TWI780545B - Filter test device and test method - Google Patents

Abstract

The present invention provides a filter test device and test method.

The filter (20) of the present invention has: a filter membrane, an input port (21), and a first output port (22). This test device is equipped with: test liquid storage container (10); test liquid infusion line (30), the test liquid is sent to the primary side of the filter membrane; the first pressure measurement mechanism (40), measures the test liquid infusion line (30 ) pressure; the filtrate infusion line (50) outputs the filtrate from the filter (20); the filtrate infusion pump (50P) is connected to the filtrate infusion line (50) to deliver the filtrate; and the adjustment fluid infusion mechanism (80) will The adjustment liquid is delivered to the test liquid storage container (10); the adjustment liquid infusion mechanism (80) is used to deliver the adjustment liquid, so that the pressure of the liquid level of the test liquid storage container (10) is measured by the first pressure measurement mechanism (40) The difference in pressure is constant. In this way, the pressure measured by the first pressure measuring means becomes constant.

Description

Filter test device and test method

The invention relates to a test device and test method for a filter.

For example, Chinese new patent CN202538643U discloses a device for filtering and concentrating ascites. Collect the patient's ascites and store it in a storage container. The ascites from the storage container is filtered through a filter to remove cellular components. The ascites from which the cellular components have been removed flows to a filter for concentration, and water is removed in the filter for concentration. to obtain a protein solution. The protein solution can be injected into a patient for treatment.

In addition, Chinese invention patent CN109200370A also discloses a body cavity fluid treatment device used in ascites treatment, which is equipped with a filter for filtration and a filter for concentration.

In the case of filters, it is necessary to test their ultra-filtration performance during design, trial production, or batch production.

The inventors of the present invention have found that in the negative pressure test in which the filtrate infusion line is equipped with a filtrate infusion pump, by making the negative pressure act on the output port side of the filter, the input of the test liquid from the test liquid storage container to the filter can be improved. When the port is transported, the liquid level in the test liquid storage container drops, and the test liquid The difference between the liquid level of the test liquid storage container and the liquid level of the pressure measurement chamber of the test liquid infusion line increases. Since the pressure of the chamber changes according to the increased liquid level difference, the pressure value measured by the manometer used to measure the pressure in the test fluid infusion line will continue to change, so it is difficult to measure or estimate the pressure on the filter membrane .

The purpose of the present invention is to provide a test device and test method for a filter that can easily measure or estimate the pressure that the filter membrane of the filter bears.

Another object of the present invention is to provide a test device and test method for a filter that can be applied to the measurement of the ultrafiltration performance of the filter.

Yet another object of the present invention is to provide a filter testing device and a testing method for a filter that can easily measure the ultrafiltration performance of a filter.

The test device for the filter of the present invention should be understood as: a filtrate infusion pump is installed in the filtrate infusion line downstream of the filter, so that the test liquid is introduced into the filter from the test liquid storage container while the filtrate is being transported. In the test of the present invention, when measuring the pressure, it is not necessary to use the infusion pump located between the test liquid storage container and the filter to transfer the test liquid from the test liquid storage container to the filter.

[1] A test device, which is a test device for a filter (20), the filter (20) has: a filter membrane; an input port (21), connected to the primary side of the filter membrane; and the first output port (22 ), which is connected to the secondary side of the filter membrane and outputs the filtrate; it has:

Test liquid storage container (10), stores test liquid;

One end of the test fluid infusion line (30) is connected to the test fluid storage container (10), the other end is connected to the input port (21), and the test fluid in the test fluid storage container (10) is sent to the primary side of the filter membrane;

The first pressure measurement mechanism (40) measures the pressure of the test fluid infusion line (30);

The filtrate infusion line (50), one end is connected to the first output port (22), and the filtrate is output from the filter (20);

A filtrate infusion pump (50P), connected to the filtrate infusion line (50), and delivering the filtrate; and

The adjustment liquid infusion mechanism (80) transports the adjustment liquid to the test liquid storage container (10); and

The adjustment liquid infusion mechanism (80) delivers the adjustment liquid so that the difference between the pressure of the liquid surface of the test liquid storage container (10) and the pressure at the measurement place of the first pressure measurement mechanism (40) is constant.

[2] The test device according to [1], further comprising:

filter (20); and

The adjustment liquid storage container (70) stores the adjustment liquid.

[3] The test device as described in [2], wherein the first pressure measuring mechanism (40) has:

the first pressure gauge (41);

the first chamber (42); and

The first pressure line (43), one end is connected to the first pressure gauge (41), and the other end is connected to the connecting port of the first chamber (42); and

The test fluid infusion circuit (30) has:

The first infusion line (31), one end is connected to the test solution storage container (10), and the other end is connected to the input port of the first chamber (42); and

The second infusion line (32), one end is connected to the output port of the first chamber (42), and the other end is connected to the input port (21) of the filter (20).

[4] The test device as described in [3], wherein the connecting terminal of the first chamber (42) is located at the vertically upper part of the first chamber (42) with gas, and the test liquid is sent to the first chamber ( 42) The lower part of the vertical direction is conveyed;

The adjustment liquid infusion mechanism (80) delivers the adjustment liquid, so that the liquid in the test liquid storage container (10) The height of the surface (11) is consistent with the height of the liquid surface (33) of the first chamber (42).

[5] The test device as described in [3] or [4], wherein the filter (20) is set at the height of the center position in the vertical direction and the height of the liquid level (33) of the first chamber (42). highly consistent.

[6] The test device according to any one of [2] to [5], wherein the adjustment fluid infusion mechanism (80) has:

Adjusting fluid infusion line (81), one end is connected to the adjusting fluid storage container (70), and the other end is connected to the test fluid storage container (10); and

The adjustment liquid infusion pump (82) is installed in the adjustment liquid infusion line (81), and transfers the adjustment liquid in the adjustment liquid storage container (70) to the test liquid storage container (10).

[7] The test device according to any one of [1] to [6], wherein the filter (20) further has a second output port (23) connected to the primary side of the filter membrane; and

It is further equipped with a waste liquid infusion line (90), one end of which is connected to the second output port (23), and the waste liquid is conveyed.

[8] The test device according to [7], further comprising:

A waste liquid infusion pump (90P), arranged on the waste liquid infusion line (90); and

The third pressure measuring mechanism (40B) is arranged on the upstream side of the waste liquid infusion pump (90P), and measures the pressure of the waste liquid infusion line (90).

[9] The test device according to any one of [1] to [8], wherein the test liquid and the adjustment liquid are the same solution.

[10] A test device, which is a test device for a filter (20), the filter (20) has: a filter membrane; an input port (21), connected to the primary side of the filter membrane; and a first output port (22) , connected to the secondary side of the filter membrane and output filtrate; it has:

Test liquid storage container (10), stores test liquid;

Test liquid infusion line (30), one end is connected to test liquid storage container (10), and the other end is connected to Connected to the input port (21), the test solution in the test solution storage container (10) is sent to the primary side of the filter membrane;

The first pressure measurement mechanism (40) measures the pressure of the test fluid infusion line (30);

The filtrate infusion line (50), one end is connected to the first output port (22), and the filtrate is output from the filter (20);

Filtrate infusion pump (50P), connected to filtrate infusion line (50), conveying filtrate; and

The test liquid level adjustment mechanism (100) is connected to the test liquid storage container (10), and adjusts the position of the liquid level of the test liquid storage container (10), so that the pressure of the liquid level of the test liquid storage container (10) and The pressure difference at the measuring point of the first pressure measuring mechanism (40) is constant.

[11] The test device as described in [10], wherein the test liquid level adjustment mechanism (100) has:

The lifting mechanism adjusts the height of the liquid level of the test liquid storage container (10) by lifting the lifting platform (120) supporting the test liquid storage container (10); or

The pressing mechanism adjusts the height of the liquid level in the liquid bag by pressing the liquid bag used as the test liquid storage container (10).

[12] The test device according to any one of [1] to [11], wherein the filter is an ascites filter.

[13] The test device according to any one of [1] to [12], wherein:

The filter (20) has a cylindrical body;

The input port (21) is located at one end of the axial direction of the body;

The first output port (22) is located on the outer periphery of the body;

The filter (20) is arranged so that the central axis of the body becomes horizontal.

[14] The test device according to any one of [1] to [13], further comprising:

The first temperature adjustment device (12) accommodates and adjusts and maintains the test liquid storage container (10) in the Specified 1st temperature; and/or

The second temperature adjustment device (25) accommodates and adjusts and maintains the filter (20) at the second specified temperature.

[15] The test device according to any one of [1] to [14], further comprising:

The second pressure measurement mechanism (40A) is arranged on the upstream side of the filtrate infusion pump (50P), and measures the pressure of the filtrate infusion line (50).

[16] A test method, which is a test method for a filter (20), the filter (20) has: a filter membrane; an input port (21), connected to the primary side of the filter membrane; and the first output port (22 ), connected to the secondary side of the filter membrane and output filtrate; its characteristics include:

By using the filtrate negative pressure mechanism connected to the first output port (22) to make the negative pressure act on the filter (20), the test liquid is connected to the test liquid storage container (10) through one end and the other end is connected to the input The test fluid infusion circuit (30) of the port (21), the steps of sucking and filtering from the test fluid storage container (10) to the filter (20);

A step of measuring the pressure of the test fluid infusion line (30) with the first pressure measuring mechanism (40); and

The step of adjusting the position of the liquid level of the test liquid storage container (10) so that the pressure difference between the liquid level of the test liquid storage container (10) and the pressure at the measuring point of the first pressure measuring mechanism (40) is constant.

[17] The test method according to [16], using the test device according to any one of [1] to [15].

In the present invention, the adjustment liquid infusion mechanism delivers the adjustment liquid to the test liquid storage container, so that the difference between the pressure of the liquid surface of the test liquid storage container and the pressure at the measurement point of the first pressure measurement mechanism is constant. In this way, the pressure measured by the first pressure measuring mechanism will become constant (also That is, there is no change), so that the test can be performed smoothly.

10: Test liquid storage container

11: liquid level

12: The first temperature adjustment device

20: filter

21: input port

22: The first output port

23: The second output port

24: liquid port

25: The second temperature adjustment device

30: Test fluid infusion line

31: The first infusion line

32: The second infusion line

33: liquid level

40: The first pressure measuring mechanism

41: 1st pressure gauge

42: 1st chamber

43: 1st pressure line

40A: The second pressure measuring mechanism

41A: 2nd pressure gauge

42A: 2nd chamber

43A: 2nd pressure line

40B: The third pressure measuring mechanism

41B: No. 3 pressure gauge

42B: Chamber 3

43B: 3rd pressure line

50: filtrate infusion line

50P: filtrate infusion pump

51: Filtrate collection container

70: Adjustment fluid storage container

80: Adjusting fluid infusion mechanism

81: Adjusting liquid infusion line

82:Adjustment fluid infusion pump

90: Waste liquid infusion line

90P: Waste liquid infusion pump

91: waste liquid collection container

100: Test liquid level adjustment mechanism

110: fixed part

120: lifting table

[FIG. 1] is a schematic diagram showing the structure of a test device for a filter according to a first embodiment of the present invention.

[FIG. 2] is a schematic diagram showing the structure of a test device for a filter according to a second embodiment of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described with reference to the drawings. These specific descriptions should be understood as: only to provide teachings on how to implement the present invention for those with ordinary knowledge in the technical field, and not to enumerate all possible implementation forms of the present invention to limit the scope of the present invention.

(the first implementation form)

As shown in Fig. 1, the present invention provides a test device for a filter. Wherein, the filter 20 can also be an ascites filter.

Although the filter 20 can be regarded as a part of the test device, it should be understood that the test device can also be used for testing the filter 20 without including the filter 20 .

The filter 20 has: a filter membrane; the input port 21 is connected to the primary side of the filter membrane (for example, the inner side of the hollow fiber); and the first output port 22 is connected to the secondary side of the filter membrane (for example, the hollow fiber outside) and output the filtrate. The filter 20 may further have: a second output port 23, which is connected to the primary side of the filter membrane and outputs waste liquid; and a liquid port 24, which is connected to the secondary side of the filter membrane, and can be sealed in this test. Filtration membrane should be understood as: not limited to membranes, but also It is a filter element including a hollow fiber membrane and the like.

The test device of this embodiment can also be equipped with: a test liquid storage container 10 for storing the test liquid; a test liquid infusion line 30, one end connected to the test liquid storage container 10, and the other end connected to the input port 21, and the test liquid is stored The test liquid in the container 10 is sent to the primary side of the filter membrane; the first pressure measuring mechanism 40 measures the pressure of the test liquid infusion line 30; Output: filtrate infusion pump 50P, connected to filtrate infusion line 50, especially set on filtrate infusion line 50, and conveying filtrate; and adjusting liquid infusion mechanism 80, conveying adjusting liquid to test liquid storage container 10.

The test device of this embodiment may further include an adjustment liquid storage container 70 for storing the adjustment liquid. The adjustment liquid infusion mechanism 80 is used to transfer the adjustment liquid in the adjustment liquid storage container 70 to the test liquid storage container 10 .

Here, the adjustment liquid infusion mechanism 80 delivers the adjustment liquid so that the difference between the pressure of the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement point of the first pressure measurement mechanism 40 is constant.

Since the liquid level 11 of the test liquid storage container 10 will drop as the test liquid is transported to the filter 20, the pressure at the measuring point of the first pressure measuring mechanism 40 will continue to change, and the changed pressure will make the test difficult to run smoothly. to carry out. In the present invention, the adjustment liquid infusion mechanism 80 delivers the adjustment liquid to the test liquid storage container 10 so that the difference between the pressure of the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement point of the first pressure measurement mechanism 40 is constant. In this way, the pressure measured by the first pressure measuring mechanism 40 becomes constant (that is, does not change), so that the test can be performed smoothly.

The adjustment liquid infusion mechanism 80 preferably delivers the adjustment liquid so that the position of the liquid surface 11 of the test liquid storage container 10 is fixed.

The first pressure measurement mechanism 40 can also have: a first pressure gauge 41; a first chamber 42; Terminals.

The test liquid infusion line 30 may also have: a first infusion line 31, one end connected to the test liquid storage container 10, and the other end connected to the input port of the first chamber 42; and a second infusion line 32, one end connected to the first The output port of the chamber 42 is connected to the input port 21 of the filter 20 at the other end.

The connection terminals of the first chamber 42 may also be located at the vertically upper part of the first chamber 42 , especially at the vertically upper end of the first chamber 42 . Certainly, the connection terminal can also be located at any other place on the top of the first chamber 42 . The upper portion of the first chamber 42 may contain gas such as air, and the vertically lower portion of the first chamber 42 introduces the test liquid. Specifically, the first liquid infusion line 31 sends the test liquid from the input port of the first chamber 42 to the first chamber 42 . The test solution is introduced into the filter 20 from the output port of the first chamber 42 through the second infusion line 32 .

Here, the adjusting liquid infusion mechanism 80 preferably delivers the adjusting liquid so that the height of the liquid level 11 of the test liquid storage container 10 is consistent with the height of the liquid level 33 of the first chamber 42 . The height of the liquid level 11 of the test solution storage container 10 and the height of the liquid level 33 of the first chamber 42 may also have a height difference, but if there is a height difference, the height difference is preferably fixed.

The filter 20 is preferably installed so that the height of the central position in the vertical direction coincides with the height of the liquid surface 33 of the first chamber 42 .

The pressure of the gas sealed in the first chamber 42 is almost equal to the pressure of the liquid surface 33 (the pressure of the liquid surface 33 is transmitted to the first pressure gauge 41 by the gas). In addition, the height of the liquid surface 33 coincides with the height of the center position of the filter 20 in the vertical direction. Therefore, since the pressure measured by the first pressure gauge 41 is almost equal to the pressure received by the filter membrane, the pressure received by the filter membrane can be easily obtained.

In this embodiment, the measurement place of the first pressure measurement mechanism 40 is the liquid surface 33 . When measuring without passing through the air, the liquid level 33 is directly measured by the first pressure measuring mechanism 40 or the first pressure gauge 41 .

In this embodiment, by providing the first chamber 42 and measuring the pressure of the gas sealed in the first chamber 42, the first pressure gauge 41 does not need to be in contact with the test liquid. Therefore, since it is possible to avoid contamination of the first pressure gauge 41 with the test liquid, it is easy to reuse the first pressure gauge 41 . This reduces the cost of testing.

The adjustment liquid infusion mechanism 80 may also have: an adjustment liquid infusion line 81, one end connected to the adjustment liquid storage container 70, and the other end connected to the test liquid storage container 10; and an adjustment liquid infusion pump 82 arranged on the adjustment liquid infusion line 81, The adjustment liquid in the adjustment liquid storage container 70 is sent to the test liquid storage container 10 . At least during the stable test period, the adjustment fluid infusion pump 82 can continue to operate. Thus, the position of the liquid surface 11 of the test liquid storage container 10 remains fixed. Setting the infusion pump described in the present invention on the infusion line should be understood as: it can also reflect that the infusion pump is connected to two infusion lines.

The test device of this embodiment may further include a waste liquid infusion line 90, one end of which is connected to the second output port 23 of the filter 20, and the waste liquid is conveyed.

Here, since the test solution and the adjustment solution can also be the same solution, the implementation of the test is simpler. However, the present invention is not limited to the above description. For example, the test liquid and the adjustment liquid may also be immiscible liquids with different densities. When the density of the adjustment liquid is higher than that of the test liquid, the liquid sent to the filter 20 is always the test liquid, and the adjustment liquid is only used to adjust the liquid level 11 of the test liquid storage container 10 .

The filter 20 may also have a cylindrical body, and the input port 21 may be provided at one end of the body in the axial direction, and the second output port 23 may be provided at the other end of the body in the axial direction. The first output port 22 and the liquid port 24 are provided on the outer periphery of the main body, and may also extend from the outer periphery of the main body in this test. Here, the filter 20 is preferably arranged so that the central axis of the main body becomes horizontal. For example, in the case where the filter membrane includes hollow fibers, the pressure on the central axis of the filter 20 body can represent the pressure that the filter membrane bears. By setting the filter 20 in this way, the filter membrane can be easily and accurately obtained. pressure. It should be understood that the filter 20 can also be arranged almost vertically (ie along a substantially vertical direction).

The test device of this embodiment may further optionally be equipped with a first temperature adjustment device 12 which accommodates, adjusts and maintains the test liquid storage container 10 at a designated first temperature. The first temperature is, for example, the body temperature of a human body of 37°C. The first temperature adjustment device 12 can also be a constant temperature bath containing liquid, and the test liquid storage container 10 is set in this liquid.

The test device of this embodiment may further optionally be equipped with a second temperature adjustment device 25 which accommodates, adjusts and maintains the filter 20 at a specified second temperature. The second temperature is, for example, the body temperature of a human body of 37°C. The second temperature adjustment device 25 may also be a constant temperature bath containing liquid, and the filter 20 is installed in the liquid.

In this way, by making the temperature of the test liquid close to the body temperature of the human body, it is possible to simulate the use condition of the real ascites filter.

The test device of this embodiment may further include a second pressure measurement mechanism 40A, which is installed on the upstream side of the filtrate infusion pump 50P, and measures the pressure of the filtrate infusion line 50. Like the first pressure measurement mechanism 40, the second pressure measurement mechanism 40A may include a second pressure gauge 41A, a second chamber 42A, and a second pressure line 43A. Since the second pressure measurement mechanism 40A is in the same form as the first pressure measurement mechanism 40 , detailed description of the second pressure measurement mechanism 40A will be omitted.

Similar to the test liquid infusion line 30, the filtrate infusion line 50 may also include two infusion lines, and the second chamber 42A is connected to the two infusion lines. The filtrate output from the filtrate infusion line 50 (the test liquid from which undesired components are removed by filtration) is collected in the filtrate collection container 51 for sampling and measurement.

The test device of this embodiment may further include: a waste liquid infusion pump 90P, which is installed in the waste liquid infusion line 90, and transports waste liquid; and a third pressure measuring mechanism, which is set Place it on the upstream side of the waste liquid infusion pump 90P, and measure the pressure of the waste liquid infusion line 90.

Like the first pressure measurement mechanism 40, the third pressure measurement mechanism 40B may include a third pressure gauge 41B, a third chamber 42B, and a third pressure line 43B. Since the third pressure measurement mechanism 40B is in the same form as the first pressure measurement mechanism 40 , detailed description of the third pressure measurement mechanism 40B will be omitted.

Similar to the test liquid infusion line 30, the waste liquid infusion line 90 may also include two infusion lines, and the third pressure line 43B is connected to the two infusion lines. The waste liquid (undesired components removed by filtration) output from the waste liquid infusion line 90 can be collected in the waste liquid collection container 91 .

Here, the infusion pumps 82, 50P, and 90P may also be roller pumps.

(Second implementation type)

Fig. 2 shows a test device for a filter according to the second embodiment of the present invention. The same reference numerals are assigned to the same or similar components as those in the first embodiment, and detailed descriptions of these components are omitted. The difference between the second embodiment and the first embodiment will be described below.

In the first embodiment, the adjustment liquid infusion mechanism 80 is to adjust the position of the liquid level 11 of the test liquid storage container 10 by transferring the adjustment liquid in the adjustment liquid storage container 70 to the test liquid storage container 10 . Therefore, the adjustment liquid storage container 70 and the adjustment liquid infusion mechanism 80 can be regarded as constituting the test liquid level adjustment mechanism.

In the second embodiment, a different test liquid level adjustment mechanism is used. The test liquid level adjustment mechanism of this embodiment is connected to the test liquid storage container 10, and adjusts the position of the liquid level 11 of the test liquid storage container 10, so that the pressure of the liquid level 11 of the test liquid storage container 10 and the first 1. The difference in pressure at the measuring point of the pressure measuring mechanism 40 is constant. In particular, the test liquid level adjustment mechanism of this embodiment adjusts the height and/or position and/or shape of the test liquid storage container 10, so that the position of the liquid level 11 of the test liquid storage container 10 is fixed (no change in height) ).

In one embodiment, as shown in Figure 2, the test liquid level adjustment mechanism 100 may also have There is an elevating mechanism including a fixing part 110 and an elevating table 120 . The test liquid storage container 10 is supported by the lifting table 120 of the lifting mechanism, and the height of the liquid surface 11 of the test liquid storage container 10 is adjusted by the lifting of the lifting table 120 . The lifting table can be raised and lowered manually or electrically.

In other embodiments, the test liquid level adjustment mechanism may also have a pressing mechanism, which adjusts the liquid level in the liquid bag by pressing the liquid bag serving as the test liquid storage container 10 .

The present invention further provides a test method for a filter that can use the test device of the present invention.

The test method of this embodiment includes: by using the filtrate negative pressure mechanism (for example, filtrate infusion pump 50P) connected to the first output port 22 to make the negative pressure act on the filter 20, thereby passing the test liquid through the test The step of suctioning and filtering the test fluid infusion line 30 from the test fluid storage container 10 to the filter 20; the step of measuring the pressure of the test fluid infusion line 30 with the first pressure measuring mechanism 40; and adjusting the liquid level 11 of the test fluid storage container 10 The step of making the difference between the pressure of the liquid surface 11 of the test liquid storage container 10 and the pressure at the measuring place of the first pressure measuring mechanism 40 constant.

The above descriptions about the structures, steps and functions of the test device of this embodiment should be understood as also applicable to the test method of this embodiment.

Based on the pressures measured by the first pressure measuring mechanism 40, the second pressure measuring mechanism 40A, and the third pressure measuring mechanism 40B, the inter-membrane differential pressure of the filter membrane (also called the transmembrane differential pressure) can be calculated. The differential pressure between the membranes can be used to calculate the ultrafiltration performance of the filter. With the test device and test method of this embodiment, since the pressure measurement by the first pressure measurement mechanism 40 is stabilized, the ultrafiltration performance test can be easily performed.

In one embodiment,

Differential pressure between membranes TMP (transfer membrane pressure) = (filter inlet side pressure + filter outlet side pressure) / 2- filtrate side pressure.

Wherein, the pressure measured by the first pressure measuring mechanism 40 can also be used as the above-mentioned process As for the pressure on the inlet side of the filter, the pressure measured by the second pressure measuring means 40A is used as the pressure on the filtrate side, and the pressure measured by the third pressure measuring means 40B is used as the pressure on the outlet side of the filter.

The test device and test method of the present invention are not limited to be used only in the measurement of ultrafiltration performance, it should be understood that: for example, the test device and test method of the present invention can also be used in the measurement of the rejection rate of the filter 20 .

It should be understood that the above-mentioned implementation forms are only examples, rather than limiting the present invention. All equivalent changes and improvements made based on the teachings of the present invention fall within the scope of the present invention.

10: Test liquid storage container

11: liquid surface

12: The first temperature adjustment device

20: filter

21: input port

22: The first output port

23: The second output port

24: liquid port

25: The second temperature adjustment device

30: Test fluid infusion line

31: The first infusion line

32: The second infusion line

33: liquid level

40: The first pressure measuring mechanism

41: 1st pressure gauge

42: 1st chamber

43: 1st pressure circuit

40A: The second pressure measuring mechanism

41A: 2nd pressure gauge

42A: 2nd chamber

43A: 2nd pressure line

40B: The third pressure measuring mechanism

41B: No. 3 pressure gauge

42B: Chamber 3

43B: 3rd pressure line

50: filtrate infusion line

50P: filtrate infusion pump

51: Filtrate collection container

70: Adjustment fluid storage container

80: Adjusting fluid infusion mechanism

81: Adjusting liquid infusion line

82:Adjustment fluid infusion pump

90: Waste liquid infusion line

90P: Waste liquid infusion pump

91: waste liquid collection container

Claims (18)

A kind of test device, it is the test device of filter (20), and this filter (20) has: filter membrane; Input port (21), is connected to the primary side of this filter membrane; And the 1st output port (22), Connected to the secondary side of the filter membrane and output the filtrate; it is characterized by: a test solution storage container (10) for storing the test solution; a test solution infusion line (30), one end connected to the test solution storage container (10), The other end is connected to the input port (21), and the test solution in the test solution storage container (10) is sent to the primary side of the filter membrane; the first pressure measurement mechanism (40) measures the test solution infusion line ( 30) pressure; filtrate infusion line (50), one end is connected to the first output port (22), and the filtrate is output from the filter (20); filtrate infusion pump (50P), connected to the filtrate infusion line ( 50), and transport the filtrate; and the adjustment liquid infusion mechanism (80), transport the adjustment liquid to the test liquid storage container (10); and the adjustment liquid infusion mechanism (80), transport the adjustment liquid, and make the test The difference between the pressure of the liquid surface of the liquid storage container (10) and the pressure at the measuring place of the first pressure measuring mechanism (40) is constant. The test device according to claim 1, further comprising: the filter (20); and an adjustment liquid storage container (70) for storing the adjustment liquid. The test device as described in claim 2, wherein the first pressure measuring mechanism (40) has: The first pressure gauge (41); the first chamber (42); and the first pressure line (43), one end is connected to the first pressure gauge (41), and the other end is connected to the first chamber (42) connection terminal; and the test fluid infusion line (30) has: a first infusion line (31), one end is connected to the test liquid storage container (10), and the other end is connected to the input port of the first chamber (42) ; And the second infusion circuit (32), one end is connected to the output port of the first chamber (42), and the other end is connected to the input port (21) of the filter (20). The test device as described in claim 3, wherein, the connecting terminal of the first chamber (42) is located at the vertically upper part of the first chamber (42) with gas, and the test liquid is sent to the first chamber (42) is conveyed at the lower part of the vertical direction; the adjustment liquid infusion mechanism (80) delivers the adjustment liquid so that the height of the liquid level (11) of the test liquid storage container (10) is the same as the height of the first chamber (42) The height of liquid surface (33) is consistent. The test device as described in Claim 3, wherein the filter (20) is set to have the height of the central position in the vertical direction consistent with the height of the liquid level (33) of the first chamber (42). The test device as described in claim 4, wherein the filter (20) is set to have the height of the center position in the vertical direction consistent with the height of the liquid level (33) of the first chamber (42). The test device as described in any one of claims 2 to 6, wherein the adjustment fluid infusion mechanism (80) has: An adjustment fluid infusion line (81), one end connected to the adjustment fluid storage container (70), and the other end connected to the test fluid storage container (10); and an adjustment fluid infusion pump (82), arranged on the adjustment fluid infusion line ( 81), transporting the adjustment liquid in the adjustment liquid storage container (70) to the test liquid storage container (10). The test device as described in any one of claims 1 to 6, wherein the filter (20) further has a second output port (23) connected to the primary side of the filter membrane; and is further equipped with a waste liquid infusion line (90), one end of which is connected to the second output port (23), and transports waste liquid. The test device as described in claim 8, further comprising: a waste liquid infusion pump (90P) installed on the waste liquid infusion line (90); and a third pressure measuring mechanism (40B) installed on the waste liquid infusion The upstream side of the pump (90P), and measure the pressure of the waste liquid infusion line (90). The test device according to claim 1, wherein the test liquid and the adjustment liquid are the same solution. A kind of test device, it is the test device of filter (20), and this filter (20) has: filter membrane; Input port (21), is connected to the primary side of this filter membrane; And the 1st output port (22), Connected to the secondary side of the filter membrane and output the filtrate; it is characterized by: a test solution storage container (10) for storing the test solution; a test solution infusion line (30), one end connected to the test solution storage container (10), The other end is connected to the input port (21), and the test solution in the test solution storage container (10) is sent to one of the filter membranes once. side delivery; the first pressure measuring mechanism (40), measures the pressure of the test fluid infusion line (30); the filtrate infusion line (50), one end is connected to the first output port (22), and the filtrate is passed from the filter ( 20) output; the filtrate infusion pump (50P), connected to the filtrate infusion line (50), transports the filtrate; and the test liquid level adjustment mechanism (100), connected to the test liquid storage container (10), and adjusts the The position of the liquid level of the test liquid storage container (10) is such that the difference between the pressure of the liquid level of the test liquid storage container (10) and the pressure at the measurement place of the first pressure measuring mechanism (40) is fixed. The test device as described in claim 11, wherein the test liquid level adjustment mechanism (100) has: a lifting mechanism, which is adjusted by lifting the lifting platform (120) supporting the test liquid storage container (10). The height of the liquid level of the test liquid storage container (10); or the pressing mechanism, by pressing the liquid bag as the test liquid storage container (10), to adjust the height of the liquid level in the liquid bag. The test device according to claim 1 or 11, wherein the filter is an ascites filter. The test device as described in claim 13, wherein the filter (20) has a cylindrical body; the input port (21) is located at one end of the body in the axial direction; the first output port (22) is located at the outer perimeter of the body; The filter (20) is arranged so that the central axis of the body is horizontal. The test device as described in claim 1 or 11, wherein it further includes: a first temperature adjustment device (12), which accommodates, adjusts and maintains the test liquid storage container (10) at a designated first temperature; and/or 2. The temperature adjustment device (25), accommodates, adjusts and maintains the filter (20) at the specified second temperature. The test device as described in any one of claims 1 to 6 or 10 to 12, further comprising: a second pressure measuring mechanism (40A), which is arranged on the upstream side of the filtrate infusion pump (50P), and measures the The pressure of the filtrate infusion line (50). A test method, which is a test method for a filter (20), the filter (20) has: a filter membrane; an input port (21), connected to a primary side of the filter membrane; and a first output port (22), Connected to the secondary side of the filter membrane and output the filtrate; its features include: by using the filtrate negative pressure mechanism connected to the first output port (22) to make the negative pressure act on the filter (20), thereby Connect the test liquid to the filter (20) from the test liquid storage container (10) through the test liquid infusion line (30) with one end connected to the test liquid storage container (10) and the other end connected to the input port (21). The steps of suction and filtration; the step of measuring the pressure of the test fluid infusion line (30) with the first pressure measuring mechanism (40); and adjusting the position of the liquid level of the test fluid storage container (10), so that the test fluid Liquid Storage Containers (10) The difference between the pressure of the liquid surface and the pressure at the measuring place of the first pressure measuring mechanism (40) is a fixed step. The test method according to claim 17, wherein the test device according to any one of claims 1 to 15 is used.

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