CN1187448C - 1,3－丙二醇脱氢酶突变体 - Google Patents

1,3－丙二醇脱氢酶突变体 Download PDF

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Publication number
CN1187448C
CN1187448C CNB008077436A CN00807743A CN1187448C CN 1187448 C CN1187448 C CN 1187448C CN B008077436 A CNB008077436 A CN B008077436A CN 00807743 A CN00807743 A CN 00807743A CN 1187448 C CN1187448 C CN 1187448C
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China
Prior art keywords
ammediol
sudden change
desaturase
pdd
escherichia
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Expired - Lifetime
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CNB008077436A
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English (en)
Chinese (zh)
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CN1352688A (zh
Inventor
D·E·特林伯
G·M·威蒂德
O·V·塞里弗诺瓦
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Danisco US Inc
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Genencor International Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CNB008077436A 1999-05-19 2000-05-16 1,3－丙二醇脱氢酶突变体 Expired - Lifetime CN1187448C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13486899P 1999-05-19 1999-05-19
US60/134,868 1999-05-19

Publications (2)

Publication Number Publication Date
CN1352688A CN1352688A (zh) 2002-06-05
CN1187448C true CN1187448C (zh) 2005-02-02

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CNB008077436A Expired - Lifetime CN1187448C (zh) 1999-05-19 2000-05-16 1,3－丙二醇脱氢酶突变体

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US (2) US6468773B1 (https=)
EP (1) EP1185667B1 (https=)
JP (1) JP4646411B2 (https=)
CN (1) CN1187448C (https=)
AT (1) ATE485378T1 (https=)
AU (1) AU777718B2 (https=)
BR (1) BR0010752A (https=)
CA (1) CA2373312C (https=)
DE (1) DE60045125D1 (https=)
IL (1) IL146172A0 (https=)
MX (1) MXPA01011766A (https=)
WO (1) WO2000070057A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1194559B1 (en) * 1999-06-18 2006-09-20 Research Foundation Of State University Of New York Groups of borrelia burgdorferi that cause lyme disease in humans
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
WO2008052595A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
US20110229942A1 (en) * 2007-12-13 2011-09-22 Glycos Biotechnologies, Incorporated Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals
US9605283B2 (en) 2012-07-11 2017-03-28 Institut National Des Sciences Appliquées Microorganism modified for the production of 1,3-propanediol
WO2015051298A2 (en) 2013-10-04 2015-04-09 Genomatica, Inc. Alcohol dehydrogenase variants
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN106609249B (zh) * 2015-10-22 2019-07-23 中国科学院上海高等研究院 克雷伯氏肺炎杆菌突变菌及其生产1,3-丙二醇的应用
US11441128B2 (en) 2015-10-30 2022-09-13 Genomatica, Inc. Methanol dehydrogenase fusion proteins
CN116622657B (zh) * 2023-07-17 2023-10-24 花安堂生物科技集团有限公司 一种1，3-丙二醇氧化还原酶突变体及含其融合蛋白与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ATE452979T1 (de) * 1996-11-13 2010-01-15 Du Pont Herstellungsverfahren von 1,3-propandiol durch rekombinante organismen

Also Published As

Publication number Publication date
IL146172A0 (en) 2002-07-25
US20030040091A1 (en) 2003-02-27
CA2373312C (en) 2010-07-20
US6468773B1 (en) 2002-10-22
CA2373312A1 (en) 2000-11-23
DE60045125D1 (en) 2010-12-02
US6558933B2 (en) 2003-05-06
CN1352688A (zh) 2002-06-05
ATE485378T1 (de) 2010-11-15
JP4646411B2 (ja) 2011-03-09
WO2000070057A2 (en) 2000-11-23
BR0010752A (pt) 2002-02-26
AU777718B2 (en) 2004-10-28
MXPA01011766A (es) 2002-05-14
WO2000070057A3 (en) 2001-02-08
EP1185667B1 (en) 2010-10-20
EP1185667A2 (en) 2002-03-13
AU5015500A (en) 2000-12-05
JP2002543843A (ja) 2002-12-24

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Granted publication date: 20050202