CN209069651U - A kind of fluid sampling device - Google Patents
A kind of fluid sampling device Download PDFInfo
- Publication number
- CN209069651U CN209069651U CN201821393815.0U CN201821393815U CN209069651U CN 209069651 U CN209069651 U CN 209069651U CN 201821393815 U CN201821393815 U CN 201821393815U CN 209069651 U CN209069651 U CN 209069651U
- Authority
- CN
- China
- Prior art keywords
- plunger pump
- liquid
- sampling
- filter
- peristaltic pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model relates to a kind of fluid sampling device, including sampling line, drain line and plunger pump, the plunger pump connection sampling line and drain line extract liquid by sampling line, liquid are discharged by drain line；Further include: peristaltic pump is arranged on sampling line, and liquid can be pumped in plunger pump；Controller, the controller is for controlling peristaltic pump and plunger pump co-operating.It further include the second pressure sensor and first pressure sensor before and after the filter and filter being arranged between peristaltic pump and plunger pump, controller can control sampler operating according to pressure signal.The utility model uses double dynamical pumping liquid, guarantees to be constantly in slight positive pressure state in plunger pump, not only can accelerating liquid extraction speed, save the Liquid extracting time, moreover it is possible to avoid generating bubble in plunger pump, improve sampling precision.
Description
Technical field
The present invention relates to a kind of samplers, belong to medicine, food, chemical field, refer in particular to a kind of liquid sampling dress
It sets.
Background technique
It is carried out in analysis experiment to drug ingredient, includes dissolution sampling process, the device of the dissolution test of drug, cup
Interior liquid is suspension.It is required according to dissolution test, needs to be taken out appropriate solution for detecting at set time point, and
It is calculated since sampling time point, the filtering of sample must be completed in 30 seconds.Existing dissolution sampling is generally by precise injection
Device or peristaltic pump form are by the sample of detection required after dissolution test into Special test tube.
Chinese patent literature CN101639420A discloses a kind of quantitative sampling device, includes mounting rack, syringe, takes
Sample valve and Bit andits control mechanism, syringe are fixed on mounting rack, the valve port and syringe pipeline connection of sampling valve, position
It moves control mechanism and acts on the movement on the piston of syringe and controlling the piston, the position of the piston by controlling syringe
The amount of distance controlling sampling liquid is moved, but when the device pipeline is longer, pipe resistance is larger, time-consuming for sampling；In sampling process
Air bubble content is big in syringe, and sampling precision is low, and since dissolution sample liquids contain particle, big to piston wear.
Existing fluid sampling device primary filter is mounted on sampling line, and secondary filter is mounted on drain line
On, drain resistance is big, and drain is slow.And filter is easy blocking, needs to frequently replace, at high cost.
In sampling process, generally drain line is cleaned with leading portion discharge liquid, the liquid of detergent line is as useless
Liquid discharge, waste fluid container and sample bottle are usually in a plane, the process switching one of removal waste fluid and stock layout product in the prior art
As be that sample needle is moved to above sample bottle again after drained waste liquid and is taken to above waste fluid container by mobile example needle
Sample, or realized by mobile waste fluid container and sample bottle stand, since waste fluid container and sample bottle are in a plane, give up
Distance is longer between liquid container and sample bottle, and whole process switching is slower, takes a long time.
In the prior art, generally there are three types of schemes for sample pin position when drain.(1) sample needle is close to sample bottle bottom.It should
Under scheme, as discharge amount of liquid increases, the length of sample needle submergence in a liquid is bigger, causes sample needle outer wall to remain, shadow
The concentration of other samples is rung, part residual is also possible to save bit by bit on the component contacted with needle, it is difficult to clean, and then pollute other samples
Product.(2) the sample crown is located at a fixed position according to total lifting rate, so that final sample solution did not had tip of specimen just.
Under the program, in discharge opeing process, sample solution has part that can splash in bottle wall, if desired injects quantitative dilution pair inward
It is diluted, this will affect the concentration after sample dilution.(3) sample needle is located at sample bottle mouth position, is always positioned at ullage.
Under the program, in addition to haveing the defects that the 2nd kind of scheme, there is also needle point hang drop the phenomenon that, that is to say, last 1 drop of liquid may
Can not drain into sample bottle leads to sampling amount there are error, while the drop may drop to other sample bottle during the motion
It is interior, or remain on the component contacted with needle.
After sample has acquired, the detection of concentration is carried out after having sample segment to need to dilute.In the prior art, accuracy is sampled
Substantially in the level of ± 0.1ml, therefore when sample size is less than 5ml, if directly injecting dilution into sample bottle, error will
It can exceed that 2% receives standard.And if sample size is greater than 5ml, it is limited to the volume (usually less than 25ml) of sample bottle, then
Maximum can only dilute 5 times.Therefore the prior art usually uses a set of dilution device to take out quantitative sample from sample bottle molten
Liquid is transferred in another bottle, then injects quantitative dilution in the bottle again.But this method there are it is following not
Foot: (1) it needs to use sample solution rinse dilution device before extracting sample, wastes a part of sample solution；(2) it needs to be additionally provided
The placing space of dilute sample bottle；(3) time-consuming for dilution, and working efficiency is low.
Summary of the invention
In view of the above defects of the prior art, the object of the present invention is to provide a kind of fluid sampling device, have
Sample the characteristics of used time is short, precision is high, long service life.
In order to achieve the above objectives, the invention adopts the following technical scheme:
A kind of fluid sampling device, including sampling line, drain line and plunger pump, the plunger pump connect sampling line
And drain line, liquid is extracted by sampling line, liquid is discharged by drain line；Further include: peristaltic pump, setting are taking
On sample pipeline, liquid can be pumped in plunger pump；Controller, the controller is for controlling peristaltic pump and plunger pump co-operating.
Preferably, the speed of peristaltic pump be by be arranged PWM(Pulse Width Modulation, pulse width modulation) duty ratio
It is adjusted.
The fluid sampling device further includes the filter being arranged between peristaltic pump and plunger pump, the filter of the filter
Hole is not more than 0.8 μm, preferably 0.45 μm.The filter can be the double filter for including primary filter and secondary filter, should
Double filter can one be also possible to it is seperated be provided separately, primary filter is 5-10 μm of filter opening aperture, secondary mistake
Filter filter opening is not more than 0.8 μm.
In order to preferably control the co-operating of peristaltic pump and plunger pump, the fluid sampling device further includes being arranged in institute
State the first pressure sensor between peristaltic pump and plunger pump or between filter and plunger pump, the controller and first pressure
The speed of sensor connection, the pressure value control peristaltic pump that controller is fed back according to first pressure sensor is allowed to and plunger pump
Speed matches.
In order to preferably monitor the working condition of peristaltic pump and the stopping state of filter, the fluid sampling device is also
Including the second pressure sensor being arranged between the peristaltic pump and filter, the controller and second pressure sensor connect
It connects.
Preferably, the controller controls peristaltic pump as follows: when monitoring control devices to first pressure sensor pressure
When force value is lower than the 95% of target value, peristaltic pump is opened at full speed；When higher than target value 105%, peristaltic pump stops；95% to 105%
Between when according to pid algorithm (PID be ratio P, integral I, differential D abbreviation) adjust wriggling revolution speed.
The controller can also control by the following method peristaltic pump: when monitoring control devices to first pressure sensor pressure
When force value is less than or equal to the pressure threshold of setting, opens peristaltic pump or increase the speed of peristaltic pump；Greater than the pressure threshold of setting
When value, closes peristaltic pump or reduce the speed of peristaltic pump.
In order to avoid the peristaltic pump influence of the liquid fluctuation that generates to liquid in specimen cup when extracting liquid in specimen cup,
The fluid sampling device further includes the check valve and pressure buffer before peristaltic pump is arranged in, for reducing peristaltic pump generation
Influence of the liquid fluctuation to liquid in specimen cup；The pressure buffer includes valve and air hose, air hose one end and sampling
Pipeline connection, the other end are communicated with the outside world by valve, and the controller is connect with valve and the opening and closing of control valve, and then controls sampling
Pipeline and extraneous on-off.
Preferably, the fluid sampling device further includes the sample of the end connection of waste liquid tank, sample bottle and drain line
Product needle, horizontally movable waste liquid tank is provided with above sample bottle, and the waste liquid tank is equipped with waste liquid hole and sampling hole；In drain
When pipe removal waste fluid, waste liquid tank, which moves horizontally, makes waste liquid hole be directed at sample needle；When drain pipe needs to exhaust the fluid into sample bottle, give up
Liquid bath, which moves horizontally, makes sampling hole be directed at sample needle, and sample needle may pass through sampling hole and protrude into sample bottle.
The sample needle, which is fixed on, on the slide unit of oscilaltion, when stock layout, to be passed through controller and control raising speed on sample needle
The drain age velocity of degree and plunger pump keeps certain ratio, and then realizes that sample needle follows liquid level to rise.Preferably, in drain
Sample needle needle mouth 1-3mm under liquid level is kept in journey, and sample needle outer wall liquid is avoided to remain.
Preferably, the sampler further includes liquid back pipe road and intermediate duct, one end connection of the intermediate duct
Liquid back pipe road, the other end are connected between the peristaltic pump of sampling line and filter, are provided in the intermediate duct by controlling
The Valve for compressing tubular liner of device control processed, intermediate duct are used for pipeline rinse and the backwash of filter.
Preferably, the plunger pump is single head plunger pump, or double end plunger pump, preferably double end plunger pump.
Fluid present invention sampler is after being discharged quantitative sample liquids, and remaining liquid is along sampling line in plunger pump
Specimen cup is returned to from liquid back pipe road after intermediate duct, liquid backwashes filter when sampling line drives in the wrong direction.Filtering
Device using backwash method restorability, filter can Reusability, save the cost, while reducing when having multiple sample points
Filter replacement number.Preferably, the liquid which aspirates during fluid infusion is also used for Filter Back Washing,
The liquid aspirated from fluid infusion cup is returned to specimen cup from liquid back pipe road after intermediate duct along sampling line by plunger pump, further right
Filter is backwashed.
The utility model has the advantages that
(1) fluid sampling device provided by the invention is double dynamical using plunger pump and peristaltic pump, can be faster by liquid
It is transferred in plunger pump from cup, shortens sample time；Coordinate the speed of peristaltic pump and plunger pump by first pressure sensor,
Peristaltic pump is adjusted using the duty ratio of PWM, guarantee to be constantly in slight positive pressure state in plunger pump, not only can accelerating liquid
Speed is extracted, the Liquid extracting time is saved, moreover it is possible to avoid generating bubble in plunger pump, improve sampling precision.
(2) present invention is preposition to probe tube by the filter for meeting pharmacopoeial requirements being placed in drain line in the prior art
It on the road, not only can abrasion to avoid the mix suspension grain that liquid contains to plunger pump, moreover it is possible to save drain time, can also utilize
Back-flushing method keeps the strainability of filter and lower pipe to hinder, and extends the service life of filter, has saved and replaced
The time of human attendance in the cost and instrument operational process of filter.
(3) present invention installs pressure buffer and check valve before peristaltic pump to reduce liquid fluctuation caused by peristaltic pump,
Probe tube (before check valve) interior residual liquid can also be arranged using gravity using pressure buffer after sampling
It returns in sampling cup, reduces the influence to dissolution system.
(4) second pressure sensor is arranged in the present invention before filter, the pressure that can be monitored according to second pressure sensor
Value judges that the stopping state of filter, the power supply state that can be combined with peristaltic pump judge whether peristaltic pump performance works normally,
In order to be safeguarded to sampler.
(5) the present invention also provides the waste liquid slot structures for improving drain efficiency, can be between removal waste fluid and row's sample liquid
It is switched fast, reduces the move distance and length of pipe of needle, sample volume needed for reducing flushing pipeline is saved drain time, mentioned
High efficiency, and then improve the accuracy of sampling.Waste liquid tank is placed in above sample bottle bottleneck, and waste liquid tank can also play positioning baffle work
With fixed sample bottle, sample bottle is lifted by sample needle when anti-stop-band bottle cap.It is equipped with small boss in waste liquid tank, has V-shaped groove on boss,
Needle point is located in V-shaped groove when removal waste fluid, and needle point can be prevented by waste liquor contamination, needle point can also be avoided residual when lifting sample needle
Stay drop.
Detailed description of the invention
Fig. 1 is one schematic diagram of fluid present invention sampler preferred embodiment；
Fig. 2 is two schematic diagram of fluid present invention sampler preferred embodiment；
Fig. 3 is three schematic diagram of fluid present invention sampler preferred embodiment；
Fig. 4 is four schematic diagram of fluid present invention sampler preferred embodiment；
Fig. 5 A is the waste liquid tank and needle-shaped one schematic diagram of state of sample of fluid present invention sampler；
Fig. 5 B is the waste liquid tank and needle-shaped two schematic diagram of state of sample of fluid present invention sampler；
Fig. 5 C is the waste liquid tank and needle-shaped three schematic diagram of state of sample of fluid present invention sampler；
Fig. 5 D is the waste liquid tank and needle-shaped four schematic diagram of state of sample of fluid present invention sampler；
Fig. 5 E is the waste liquid tank and needle-shaped five schematic diagram of state of sample of fluid present invention sampler；
Sampling line pressure monitoring situation when Fig. 6 is peristaltic pump and plunger pump cooperation drawing liquid；
Fig. 7 is that fluid present invention sampler uses backwash to wash blocking state of filter comparison with prior art non-recoil
Figure.
In figure: 1, specimen cup, 2, pressure buffer, 3, check valve, 4, peristaltic pump, 5, second pressure sensor, 6, filtering
Device, 7, first pressure sensor, 8, plunger pump, 9, three-way magnetic valve one, 10, sample needle, 11, sample bottle, 12, Valve for compressing tubular liner, 13,
Three-way magnetic valve two, 14, three-way magnetic valve three, 15, fluid infusion cup, 16, two-way electromagnetic valve one, 17, two-way electromagnetic valve two, 18, double
Head plunger pump, 19, waste liquid tank.
Specific embodiment:
More excellent embodiment of the invention is described in detail with reference to the accompanying drawing.
Preferred embodiment one:
As shown in Figure 1, a kind of fluid sampling device, including sampling line, drain line and plunger pump 8, the plunger pump 8
Sampling line and drain line are connected, liquid is extracted from specimen cup 1 by sampling line, liquid is discharged by drain line
Into sampling bottle；The setting structure of plunger pump 8 can use the common structure of the prior art, as referred in background technique
A kind of setting structure of the plunger pump 8 of quantitative sampling device, the set-up mode disclosed in CN101639420A are not belonging to the present invention
Improvements do not do excessive description.The present invention increases on sampling line is provided with peristaltic pump 4, and peristaltic pump 4 can be toward column after opening
Liquid is pumped in plug pump 8；In order to coordinate plunger pump 8 and 4 speed of peristaltic pump, which is configured with controller, the control
Device processed can be PLC or single-chip microcontroller, the speed of peristaltic pump 4 be adjusted according to setting program, the speed of peristaltic pump 4 is in the present embodiment
By be arranged PWM(Pulse Width Modulation, pulse width modulation) duty ratio be adjusted, guarantee plunger pump 8
Inside be constantly in slight positive pressure state, not only can accelerating liquid extraction speed, save the Liquid extracting time, moreover it is possible to avoid plunger pump
Bubble is generated in 8, improves sampling precision.
In order to preferably control the speed of peristaltic pump 4, the present invention is provided with the first pressure between peristaltic pump 4 and plunger pump 8
Force snesor 7, the controller are connect with first pressure sensor 7, the pressure that controller is fed back according to first pressure sensor 7
The speed of value control peristaltic pump 4 is allowed to match with the speed of plunger pump 8.So as to control peristaltic pump 4 when extracting liquid
Speed in order to avoid excessive velocities make in plunger pump 8 pressure cause pipeline to collapse out because pressure is excessive, play the role of protecting pipeline,
Also can avoid 4 speed of peristaltic pump causes negative pressure in plunger pump 8 to generate a large amount of bubbles slowly excessively, to improve sampling accuracy.Work as control
When device monitors that 7 pressure value of first pressure sensor is lower than the 95% of target value, peristaltic pump 4 is opened at full speed；When monitoring control devices arrive
When 7 pressure value of first pressure sensor is higher than target value 105%, peristaltic pump 4 stops；When monitoring control devices to first pressure sense
It is adjusted when 7 pressure value of device is between the 95% to 105% of target value according to pid algorithm (abbreviation that PID is ratio P, integral I, differential D)
Save 4 revolving speed of peristaltic pump.Alternatively, controller can also control by the following method peristaltic pump 4: when monitoring control devices to first pressure
When 7 pressure value of sensor is less than or equal to the pressure threshold of setting, peristaltic pump 4 is opened；Greater than setting pressure threshold when, close
Peristaltic pump 4；The pressure threshold is generally located on 105 kPa between 160kPa, preferably 125kPa.
Fluid present invention sampler further includes the filter 6 on the sampling line being arranged in, and is being sampled with the prior art
Pipeline be arranged primary filter (filter opening be not more than 10 μm), drain line be arranged secondary filter (filter opening is not more than 0.8 μm,
Preferably not greater than 0.45 μm) unlike, secondary filter is advanced on sampling line by the present invention from drain line, setting
Between peristaltic pump 4 and plunger pump 8, so that sampler can be sampled suspended liquid, and can be complete while sampling
It, not only can abrasion to avoid the mix suspension grain that liquid contains to plunger pump 8, moreover it is possible to save drain time at filtration.This
The filter 6 that embodiment uses for the double filter with primary filter and secondary filter, press in peristaltic pump 4 and first by setting
Between force snesor 7, the speed for the pressure value dynamic regulation peristaltic pump 4 that controller is fed back according to first pressure sensor 7, so that
Do not changed by the change of 6 permeability of filter by the flow rate of liquid of filter 6, always with the speed phase of plunger pump 8
Matching.
In order to preferably monitor the working condition of peristaltic pump 4 and the stopping state of filter 6, the fluid sampling device
It further include the second pressure sensor 5 being arranged between the peristaltic pump 4 and filter 6, the controller and second pressure pass
Sensor 5 connects.It can judge that the stopping state of filter 6, peristaltic pump 4 are run according to the pressure value that second pressure sensor 5 monitors
In the process, if monitor that 5 pressure of second pressure sensor is greater than alert thresholds (preferably 180kPa), determine that filter 6 is stifled
Plug issues information warning and user is reminded to replace filter 6.When monitoring that 5 pressure of second pressure sensor is greater than that endanger threshold value (excellent
Select 240kPa) when, the peristaltic pump 4 of controller control at this time stops working in order to avoid pipeline or connector burst apart, and peristaltic pump 4 is damaged, and plays
Protect the effect of pipeline and peristaltic pump 4.If the power supply state of peristaltic pump 4 is normal, but monitors that first pressure sensor 7 is average
It is worth and is lower than normal value, and second pressure sensor 5 and not up to alert thresholds, then it can determine that 4 failure of peristaltic pump, user prompted to answer
Instrument is overhauled.Controller can also integrate the pressure according to first pressure sensor 7, the monitoring of second pressure sensor 5
Value judge whether the filter membrane of filter 6 penetrates, pipeline whether leakage.
In order to avoid peristaltic pump 4 when extracting liquid in specimen cup 1 shadow of the liquid fluctuation that generates to liquid in specimen cup 1
It rings, fluid present invention sampler further includes the check valve 3 before peristaltic pump 4 is arranged in, and pressure buffer is arranged before check valve 3
2.The pressure buffer 2 includes valve and air hose, and air hose one end is connected to sampling line, and the other end passes through valve and the external world
It communicates, the controller is connect with valve and the opening and closing of control valve, and then controls sampling line and extraneous on-off.Sampling terminates
Afterwards, controller control valve opening so that pipeline is in communication with the outside, under atmospheric pressure and liquid self gravitation effect, check valve 3 it
Residual liquid will flow back into sampling cup in preceding probe tube, to reduce the influence to dissolution system.
The end of sampler drain line is generally connected with sample needle 10, and liquid is discharged to sample by sample needle 10
In bottle 11.Sample bottle 11 is usually bottle with cover or not with cover.
Therefore the present embodiment further includes that be provided with can horizontal sliding for the top of waste liquid tank, sample bottle 11 and sample bottle 11
Waste liquid tank, as shown in figures 5 a-5e, the waste liquid tank are equipped with waste liquid hole and sampling hole, and sample needle 10 is fixed on can oscilaltion
On slide unit；Corresponding position is provided with the cavity for accommodating liquid below waste liquid hole, be provided with below the cavity waste liquid outlet with it is soft
Pipe connection exports the liquid for being discharged to waste liquid tank.It is equipped with small boss in waste liquid tank, there is V-shaped groove on boss, needle point position when removal waste fluid
In needle point in V-shaped groove, can be prevented by waste liquor contamination, needle point can also be avoided to remain drop when lifting sample needle 10.Drain
Detailed process is as follows: as shown in Figure 5A, in drain line removal waste fluid, waste liquid tank, which moves horizontally, makes waste liquid hole be directed at sample needle
10, the slightly downlink of sample needle 10, waste liquid is discharged to export in waste liquid tank cavity by sample needle 10；As shown in Figure 5 B, discharging of waste liquid
It finishes, the slightly uplink of sample needle 10 resets, and quickly sliding waste liquid tank makes sampling hole be directed at sample needle 10, as shown in Figure 5 C；Sample
Needle 10, which passes through sampling hole and quickly protrudes into sample bottle 11, starts drain close to bottom of bottle position, as shown in Figure 5 D；In discharge opeing process, lead to
The drain age velocity for crossing controller control 10 rate of climb of sample needle and plunger pump 8 keeps certain ratio, and then realizes sample needle
10 follow liquid level to rise, and keep 10 needle mouth of sample needle 2mm or so under liquid level, and 10 outer wall liquid of sample needle is avoided to remain, and such as scheme
Shown in 5E.
Preferred embodiment two:
On the basis of example 1, the sampler further includes liquid back pipe road and intermediate duct.Liquid back pipe road one
End is connected to plunger pump 8 by valve, is usually connected in drain line by three-way magnetic valve 2 13, passes through three-way magnetic valve two
13 switching realizes that plunger pump is to be connected to drain line or be connected to liquid back pipe road.The other end on liquid back pipe road is placed in sample
The top of product cup 1.One end of the intermediate duct connects back to liquid pipeline, and the other end is connected to the peristaltic pump 4 and mistake of sampling line
Between filter 6, be provided with the Valve for compressing tubular liner 12 controlled by controller in the intermediate duct, intermediate duct for peristaltic pump 4 and
The backwash of pipeline rinse and filter 6 before.
Valve for compressing tubular liner 12 on conventional sense, intermediate duct is closed, and intermediate duct is closed, and quantitative sample liquids are being discharged
After completing sampling, controller opens Valve for compressing tubular liner 12, and the valve on plunger pump 8 and drain line and liquid back pipe road is closed, and opens
Open the valve of plunger pump 8 Yu sampling line, starting plunger pump 8 makes in plunger pump 8 remaining liquid along sampling line through intermediate tube
Lu Houcong liquid back pipe road returns to specimen cup 1, and liquid backwashes filter 6 when sampling line drives in the wrong direction.Filter 6 uses
The method restorability of backwash, filter 6 can Reusability, save the cost.Before intermediate duct can be also used for peristaltic pump 4
The rinse of sampling line reduces the logical of filter 6 in each sampling process to reduce the amount by the rinse liquid of filter 6
Amount, to improve the access times of filter 6.
Preferred embodiment three
In drug dissolution experiment sampling process, since sampling consumes part solution, it is sometimes desirable to toward the sample of drug dissolution
Purified solution is added in product cup 1, for this purpose, on the basis of example 2, the present embodiment fluid sampling device further includes liquid supplementation pipe,
Liquid supplementation pipe one end is placed in the fluid infusion cup 15 for filling purified solution to be supplemented, and the other end is connected to plunger pump 8 by valve, usually
It is connected on sampling line by three-way magnetic valve 3 14, tie point leans on as far as possible between filter 6 and first pressure sensor 7
Nearly first pressure sensor 7, can shorten the pipeline of suction make-up solution, can also reduce pipe resistance, shorten the time-consuming for extracting solution.
By monitoring first pressure sensor 7, it can be determined that whether the suction action of make-up solution is completed.
After plunger pump 8 aspirates make-up solution, remaining liq is returned into the identical side of specimen cup 1 using with embodiment two
The liquid aspirated from fluid infusion cup 15 is returned to specimen cup 1 from liquid back pipe road after intermediate duct along sampling line by method, plunger pump 8,
Filter 6 is backwashed using the purified solution of supplement.
The present embodiment can also be used in the dilution of sample.Plunger pump 8 extracts from fluid infusion cup 15 a certain amount of pure through liquid supplementation pipe
Net solution drains into waste liquid tank through drain pipe as dilution medium, completes the rinse of pipeline and plunger pump 8 in triplicate.Then column
Plug pump 8 extracts dilution medium through liquid supplementation pipe, directly arranges through drain pipe walkthrough 0.2ml to waste liquid tank, then by quantitative dilution medium
To sample bottle 11.
Preferred embodiment four
Above-described embodiment one is into embodiment three, and the plunger pump 8 can (plunger pump only has one using single head plunger pump
A interface, inlet and liquid outlet share), can also be using double end plunger pump 18(plunger pump there are two interface, it can be respectively as
Inlet and liquid outlet).
When using single head plunger pump, 8 interface of plunger pump passes through three-way magnetic valve 1 or the valve with similar functions point
It is not connect with sampling line and drain line, the common interface of three-way magnetic valve 1 connects 8 interface of plunger pump, and normally opened interface connects
Pick up sample line end, the head end of normally closed interface connected drainage pipeline.Usually, plunger pump 8 is connected to sampling line, for extracting
Sample solution or make-up solution are also used for the backwash of filter 6.When plunger pump 8 needs to be discharged liquid to drain line or returns
When liquid pipeline, controller controls three-way magnetic valve 1 and switches, and closes the connection with sampling line, opens the company with drain line
It connects.
When using double end plunger pump 18, an interface of plunger pump 8 is connected by two-way electromagnetic valve 1 and sampling line
It connects, another interface is connect by two-way electromagnetic valve 2 17 with drain line.Control double end plunger respectively by two-way electromagnetic valve
The on-off of pump 18 and sampling line or drain line, rinse pipeline when, move up the piston 0.5- of double end plunger pump 18
2mm to form certain chamber passageway in plunger pump, and opening two-way electromagnetic valve 1 and two-way electromagnetic valve 2 17 makes at pipeline
In connected state, switching three-way solenoid valve 2 13 is connected to liquid back pipe road, and under the effect of peristaltic pump 4, liquid is from specimen cup 1 ---
--- --- --- liquid back pipe road --- specimen cup 1 of plunger pump 8 circulation, carries out the rinse of respective line to peristaltic pump 4 to sampling line.
Therefore the process that single head plunger pump extracts liquid, liquid is discharged is avoided using double end plunger pump 18, pipeline can be greatly shortened
The time of rinse, furthermore dead volume is not present in double end plunger pump 18, and rinse effect is more preferable, while further increasing sampling precision.
Experiment test:
(1) peristaltic pump and plunger pump fiting effect are tested:
Filter :+0.45 μm of cellulose acetate filter of 5 μm of nylon filters
Plunger pump type: double end plunger pump
Pid algorithm: when monitoring control devices to first pressure sensor pressure value are lower than the 95% of target value, peristaltic pump is complete
Speed is opened；When monitoring control devices to first pressure sensor pressure value are higher than target value 105%, peristaltic pump stops；Work as controller
It monitors to adjust wriggling revolution speed according to pid algorithm when first pressure sensor pressure value is between the 95% to 105% of target value
Pid parameter: Kp=0.1, Ki=0.001, Kd=0.001
Sampling line pressure monitoring situation when attached drawing 6 is peristaltic pump and plunger pump cooperation drawing liquid, the experimental results showed that, it wriggles
Pump can well cooperate with plunger pump, and the pressure value that first pressure sensor monitors during pumping liquid is steady,
It illustrates that plunger pump pressure is stablized, is in barotropic state, the liquid of extraction is clarified, bubble-free.
(2) sample time measures:
Filter :+0.45 μm of cellulose acetate filter of 5 μm of nylon filters
Sampling amount: 10ml
Plunger pump type: double end plunger pump
Operation: taking 0.45g tablet, is added into 900ml water, is kept stirring with 75 rpm speed, suspension is obtained, to this
Suspension is sampled, and measures the sampling used time
。
(3) filter access times are tested:
Filter :+0.45 μm of cellulose acetate filter of 5 μm of nylon filters
Plunger pump type: single head plunger pump
Rinse: 4 times, be respectively 6 ml, 3 ml, 3 ml, 3ml every time
Sampling: 11ml, walkthrough 1ml sample 10ml
Fluid infusion (backwash filter): 5ml(water)
Operation: taking 0.45g tablet, is added into 900ml water, is kept stirring with 75 rpm speed, suspension is obtained, to this
Suspension carries out rinse, sampling and fluid infusion (backwash) operation, repeatedly, recording filter pressure changing.As a result such as
Under:
As a comparison, cancel fluid infusion (backwash) operation, as a result as follows:
Comparative result is as shown in fig. 7, experiment shows the filter to can be used to carry out sample repeatedly anti-by backwash
Multiple to sample, filter just reaches the threshold value (180 kPa) of blocking early warning after sampling up to 24 times, samples 24 times and much meets once
The needs of experiment (usually measurement dissolution curve only needs 6 sub-samplings)；Without backwashing, which can only be used 2 times.
(4) rinse efficiency test:
Plunger pump type: double end plunger pump
Pipeline before rinse: 6 seconds
Pipeline after rinse: 10 seconds
Plunger pump piston is displaced when rinse pipeline: 1 mm
Sampling: 4ml, walkthrough 1ml
Operation: prepare the p-methyl benzenesulfonic acid solution (0.3108g adds water 800ml to make to dissolve) of known concentration, to the solution into
Row rinse, after sampling 4ml, walkthrough 1ml to waste liquid, remaining 3ml sample is measured, as a result as follows:
The result shows that rinse works well, meet the requirements (98%-102%), and rinse dosage is less.
(5) sampling precision and accuracy test:
Filter :+0.45 μm of cellulose acetate filter of 5 μm of nylon filters
Plunger pump type: single head plunger pump
Sampling: 1ml
Operation: weighing to bottle, the weight of weighed bottle+sample after sampling, calculates the RSD's and sampling repeatedly sampled
The difference of average weight and theoretical weight
The result shows that sampling precision reaches 0.09%, accuracy reaches 0.20%.
(6) rinse and dilution whole efficiency test:
Plunger pump type: double end plunger pump
Pipeline before rinse: 6 seconds
Pipeline after rinse: 10 seconds
Plunger pump piston is displaced when rinse pipeline: 1 mm
Sampling: 2ml, walkthrough 1ml to waste liquid tank, row 1ml to sample bottle
Dilution medium: water
Dilution medium volume: 19ml
Operation: prepare the p-methyl benzenesulfonic acid solution (6.5215g adds water 800ml to make to dissolve) of known concentration, to the solution into
Row rinse, after sampling 2ml, walkthrough 1ml to waste liquid, remaining 1ml drains into sample bottle.Plunger pump and pipeline dilution medium rinse 3
It is secondary, 9.5 ml every time.Plunger pump extracts dilution medium 9.9ml, walkthrough 0.2ml to waste liquid tank, row 9.5ml to sample through replenishing line
In product bottle, it is repeated 2 times.
Accurate measuring mother liquor 10ml, sets in 200ml volumetric flask, is diluted with water to scale, shake up, as contrast solution.
As a result as follows:
The result shows that rinse dilution overall effect is good, meet the requirements (98%-102%).
Claims (10)
1. a kind of fluid sampling device, including sampling line, drain line and plunger pump, the plunger pump connection sampling line and
Drain line extracts liquid by sampling line, liquid is discharged by drain line；It is characterized by: the liquid sampling fills
It sets further include:
Peristaltic pump is arranged on sampling line, and liquid can be pumped in plunger pump；
Controller, the controller is for controlling peristaltic pump and plunger pump co-operating.
2. a kind of fluid sampling device according to claim 1, it is characterised in that: the fluid sampling device further includes setting
The first pressure sensor between the peristaltic pump and plunger pump is set, the controller is connect with first pressure sensor, control
The speed for the pressure value control peristaltic pump that device processed is fed back according to first pressure sensor is allowed to match with the speed of plunger pump.
3. a kind of fluid sampling device according to claim 1, it is characterised in that:
The fluid sampling device further includes the filter being arranged between peristaltic pump and plunger pump, and the filter opening of the filter is not
Greater than 0.8 μm.
4. a kind of fluid sampling device according to claim 3, it is characterised in that:
The fluid sampling device further includes the first pressure sensor being arranged between the filter and plunger pump, the control
Device processed is connect with first pressure sensor, the speed for the pressure value control peristaltic pump that controller is fed back according to first pressure sensor
It is allowed to match with the speed of plunger pump.
5. a kind of fluid sampling device according to claim 3 or 4, it is characterised in that:
The fluid sampling device further includes the second pressure sensor being arranged between the peristaltic pump and filter, the control
Device processed is connect with second pressure sensor.
6. a kind of fluid sampling device according to claim 1-4, it is characterised in that:
The fluid sampling device further includes the check valve and pressure buffer before peristaltic pump is arranged in, and is produced for reducing peristaltic pump
Influence of the raw liquid fluctuation to liquid in specimen cup；The pressure buffer includes valve and air hose, air hose one end with
Sampling line connection, the other end are communicated with the outside world by valve, and the controller is connect with valve and the opening and closing of control valve, and then controls
Sampling line and extraneous on-off.
7. a kind of fluid sampling device according to claim 1-4, it is characterised in that:
The fluid sampling device further includes the sample needle of the end connection of waste liquid tank, sample bottle and drain line, sample bottle
Top be provided with horizontally movable waste liquid tank, the waste liquid tank is equipped with waste liquid hole and sampling hole；In drain pipe removal waste fluid,
Waste liquid tank, which moves horizontally, makes waste liquid hole be directed at sample needle；When drain pipe needs to exhaust the fluid into sample bottle, waste liquid tank level is moved
Dynamic that sampling hole is made to be directed at sample needle, sample needle may pass through sampling hole and protrude into sample bottle.
8. a kind of fluid sampling device according to claim 7, it is characterised in that:
The sample needle be fixed on can on the slide unit of oscilaltion, when stock layout, by controller control the sample needle rate of climb with
The drain age velocity of syringe pump keeps certain ratio, and then realizes that sample needle follows liquid level to rise.
9. a kind of fluid sampling device according to claim 3 or 4, it is characterised in that:
The sampler further includes liquid back pipe road and intermediate duct, and one end of the intermediate duct connects back to liquid pipeline, separately
One end is connected between the peristaltic pump of sampling line and filter, and the pressure controlled by controller is provided in the intermediate duct
Pipe valve.
10. a kind of fluid sampling device according to claim 9, it is characterised in that: the plunger pump is single head plunger
Pump or double end plunger pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821393815.0U CN209069651U (en) | 2018-08-28 | 2018-08-28 | A kind of fluid sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821393815.0U CN209069651U (en) | 2018-08-28 | 2018-08-28 | A kind of fluid sampling device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209069651U true CN209069651U (en) | 2019-07-05 |
Family
ID=67091079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821393815.0U Active CN209069651U (en) | 2018-08-28 | 2018-08-28 | A kind of fluid sampling device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209069651U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108827715A (en) * | 2018-08-28 | 2018-11-16 | 福建龙岩龙瑆医药科技有限公司 | A kind of fluid sampling device |
| TWI780545B (en) * | 2019-12-27 | 2022-10-11 | 日商旭化成醫療股份有限公司 | Filter test device and test method |
| CN117969629A (en) * | 2024-04-02 | 2024-05-03 | 四川省疾病预防控制中心(四川省预防医学科学研究院四川省卫生监测检验中心) | System and method for detecting physiological index |
-
2018
- 2018-08-28 CN CN201821393815.0U patent/CN209069651U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108827715A (en) * | 2018-08-28 | 2018-11-16 | 福建龙岩龙瑆医药科技有限公司 | A kind of fluid sampling device |
| TWI780545B (en) * | 2019-12-27 | 2022-10-11 | 日商旭化成醫療股份有限公司 | Filter test device and test method |
| CN117969629A (en) * | 2024-04-02 | 2024-05-03 | 四川省疾病预防控制中心(四川省预防医学科学研究院四川省卫生监测检验中心) | System and method for detecting physiological index |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108827715A (en) | A kind of fluid sampling device | |
| CN209069651U (en) | A kind of fluid sampling device | |
| WO2019127562A1 (en) | Sample analyzer and reagent supply method therefor | |
| CN204649763U (en) | A kind of is the automatic liquid feeder of volumetric flask constant volume | |
| CN109580321B (en) | Liquid path bubble removing device and method | |
| CN107271707A (en) | The sampling device of a kind of sampler and the use device, detecting system | |
| CN106442075A (en) | Fully-automatic liquid mixing and changing device | |
| CN111721956A (en) | Liquid path system of full-automatic biochemical analyzer | |
| CN205246139U (en) | Gas content tester | |
| CN104807753B (en) | A kind of two-chamber flow cell turbidimetry system and its control method | |
| CN202018437U (en) | Double-flow-path electrolyte analyzer | |
| CN106391606B (en) | A kind of detecting instrument and its reaction vessel cleaning method | |
| CN208206942U (en) | A kind of food additives fast detector | |
| CN104730202B (en) | A kind of acid alkaline titrimeter automatically | |
| CN107449641B (en) | Device and method for continuously collecting shale desorption gas without interruption | |
| CN208193738U (en) | A kind of Full Automatic Liquid liquid abstraction instrument analyzed for oils in seawater | |
| CN103454129B (en) | A kind of online sodium table | |
| CN104111342B (en) | Accurate sample adding system, accurate loading methods and biochemistry analyzer | |
| CN204514887U (en) | A kind of acid alkaline titrimeter automatically | |
| US5287733A (en) | Apparatus for receiving liquid treatment samples for disposal | |
| CN206649027U (en) | Automatic water quality monitoring system external hanging type automated quality control device | |
| CN215641318U (en) | Non-contact trace liquid transfer device and biochemical instrument | |
| CN214585502U (en) | Automatic sample adding system | |
| CN209946178U (en) | Liquid path system of full-automatic biochemical analyzer | |
| CN205308360U (en) | Move device of getting solution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |