 1984-03-28 | Res Inst For Prod Dev | クマリン誘導体 |
JPH01235036A (ja) * | 1988-03-15 | 1989-09-20 | Sony Corp | 光学ピックアップ装置 |
JPH0459733A (ja) * | 1990-06-29 | 1992-02-26 | Ota Isan:Kk | 蛇床子抽出・精製物を有効成分とするストレスによる機能障害改善剤 |
AU674602B2 (en) * | 1993-09-14 | 1997-01-02 | Hyung Ki Choi | Pharmaceutical composition for prophylaxis and treatment of premature ejaculation |
CN1102993A (zh) * | 1993-12-21 | 1995-05-31 | 吴文才 | 多酶体系加工中草药的制剂方法 |
JP3577110B2 (ja) * | 1994-08-29 | 2004-10-13 | 株式会社ヤクルト本社 | Acat阻害剤 |
US5961997A (en) * | 1997-03-25 | 1999-10-05 | Swinehart; James M. | Antipruritic composition |
JP2002255812A (ja) * | 2001-03-02 | 2002-09-11 | Dai Ichi Seiyaku Co Ltd | 抗掻痒剤 |
CN1197867C (zh) * | 2002-02-27 | 2005-04-20 | 杨利平 | 蛇床子总香豆素在制备治疗银屑病药物中的应用 |
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CN100404524C (zh) * | 2005-07-22 | 2008-07-23 | 中国医学科学院放射医学研究所 | 高纯度蛇床子素及其制备方法和以该化合物为活性成分的药物组合物 |
Also Published As
Publication number | Publication date |
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KR101016680B1 (ko) | 2011-02-25 |
CN1327837C (zh) | 2007-07-25 |
KR101207479B1 (ko) | 2012-12-03 |
RU2004128461A (ru) | 2005-03-27 |
US20150038568A1 (en) | 2015-02-05 |
AU2003221280A1 (en) | 2003-09-09 |
AU2003221280B2 (en) | 2007-06-28 |
DK1486213T3 (da) | 2012-05-14 |
CA2477019A1 (en) | 2003-09-04 |
US8518460B2 (en) | 2013-08-27 |
EP1486213B1 (en) | 2012-01-18 |
CN1701791A (zh) | 2005-11-30 |
KR20100099352A (ko) | 2010-09-10 |
EP1486213A4 (en) | 2006-04-26 |
US20120115940A1 (en) | 2012-05-10 |
RU2311188C2 (ru) | 2007-11-27 |
EP1486213A1 (en) | 2004-12-15 |
ATE541579T1 (de) | 2012-02-15 |
JP4613012B2 (ja) | 2011-01-12 |
WO2003072120A1 (fr) | 2003-09-04 |
CN1374309A (zh) | 2002-10-16 |
US8124133B2 (en) | 2012-02-28 |
JP2005530697A (ja) | 2005-10-13 |
KR20040083461A (ko) | 2004-10-01 |
US10383843B2 (en) | 2019-08-20 |
US20050123636A1 (en) | 2005-06-09 |
CA2477019C (en) | 2009-10-27 |
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