CN118765272A - 制备用作药物活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)联苯-4-基]甲氧基}苯基)乙基]氨基}-5,6,7,8-四氢喹啉-2-甲酸及其结晶形式的方法 - Google Patents

制备用作药物活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)联苯-4-基]甲氧基}苯基)乙基]氨基}-5,6,7,8-四氢喹啉-2-甲酸及其结晶形式的方法 Download PDF

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Publication number
CN118765272A
CN118765272A CN202280092729.9A CN202280092729A CN118765272A CN 118765272 A CN118765272 A CN 118765272A CN 202280092729 A CN202280092729 A CN 202280092729A CN 118765272 A CN118765272 A CN 118765272A
Authority
CN
China
Prior art keywords
formula
compound
ethyl
monohydrate
biphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280092729.9A
Other languages
English (en)
Chinese (zh)
Inventor
B·奥勒尼克
B·凯尔
B·罗斯勒
P·费
H·施尔默
G·贝克
J·艾格
C·博特
H·费伯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Pharma AG
Original Assignee
Bayer AG
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Pharma AG filed Critical Bayer AG
Publication of CN118765272A publication Critical patent/CN118765272A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202280092729.9A 2021-12-29 2022-12-28 制备用作药物活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)联苯-4-基]甲氧基}苯基)乙基]氨基}-5,6,7,8-四氢喹啉-2-甲酸及其结晶形式的方法 Pending CN118765272A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21218163 2021-12-29
EP21218163.0 2021-12-29
PCT/EP2022/087952 WO2023126436A1 (en) 2021-12-29 2022-12-28 Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound

Publications (1)

Publication Number Publication Date
CN118765272A true CN118765272A (zh) 2024-10-11

Family

ID=79185525

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280092729.9A Pending CN118765272A (zh) 2021-12-29 2022-12-28 制备用作药物活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)联苯-4-基]甲氧基}苯基)乙基]氨基}-5,6,7,8-四氢喹啉-2-甲酸及其结晶形式的方法

Country Status (12)

Country Link
US (2) US12202805B2 (enExample)
EP (1) EP4457215A1 (enExample)
JP (1) JP2025502842A (enExample)
KR (1) KR20240144177A (enExample)
CN (1) CN118765272A (enExample)
AR (1) AR128147A1 (enExample)
AU (1) AU2022429647A1 (enExample)
CA (1) CA3244893A1 (enExample)
IL (1) IL313922A (enExample)
MX (1) MX2024008172A (enExample)
TW (1) TW202342012A (enExample)
WO (1) WO2023126436A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202342034A (zh) 2021-12-29 2023-11-01 德商拜耳廠股份有限公司 心肺病症之治療
AU2022429647A1 (en) 2021-12-29 2024-07-04 Bayer Aktiengesellschaft Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound

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AU2022429647A1 (en) 2021-12-29 2024-07-04 Bayer Aktiengesellschaft Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound

Also Published As

Publication number Publication date
KR20240144177A (ko) 2024-10-02
US20240116874A1 (en) 2024-04-11
MX2024008172A (es) 2025-04-02
US12202805B2 (en) 2025-01-21
CA3244893A1 (en) 2023-07-06
US20250263381A1 (en) 2025-08-21
AU2022429647A1 (en) 2024-07-04
EP4457215A1 (en) 2024-11-06
IL313922A (en) 2024-08-01
WO2023126436A1 (en) 2023-07-06
AR128147A1 (es) 2024-03-27
JP2025502842A (ja) 2025-01-28
TW202342012A (zh) 2023-11-01

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