CN118165076A - 基质金属蛋白酶底物和其它可切割部分及其使用方法 - Google Patents
基质金属蛋白酶底物和其它可切割部分及其使用方法 Download PDFInfo
- Publication number
- CN118165076A CN118165076A CN202410265535.5A CN202410265535A CN118165076A CN 118165076 A CN118165076 A CN 118165076A CN 202410265535 A CN202410265535 A CN 202410265535A CN 118165076 A CN118165076 A CN 118165076A
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- seq
- amino acid
- acid sequence
- antibody
- activatable antibody
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361882377P | 2013-09-25 | 2013-09-25 | |
| US61/882377 | 2013-09-25 | ||
| US201461971332P | 2014-03-27 | 2014-03-27 | |
| US61/971332 | 2014-03-27 | ||
| PCT/US2014/057523 WO2015048329A2 (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| CN201480064185.0A CN106163556B (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480064185.0A Division CN106163556B (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118165076A true CN118165076A (zh) | 2024-06-11 |
Family
ID=51691175
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410265536.XA Pending CN118146306A (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
| CN201480064185.0A Active CN106163556B (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
| CN202410265535.5A Pending CN118165076A (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410265536.XA Pending CN118146306A (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
| CN201480064185.0A Active CN106163556B (zh) | 2013-09-25 | 2014-09-25 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20150087810A1 (enExample) |
| EP (1) | EP3049111A2 (enExample) |
| JP (5) | JP6915987B2 (enExample) |
| KR (3) | KR20250051130A (enExample) |
| CN (3) | CN118146306A (enExample) |
| AU (3) | AU2014324884B2 (enExample) |
| CA (2) | CA2925106C (enExample) |
| IL (3) | IL322893A (enExample) |
| MX (2) | MX379106B (enExample) |
| NZ (2) | NZ756892A (enExample) |
| RU (1) | RU2715232C2 (enExample) |
| WO (1) | WO2015048329A2 (enExample) |
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| CN118146306A (zh) | 2013-09-25 | 2024-06-07 | 西托姆克斯治疗公司 | 基质金属蛋白酶底物和其它可切割部分及其使用方法 |
| JP6835586B2 (ja) | 2014-01-31 | 2021-02-24 | シトムクス セラピューティクス，インコーポレイティド | マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法 |
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| DK3298033T4 (da) | 2015-05-18 | 2023-10-02 | Tcr2 Therapeutics Inc | Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner |
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