CN118878688A - 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞 - Google Patents

包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞 Download PDF

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Publication number
CN118878688A
CN118878688A CN202411248012.6A CN202411248012A CN118878688A CN 118878688 A CN118878688 A CN 118878688A CN 202411248012 A CN202411248012 A CN 202411248012A CN 118878688 A CN118878688 A CN 118878688A
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seq
car
cells
cell
nucleic acid
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Chinese (zh)
Inventor
M·普勒
S·科多巴
S·托马斯
S·奥诺哈
A·W·基纳
M·费拉里
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Autolus Ltd
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Autolus Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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CN202411248012.6A 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞 Pending CN118878688A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1813178.9A GB201813178D0 (en) 2018-08-13 2018-08-13 Cell
GB1813178.9 2018-08-13
PCT/GB2019/052275 WO2020035676A1 (en) 2018-08-13 2019-08-13 Car t-cells comprising an anti cd33, an anti cll1 and at least one further car anti cd123 and/or ftl3
CN201980053953.5A CN112566941B (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞

Related Parent Applications (1)

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CN201980053953.5A Division CN112566941B (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞

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CN118878688A true CN118878688A (zh) 2024-11-01

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ID=63667077

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Application Number Title Priority Date Filing Date
CN202411248012.6A Pending CN118878688A (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN201980053953.5A Active CN112566941B (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN202411247931.1A Pending CN118909124A (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN202411248075.1A Pending CN118930653A (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201980053953.5A Active CN112566941B (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN202411247931.1A Pending CN118909124A (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞
CN202411248075.1A Pending CN118930653A (zh) 2018-08-13 2019-08-13 包含抗cd33，抗cll1和至少一个另外的抗cd123和/或flt3 car的car t细胞

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Country Link
US (2) US20230330139A1 (https=)
EP (1) EP3837284A1 (https=)
JP (2) JP7416762B2 (https=)
CN (4) CN118878688A (https=)
AU (1) AU2019321066A1 (https=)
CA (1) CA3109752A1 (https=)
GB (1) GB201813178D0 (https=)
WO (1) WO2020035676A1 (https=)

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US20250082754A1 (en) * 2021-07-30 2025-03-13 Nanjing Legend Biotech Co., Ltd. Anti-cd33 antibodies and uses thereof
CN116018351A (zh) * 2021-08-16 2023-04-25 上海优替济生生物医药有限公司 靶向cd123的抗体、嵌合抗原受体及其用途
CN116063490A (zh) * 2021-09-07 2023-05-05 苏州晟济药业有限公司 一种vhh抗体或其抗原片段的突变体及其用途
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CN116239690B (zh) * 2022-12-27 2024-01-30 四川大学 一种抗cd123的纳米抗体及其制备方法和应用
CN117482246B (zh) * 2022-12-30 2024-10-15 英百瑞(杭州)生物医药有限公司 抗cd33/cll1双特异性抗体-自然杀伤细胞偶联物及其用途
CN117964760B (zh) * 2023-12-21 2024-09-03 四川大学华西医院 抗人cll1/cd3的双特异性抗体及其应用
WO2026015644A1 (en) * 2024-07-10 2026-01-15 The Trustees Of The University Of Pennsylvania Cadherin-17 targeting antigen biding polypeptides, chimeric antigen receptors, car-t cells and methods of treating cadherin-17 positive cancers
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US20250381224A1 (en) 2025-12-18
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