CA2294616A1 - Production of polyketides in plants - Google Patents
Production of polyketides in plants Download PDFInfo
- Publication number
- CA2294616A1 CA2294616A1 CA002294616A CA2294616A CA2294616A1 CA 2294616 A1 CA2294616 A1 CA 2294616A1 CA 002294616 A CA002294616 A CA 002294616A CA 2294616 A CA2294616 A CA 2294616A CA 2294616 A1 CA2294616 A1 CA 2294616A1
- Authority
- CA
- Canada
- Prior art keywords
- plant
- pks
- plants
- expression system
- polyketide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 claims abstract description 46
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- 150000003881 polyketide derivatives Chemical class 0.000 claims description 50
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- 101710182762 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase Proteins 0.000 claims description 22
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- 125000003729 nucleotide group Chemical group 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1258—Polyribonucleotide nucleotidyltransferase (2.7.7.8), i.e. polynucleotide phosphorylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5221197P | 1997-07-10 | 1997-07-10 | |
| US60/052,211 | 1997-07-10 | ||
| PCT/US1998/014570 WO1999002669A2 (en) | 1997-07-10 | 1998-07-10 | Production of polyketides in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2294616A1 true CA2294616A1 (en) | 1999-01-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002294616A Abandoned CA2294616A1 (en) | 1997-07-10 | 1998-07-10 | Production of polyketides in plants |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6262340B1 (enExample) |
| EP (1) | EP1007689A2 (enExample) |
| JP (1) | JP2001509379A (enExample) |
| KR (1) | KR100540287B1 (enExample) |
| CN (1) | CN1188520C (enExample) |
| AU (1) | AU744751C (enExample) |
| CA (1) | CA2294616A1 (enExample) |
| IL (1) | IL133716A0 (enExample) |
| NZ (1) | NZ501998A (enExample) |
| WO (1) | WO1999002669A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
| WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| US6358712B1 (en) | 1999-01-05 | 2002-03-19 | Trustee Of Boston University | Ordered gene assembly |
| DE60042730D1 (de) | 1999-01-05 | 2009-09-24 | Univ Boston | Verbessertes klonierungsverfahren |
| AU3604100A (en) * | 1999-03-15 | 2000-10-04 | Pioneer Hi-Bred International, Inc. | Methods for enhancing the disease resistance of plants |
| AU1231701A (en) * | 1999-10-25 | 2001-05-08 | Kosan Biosciences, Inc. | Production of polyketides |
| US7011959B1 (en) * | 1999-10-27 | 2006-03-14 | Kosan Biosciences, Inc. | Heterologous production of polyketides |
| US7256888B2 (en) * | 2003-11-07 | 2007-08-14 | Cardial Health 303, Inc. | Fluid verification system and method for infusions |
| US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
| CN108570420A (zh) * | 2011-06-23 | 2018-09-25 | Rho可再生股份有限公司 | 芳族分子的重组生产系统 |
| US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
| CN106916834B (zh) * | 2015-12-24 | 2022-08-05 | 武汉合生科技有限公司 | 化合物的生物合成基因簇及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3587548T2 (de) | 1984-12-28 | 1993-12-23 | Bayer Ag | Rekombinante DNA, die in pflanzliche Zellen eingebracht werden kann. |
| US5098837A (en) | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| DE69434408T2 (de) | 1993-09-20 | 2006-03-16 | The Leland Stanford Junior University, Palo Alto | Recombinante Herstellung aromatischer Polyketiden |
| US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| GB9319722D0 (en) | 1993-09-24 | 1993-11-10 | John Innes Foundation | Plant genetic manipulation |
| US5716849A (en) | 1994-06-08 | 1998-02-10 | Novartis Finance Corporation | Genes for the biosynthesis of soraphen |
| CA2232230C (en) * | 1995-10-13 | 2005-06-28 | Ralph H. Lambalot | Phosphopantetheinyl transferases and uses thereof |
| CA2197524A1 (en) | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| WO1998001546A2 (en) | 1996-07-05 | 1998-01-15 | Biotica Technology Limited | Polyketides and their synthesis |
| ATE235765T1 (de) | 1996-09-02 | 2003-04-15 | St Microelectronics Nv | Verbesserungen bei, oder in bezug auf mehrträgerübertragungssysteme |
| US6033883A (en) | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
| EP1003869A1 (en) | 1997-06-04 | 2000-05-31 | Calgene LLC | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants |
-
1998
- 1998-07-10 CA CA002294616A patent/CA2294616A1/en not_active Abandoned
- 1998-07-10 IL IL13371698A patent/IL133716A0/xx unknown
- 1998-07-10 KR KR1020007000041A patent/KR100540287B1/ko not_active Expired - Fee Related
- 1998-07-10 AU AU84033/98A patent/AU744751C/en not_active Ceased
- 1998-07-10 EP EP98934536A patent/EP1007689A2/en not_active Withdrawn
- 1998-07-10 CN CNB988070812A patent/CN1188520C/zh not_active Expired - Fee Related
- 1998-07-10 US US09/114,083 patent/US6262340B1/en not_active Expired - Lifetime
- 1998-07-10 JP JP2000502167A patent/JP2001509379A/ja active Pending
- 1998-07-10 WO PCT/US1998/014570 patent/WO1999002669A2/en not_active Ceased
- 1998-07-10 NZ NZ501998A patent/NZ501998A/en unknown
-
2001
- 2001-05-01 US US09/847,089 patent/US20020002712A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| AU744751C (en) | 2005-11-24 |
| EP1007689A2 (en) | 2000-06-14 |
| CN1188520C (zh) | 2005-02-09 |
| AU8403398A (en) | 1999-02-08 |
| US6262340B1 (en) | 2001-07-17 |
| AU744751B2 (en) | 2002-02-28 |
| CN1263557A (zh) | 2000-08-16 |
| KR20010021509A (ko) | 2001-03-15 |
| NZ501998A (en) | 2001-04-27 |
| US20020002712A1 (en) | 2002-01-03 |
| IL133716A0 (en) | 2001-04-30 |
| WO1999002669A2 (en) | 1999-01-21 |
| WO1999002669A3 (en) | 1999-04-01 |
| KR100540287B1 (ko) | 2006-01-10 |
| JP2001509379A (ja) | 2001-07-24 |
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