CN117982380A - Formula and preparation method of compound clove mouthwash - Google Patents
Formula and preparation method of compound clove mouthwash Download PDFInfo
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- CN117982380A CN117982380A CN202211373189.XA CN202211373189A CN117982380A CN 117982380 A CN117982380 A CN 117982380A CN 202211373189 A CN202211373189 A CN 202211373189A CN 117982380 A CN117982380 A CN 117982380A
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Abstract
The invention discloses a formula composition and a preparation method of a compound clove mouthwash. Comprises the following steps: the formula comprises the following components: 2-10 parts of clove, 2-10 parts of mint, 2-10 parts of wrinkled giant hyssop, 0-5 parts of jasmine flower and 0-5 parts of liquorice. The preparation method comprises the following steps: adding 10-30 times of water into the clove, heating and extracting volatile oil for 2-10 hours, and collecting volatile oil distillate and water decoction. Adding 10-30 times of water into herba Menthae, herba Agastaches and flos et flos Hibisci, heating to extract volatile oil, collecting volatile oil distillate and water decoction for 1-6 hr. Adding 4-20 times of water into licorice, heating and decocting for 2 times, the first time is 1-4 hours, the second time is 1-3 hours, and combining the extracting solutions. Mixing the volatile oil extract and the water decoction uniformly. The gargle is characterized by being prepared from clove, peppermint, wrinkled giant hyssop, jasmine and liquorice, is used for eliminating halitosis, cleaning and nursing oral cavity, and is suitable for all people by spraying or gargling.
Description
Technical Field
The invention relates to a formula of a compound clove mouthwash and a preparation method thereof.
Background
The mouthwash has the functions of eliminating halitosis and freshening breath; secondly, can reduce oral microorganisms, clean the oral cavity and prevent oral diseases.
Literature reports that 10% -65% of people worldwide suffer from bad breath. Bad breath refers to the odor emitted from the mouth or other air-filled cavities during breathing, also known as breath. The world health organization has listed bad breath as a disease. The influence of bad breath on people's social contact is increasingly remarkable, 86% of bad breath patients have a bad influence on people's life, work and social contact because of the normal communication between bad breath and others, and repeated bad breath may cause the patients to spell, depression and social contact, and the quality of life is seriously affected. The reasons for bad breath mainly include two types, one is oral pathogen infection and the other is the manifestation of systemic diseases. Up to 300 microorganisms in the human mouth, about 5 hundred million bacteria per 1ml of saliva, are far more than the large intestine, both in variety and quantity, including pathogenic and non-pathogenic. When the resistance of the human body is reduced, microorganisms in the oral cavity are greatly propagated and invade the human body to cause diseases. Bacteria capable of causing oral infection are mainly gram-negative bacilli, staphylococcus aureus, etc. Various pathogenic bacteria are propagated in a large quantity in the oral cavity, and oral diseases such as halitosis, canker sore, gingivitis, hemorrhage, decayed tooth and the like are very easy to occur. About 80% to 90% of bad breath is statistically derived from the oral cavity. The third national health epidemiological investigation result in China shows that the caries rate of children aged 5 reaches 66.0%, and 5 caries are found in each oral cavity. The suffering rate of the middle aged 35-44 years reaches 88.1 percent, and the suffering rate of the 65-74 years reaches 98.4 percent. Caries is an infectious disease caused by multiple factors, and food factors and microbial factors play a role. Oral lesions occur, organic compounds ferment, sulfide and hydrocarbon overflow more, bad breath is obvious, and bad breath affects life and work. Bad oral habits and oral hygiene cause increased and thickened tongue back plaque to cause halitosis; untreated caries, stump, residual crown, gingivitis, periodontitis, suppurative pulpitis, oral mucosa diseases, etc., can cause halitosis; periodontal disease patients often suffer from a large amount of dental calculus, plaque, residual food residues, bacteria, and fermentation to produce hydrogen sulfide, indole and ammonia, thereby generating odor; bad breath may be caused by eating certain drugs or irritating foods such as onion and garlic, smoking, bacterial decomposition food residues due to reduced salivary secretion during sleep, and the like. In addition, suppurative tonsillitis, chronic maxillary sinusitis, atrophic rhinitis and other diseases of adjacent tissues of the oral cavity generate purulent secretion to generate odor; the common clinical medical diseases such as acute and chronic gastritis and peptic ulcer can cause acid odor; pylorus obstruction and late gastric cancer can cause bad duck egg type halitosis; patients with diabetic ketoacidosis exhale acetone flavor gas, and patients with uremia exhale apple flavor. Leukemia, vitamin deficiency and other diseases can cause halitosis.
The mouthwash can enter all parts of the oral cavity, including the gingival margin and the tooth gap which are difficult to contact by the toothbrush, not only can remove food scraps left in the oral cavity after meals, especially in the tooth gap, but also has the functions of sterilizing, controlling bacterial plaque, protecting teeth and oral soft tissues, effectively reducing halitosis and oral peculiar smell, reducing the aggregation of pathogenic bacteria at the oropharynx and reducing the oral infection rate. The mouthwash is convenient to use and easy to master, is suitable for use in home use and work business trip, and can achieve the effect in a short period of time. A good mouthwash should possess the following characteristics: cleaning oral cavity and reducing dental calculus; inhibit bacteria and reduce bacterial plaque; removing peculiar smell, and keeping breath fresh and durable; preventing diseases, etc.
The common mouthwash comprises essential oil, metronidazole, tinidazole, chlorhexidine, 3% hydrogen peroxide, iodophor and triclosan.
Essential oils are derived from plants and have little side effects, but are forbidden to patients who cannot tolerate high concentration alcohol and other alcohol sensitive people because of the 26.9% alcohol; metronidazole and tinidazole are mainly used for preventing and treating infection caused by anaerobic bacteria, and have extremely bitter taste and influence on taste; the concentration of the chlorhexidine mouthwash is 0.1% -0.5%, and the chlorhexidine mouthwash is the most widely applied disinfectant with the strongest antiplaque capability, but can cause staining and bitter taste of tooth surfaces and tongue mucous membranes and can also cause dysgeusia; the 3% hydrogen peroxide is a strong oxidant, has the functions of corrosion prevention, sterilization, deodorization and cleaning, is also applicable to mold infection, but can produce side effects of tooth surface decalcification, black hair tongue and the like after long-term application; the iodophor is a novel iodine-containing sterilizing agent and has strong killing effect on various bacteria, virus fungi and the like, but the effective iodine can be reduced by more than 50% after being diluted for 2 hours due to unstable diluted iodophor, so that the iodophor mouthwash is inconvenient to prepare in situ; triclosan is a mild antibacterial agent, namely triclosan, which is the most commonly used component in the existing mouthwash, but recent researches find that triclosan is easily absorbed by skin and mucous membranes due to its lipophilicity, is accumulated and is converted into a series of toxic derivatives in the environment, has potential toxicity, can interfere with the glucocorticoid barrier of placenta, affects the growth and development of fetuses, interferes with the metabolism of thyroxine, affects the activity of steroid enzymes, and has been classified as a third type of product by the U.S. FDA. Therefore, it is necessary to develop a mouthwash with good taste, safety and no toxicity.
The Chinese herbal medicine has long history of preventing and treating halitosis, is safe and has no toxic or side effect, has incomparable advantages with other medicines in preventing and treating halitosis, is also a unique advantage of China, and has been widely paid attention to researchers at home and abroad in recent years. There are fourteen hundred million people in China, the mouth diseases are numerous, and the mouthwash needs a huge market. The national institute has printed the schema of traditional Chinese medicine development strategy (2016-2030) in 2016, and the national-level traditional Chinese medicine schema proposes that by 2020, people basically enjoy traditional Chinese medicine services, and the traditional Chinese medicine industry becomes one of important supports of national economy; by 2030, the full coverage of the field of traditional Chinese medicine service is realized, the health service capability of the traditional Chinese medicine is obviously enhanced, and the economic and social development is greatly contributed. The health service industry is vigorously developed, the people have more and more vigorous demands on the medical service, and the traditional Chinese medicine is urgently needed to be inherited, developed and utilized, so that the effect of the traditional Chinese medicine in deepening the improvement of the medical health system is fully exerted, and the health of people is benefited.
The compound clove mouthwash is prepared from medicaments such as clove, peppermint, wrinkled giant hyssop, jasmine, liquorice and the like by refining, and can be sprayed or gargled. The clove, the peppermint, the agastache rugosa, the jasmine and the liquorice are medicinal and edible dual-purpose medicinal materials, and have no toxic or side effect, and are the most commonly used oral care medicaments in the past, so the invention prepares the mouthwash by adopting the clove as a main medicament and matching with mint and other raw materials. The antibacterial effect of the clove is studied for more than ten years, and the clove and the volatile oil thereof are found to have stronger antibacterial effect on more than 10 bacteria and fungi such as staphylococcus aureus, escherichia coli, he Liji bacillus, pseudomonas aeruginosa, salmonella enteritidis, bacillus subtilis, klebsiella oxytoca, staphylococcus epidermidis, candida albicans and the like. Recent literature has also demonstrated that it is very sensitive to these bacteria. The clove oil has obvious inhibition and killing effects on partial deep fungi, saccharomycetes and saccharomycetes, and also has inhibition effect on the growth of oral clinical common pathogenic bacteria model strains such as streptococcus mutans and porphyromonas gingivalis. The herba Agastaches volatile oil extract has strong inhibiting activity on Staphylococcus aureus and Escherichia coli. The mint has good antibacterial effect on streptococcus stomatitis, streptococcus mutans, porphyromonas gingivalis and the like, and is a common oral freshener. Glycyrrhrizae radix has strong in vitro inhibitory activity on cariogenic bacteria such as Streptococcus mutans, streptococcus sorbinus, lactobacillus and Lactobacillus casei.
The current state of research on these several drugs is reviewed as follows:
Flos Caryophylli is a dry bud of flos Caryophylli of Myrtaceae, has pungent taste and warm nature, and has effects of warming middle warmer, lowering adverse qi, warming kidney and supporting yang. Flos Caryophylli has long been used to remove halitosis. Song Daishen, in the "Mengxi Pen Jiu": "Sanprovince Story Lang Guan takes the fragrance of chicken tongue orally, and want to play it, answer it with a fragrant smell. This is known as "the treatment of halitosis" by clove. "because the aromatic smell of clove can press halitosis caused by rising stomach fire or periodontitis, the flavor of clove is treated by chewing, and thus, the flavor of clove is called ancient chewing gum. Modern pharmacological researches show that the clove has the functions of resisting bacteria, resisting viruses, resisting oxidation, relieving fever and pain, enhancing memory, anesthesia and the like, has good pharmacological basis and treatment effect in disease prevention and treatment, and is a traditional Chinese medicine with great development potential. The antibacterial effect research of the clove shows that the clove has wide antibacterial spectrum and has stronger inhibition and killing effects on pathogenic bacteria such as enterococcus, staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes, shigella flexneri, pseudomonas aeruginosa, acinetobacter, escherichia coli, salmonella and the like. In addition, the clove has stronger antifungal activity and a certain antiviral capability. The components of the composition, such as clove oil, eugenol, syringin, oleuropein, 3, 4-dihydroxyphenethyl alcohol, eugenol acetate and the like, can be the main active components of the antibacterial and antiviral activity of the clove. The antibacterial mechanism of clove may be caused by its destruction of the bacterial cell membrane. The application of the clove in the oral cavity is mainly based on the anti-inflammatory, antipyretic and analgesic effects, and is used for deep caries analgesia, dental pulp inactivation, dry groove disease, dental ulcer treatment and the like. Studies have found that Syringa oblonga has an inhibitory effect on the growth of Streptococcus mutans and Porphyromonas gingivalis, where the bacteriostatic effect of Syringa oblonga on Streptococcus mutans may be related to the inhibition of extracellular water-soluble and water-insoluble glucan synthesis by eugenol. In addition, clinical researches show that the gargle leaf preparation can be used for treating periodontitis, so that the content of peripheral blood TNF-alpha of periodontitis patients can be reduced, and the content of serum PEG2 of moderately severe periodontitis patients can be reduced.
Peppermint is dry aerial part of Mentha haplocalyx of Labiatae, and has effects of dispelling pathogenic wind-heat, clearing heat, relieving exterior syndrome, relieving sore throat, promoting eruption, dispelling pathogenic wind, relieving swelling, relieving sore throat, and relieving pain, and can be used for common cold due to wind-heat, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, chest distress, etc. Peppermint was first collected in Tang Ben Cao (Tang Ben Cao), "main Equisetum wind, sweating, (treating) malignant-qi abdominal distention, cholera, indigestion, descending qi". Mention is made in Ben Cao gang mu: the throat and mouth and teeth diseases are treated. It is indicated for scrofula, scabies, wind-caused pruritus and urticaria. The mint has rich chemical components and mainly contains volatile oil, flavonoids, anthraquinones, organic acids, amino acids, trace elements and the like. Modern pharmacological researches have shown that peppermint has the effects of protecting liver, promoting function of gallbladder, exciting central nervous system, resisting inflammation, easing pain, resisting virus, promoting transdermal absorption and the like. The volatile oil contains antibacterial and antiviral components such as menthol, menthyl acetate, limonene, menthone, etc. The dietetic therapy value of the mint has great development potential, and can be used for treating sore throat, dispelling wind and heat, eliminating pathogenic toxin, eliminating fatigue, relieving sleepiness, refreshing brain, refreshing and cleaning the fragrance of population, and the like. The mint and mint extract can be used as natural food additives, flavoring agents, antioxidants and the like, and besides, the volatile oil contained in the mint is also used as spice and essence to be widely applied to foods, cosmetics and daily necessities.
Herba Pogostemonis, which is one of the representatives of the drugs with the effect of eliminating dampness with aromatics, has the effects of eliminating turbid pathogen with aromatics, stimulating appetite and relieving vomiting, and relieving summer-heat, and is a common drug for treating summer-heat and dampness. With the intensive research of modern agastache rugosa, the agastache rugosa has wide pharmacological actions, and has potential medicinal values in the aspects of antibiosis, gastrointestinal tract regulation, anti-inflammation, pain relief, antiallergic, immunoregulation and the like. The herba Agastaches contains a large amount of volatile oil components, mainly terpenes, ketones, phenols, alcohols, ethers, esters, etc. The non-volatile oil component mainly comprises chemical components such as flavonoids, phenolic acids, phenylpropanoids, quinones, steroids and the like. The agastache rugosa extract has a strong inhibition effect on gram-positive bacteria such as bacillus cereus and has a general inhibition effect on streptococcus mutans, wherein the inhibition effect of the agastache rugosa alcohol extract is the best. The combination of volatile oil components and ketoconazole contained in herba Agastaches has strong inhibiting effect on bacillus. The volatile oil extract of herba Agastaches has strong inhibitory activity on Staphylococcus aureus and Escherichia coli. The volatile oil extract of herba Pogostemonis has effect in inhibiting skin tinea bacterial colony formation. The herba Agastaches leaf extract can inhibit expression of nitric oxide synthase in active oxygen cells by regulating TNF alpha and IL-11 levels, and treat inflammatory diseases mediated by nitric oxide, thereby having antiinflammatory activity.
Jasmine flower is a natural high-grade spice plant, and is a plant of the genus jasmine of the family Oleaceae. The chemical components of jasmine flower are mainly volatile oil, glycoside compounds, flavonoid compounds, terpenes, lignans, alkaloids and the like. The jasmine dreg flavone has a certain antibacterial effect on common bacillus, escherichia coli, staphylococcus and bacillus subtilis. The jasmine tea extract, jasmine flower brain-removing oil and B-II have certain immunity promoting effect. Jasmine flower is pungent and sweet in flavor and warm in nature. Refreshing, resolving depression, tranquilizing nerve, relieving gastrointestinal discomfort and menstrual pain, moistening skin, caring skin. Jasmine flower is extremely fragrant, and is a famous scented tea raw material and an important essence raw material. The jasmine tea has the advantages of refreshing and delicious taste and long aftertaste.
Glycyrrhrizae radix is dry root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza uralensis Fisch or Glycyrrhiza glabra of Leguminosae, and is originally carried in Shennong Ben Cao Jing, which has been used as traditional Chinese medicine for thousands of years, and has various chemical components and wide pharmacological effects. Licorice root, radix Glycyrrhizae is sweet in nature and flat in nature. Has the functions of invigorating spleen, replenishing qi, clearing away heat and toxic material, eliminating phlegm, relieving cough, relieving spasm, relieving pain and harmonizing the medicines. The Chinese medicine "king" is called, licorice has been used clinically for more than two thousand years, and is listed as superior in Shennong Ben Cao Jing (Shen nong's herbal medicine), and "Sheng He xi Gu Jisha mountain" is recorded in Ming Yi Bie Ji, and the Chinese calendar is listed as superior in the aspect of quality, and is mainly used for treating diseases of vascular system, digestive system, respiratory system, immune system and the like. The licorice extract has strong inhibiting effect on staphylococcus aureus, bacillus subtilis, escherichia coli and saccharomyces cerevisiae, and has the effects of regulating body immunity and the like.
Disclosure of Invention
The invention aims to provide a compound clove mouthwash. The liquid is characterized by being prepared by refining medicaments such as clove, peppermint, wrinkled giant hyssop, jasmine, liquorice and the like, and can be used for refreshing, cleaning and nursing oral cavity, and can be sprayed or used for gargling.
The basic principle of the invention is that the inventor selects medicinal and edible dual-purpose medicinal materials of clove, peppermint, wrinkled giant hyssop, jasmine and liquorice which can refresh breath according to the cause of bad breath, and selects the compatibility of the clove, the mint and the wrinkled giant hyssop according to the modern research and the compatibility theory of traditional Chinese medicine, so that the compatibility of the clove, the mint and the wrinkled giant hyssop can mutually stabilize the property of cold and heat, and the compatibility of the jasmine and the liquorice ensures that the taste is faint and pleasant. Through the proportion of the medicines, experiments are carried out for hundreds of times by taking the antibacterial effect and the taste as indexes, and finally the formula composition and the preparation process of the mouthwash are determined. The result proves that the mouthwash prepared by the formula and the process has good taste and antibacterial effect, and can refresh breath, reduce oral microorganisms and eliminate halitosis after being used.
The invention is realized in the following way:
1. The formula comprises the following components: 2-10 parts of clove, 2-10 parts of mint, 2-10 parts of wrinkled giant hyssop, 0-5 parts of jasmine flower and 0-5 parts of liquorice.
2. The preparation method comprises the following steps: placing flos Caryophylli in a traditional Chinese medicine extractor, adding 10-30 times of water, heating to extract volatile oil, collecting volatile oil distillate and water decoction for 2-10 hours. Adding herba Menthae, herba Agastaches and flos Rosae Rugosae into a traditional Chinese medicine extractor, adding 10-30 times of water, heating to extract volatile oil, 1-6 hr, and collecting volatile oil distillate and water decoction. Placing Glycyrrhrizae radix into a traditional Chinese medicine extractor, adding 4-20 times of water, heating and decocting for 2 times, 1-4 hr for the first time and 1-3 hr for the second time, and mixing the extractive solutions. Mixing the volatile oil extract and the water decoction, and packaging.
The invention has the advantages that the used raw materials of clove, peppermint, wrinkled giant hyssop, jasmine flower, liquorice and the like are used as medicines and foods, are pharmaceutically acceptable, edible, safe and free from toxic and side effects, are used for liquid for refreshing, cleaning and nursing oral cavity, are suitable for all people, can be sprayed, can be used by gargling, can be used for swallowing without spitting, and are convenient to use.
The invention achieves the object by implementing the following technical scheme.
Detailed Description
Example 1
Mouthwash 1: 200.00g of clove medicinal material is weighed and put into a traditional Chinese medicine extractor, water which is 10-30 times of the weight of the material is added, volatile oil is extracted by heating for 2-10 hours, 4000ml of volatile oil distillate and 1000ml of water decoction are collected. 150g of peppermint, 100g of wrinkled giant hyssop and 50g of jasmine are put into a traditional Chinese medicine extractor, water with the weight of 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 1-6 hours, and 2000ml of volatile oil distillate and 1000ml of water decoction are collected. Placing 50g of liquorice into a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, the second time is 1-3 hours, and combining 1000ml of extracting solution. Mixing the volatile oil extract and water decoction with tween 80 at a ratio of 0.01% to obtain 10000ml, and packaging.
Example 2
Mouthwash 2: 200.00g of clove medicinal material is weighed and put into a traditional Chinese medicine extractor, water which is 10-30 times of the weight of the material is added, volatile oil is extracted by heating for 2-10 hours, 4000ml of volatile oil distillate and 1000ml of water decoction are collected. 100g of peppermint and 50g of agastache rugosa are put into a traditional Chinese medicine extractor, water with the weight of 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 1-6 hours, and 2000ml of volatile oil distillate and 1000ml of water decoction are collected. Placing 50g of liquorice into a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, the second time is 1-3 hours, and combining 1000ml of extracting solution. Mixing the volatile oil extract and water decoction with tween 80 at a ratio of 0.01% to obtain 10000ml, and packaging.
Example 3
Mouthwash 3: 200.00g of clove medicinal material is weighed and put into a traditional Chinese medicine extractor, water which is 10-30 times of the weight of the material is added, volatile oil is extracted by heating for 2-10 hours, 4000ml of volatile oil distillate and 1000ml of water decoction are collected. 50g of peppermint and 150g of ageratum 100g of jasmine are put into a traditional Chinese medicine extractor, water with the weight of 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 1-6 hours, and 2000ml of volatile oil distillate and 1000ml of water decoction are collected. Placing 50g of liquorice into a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, the second time is 1-3 hours, and combining 1000ml of extracting solution. Mixing the volatile oil extract and water decoction with tween 80 at a ratio of 0.01% to obtain 10000ml, and packaging.
Example 4
Mouthwash 4: 200.00g of clove medicinal material is weighed and put into a traditional Chinese medicine extractor, water which is 10-30 times of the weight of the material is added, volatile oil is extracted by heating for 2-10 hours, 4000ml of volatile oil distillate and 1000ml of water decoction are collected. 200g of peppermint and 50g of agastache rugosa with 10g of jasmine are placed in a traditional Chinese medicine extractor, water with the weight of 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 1-6 hours, and 2000ml of volatile oil distillate and 1000ml of water decoction are collected. Placing 30g of liquorice in a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, the second time is 1-3 hours, and combining 1000ml of extracting solution. Mixing the volatile oil extract and water decoction with tween 80 at a ratio of 0.01% to obtain 10000ml, and packaging.
Example 5
Mouthwash 5: 200.00g of clove medicinal material, 200g of mint, 100g of wrinkled giant hyssop, 50g of jasmine flower and 30g of liquorice are weighed and put into a traditional Chinese medicine extractor, water with the weight 10-30 times of the weight of the materials is added, the materials are heated and decocted for 2 times, the first time is 1-4 hours, the second time is 1-3 hours, the extracting solution is combined to obtain 10000ml, and the obtained product is split charging.
Trial experience:
1. A woman, 56 years old, has diabetes for 8 years, and is complicated with oral infection such as canker sore, gingivitis, periodontitis, etc., and bad breath. The gargle liquid is 1 by using the compound clove mouthwash, the gargle liquid is 5-10 ml each time after meals, the time is maintained for 3min, the mouth is fresh after gargling for 3 times each day, the mouth is sprayed by the gargle liquid, the mouth smell is immediately faint, and the halitosis is eliminated.
2. A woman, 33 years old, a store bathroom salesman. There is serious bad breath, talking with clients and trouble, and it affects sales performance. The compound clove mouthwash 2 is used for spraying the mouth cavity, so that the mouth smell is immediately faint, and the halitosis is eliminated when the compound clove mouthwash 2 is used for communicating with customers each time.
3. A male, 21 years old, student. There are serious periodontal diseases, bad breath, and ordinary mood, which affect normal social contact. The compound clove mouthwash 3 is used, the gargle liquid is 5-10 ml each time after meals, the time is maintained for 3min, the mouth is fresh after gargling for 3 times a day, and the self-confidence is multiplied.
4. A Halimeer halitosis tester (RH 17K type, produced by American INTERSCAN) detects 30 halitosis patients, the H 2 S content of all patients is larger than 50 mug/L, the average is 97.32 +/-33.17, the oral cavity gas is treated for 3 times a day by using the compound clove mouthwash 4 gargle, the oral cavity gas has reduced H 2 S content after each time of 5-10 ml of mouthwash after meals, the oral cavity gas has reduced H 2 S content after 1 week of treatment, the H 2 S content in the oral cavity gas is 46.27 +/-18.51, and the comparison difference between the oral cavity gas content before and after treatment is obvious (P < 0.05).
The crowd experience results indicate that the compound clove mouthwash has obvious halitosis treatment effect, can effectively maintain the oral health of patients, and reduces oral cavity odor and oral cavity infection.
Claims (8)
1. A formula of a compound clove mouthwash and a preparation method thereof. It is characterized in that
(1) The formula comprises the following components: 2-10 parts of clove, 2-10 parts of mint, 2-10 parts of wrinkled giant hyssop, 0-5 parts of jasmine flower and 0-5 parts of liquorice.
(2) The preparation method comprises the following steps: placing flos Caryophylli in a traditional Chinese medicine extractor, adding 10-30 times of water, heating to extract volatile oil, collecting volatile oil distillate and water decoction for 2-10 hours. Adding herba Menthae, herba Agastaches and flos Rosae Rugosae into a traditional Chinese medicine extractor, adding 10-30 times of water, heating to extract volatile oil, 1-6 hr, and collecting volatile oil distillate and water decoction. Placing Glycyrrhrizae radix into a traditional Chinese medicine extractor, adding 4-20 times of water, heating and decocting for 2 times, 1-4 hr for the first time and 1-3 hr for the second time, and mixing the extractive solutions. Mixing the volatile oil extract and the water decoction, and packaging.
2. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove, 2-10 parts of mint and 2-10 parts of agastache rugosus are weighed, the mixture is placed in a traditional Chinese medicine extractor, water with the weight being 10-30 times of that of the materials is added, the volatile oil is extracted by heating, the volatile oil distillate and the water decoction are collected for 2-10 hours, and the volatile oil distillate and the water decoction are combined, added with tween 80 according to the proportion of 0.01% and mixed uniformly, and split charging is carried out.
3. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove, 2-10 parts of mint and 1-5 parts of flos mori are weighed, put into a traditional Chinese medicine extractor, water with the weight 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 2-10 hours, volatile oil distillate and water decoction are collected, and the mixture is mixed, added with tween 80 according to the proportion of 0.01% and evenly mixed, and split-packed.
4. The formula and the preparation method of the compound clove mouthwash according to claim 1, which are characterized in that 2 to 10 parts of clove, 2 to 10 parts of mint and 1 to 5 parts of flos mori are weighed and put into a traditional Chinese medicine extractor, water with the weight 10 to 30 times of the weight of the materials is added, volatile oil is extracted by heating for 2 to 10 hours, volatile oil distillate and water decoction are collected and combined; placing Glycyrrhrizae radix into a traditional Chinese medicine extractor, adding 4-20 times of water, heating and decocting for 2 times, 1-4 hr for the first time and 1-3 hr for the second time, and mixing the extractive solutions. Adding tween 80 at a ratio of 0.01%, mixing, and packaging.
5. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove, 2-10 parts of mint and 2-10 parts of agastache rugosus are weighed, put into a traditional Chinese medicine extractor, added with water 10-30 times of the weight of the materials, heated and extracted for 2-10 hours, and then the volatile oil distillate and the water decoction are collected and combined; adding 1-5 parts of liquorice into a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, and the second time is 1-3 hours, and combining the extracting solutions. Packaging.
6. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove and 2-10 parts of wrinkled giant hyssop are weighed and put into a traditional Chinese medicine extractor, water with the weight 10-30 times of the weight of the materials is added, the volatile oil is extracted by heating for 2-10 hours, volatile oil distillate and water decoction are collected and combined; adding 1-5 parts of liquorice into a traditional Chinese medicine extractor, adding 4-20 times of water, heating, decocting and extracting for 2 times, wherein the first time is 1-4 hours, and the second time is 1-3 hours, and combining the extracting solutions. Packaging.
7. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove, 2-10 parts of mint, 2-10 parts of agastache rugosus, 0-5 parts of flos mori and 0-5 parts of liquorice are weighed, can be combined in any proportion, can be mixed together, and can be added with a proper amount of water according to materials to extract volatile oil and aromatic water, or can be respectively extracted for 2-10 hours, volatile oil distillate and water decoction are collected, and the mixture is mixed, split-packed, so that the compound clove mouthwash is obtained.
8. The formula and preparation method of the compound clove mouthwash according to claim 1, wherein 2-10 parts of clove, 2-10 parts of mint, 2-10 parts of agastache rugosus, 0-5 parts of Li flower and 0-5 parts of liquorice are weighed, can be combined together according to any proportion, can be mixed together, and can be added with a proper amount of water according to materials, volatile oil and aromatic water can be extracted, and the volatile oil and the aromatic water can be extracted respectively, the extraction time is 2-10 hours, the volatile oil and the water decoction are collected, and the water decoction is concentrated and dried to be prepared into formulations such as buccal tablets, capsules and the like together with the volatile oil.
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