CN118076585A - 革兰氏阴性菌外排泵抑制剂 - Google Patents

革兰氏阴性菌外排泵抑制剂 Download PDF

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Publication number
CN118076585A
CN118076585A CN202280059217.2A CN202280059217A CN118076585A CN 118076585 A CN118076585 A CN 118076585A CN 202280059217 A CN202280059217 A CN 202280059217A CN 118076585 A CN118076585 A CN 118076585A
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chloro
piperazin
quinolinyl
dihydrochloride
group
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CN202280059217.2A
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Chinese (zh)
Inventor
A·维埃拉·达·克鲁兹
C·普勒
M·弗利波
N·康姆帕尼
N·维兰德
H-K·谭
J·C·吉梅内斯·卡斯特拉诺斯
K·M·波斯
R·C·哈特库恩
R·T·米勒
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John Wolfgang Goethe University Of Frankfurt Am Main
Lille Hospital
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Lille
Original Assignee
John Wolfgang Goethe University Of Frankfurt Am Main
Lille Hospital
Centre National de la Recherche Scientifique CNRS
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Lille
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Publication of CN118076585A publication Critical patent/CN118076585A/zh
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200024B1 (de) * 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
AU2001280091A1 (en) * 2000-08-01 2002-02-13 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes
US7074794B2 (en) * 2000-08-10 2006-07-11 Mitsubishi Pharma Corporation Proline derivatives and the use thereof as drugs
JP2007507514A (ja) * 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノキサリン化合物
EP1836189A1 (en) * 2005-01-06 2007-09-26 AstraZeneca AB Novel pyridine compounds
EP1987827A1 (en) * 2006-02-20 2008-11-05 Takeda Pharmaceutical Company Limited Novel pharmaceutical
TW200815426A (en) * 2006-06-28 2008-04-01 Astrazeneca Ab New pyridine analogues II 333
MX2009000577A (es) * 2006-07-14 2009-03-09 Schering Corp Compuestos de piperazina sustituida heterociclica con actividad antagonista de cxcr3.
TW201204727A (en) * 2010-03-10 2012-02-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
JP2011246461A (ja) * 2010-04-27 2011-12-08 Mitsubishi Tanabe Pharma Corp 新規アミド誘導体を含有する医薬組成物
EA201390476A1 (ru) * 2010-09-28 2013-08-30 Бристол-Майерс Сквибб Компани Новые пиперазиновые аналоги с замещенными гетероарильными группами в качестве противовирусных средств широкого применения против гриппа
EP3371164B1 (en) * 2015-11-06 2022-03-16 Neurocrine Biosciences, Inc. N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(pyrazin-2-yl)-piperazine-1-carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases
WO2017097927A1 (en) * 2015-12-11 2017-06-15 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
US20190119236A1 (en) * 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
WO2017160069A1 (ko) * 2016-03-15 2017-09-21 재단법인 의약바이오컨버젼스연구단 신규한 벤젠설폰아미드 유도체 및 이의 용도
MX393606B (es) * 2016-12-30 2025-03-19 Mitobridge Inc Inhibidores de poli-adp ribosa polimerasa (parp)
US11518764B2 (en) * 2018-02-06 2022-12-06 Ontario Institute For Cancer Research (Oicr) Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
JP7637328B2 (ja) * 2019-02-07 2025-02-28 ベイジーン リミテッド Ｔｌｒ７アゴニストとしてのイミダゾ［２，１－ｆ］［１，２，４］トリアジン－４－アミン誘導体
WO2021067859A1 (en) * 2019-10-03 2021-04-08 Tenaya Therapeutics, Inc. 5-fluoronicotinamide derivatives and uses thereof
WO2021127333A1 (en) * 2019-12-19 2021-06-24 Casma Therapeutics, Inc. Trpml modulators

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