CN119552120A - 用于抑制IL-17和RORγ的吡唑和咪唑化合物 - Google Patents

用于抑制IL-17和RORγ的吡唑和咪唑化合物 Download PDF

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Publication number
CN119552120A
CN119552120A CN202411693570.3A CN202411693570A CN119552120A CN 119552120 A CN119552120 A CN 119552120A CN 202411693570 A CN202411693570 A CN 202411693570A CN 119552120 A CN119552120 A CN 119552120A
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compound
mmol
alkyl
cycloalkyl
aryl
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Chinese (zh)
Inventor
江昕
米莲恩·维斯尼克
克里斯多福·F·班德
盖瑞·伯顿
布萊德利·开普利
奇塔斯·里
布萊恩·康柏格
帕特里克·奥布莱恩
玛莎·R·洪德玛
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Reata Pharmaceuticals Inc
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Reata Pharmaceuticals Inc
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Publication of CN119552120A publication Critical patent/CN119552120A/zh
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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CN202411693570.3A 2018-06-15 2019-06-17 用于抑制IL-17和RORγ的吡唑和咪唑化合物 Pending CN119552120A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862685742P 2018-06-15 2018-06-15
US62/685,742 2018-06-15
US201862687602P 2018-06-20 2018-06-20
US62/687,602 2018-06-20
PCT/US2019/037543 WO2019241796A1 (en) 2018-06-15 2019-06-17 Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma
CN201980052795.1A CN112654610B (zh) 2018-06-15 2019-06-17 用于抑制IL-17和RORγ的吡唑和咪唑化合物

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CN119552120A true CN119552120A (zh) 2025-03-04

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CN202411693570.3A Pending CN119552120A (zh) 2018-06-15 2019-06-17 用于抑制IL-17和RORγ的吡唑和咪唑化合物
CN201980052795.1A Active CN112654610B (zh) 2018-06-15 2019-06-17 用于抑制IL-17和RORγ的吡唑和咪唑化合物

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US (2) US11993574B2 (https=)
EP (1) EP3807265A1 (https=)
JP (1) JP7498122B2 (https=)
KR (1) KR102887518B1 (https=)
CN (2) CN119552120A (https=)
AU (1) AU2019286531B2 (https=)
BR (1) BR112020025605A2 (https=)
CO (1) CO2021000229A2 (https=)
IL (2) IL279348B2 (https=)
MX (1) MX2020013692A (https=)
WO (1) WO2019241796A1 (https=)

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Publication number Priority date Publication date Assignee Title
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
WO2021220183A1 (en) * 2020-04-30 2021-11-04 Janssen Pharmaceutica Nv Imidazopyrimidines as modulators of il-17
CN114409724A (zh) * 2022-01-10 2022-04-29 南京联智医药科技有限公司 一种新的达那唑制备方法
CN118852108B (zh) * 2024-07-15 2025-09-26 南京林业大学 一种用于检测有机磷农药敌敌畏和敌百虫的新型樟脑基荧光探针及其制备方法与应用

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