CN1196927A - 化学组合物 - Google Patents
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Abstract
一种诸如淋浴凝胶或洗浴凝胶、或者霜剂或洗液用于表面皮肤制剂中的组合物,它包括聚醇湿润剂、一种至少含两种聚季铵化合物的混合物,其中一种为阳离子共聚物,另一种为两性共聚物,共聚物中阳离子共聚物与两性共聚物的重量比为1∶1.75至1∶6,在此聚醇湿润剂与所说混合物的重量比在1∶0.06至1∶0.1的范围内。当用在表面皮肤制剂中时,这些湿润剂的联合应用可改善加湿效果。
Description
本发明涉及一种化学组合物，特别涉及但不仅限于一种用于身体洗浴的化学组合物。
人的皮肤是由生理上不同的三层组成。最外层称作表皮，它由称为角质层的外层和称为基底层的内层组成，角质层由死亡的角质化扁平细胞构成，基底层所组成的细胞分裂并向上移行而形成角质层。
因此表皮是由死亡的无血管的分层鳞状上皮层组成。它对人体具有重要的保护作用，以阻止微生物、细菌和真菌的侵袭。
角质层在内部机体和外环境之间形成一种屏障，而且它还维持机体正常的水分丢失，以平衡水分供应和蒸发率。角质层的水含量在水分获得和水分丢失之间为一种平衡。在细胞分裂时以及通过在皮肤外部加用霜、洗液等，皮肤获得水分。随着皮肤在外界环境中自然干燥，水分从皮肤中丢失。因此为了使皮肤获得水分，必须增加角质层的水含量。
为了减少丢失至外界环境水分的量，惯用的方法包括将一种组合物的残余膜用于皮肤表面，此组合物包括一种吸附剂或湿润剂。吸附剂留下一种残留膜，此残余膜是一种机械屏障，可阻止水分从角质层蒸发，并可阻止水分从外界环境进入皮肤。湿润剂是一种吸湿性材料，它象一个海绵，将水分吸在皮肤附近，并使角质层中的水分保持较高的水平。
过去在各种皮肤护理产品中已经提到过许多湿润剂。例如，WO 94/17783(Unilever N.V.等)描述了一种清洁组合物，它可用作一种身体洗浴产品，诸如洗面奶、浴液和洗发液，其中此组合物包括作为表面活性剂的酰基甘醇酸酯和一种辅助表面活性剂，并可任意包括一种诸如甘油的湿润剂和一种诸如阳离子聚合物的泡沫调节剂，例如聚季铵-24或聚季铵-10。
本发明的一个目的是提供一种由应用于人皮肤的性能得到改善的湿润剂混合物组成的组合物。
本发明的另一个目的是提供一种由湿润剂混合物和用于洗浴人皮肤的表面活性剂组成的组合物。
本发明的再一个目的是提供一种由表面活性剂和湿润剂混合物组成的组合物，其形式为一种淋浴凝胶，其中淋浴凝胶可改善加湿作用和皮肤感应。
根据本发明，在此提供一种用于表面皮肤制剂的组合物，它包括：
(i)聚醇湿润剂；
(ii)至少两个聚季铵化合物的混合物，其中之一是一种阳离子共聚物，而另一个为一种两性共聚物，共聚物中阳离子共聚物与两性共聚物的重量比为1∶1.75至1∶6；在此聚醇湿润剂与所说混合物的重量比在1∶0.06至1∶0.1的范围中。
聚醇湿润剂优先选自由甘油、丙二醇、丁二醇和其混合物组成的物质组。此聚醇湿润剂优选甘油，它对人皮肤具有良好的加湿特性。
当应用时，例如作为淋浴凝胶的一部分，这种为水溶性的聚醇湿润剂可在冲洗皮肤时被快速除去。为了提高例如甘油的直接性，此阳离子共聚物也充当一种加湿剂，优选聚季铵-7，此聚季铵-7为一种氯化二甲基己二烯铵和丙烯酰胺的共聚物。
两性共聚物优选聚季铵-39，它是丙烯酸、氯化二甲基己二烯铵和丙烯酰胺的三元共聚物，其重量比为1∶2∶1。
此两性聚合物使组合物的皮肤感觉良好，并使它易于应用。此两性聚合物的存在可潜在地影响阳离子共聚物提高甘油直接性的能力。然而，依据本发明，至少目前三种组分的结合可提供一种协同加湿作用，其作用大于它们单独所起作用的总和。
阳离子共聚物与两性共聚物的重量比优选在1∶1.75至1∶3的范围中。最佳为1∶2。
此组合物适宜含有一种表面活性剂。此表面活性剂可为适于在身体清洁产品中应用的任意表面活性剂，或者是表面活性剂的混合物。此表面活性剂以一种阴离子表面活性剂为宜。此表面活性剂优选为月桂基乙醚硫酸钠。
季铵化聚合物为高分子量、水溶性聚合物，它具有阳离子或两性的特性。不同的聚合物可具有不同的季铵化水平。可在市场上从许多供应商处获得诸如聚季铵7和聚季铵39等季铵化聚合物。例如它们可以10wt％水溶液的形式从Chemviron Speciality Chemicals处获得，其商品名为“Merquat”。
适用于本发明的特殊实施例包括“Merquat S”和“Merquat Plus3330”，“Merquat S”为一种氯化二甲基己二烯铵和丙烯酰胺的高度带电阳离子共聚物的10wt％水溶液，其共聚物的分子量为7×106，并且于25℃在10RPM的Brookfield RVF#4轴上测定的粘度为9000至15000 cps；“Merquat Plus3330”为一种聚两性电解质三元共聚物的10wt％水溶液，其三元共聚物由丙烯酸、氯化二甲基己二烯铵和丙烯酰胺组成，丙烯酸∶氯化二甲基己二烯铵∶丙烯酰胺的重量比为25∶50∶25，此三元共聚物的分子量为4×106，该溶液于25℃在30RPM的Brookfield LVF#4轴上测定的粘度为4,400至10,400。
本发明组合物由10至20wt％阴离子表面活性剂、1.5至6.0wt％聚醇湿润剂、0.225至0.425wt％聚季铵化合物的混合物和水组成的组合物。阳离子共聚物的水平优选在0.025wt％至0.125wt％之间，而两性共聚物优选在0.175wt％至0.30wt％之间。
更为优选的是本发明组合物包括：
15wt％月桂基乙醚硫酸钠
4wt％甘油
0.2wt％丙烯酸、氯化二甲基己二烯铵和丙烯酰胺的1∶2∶1三元共聚物
0.1wt％氯化二甲基己二烯铵和丙烯酰胺的共聚物
以及加水至100％。
所述聚季铵化合物的重量百分比为在此组合物中的绝对量；而不是加在例如由制造商提供的水溶液形式中的量。
本发明组合物的形式优选为一种淋浴凝胶或洗浴凝胶。但不排除其他的形式，它们包括皂条、霜剂、洗液、防晒产品、修面霜、调节剂等。次要组分可包括诸如香料、染料、珠光剂、增稠剂、PH调节剂、防晒剂、防腐剂等等。
通过将这些组分掺和在一起可制备本发明组合物。
现在仅通过实施例来说明本发明的实施方式。
按照表1中的配方制备16种组合物。表I
wt％Empicol 0251\70J 15氯化钠 适量Euxyl K400 0.2柠檬酸 适量甘油 4Merquat S 0.5，1.0，1.5，2.0Merquat Plus 3330 0.5，1.0，1.5，2.0净化水 至100
Empicol 0251\70J为月桂基乙醚硫酸钠，Euxyl K400为甲基二溴葡糖腈和苯氧基乙醇的混合物。Merquat S和Merquat Plus 3330已在前面进行了详述。Merquat S和Merquat Plus 3330在表I中的重量百分比含量参照制造商所提供的它们10wt％水溶液形式中的成分。
在制备制剂的每一种情况中，首先将Empicol加入水中，搅拌至完全溶解，然后加入甘油，并搅拌10分钟。然后加入两种Merquat，接着加入Euxyl，再进一步搅拌。用柠檬酸将所得溶液缓冲至PH为5.5，用氯化钠提高其粘度。
根据四种水平的Merquat Plus 3330与四种不同水平的Merquat S的每一种组合总共制备16种制剂。
还制备溶液A、B、C和D作为对照，它们如下：
对照A：按照表I删去甘油+Merquat S+Merquat Plus 3330的制剂。
对照B：4wt％甘油溶液。
对照C：1wt％Merquat S溶液。
对照D：2wt％Merquat Plus 3330溶液。
在一些志愿者的前臂皮肤上试验表I中的每种制剂和每种对照制剂。按照严格的协议执行，以确保结果的可靠性。每个试验的目的都是为了测定此产品对人皮肤的加湿效果。
此试验方法包括下面步骤：
1.志愿者适应试验室环境至少10分钟。
2.在前臂内侧上标记相同的试验区域。
3.应用Corneometer CM82皮肤诊断中心记录每个试验区的基线读数。
4.用温水打湿前臂内侧。
5.用一个小喷水器将1ml的产品应用于每个试验区上(或者对照剂用棉棒)。
6.此产品均匀地分布在每个试验区内。
7.让该产品在皮肤上保留1.5分钟。
8.用干净柔软的薄纸擦去该产品。
9.应用Corneometer CM82皮肤诊断中心记录每个试验区的起始读数，10分钟后记录重复读数。
Corneometer CM82皮肤诊断中心(例如Courage&Khazaka ElectronicGmbH)是一种用于测定皮肤湿度的仪器。此仪器包括一个敏感探针，它置于试验区皮肤表面，通过容量测定值显示皮肤表面的湿度。自动地记录此测定值。
从所记录的结果中计算该试验产品所致的湿度增加的百分比。为顾及皮肤中的瞬间变化和皮肤单独从清洁基础制剂中获得的水分量，校正湿度增加的量。其结果列在下面的表II和表III中，并计算如下：
％湿度增加＝(试验-基线)-(对照A-基线)
在此
表II给出由其Merquat S和Merquat Plus 3330wt％含量所确定的16种试验产物的湿度增加百分数。表II
Merquat SMerquat Plus 3330 0.5 1.0 1.5 2.00.5 1.43 1.69 -0.86 2.851.0 -7.81 0.08 -0.64 1.281.5 -0.31 1.09 0.69 4.352.0 5.8 9.32 1.7 0.78
从表II中可以看到，在Merquat S为1wt％，同时Merquat Plus 3330为2.0 wt％时湿度增加最大。
下面表III给出对照A、B、C和D的湿度增加百分比。表III试验溶液 10分钟后湿度％增加数对照A 2.65对照B -2.14对照C -2.17对照D -1.39
表III中的数值与表II中含有4wt％甘油、2wt％Merquat Plus 3330和1wt％Merquat S的制剂的结果的比较显示甘油、Merquat Plus 3330和MerquatS对皮肤有效的加湿作用是当它们一起在制剂中发挥作用时才表现出来。
在表I所列的一系列配方中研究甘油的水平，但配方中不含两种Merquat，而且甘油水平为1、2、3、4和5wt％。按照上面的协议在人皮肤上对每一种制剂进行试验，所得结果列于下面表IV中。表IV甘油wt％ 湿度％1 0.832 3.383 5.324 6.045 6.11
因此根据效果和成本，本制剂中甘油的最适水平选为4wt％。
Claims (10)
1.一种用于一种表面皮肤制剂的组合物，它包括：
(i)聚醇湿润剂；
(ii)至少两个聚季铵化合物的混合物，其中之一是一种阳离子共聚物，而另一个为一种两性共聚物，共聚物中阳离子共聚物与两性共聚物的重量比为1∶1.75至1∶6；在此聚醇湿润剂与所说混合物的重量比在1∶0.06至1∶0.1的范围中。
2.一种根据权利要求1的组合物，它包括一种表面活性剂。
3.一种根据权利要求2的组合物，它包括10至20wt％阴离子表面活性剂、1.5至6.0wt％聚醇湿润剂和0.225至0.475wt％聚季铵化合物的混合物。
4.一种根据权利要求2或权利要求3的组合物，其中表面活性剂为月桂基乙醚硫酸钠。
5.一种根据上面任一权利要求的组合物，其中聚醇湿润剂选自由甘油、丙二醇、丁二醇和其混合物组成的物质组。
6.一种根据上面任一权利要求的组合物，其中阳离子共聚物为一种氯化二甲基己二烯铵和丙烯酰胺的共聚物。
7.一种根据上面任一权利要求的组合物，其中两性共聚物为一种丙烯酸、氯化二甲基己二烯铵和丙烯酰胺的三元共聚物。
8.一种根据上面任一权利要求的组合物，它包括：
15wt％月桂基乙醚硫酸钠
4wt％甘油
0.2wt％丙烯酸、氯化二甲基己二烯铵和丙烯酰胺的1∶2∶1三元共聚物
0.1wt％氯化二甲基己二烯铵和丙烯酰胺的共聚物
以及加水至100％。
9.一种根据权利要求8的组合物，其形式为一种淋浴凝胶或洗浴凝胶。
10.一种根据权利要求1至8中的任一权利要求的组合物，其形式为一种霜剂或洗液。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9704643.7 | 1997-03-06 | ||
| GBGB9704643.7A GB9704643D0 (en) | 1997-03-06 | 1997-03-06 | Chemical composition |
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| Publication Number | Publication Date |
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| CN1196927A true CN1196927A (zh) | 1998-10-28 |
| CN1098065C CN1098065C (zh) | 2003-01-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN98107388A Expired - Fee Related CN1098065C (zh) | 1997-03-06 | 1998-03-06 | 化学组合物 |
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| US (1) | US6183732B1 (zh) |
| JP (1) | JP4149024B2 (zh) |
| KR (1) | KR100539985B1 (zh) |
| CN (1) | CN1098065C (zh) |
| AR (1) | AR011454A1 (zh) |
| AU (1) | AU699057B2 (zh) |
| GB (1) | GB9704643D0 (zh) |
| ZA (1) | ZA981893B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107699833A (zh) * | 2017-08-16 | 2018-02-16 | 江苏飞拓界面工程科技有限公司 | 助镀用添加剂、助镀液及热浸镀方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030204180A1 (en) * | 2002-04-30 | 2003-10-30 | Kimberly-Clark Worldwide, Inc. | Temperature responsive delivery systems |
| US9044462B2 (en) | 2004-12-08 | 2015-06-02 | Avent, Inc. | Method for oxygen treatment of intact skin |
| US20060121101A1 (en) * | 2004-12-08 | 2006-06-08 | Ladizinsky Daniel A | Method for oxygen treatment of intact skin |
| US9017652B1 (en) | 2010-04-09 | 2015-04-28 | Lubrizol Advanced Materials, Inc. | Combination of crosslinked cationic and ampholytic polymers for personal and household applications |
| US9309462B1 (en) | 2010-06-09 | 2016-04-12 | Flo-Tec Automation Associates, Inc. | Polymer-surfactant composition for soil and method of use |
| JP2015040180A (ja) * | 2013-08-20 | 2015-03-02 | 株式会社マンダム | シェービング用ジェル状組成物 |
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| LU76955A1 (zh) * | 1977-03-15 | 1978-10-18 | ||
| US4157388A (en) * | 1977-06-23 | 1979-06-05 | The Miranol Chemical Company, Inc. | Hair and fabric conditioning compositions containing polymeric ionenes |
| FR2470596A1 (fr) * | 1979-11-28 | 1981-06-12 | Oreal | Composition destinee au traitement des fibres keratiniques a base de polymeres amphoteres et de polymeres cationiques |
| GB2172298B (en) | 1985-03-01 | 1988-11-23 | Procter & Gamble | Mild detergent mousse |
| EP0217274A3 (en) | 1985-09-30 | 1988-06-29 | Kao Corporation | Hair cosmetic composition |
| DE3930725A1 (de) * | 1989-09-14 | 1991-03-21 | Benckiser Gmbh Joh A | Extra-milde duschgel- und haarshampoo-formulierung mit niedriger tensidkonzentration |
| ES2065029T3 (es) | 1990-04-16 | 1995-02-01 | Minnesota Mining & Mfg | Aditivos de suavidad para composiciones limpiadoras de la piel. |
| EG19610A (en) | 1990-10-12 | 1995-07-27 | Procter & Gamble | Cleansing compositions |
| GB9200764D0 (en) | 1992-01-15 | 1992-03-11 | Unilever Plc | Cosmetic composition |
| EP0636166A4 (en) | 1992-03-25 | 1999-02-03 | Procter & Gamble | CLEANING COMPOSITIONS. |
| GB9216854D0 (en) | 1992-08-07 | 1992-09-23 | Unilever Plc | Detergent composition |
| GB9216758D0 (en) | 1992-08-07 | 1992-09-23 | Unilever Plc | Detergent composition |
| GB9301295D0 (en) | 1993-01-23 | 1993-03-17 | Procter & Gamble | Cleansing compositions |
| DE4302315A1 (de) | 1993-01-28 | 1994-08-04 | Henkel Kgaa | Oberflächenaktive Mischungen |
| GB9302130D0 (en) | 1993-02-03 | 1993-03-24 | Unilever Plc | Cleasing composition |
| GB9302710D0 (en) | 1993-02-11 | 1993-03-24 | Procter & Gamble | Cleansing compositions |
| EG20886A (en) | 1993-06-18 | 2000-05-31 | Procter & Gamble | Personal cleansing system comprising a plolymeric diamon-mesh bath sponge and a liquid cleanser with moisturizer |
| EP0730442A1 (en) | 1993-11-24 | 1996-09-11 | The Procter & Gamble Company | Ultra mild lathering personal cleansing composition |
| US5518647A (en) | 1993-12-20 | 1996-05-21 | Colgate-Palmolive Company | Foaming liquid emulsion composition |
| ES2153026T5 (es) | 1994-02-18 | 2004-05-16 | Unilever N.V. | Composiciones de lavado personal. |
| GB9414575D0 (en) | 1994-07-19 | 1994-09-07 | Unilever Plc | Detergent composition |
| GB9414574D0 (en) | 1994-07-19 | 1994-09-07 | Unilever Plc | Detergent composition |
| US5476660A (en) * | 1994-08-03 | 1995-12-19 | Lever Brothers Company, Division Of Conopco, Inc. | Deposition of materials to surfaces using zwitterionic carrier particles |
| GB9421185D0 (en) | 1994-10-20 | 1994-12-07 | Unilever Plc | Personal car composition |
| CA2143558A1 (en) | 1995-02-28 | 1996-08-29 | Ezzat Khalil | Sulfate-free shampoo |
| US5785979A (en) | 1997-01-21 | 1998-07-28 | The Procter & Gamble Company | Personal cleansing compositions |
-
1997
- 1997-03-06 GB GBGB9704643.7A patent/GB9704643D0/en not_active Ceased
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1998
- 1998-02-26 AU AU56341/98A patent/AU699057B2/en not_active Ceased
- 1998-02-27 US US09/032,571 patent/US6183732B1/en not_active Expired - Lifetime
- 1998-03-04 KR KR1019980007007A patent/KR100539985B1/ko not_active IP Right Cessation
- 1998-03-05 JP JP06922198A patent/JP4149024B2/ja not_active Expired - Lifetime
- 1998-03-05 AR ARP980100988A patent/AR011454A1/es active IP Right Grant
- 1998-03-05 ZA ZA9801893A patent/ZA981893B/xx unknown
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107699833A (zh) * | 2017-08-16 | 2018-02-16 | 江苏飞拓界面工程科技有限公司 | 助镀用添加剂、助镀液及热浸镀方法 |
| CN107699833B (zh) * | 2017-08-16 | 2021-10-22 | 江苏飞拓界面工程科技有限公司 | 助镀用添加剂、助镀液及热浸镀方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9704643D0 (en) | 1997-04-23 |
| ZA981893B (en) | 1999-09-06 |
| AR011454A1 (es) | 2000-08-16 |
| AU5634198A (en) | 1998-10-01 |
| JP4149024B2 (ja) | 2008-09-10 |
| JPH10251138A (ja) | 1998-09-22 |
| KR19980079851A (ko) | 1998-11-25 |
| KR100539985B1 (ko) | 2006-04-12 |
| AU699057B2 (en) | 1998-11-19 |
| CN1098065C (zh) | 2003-01-08 |
| US6183732B1 (en) | 2001-02-06 |
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