CN117969629A - System and method for detecting physiological index - Google Patents
System and method for detecting physiological index Download PDFInfo
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- CN117969629A CN117969629A CN202410395091.7A CN202410395091A CN117969629A CN 117969629 A CN117969629 A CN 117969629A CN 202410395091 A CN202410395091 A CN 202410395091A CN 117969629 A CN117969629 A CN 117969629A
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- 238000000034 method Methods 0.000 title description 4
- 210000004369 blood Anatomy 0.000 claims abstract description 80
- 239000008280 blood Substances 0.000 claims abstract description 80
- 238000001514 detection method Methods 0.000 claims abstract description 67
- 230000036772 blood pressure Effects 0.000 claims abstract description 55
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 238000000926 separation method Methods 0.000 claims abstract description 19
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 15
- 239000002699 waste material Substances 0.000 claims abstract description 12
- 239000012528 membrane Substances 0.000 claims abstract description 11
- 210000002966 serum Anatomy 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims description 66
- 230000005540 biological transmission Effects 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 238000007689 inspection Methods 0.000 abstract description 2
- 239000011148 porous material Substances 0.000 description 3
- 238000009534 blood test Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 239000011540 sensing material Substances 0.000 description 1
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- External Artificial Organs (AREA)
Abstract
The invention belongs to the technical field of inspection and detection, and discloses a physiological index detection system and a physiological index detection method, wherein the physiological index detection system comprises a liquid inlet pipe, the liquid inlet pipe is connected with a high-pressure peristaltic pump, the high-pressure peristaltic pump is connected with a blood buffer container through a first one-way valve, and the blood buffer container is connected with a blood detection container through a first electromagnetic valve; the blood detection container is connected with the waste liquid collection container through a second electromagnetic valve; the blood buffer container is connected with the waste liquid collecting container through a third electromagnetic valve; a first pressure sensor is arranged in the blood buffer container, a physiological index sensor component is arranged in the blood detection container, and the physiological index sensor component comprises a separation sensing film, a reference electrode and a counter electrode; the separation sensing membrane is connected with the serum collection container. According to the invention, the blood buffer container is arranged, so that the blood pressure entering the blood detection container is in a constant range, and the detection stability of the physiological index sensor component is ensured.
Description
Technical Field
The invention belongs to the technical field of inspection and detection, and particularly relates to a physiological index detection system and method.
Background
Physiological indexes such as blood sugar, blood lactic acid, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and the like have important significance for maintaining normal physiological activities of human organs and indicating physiological lesions, and concentration mutation of the indexes is easy to occur under specific conditions, so that the indexes are not easy to feed back in time.
Currently, the existing blood physiological index detection mainly comprises a blood gas analyzer and a biochemical analyzer; the search finds that the current Jin Moqin professor team of Nanjing industrial university prepares the separation sensing membrane which can be used for rapid separation of blood and accurate detection at the same time by regulating and controlling the nanometer self-assembly behavior of inorganic materials on the ceramic surface. However, how to use the separation sensing membrane to perform stable physiological index detection and realize stable operation of the detection system is a problem to be solved at present.
Disclosure of Invention
The present invention aims to solve the above technical problems at least to some extent. Therefore, the present invention is directed to a system and a method for detecting physiological indexes.
The technical scheme adopted by the invention is as follows:
The physiological index detection system comprises a liquid inlet pipe, wherein the liquid inlet pipe is connected with a high-pressure peristaltic pump, the high-pressure peristaltic pump is connected with a blood buffer container through a first one-way valve, and the blood buffer container is connected with a blood detection container through a first electromagnetic valve; the blood detection container is connected with the waste liquid collection container through a second electromagnetic valve; the blood buffer container is connected with the waste liquid collecting container through a third electromagnetic valve; a first pressure sensor is arranged in the blood buffer container, a physiological index sensor component is arranged in the blood detection container, and the physiological index sensor component comprises a separation sensing film, a reference electrode and a counter electrode; the separation sensing membrane is connected with the serum collection container; the main control module is respectively and electrically connected with the physiological index sensor assembly, the high-pressure peristaltic pump, the first electromagnetic valve, the second electromagnetic valve, the third electromagnetic valve and the first pressure sensor; the first pressure sensor is used for collecting the blood pressure in the blood buffer container in real time and recording the blood pressure as first blood pressure data, and when the main control module detects that the first blood pressure data is smaller than the lower limit of a first preset blood pressure range, the main control module controls the high-pressure peristaltic pump to be started; when the main control module detects that the first blood pressure data is larger than the upper limit of the first preset blood pressure range, the main control module controls the third electromagnetic valve to be opened.
Preferably, a second pressure sensor is arranged in the blood detection container, the second pressure sensor is used for collecting the blood pressure in the blood detection container in real time and recording the blood pressure as second blood pressure data, and when the main control module detects that the second blood pressure data is smaller than the lower limit of a second preset blood pressure range, the main control module controls the first electromagnetic valve to be opened; when the main control module detects that the second blood pressure data is larger than the upper limit of the second preset blood pressure range, the main control module controls the second electromagnetic valve to be opened.
Preferably, the blood detection container is provided with a mounting assembly, the mounting assembly comprises a limiting piece, a sealing convex block, a sealing concave block, a force transmission piece and an end cover, the blood detection container is provided with a mounting opening, a circle of limiting steps are arranged on the mounting opening, one end of the limiting piece is abutted to the limiting steps, the other end of the limiting piece is abutted to the plane end of the sealing convex block, the protruding end of the sealing convex block is embedded into the concave end of the sealing concave block, the plane end of the sealing concave block is abutted to one end of the force transmission piece, the other end of the force transmission piece is abutted to the end cover, and the end cover is arranged on the blood detection container; the protecting tube, the reference electrode and the counter electrode are sequentially arranged on the end cover, the sealing concave block, the sealing convex block and the limiting piece in a penetrating mode, and the separation sensing film is arranged in the protecting tube.
Preferably, limiting holes for attaching the protective tube, the reference electrode and the counter electrode are respectively formed in the limiting piece.
Preferably, sealing holes for attaching the protection tube, the reference electrode and the counter electrode are formed in the sealing convex block and the sealing concave block.
Preferably, the sealing projection and the sealing recess are made of rubber or silicone.
Preferably, the liquid inlet pipe is connected with a quick connector, and the quick connector is connected with the blood taking needle or the blood taking pipe.
A physiological index detection method adopts the physiological index detection system to detect physiological indexes.
The beneficial effects of the invention are as follows:
According to the invention, the blood buffer container is arranged, so that the blood pressure entering the blood detection container is in a constant range, and the detection stability of the physiological index sensor component is ensured.
Drawings
FIG. 1 is a schematic diagram of a physiological index detection system according to the present invention.
Fig. 2 is a cross-sectional view of the mounting assembly of the present invention.
Fig. 3 is a schematic view of a stop member of the present invention.
Fig. 4 is a schematic view of a sealing bump of the present invention.
In the figure: 1-a liquid inlet pipe; 2-a high pressure peristaltic pump; 3-a first one-way valve; 4-a blood buffer container; 5-a first solenoid valve; 6-a blood test vessel; 61-limiting steps; 7-a second solenoid valve; 8-a waste liquid collection container; 9-a third solenoid valve; 10-a first pressure sensor; 11-a second pressure sensor; 12-a physiological index sensor assembly; 121-separating the sensing membrane; 122-a reference electrode; 123-a counter electrode; 13-mounting an assembly; 131-a limiting piece; 132-sealing the bumps; 133-sealing the concave block; 134-force-transmitting member; 135-end cap; 136-protecting tube; 137-limit holes; 138-sealing the hole; 14-serum collection container; 15-quick connector.
Detailed Description
The following description of the embodiments of the present invention will be made more apparent and fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should also be appreciated that in the embodiments, the functions/acts may occur in a different order than the figures. For example, two figures shown in succession may in fact be executed substantially concurrently or the figures may sometimes be executed in the reverse order, depending upon the functionality/acts involved.
As shown in fig. 1 to 4, a physiological index detection system of the present embodiment includes a liquid inlet pipe 1, the liquid inlet pipe 1 is connected to a high-pressure peristaltic pump 2, the high-pressure peristaltic pump 2 is connected to a blood buffer container 4 through a first check valve 3, and the blood buffer container 4 is connected to a blood detection container 6 through a first electromagnetic valve 5; the blood detection container 6 is connected with the waste liquid collection container 8 through a second electromagnetic valve 7; the blood buffer container 4 is connected with the waste liquid collection container 8 through a third electromagnetic valve 9; the blood buffer container 4 is provided with a first pressure sensor 10, and the first pressure sensor 10 is used for collecting the blood pressure in the blood buffer container 4 in real time and recording as first blood pressure data.
The blood detection container 6 is internally provided with a physiological index sensor assembly 12, the physiological index sensor assembly 12 comprises a separation sensing membrane 121, a reference electrode 122 and a counter electrode 123, and the separation sensing membrane 121 is used as a working electrode; the separation sensor membrane 121 is connected to the serum collection container 14.
The physiological index sensor component 12, the high-pressure peristaltic pump 2, the first electromagnetic valve 5, the second electromagnetic valve 7, the third electromagnetic valve 9 and the first pressure sensor 10 are all electrically connected with the main control module. The liquid inlet pipe 1 is connected and is equipped with quick-operation joint 15, and quick-operation joint 15 links to each other with blood taking needle or heparin tube to with the blood that awaits measuring pumps into blood buffer container 4 through high-pressure peristaltic pump 2, the setting of first check valve 3 can guarantee that blood can only unilaterally get into blood buffer container 4, and blood buffer container 4 plays the effect of buffering steady voltage. When the physiological index detection system works, the blood pressure of the blood buffer container 4 needs to be maintained within a first preset blood pressure range, so that the blood pressure entering the blood detection container 6 is within a certain range, the smooth work of the physiological index sensor component 12 is ensured, and the detection stability is ensured; when the main control module detects that the first blood pressure data is greater than the upper limit of the first preset blood pressure range, the main control module controls the third electromagnetic valve 9 to be opened, and part of blood is discharged into the waste liquid collecting container 8, so that the blood pressure of the blood buffer container 4 is reduced until the first blood pressure data falls into the first preset blood pressure range.
In order to further control the blood pressure in the blood detection container 6, a second pressure sensor 11 is further arranged in the blood detection container 6, and the second pressure sensor 11 is used for collecting the blood pressure in the blood detection container 6 in real time and recording the blood pressure as second blood pressure data; when the physiological index sensor assembly 12 works, the main control module detects that the second blood pressure data is smaller than the lower limit of the second preset blood pressure range, and controls the first electromagnetic valve 5 to be opened, and the blood buffer container 4 is supplemented with blood to increase the blood pressure in the blood detection container 6 until the second blood pressure data falls into the second preset blood pressure range; when the main control module detects that the second blood pressure data is greater than the upper limit of the second preset blood pressure range, the main control module controls the second electromagnetic valve 7 to open, and discharges the waste liquid into the waste liquid collecting container 8 so as to reduce the blood pressure in the blood detecting container 6 until the second blood pressure data falls into the second preset blood pressure range.
Under the action of blood pressure in the blood detection container 6, the separation sensing membrane 121 separates serum in blood and flows into the inner pore canal by utilizing pore size screening, the biological sensing material in the inner pore canal can perform catalytic reaction with specific physiological components, concentration signals are converted into electric signals with the aid of the reference electrode 122 and the counter electrode 123 to form a loop, and the signals are transmitted into the main control module to be analyzed and then output component concentration values, so that the detection of blood physiological indexes is realized.
Because the blood detection container 6 has a certain pressure during operation, in order to ensure the air tightness of the physiological index sensor assembly 12 under the pressure, as shown in fig. 2, the blood detection container 6 is provided with a mounting assembly 13, the mounting assembly 13 comprises a limiting piece 131, a sealing convex block 132, a sealing concave block 133, a force transmission piece 134 and an end cover 135, the blood detection container 6 is provided with a mounting opening, a circle of limiting step 61 is arranged on the mounting opening, one end of the limiting piece 131 is abutted with the limiting step 61, the other end is abutted with the plane end of the sealing convex block 132, the convex end of the sealing convex block 132 is embedded into the concave end of the sealing concave block 133, the plane end of the sealing concave block 133 is abutted with one end of the force transmission piece 134, the other end of the force transmission piece 134 is abutted with the end cover 135, and the end cover 135 is mounted on the blood detection container 6; the protecting tube 136, the reference electrode 122 and the counter electrode 123 are sequentially arranged through the end cover 135, the sealing concave block 133, the sealing convex block 132 and the limiting piece 131 in a penetrating manner, and the separation sensing film 121 is arranged in the protecting tube 136.
As shown in fig. 3, the limiting member 131 is provided with limiting holes 137 for attaching the protecting tube 136, the reference electrode 122 and the counter electrode 123, respectively, and the limiting holes 137 are only used for ensuring that the reference electrode 122 and the counter electrode 123 are located at two sides of the protecting tube 136, and do not have a sealing effect.
As shown in fig. 4, sealing holes 138 for attaching the protection tube 136, the reference electrode 122 and the counter electrode 123 are respectively formed in the sealing convex block 132 and the sealing concave block 133, and the diameters of the three sealing holes are respectively the same as the outer diameter of the protection tube, the outer diameter of the reference electrode and the outer diameter of the counter electrode.
The sealing bump 132 is a cylinder, and a truncated cone structure (i.e. a protruding end) is disposed on the cylinder, and the truncated cone structure has an outer conical surface; correspondingly, the sealing concave block 133 is a cylinder provided with a concave space (i.e. a concave end) matched with the truncated cone structure, the concave space is provided with an inner conical surface, the inclination of the inner conical surface is the same as that of the outer conical surface, and the depth of the concave space is larger than the height of the truncated cone structure.
The end cap 135 may be mounted on the mounting port of the blood test container 6 by a screw or a bolt, the end cap 135 is in pressure contact with one end of the force transmission member 134, the other end of the force transmission member 134 is a plane equal to the sealing concave block 133, and the force transmission member 134 transmits pressure uniformly to the sealing concave block 133, and the sealing concave block 133 directly presses the sealing convex block 132 because the sealing convex block 132 is abutted against the limiting member 131. The sealing convex block 132 and the sealing concave block 133 are made of rubber or silica gel, so that the sealing convex block 132 and the sealing concave block 133 are easy to be pressed and deformed, the truncated cone structure of the sealing convex block 132 is tightly contacted with the concave space of the sealing concave block 133 under the action of pressure, the inner conical surface and the outer conical surface form good sealing, and meanwhile, the sealing convex block 132 and the sealing concave block 133 are integrally deformed, so that the outer wall of the sealing convex block 132 and the outer wall of the sealing concave block 133 are well sealed with the inner wall of the mounting opening of the blood detection container 6; and meanwhile, the sealing hole is deformed, and the inner wall of the sealing hole is well sealed with the outer wall of the protection tube, the outer wall of the reference electrode and the outer wall of the counter electrode respectively.
Because the sealing convex block 132 and the sealing concave block 133 have a certain pressure when being sealed, the protection tube can effectively protect the separation sensing film 121, the separation sensing film 121 is approximately cylindrical, and the outer wall of one section of the separation sensing film 121 is in sealing connection with the inner wall of the protection tube.
A physiological index detection method adopts the physiological index detection system to detect physiological indexes.
The invention is not limited to the above-described alternative embodiments, and any person who may derive other various forms of products in the light of the present invention, however, any changes in shape or structure thereof, all falling within the technical solutions defined in the scope of the claims of the present invention, fall within the scope of protection of the present invention.
Claims (8)
1. A physiological index detection system, characterized in that: the device comprises a liquid inlet pipe (1), wherein the liquid inlet pipe (1) is connected with a high-pressure peristaltic pump (2), the high-pressure peristaltic pump (2) is connected with a blood buffer container (4) through a first one-way valve (3), and the blood buffer container (4) is connected with a blood detection container (6) through a first electromagnetic valve (5); the blood detection container (6) is connected with the waste liquid collection container (8) through a second electromagnetic valve (7); the blood buffer container (4) is connected with the waste liquid collection container (8) through a third electromagnetic valve (9); a first pressure sensor (10) is arranged in the blood buffer container (4), a physiological index sensor assembly (12) is arranged in the blood detection container (6), and the physiological index sensor assembly (12) comprises a separation sensing membrane (121), a reference electrode (122) and a counter electrode (123); the separation sensing membrane (121) is connected with the serum collection container (14); the main control module is respectively and electrically connected with the physiological index sensor assembly (12), the high-pressure peristaltic pump (2), the first electromagnetic valve (5), the second electromagnetic valve (7), the third electromagnetic valve (9) and the first pressure sensor (10); the first pressure sensor (10) is used for collecting the blood pressure in the blood buffer container (4) in real time and recording the blood pressure as first blood pressure data, and when the main control module detects that the first blood pressure data is smaller than the lower limit of a first preset blood pressure range, the main control module controls the high-pressure peristaltic pump (2) to be started; when the main control module detects that the first blood pressure data is larger than the upper limit of the first preset blood pressure range, the main control module controls the third electromagnetic valve (9) to be opened.
2. The physiological index detection system of claim 1, wherein: the blood detection container (6) is internally provided with a second pressure sensor (11), the second pressure sensor (11) is used for collecting the blood pressure in the blood detection container (6) in real time and recording the blood pressure as second blood pressure data, and when the main control module detects that the second blood pressure data is smaller than the lower limit of a second preset blood pressure range, the main control module controls the first electromagnetic valve (5) to be opened; when the main control module detects that the second blood pressure data is larger than the upper limit of the second preset blood pressure range, the main control module controls the second electromagnetic valve (7) to be opened.
3. The physiological index detection system of claim 1, wherein: the blood detection container (6) is provided with a mounting assembly (13), the mounting assembly (13) comprises a limiting piece (131), a sealing convex block (132), a sealing concave block (133), a force transmission piece (134) and an end cover (135), the blood detection container (6) is provided with a mounting opening, a circle of limiting step (61) is arranged on the mounting opening, one end of the limiting piece (131) is abutted with the limiting step (61), the other end of the limiting piece is abutted with the plane end of the sealing convex block (132), the convex end of the sealing convex block (132) is embedded into the concave end of the sealing concave block (133), the plane end of the sealing concave block (133) is abutted with one end of the force transmission piece (134), the other end of the force transmission piece (134) is abutted with the end cover (135), and the end cover (135) is arranged on the blood detection container (6); the protection tube (136), the reference electrode (122) and the counter electrode (123) sequentially penetrate through the end cover (135), the sealing concave block (133), the sealing convex block (132) and the limiting piece (131), and the separation sensing film (121) is installed in the protection tube (136).
4. A physiological index detection system according to claim 3, wherein: and limiting holes (137) for attaching the protective tube (136), the reference electrode (122) and the counter electrode (123) are respectively formed in the limiting piece (131).
5. A physiological index detection system according to claim 3, wherein: sealing holes (138) for attaching the protection tube (136), the reference electrode (122) and the counter electrode (123) are formed in the sealing convex block (132) and the sealing concave block (133).
6. The physiological index detection system according to claim 3 or 5, wherein: the sealing convex block (132) and the sealing concave block (133) are made of rubber or silica gel.
7. The physiological index detection system of claim 1, wherein: the liquid inlet pipe (1) is connected with a quick connector (15), and the quick connector (15) is connected with a blood taking needle or a blood taking pipe.
8. A physiological index detection method is characterized in that: the use of the physiological index detection system according to any one of claims 1 to 7 for physiological index detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410395091.7A CN117969629B (en) | 2024-04-02 | System and method for detecting physiological index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410395091.7A CN117969629B (en) | 2024-04-02 | System and method for detecting physiological index |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117969629A true CN117969629A (en) | 2024-05-03 |
| CN117969629B CN117969629B (en) | 2024-07-02 |
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