CN118127019A - Apol1表达的调节剂 - Google Patents
Apol1表达的调节剂 Download PDFInfo
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- CN118127019A CN118127019A CN202410386618.XA CN202410386618A CN118127019A CN 118127019 A CN118127019 A CN 118127019A CN 202410386618 A CN202410386618 A CN 202410386618A CN 118127019 A CN118127019 A CN 118127019A
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- Prior art keywords
- certain embodiments
- modified
- compound
- oligonucleotide
- apol1
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- C12N2310/00—Structure or type of the nucleic acid
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| USRE49076E1 (en) | 2010-04-18 | 2022-05-17 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating renal disease |
| IL316397A (en) | 2018-05-22 | 2024-12-01 | Ionis Pharmaceuticals Inc | Modulators of APOL1 expression |
| IL283592B2 (en) | 2018-12-17 | 2025-08-01 | Vertex Pharma | Inhibitors of apol1 and methods of using same |
| EP4097083A1 (en) | 2020-01-29 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| CN116157393A (zh) | 2020-06-12 | 2023-05-23 | 弗特克斯药品有限公司 | Apol1的抑制剂及其用途 |
| EP4165036A1 (en) | 2020-06-12 | 2023-04-19 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitor and using the same |
| KR20240149461A (ko) | 2022-01-18 | 2024-10-14 | 메이즈 테라퓨틱스, 인코퍼레이티드 | Apol1 저해제 및 사용 방법 |
| EP4573077A1 (en) * | 2022-08-19 | 2025-06-25 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
| TW202545540A (zh) | 2024-05-21 | 2025-12-01 | 瑞典商阿斯特捷利康公司 | 用於治療ａｐｏｌ１介導之腎病之方法 |
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| EP1867338A1 (en) | 2006-05-30 | 2007-12-19 | Université Libre De Bruxelles | Pharmaceutical composition comprising apolipoproteins for the treatment of human diseases |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| CA2739464C (en) | 2008-10-03 | 2020-03-31 | Curna, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| CN102307997B (zh) | 2008-12-04 | 2018-03-30 | 库尔纳公司 | 通过抑制针对沉默调节蛋白1的天然反义转录物来治疗沉默调节蛋白1(sirt1)相关的疾病 |
| WO2011020865A1 (en) | 2009-08-18 | 2011-02-24 | Universite Libre De Bruxelles | Apolipoprotein l- i variants and their use |
| JP5991922B2 (ja) | 2009-11-13 | 2016-09-14 | サレプタ セラピューティクス， インコーポレイテッド | アンチセンス抗ウイルス性化合物およびインフルエンザウイルス感染を処置するための方法 |
| JP6031356B2 (ja) | 2009-12-23 | 2016-11-24 | カッパーアールエヌエー，インコーポレイテッド | Ｕｃｐ２に対する天然アンチセンス転写産物の阻害による脱共役タンパク質２（ｕｃｐ２）関連疾患の治療 |
| US9023355B2 (en) * | 2010-04-13 | 2015-05-05 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating renal disease |
| US20120003644A1 (en) | 2010-06-07 | 2012-01-05 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kits for determining predisposition to develop kidney diseases |
| CA2863958A1 (en) * | 2012-02-08 | 2013-08-15 | Isis Pharmaceuticals, Inc. | Methods and compositions for modulating factor vii expression |
| HUE051680T2 (hu) | 2012-05-24 | 2021-03-29 | Ionis Pharmaceuticals Inc | Apolipoprotein(a) expressziójának módosítására szolgáló eljárások és készítmények |
| WO2014078213A2 (en) | 2012-11-16 | 2014-05-22 | Merck Sharp & Dohme Corp. | Modified apol1 polypeptides |
| WO2014085154A1 (en) | 2012-11-27 | 2014-06-05 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| US20160003808A1 (en) | 2013-03-14 | 2016-01-07 | Galapagos Nv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition |
| GB201311057D0 (en) | 2013-06-21 | 2013-08-07 | Univ Greenwich | Antisense oligonucleotide compositions |
| TWI657819B (zh) * | 2013-07-19 | 2019-05-01 | 美商Ionis製藥公司 | 用於調節τ蛋白表現之組合物 |
| WO2015136509A2 (en) | 2014-03-14 | 2015-09-17 | Genesis Theranostix Korlatolt Felelossegu Tarsasag | Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy |
| CN116970607A (zh) | 2014-03-19 | 2023-10-31 | Ionis制药公司 | 用于调节共济失调蛋白2表达的组合物 |
| EP3020813A1 (en) | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
| TW201718010A (zh) * | 2015-06-19 | 2017-06-01 | 健臻公司 | 治療原發性局部節段性腎小球硬化症之方法 |
| IL318703A (en) | 2015-06-29 | 2025-03-01 | Caris Science Inc | Therapeutic oligonucleotides |
| HK1255699A1 (zh) * | 2015-09-24 | 2019-08-23 | Ionis Pharmaceuticals, Inc. | Kras表达的调节剂 |
| IL316397A (en) | 2018-05-22 | 2024-12-01 | Ionis Pharmaceuticals Inc | Modulators of APOL1 expression |
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