KR100540287B1 - 식물체 내에서 폴리케티드의 생산 - Google Patents

식물체 내에서 폴리케티드의 생산 Download PDF

Info

Publication number
KR100540287B1
KR100540287B1 KR1020007000041A KR20007000041A KR100540287B1 KR 100540287 B1 KR100540287 B1 KR 100540287B1 KR 1020007000041 A KR1020007000041 A KR 1020007000041A KR 20007000041 A KR20007000041 A KR 20007000041A KR 100540287 B1 KR100540287 B1 KR 100540287B1
Authority
KR
South Korea
Prior art keywords
plant
cell
leaf
polyketide
synthase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007000041A
Other languages
English (en)
Korean (ko)
Other versions
KR20010021509A (ko
Inventor
베트라취메리씨.
Original Assignee
코산 바이오사이언시즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코산 바이오사이언시즈, 인코포레이티드 filed Critical 코산 바이오사이언시즈, 인코포레이티드
Publication of KR20010021509A publication Critical patent/KR20010021509A/ko
Application granted granted Critical
Publication of KR100540287B1 publication Critical patent/KR100540287B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1258—Polyribonucleotide nucleotidyltransferase (2.7.7.8), i.e. polynucleotide phosphorylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polyesters Or Polycarbonates (AREA)
KR1020007000041A 1997-07-10 1998-07-10 식물체 내에서 폴리케티드의 생산 Expired - Fee Related KR100540287B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5221197P 1997-07-10 1997-07-10
US60/052,211 1997-07-10
PCT/US1998/014570 WO1999002669A2 (en) 1997-07-10 1998-07-10 Production of polyketides in plants

Publications (2)

Publication Number Publication Date
KR20010021509A KR20010021509A (ko) 2001-03-15
KR100540287B1 true KR100540287B1 (ko) 2006-01-10

Family

ID=21976131

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007000041A Expired - Fee Related KR100540287B1 (ko) 1997-07-10 1998-07-10 식물체 내에서 폴리케티드의 생산

Country Status (10)

Country Link
US (2) US6262340B1 (enExample)
EP (1) EP1007689A2 (enExample)
JP (1) JP2001509379A (enExample)
KR (1) KR100540287B1 (enExample)
CN (1) CN1188520C (enExample)
AU (1) AU744751C (enExample)
CA (1) CA2294616A1 (enExample)
IL (1) IL133716A0 (enExample)
NZ (1) NZ501998A (enExample)
WO (1) WO1999002669A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
IL143069A0 (en) 1998-11-20 2002-04-21 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
ATE439437T1 (de) 1999-01-05 2009-08-15 Univ Boston Verbessertes klonierungsverfahren
AU3604100A (en) * 1999-03-15 2000-10-04 Pioneer Hi-Bred International, Inc. Methods for enhancing the disease resistance of plants
ATE319848T1 (de) * 1999-10-25 2006-03-15 Kosan Biosciences Inc Herstellung von polyketiden
JP2003512073A (ja) 1999-10-27 2003-04-02 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドの異種産生
US7256888B2 (en) * 2003-11-07 2007-08-14 Cardial Health 303, Inc. Fluid verification system and method for infusions
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
BR112013033021A2 (pt) * 2011-06-23 2017-01-31 Rho Renewables Inc "célula hospedeira e métodos para produzir composto fenólico usando policetídeo sintases aromáticas"
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189707B1 (en) 1984-12-28 1993-08-25 Plant Genetic Systems N.V. Recombinant dna which can be introduced into plant cells
US5098837A (en) 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5639949A (en) 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2171629A1 (en) 1993-09-20 1995-03-30 Chaitan Khosla Recombinant production of novel polyketides
GB9319722D0 (en) 1993-09-24 1993-11-10 John Innes Foundation Plant genetic manipulation
US5716849A (en) 1994-06-08 1998-02-10 Novartis Finance Corporation Genes for the biosynthesis of soraphen
WO1997013845A2 (en) * 1995-10-13 1997-04-17 President And Fellows Of Harvard College Phosphopantetheinyl transferases and uses thereof
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
AU731301B2 (en) 1996-07-05 2001-03-29 Biotica Technology Limited Erythromycins and process for their preparation
JP2001505373A (ja) 1996-09-02 2001-04-17 テリア アクティエ ボラーグ 多重搬送波伝送システムにおける、あるいはそれに関する改良
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
EP1003869A1 (en) 1997-06-04 2000-05-31 Calgene LLC Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants

Also Published As

Publication number Publication date
IL133716A0 (en) 2001-04-30
WO1999002669A2 (en) 1999-01-21
JP2001509379A (ja) 2001-07-24
AU744751B2 (en) 2002-02-28
CN1263557A (zh) 2000-08-16
AU744751C (en) 2005-11-24
US6262340B1 (en) 2001-07-17
US20020002712A1 (en) 2002-01-03
KR20010021509A (ko) 2001-03-15
CN1188520C (zh) 2005-02-09
EP1007689A2 (en) 2000-06-14
NZ501998A (en) 2001-04-27
WO1999002669A3 (en) 1999-04-01
AU8403398A (en) 1999-02-08
CA2294616A1 (en) 1999-01-21

Similar Documents

Publication Publication Date Title
Chen et al. Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation
CA2287776C (en) Regulation of quinolate phosphoribosyl transferase expression
US9752130B2 (en) Chalcone synthase dihyrdoflavonol 4-reductase and leucoanthocyanidine reductase from clover, medic ryegrass or fescue
KR100540287B1 (ko) 식물체 내에서 폴리케티드의 생산
US20050069884A1 (en) Manipulation of flavonoid biosynthesis in plants
JPH11262394A (ja) グルタミン合成酵素阻害剤に対する耐性を有する遺伝子操作により得られた植物細胞及び植物、前記細胞及び植物を産生するために使用するｄｎａフラグメント及び組換え体
AU2006236392B2 (en) Plant promoters, terminators, genes, vectors and related transformed plants
US20040088752A1 (en) Divinyl ether synthase gene, and protein and uses thereof
IE20020633A1 (en) Plasmids for the Production of Transgenic Plants that are Modified in Habit and Yield
HU222268B1 (hu) Hímsteril és megváltozott virágszínű transzgenikus növények és az előállításukra alkalmas DNS-konstrukciók
JPH05507626A (ja) トランスジェニック植物におけるシクロデキストリンの生産
AU739905B2 (en) Transgenic plant cells and plants with modified acetyl coa production
JP4582853B2 (ja) グルタチオン−ｓ−トランスフェラーゼ遺伝子を導入した低温抵抗性イネ
MXPA00000404A (en) Production of polyketides in plants
KR100240356B1 (ko) 자가-접합 활성을 갖는 복유전자 알엔에이의 발현
CA2264677A1 (en) Adenylosuccinate synthetase
AU2013202736B2 (en) Manipulation of flavonoid biosynthesis in plants (5)
Kempken Biotechnology with Plants-an Overview
HUP0104974A2 (hu) Eljárás fehérjék gazdaszervezetekben történő, betakarítás utáni, szabályozott termelésére
NZ284494A (en) Transformed cells with streptothricin resistance

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20080721

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20091225

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20091225