KR102887518B1 - Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물 - Google Patents

Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물

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Publication number
KR102887518B1
KR102887518B1 KR1020207036895A KR20207036895A KR102887518B1 KR 102887518 B1 KR102887518 B1 KR 102887518B1 KR 1020207036895 A KR1020207036895 A KR 1020207036895A KR 20207036895 A KR20207036895 A KR 20207036895A KR 102887518 B1 KR102887518 B1 KR 102887518B1
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phenyl
pyridin
delete delete
methyl
biphenyl
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KR20210032936A (ko
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신 지앙
멜린 비스니크
크리스토퍼 에프. 벤더
게리 볼턴
브래들리 카프라데
치타제 이
브라이언 코른버그
패트릭 오브라이언
마사 알. 호테마
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리아타 파마슈티컬즈, 아이엔씨.
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    • C07—ORGANIC CHEMISTRY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207036895A 2018-06-15 2019-06-17 Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물 Active KR102887518B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862685742P 2018-06-15 2018-06-15
US62/685,742 2018-06-15
US201862687602P 2018-06-20 2018-06-20
US62/687,602 2018-06-20
PCT/US2019/037543 WO2019241796A1 (en) 2018-06-15 2019-06-17 Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma

Publications (2)

Publication Number Publication Date
KR20210032936A KR20210032936A (ko) 2021-03-25
KR102887518B1 true KR102887518B1 (ko) 2025-11-18

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KR1020207036895A Active KR102887518B1 (ko) 2018-06-15 2019-06-17 Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물

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US (2) US11993574B2 (https=)
EP (1) EP3807265A1 (https=)
JP (1) JP7498122B2 (https=)
KR (1) KR102887518B1 (https=)
CN (2) CN119552120A (https=)
AU (1) AU2019286531B2 (https=)
BR (1) BR112020025605A2 (https=)
CO (1) CO2021000229A2 (https=)
IL (2) IL279348B2 (https=)
MX (1) MX2020013692A (https=)
WO (1) WO2019241796A1 (https=)

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TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
WO2021220183A1 (en) * 2020-04-30 2021-11-04 Janssen Pharmaceutica Nv Imidazopyrimidines as modulators of il-17
CN114409724A (zh) * 2022-01-10 2022-04-29 南京联智医药科技有限公司 一种新的达那唑制备方法
CN118852108B (zh) * 2024-07-15 2025-09-26 南京林业大学 一种用于检测有机磷农药敌敌畏和敌百虫的新型樟脑基荧光探针及其制备方法与应用

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