CN1188520C - 在植物中生产聚酮化合物 - Google Patents

在植物中生产聚酮化合物 Download PDF

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Publication number
CN1188520C
CN1188520C CNB988070812A CN98807081A CN1188520C CN 1188520 C CN1188520 C CN 1188520C CN B988070812 A CNB988070812 A CN B988070812A CN 98807081 A CN98807081 A CN 98807081A CN 1188520 C CN1188520 C CN 1188520C
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CN
China
Prior art keywords
pks
polyketide
expression system
plant
gene
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Expired - Fee Related
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CNB988070812A
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English (en)
Chinese (zh)
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CN1263557A (zh
Inventor
M·C·贝拉雪
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Kosan Biosciences Inc
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Kosan Biosciences Inc
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Publication of CN1263557A publication Critical patent/CN1263557A/zh
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Publication of CN1188520C publication Critical patent/CN1188520C/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1258—Polyribonucleotide nucleotidyltransferase (2.7.7.8), i.e. polynucleotide phosphorylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polyesters Or Polycarbonates (AREA)
CNB988070812A 1997-07-10 1998-07-10 在植物中生产聚酮化合物 Expired - Fee Related CN1188520C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5221197P 1997-07-10 1997-07-10
US60/052,211 1997-07-10

Publications (2)

Publication Number Publication Date
CN1263557A CN1263557A (zh) 2000-08-16
CN1188520C true CN1188520C (zh) 2005-02-09

Family

ID=21976131

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988070812A Expired - Fee Related CN1188520C (zh) 1997-07-10 1998-07-10 在植物中生产聚酮化合物

Country Status (10)

Country Link
US (2) US6262340B1 (enExample)
EP (1) EP1007689A2 (enExample)
JP (1) JP2001509379A (enExample)
KR (1) KR100540287B1 (enExample)
CN (1) CN1188520C (enExample)
AU (1) AU744751C (enExample)
CA (1) CA2294616A1 (enExample)
IL (1) IL133716A0 (enExample)
NZ (1) NZ501998A (enExample)
WO (1) WO1999002669A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
EP1135470A2 (en) 1998-11-20 2001-09-26 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
WO2000040715A2 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Improved nucleic acid cloning
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
WO2000055340A1 (en) * 1999-03-15 2000-09-21 Pioneer Hi-Bred International, Inc. Methods for enhancing the disease resistance of plants
DE60026563D1 (de) * 1999-10-25 2006-05-04 Kosan Biosciences Inc Herstellung von polyketiden
CA2388422A1 (en) * 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides
US7256888B2 (en) * 2003-11-07 2007-08-14 Cardial Health 303, Inc. Fluid verification system and method for infusions
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
RU2628097C2 (ru) * 2011-06-23 2017-08-14 АрЭйчОу РЕНЬЮЭБЛС, ИНК. Рекомбинантная клетка для производства фенольного соединения и способ производства фенольного соединения
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587548T2 (de) 1984-12-28 1993-12-23 Bayer Ag Rekombinante DNA, die in pflanzliche Zellen eingebracht werden kann.
US5098837A (en) 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
JPH09505983A (ja) 1993-09-20 1997-06-17 ザ リーランド スタンフォード ジュニア ユニバーシティ 新規ポリケチドの組換え産生
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
GB9319722D0 (en) 1993-09-24 1993-11-10 John Innes Foundation Plant genetic manipulation
US5716849A (en) 1994-06-08 1998-02-10 Novartis Finance Corporation Genes for the biosynthesis of soraphen
EP0861321B1 (en) * 1995-10-13 2006-05-31 President And Fellows Of Harvard College Phosphopantetheinyl transferases and uses thereof
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
CN1179046C (zh) 1996-07-05 2004-12-08 拜奥蒂卡技术有限公司 新型红霉素、其制备方法、用途和含其的药物组合物
WO1998010546A2 (en) 1996-09-02 1998-03-12 Telia Ab (Publ) Improvements in, or relating to, multi-carrier transmission systems
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
CA2283422A1 (en) 1997-06-04 1998-12-10 Calgene, Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants

Also Published As

Publication number Publication date
WO1999002669A2 (en) 1999-01-21
CN1263557A (zh) 2000-08-16
IL133716A0 (en) 2001-04-30
AU744751B2 (en) 2002-02-28
EP1007689A2 (en) 2000-06-14
US20020002712A1 (en) 2002-01-03
CA2294616A1 (en) 1999-01-21
WO1999002669A3 (en) 1999-04-01
JP2001509379A (ja) 2001-07-24
NZ501998A (en) 2001-04-27
AU8403398A (en) 1999-02-08
KR100540287B1 (ko) 2006-01-10
US6262340B1 (en) 2001-07-17
AU744751C (en) 2005-11-24
KR20010021509A (ko) 2001-03-15

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