JP7498122B2 - ＩＬ－１７およびＲＯＲγの阻害用のピラゾール化合物およびイミダゾール化合物 - Google Patents

ＩＬ－１７およびＲＯＲγの阻害用のピラゾール化合物およびイミダゾール化合物 Download PDF

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JP7498122B2
JP7498122B2 JP2020569890A JP2020569890A JP7498122B2 JP 7498122 B2 JP7498122 B2 JP 7498122B2 JP 2020569890 A JP2020569890 A JP 2020569890A JP 2020569890 A JP2020569890 A JP 2020569890A JP 7498122 B2 JP7498122 B2 JP 7498122B2
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alkyl
cycloalkyl
arenediyl
aryl
heteroaryl
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シン チアン
メレアン ビスニック
クリストファー エフ． ベンダー
ゲイリー ボルトン
ブラッドリー カプレイズ
チタセ リー
ブライアン コーンバーグ
パトリック オブライエン
マーサ アール． ホータマー
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リアタ ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
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  • Pulmonology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2020569890A 2018-06-15 2019-06-17 ＩＬ－１７およびＲＯＲγの阻害用のピラゾール化合物およびイミダゾール化合物 Active JP7498122B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862685742P 2018-06-15 2018-06-15
US62/685,742 2018-06-15
US201862687602P 2018-06-20 2018-06-20
US62/687,602 2018-06-20
PCT/US2019/037543 WO2019241796A1 (en) 2018-06-15 2019-06-17 Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma

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JP2021527650A JP2021527650A (ja) 2021-10-14
JP2021527650A5 JP2021527650A5 (https=) 2022-06-22
JPWO2019241796A5 JPWO2019241796A5 (https=) 2022-06-22
JP7498122B2 true JP7498122B2 (ja) 2024-06-11

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US (2) US11993574B2 (https=)
EP (1) EP3807265A1 (https=)
JP (1) JP7498122B2 (https=)
KR (1) KR102887518B1 (https=)
CN (2) CN119552120A (https=)
AU (1) AU2019286531B2 (https=)
BR (1) BR112020025605A2 (https=)
CO (1) CO2021000229A2 (https=)
IL (2) IL279348B2 (https=)
MX (1) MX2020013692A (https=)
WO (1) WO2019241796A1 (https=)

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TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
WO2021220183A1 (en) * 2020-04-30 2021-11-04 Janssen Pharmaceutica Nv Imidazopyrimidines as modulators of il-17
CN114409724A (zh) * 2022-01-10 2022-04-29 南京联智医药科技有限公司 一种新的达那唑制备方法
CN118852108B (zh) * 2024-07-15 2025-09-26 南京林业大学 一种用于检测有机磷农药敌敌畏和敌百虫的新型樟脑基荧光探针及其制备方法与应用

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JP2017503840A (ja) 2014-01-24 2017-02-02 アッヴィ・インコーポレイテッド 抗酸化性炎症調節剤としてのアリールおよびアリールアルキル置換されたピラゾリルおよびピリミジニル三環式エノン類
JP2018505196A (ja) 2015-02-12 2018-02-22 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化性炎症調節剤としてのイミダゾリル三環式エノン
JP2018510135A (ja) 2015-02-11 2018-04-12 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用
JP2018515494A (ja) 2015-05-07 2018-06-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子としての三環式スルホン類

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