JP7335161B2 - Filter testing device and testing method - Google Patents
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本発明は、濾過器の試験装置及び試験方法に関する。 TECHNICAL FIELD The present invention relates to a filter testing apparatus and testing method.
例えば、中国実用新案ＣＮ２０２５３８６４３Ｕには腹水濾過濃縮装置が開示されている。患者の腹水は収集されて貯留容器内に貯留され、貯留容器からの腹水は濾過用濾過器の濾過によって細胞成分が除去され、細胞成分が除去された腹水は濃縮用濾過器へ流れ、濃縮用濾過器において水分などが除去されて蛋白質溶液が得られる。該蛋白質溶液は治療のために患者の体内へ注射されることが可能となる。 For example, Chinese utility model CN202538643U discloses an ascites filtering and concentrating device. The patient's ascites is collected and stored in a storage container, the ascites from the storage container is filtered through a filtration filter to remove cellular components, and the ascites from which the cellular components have been removed flows to the concentration filter, where it is used for concentration. Moisture and the like are removed in a filter to obtain a protein solution. The protein solution can be injected into a patient's body for treatment.
また、中国特許ＣＮ１０９２００３７０Ａには、濾過用濾過器と、濃縮用濾過器と、を備え、腹水の処理に用いられる体腔液処理装置も開示されている。 Chinese patent CN109200370A also discloses a body cavity fluid treatment device for treating ascites, comprising a filtration filter and a concentration filter.
濾過器の場合、設計・試作時またはバッチ製造時にその限外濾過性能などについて試験を行う必要がある。 In the case of a filter, it is necessary to test its ultrafiltration performance, etc. at the time of design/prototyping or batch production.
本発明の発明者は、濾液送液ラインに濾液送液ポンプを備えた陰圧式試験では、濾過器の出力ポート側に陰圧を作用させることにより、試験液貯留容器から濾過器の入力ポートへと試験液を送液したとき、試験液貯留容器内の液面が下がり、試験液貯留容器の液面と試験液送液ラインにおける圧力測定用のチャンバーの液面との差が拡大することを発見した。チャンバーの圧力がその拡大する液面差に応じて変化することで、試験液送液ラインでの圧力を測定するための圧力計で計測された圧力値は変化し続けることにより、濾過器の濾過膜の受けた圧力を計測または推算することは困難になる。 The inventors of the present invention have found that, in a negative pressure type test in which a filtrate-sending pump is provided in a filtrate-sending line, negative pressure is applied to the output port side of the filter, from the test liquid storage container to the input port of the filter. The liquid level in the test liquid storage container drops when the test liquid is sent with discovered. As the pressure in the chamber changes in response to the expanding liquid level difference, the pressure value measured by the pressure gauge for measuring the pressure in the test liquid delivery line continues to change, thereby increasing the filtration rate of the filter. It becomes difficult to measure or estimate the pressure experienced by the membrane.
本発明の目的は、濾過器の濾過膜の受けた圧力を容易に計測または推算可能な濾過器の試験装置及び試験方法を提供することにある。 SUMMARY OF THE INVENTION It is an object of the present invention to provide a filter testing apparatus and a test method that can easily measure or estimate the pressure applied to the filter membrane of the filter.
本発明は、濾過器の限外濾過性能などの計測に適用可能な濾過器の試験装置及び試験方法を提供することをも目的とする。 Another object of the present invention is to provide a filter test apparatus and test method applicable to the measurement of the ultrafiltration performance of the filter.
本発明のもう１つの目的は、濾過器の限外濾過性能などの計測を容易に実行可能な濾過器の試験装置濾過器に係る試験装置及び試験方法を提供することにある。 Another object of the present invention is to provide a test apparatus and a test method for a filter which can easily measure the ultrafiltration performance of the filter.
本発明の濾過器の試験装置では、濾過器の下流における濾液送液ラインには濾液送液ポンプが設置されていることにより、濾液を送液するとともに、試験液を試験液貯留容器から濾過器へ引き込むと理解すべきである。本発明の試験では、圧力を計測するとき、試験液貯留容器と濾過器との間に位置する送液ポンプを用いて試験液を試験液貯留容器から濾過器へ送液する必要がない。
[１]濾過膜と、濾過膜の一次側に連通する入力ポート（２１）と、濾過膜の二次側に連通して濾液が出力される第１出力ポート（２２）と、を有する濾過器（２０）の試験装置であって、
試験液が貯留される試験液貯留容器（１０）と、
一端が試験液貯留容器（１０）に接続され、他端が入力ポート（２１）に接続され、試験液貯留容器（１０）内の試験液が濾過膜の一次側へ送液される試験液送液ライン（３０）と、
試験液送液ライン（３０）での圧力を測定する第１圧力測定手段（４０）と、
第１出力ポート（２２）に一端が接続され、濾液が濾過器（２０）から出力される濾液送液ライン（５０）と、
濾液送液ライン（５０）に接続され、濾液を送液する濾液送液ポンプ（５０Ｐ）と、
調整液を試験液貯留容器（１０）へ送液する調整液送液手段（８０）と、を備え、
調整液送液手段（８０）は、試験液貯留容器（１０）の液面における圧力と、第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように調整液を送液する、試験装置。
[２]濾過器（２０）と、
調整液が貯留される調整液貯留容器（７０）と、
をさらに備える、[１]に記載の試験装置。
[３]第１圧力測定手段（４０）は、
第１圧力計（４１）と、
第１チャンバー（４２）と、
一端が第１圧力計（４１）に接続され、他端が第１チャンバー（４２）の接続端子に接続される第１圧力ライン（４３）と、を有し、
試験液送液ライン（３０）は、
一端が試験液貯留容器（１０）に接続され、他端が第１チャンバー（４２）の入力ポートに接続される第１送液ライン（３１）と、
一端が第１チャンバー（４２）の出力ポートに接続され、他端が濾過器（２０）の入力ポート（２１）に接続される第２送液ライン（３２）と、を有する、[２]に記載の試験装置。
[４]第１チャンバー（４２）の接続端子が、第１チャンバー（４２）のガスを有する鉛直方向上部に位置し、第１チャンバー（４２）の鉛直方向下部に試験液が送液され、
調整液送液手段（８０）は、試験液貯留容器（１０）の液面（１１）の高さと、第１チャンバー（４２）の液面（３３）の高さと、が揃うように調整液を送液する、[３]に記載の試験装置。
[５]濾過器（２０）は、その鉛直方向における中心位置の高さが第１チャンバー（４２）の液面（３３）の高さに揃うように設置されている、[３]又は[４]に記載の試験装置。
[６]調整液送液手段（８０）は、
一端が調整液貯留容器（７０）に接続され、他端が試験液貯留容器（１０）に接続される調整液送液ライン（８１）と、
調整液送液ライン（８１）に設置され、調整液貯留容器（７０）内の調整液を試験液貯留容器（１０）へ送液する調整液送液ポンプ（８２）と、を有する、[２]～[５]のいずれか一項に記載の試験装置。
[７]濾過器（２０）は、濾過膜の一次側に連通する第２出力ポート（２３）をさらに有し、
第２出力ポート（２３）に一端が接続され、廃液が送液される廃液送液ライン（９０）をさらに備える、[１]～[６]のいずれか一項に記載の試験装置。
[８]廃液送液ライン（９０）に設置されている廃液送液ポンプ（９０Ｐ）と、
廃液送液ポンプ（９０Ｐ）の上流側に設置され、廃液送液ライン（９０）での圧力を測定する第３圧力測定手段（４０Ｂ）と、
をさらに備える、[７]に記載の試験装置。
[９]試験液と調整液とは同一の溶液である、[１]～[８]のいずれか一項に記載の試験装置。
[１０]濾過膜と、濾過膜の一次側に連通する入力ポート（２１）と、濾過膜の二次側に連通して濾液が出力される第１出力ポート（２２）と、を有する濾過器（２０）の試験装置であって、
試験液が貯留される試験液貯留容器（１０）と、
一端が試験液貯留容器（１０）に接続され、他端が入力ポート（２１）に接続され、試験液貯留容器（１０）内の試験液が濾過膜の一次側へ送液される試験液送液ライン（３０）と、
試験液送液ライン（３０）での圧力を測定する第１圧力測定手段（４０）と、
第１出力ポート（２２）に一端が接続され、濾液が濾過器（２０）から出力される濾液送液ライン（５０）と、
濾液送液ライン（５０）に接続され、濾液を送液する濾液送液ポンプ（５０Ｐ）と、
試験液貯留容器（１０）に接続され、試験液貯留容器（１０）の液面における圧力と、第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように試験液貯留容器（１０）の液面の位置を調整する試験液液面調整手段（１００）と、
を備える、試験装置。
[１１]試験液液面調整手段（１００）は、
試験液貯留容器（１０）を支持する昇降台（１２０）の昇降によって試験液貯留容器（１０）の液面の高さを調整する昇降手段、または、
試験液貯留容器（１０）である液袋を押圧することによって液袋内の液面の高さを調整する押圧手段
を有する、[１０]に記載の試験装置。
[１２]濾過器は、腹水濾過器である、[１]～[１１]のいずれか一項に記載の試験装置。
[１３]濾過器（２０）は、円柱状の本体を有し、
入力ポート（２１）は、本体の軸方向の一端に設けられ、
第１出力ポート（２２）は、本体の外周に設けられ、
濾過器（２０）は、本体の中心軸が水平となるように設置されている、[１]～[１２]のいずれか一項に記載の試験装置。
[１４]試験液貯留容器（１０）を所定の第１温度に調節して保持するように収容する第１温度調整装置（１２）、および／または、
濾過器（２０）を所定の第２温度に調節して保持するように収容する第２温度調整装置（２５）
をさらに備える、[１]～[１３]のいずれか一項に記載の試験装置。
[１５]濾液送液ポンプ（５０Ｐ）の上流側に設置され、濾液送液ライン（５０）での圧力を測定する第２圧力測定手段（４０Ａ）をさらに備える、[１]～[１４]のいずれか一項に記載の試験装置。
[１６]濾過膜と、濾過膜の一次側に連通する入力ポート（２１）と、濾過膜の二次側に連通して濾液が出力される第１出力ポート（２２）と、を有する濾過器（２０）の試験方法であって、
第１出力ポート（２２）に接続される濾液陰圧手段で濾過器（２０）に陰圧を作用させることによって、試験液を、一端が試験液貯留容器（１０）に接続され、他端が入力ポート（２１）に接続される試験液送液ライン（３０）を介して、試験液貯留容器（１０）から濾過器（２０）へ吸引して濾過するステップと、
第１圧力測定手段（４０）で試験液送液ライン（３０）での圧力を測定するステップと、
試験液貯留容器（１０）の液面における圧力と、第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように試験液貯留容器（１０）の液面の位置を調整するステップと、
を含む、試験方法。
[１７][１]～[１５]のいずれか一項に記載の試験装置を用いる、[１６]に記載の試験方法。
In the filter test apparatus of the present invention, a filtrate liquid transfer pump is installed in the filtrate liquid transfer line downstream of the filter, so that the filtrate is transferred and the test liquid is transferred from the test liquid storage container to the filter. should be understood as drawing into In the test of the present invention, when measuring the pressure, it is not necessary to transfer the test liquid from the test liquid reservoir to the filter using a liquid transfer pump positioned between the test liquid reservoir and the filter.
[1] A filter having a filtration membrane, an input port (21) that communicates with the primary side of the filtration membrane, and a first output port (22) that communicates with the secondary side of the filtration membrane and outputs filtrate. (20) the test device,
a test liquid storage container (10) in which the test liquid is stored;
One end is connected to the test liquid storage container (10), the other end is connected to the input port (21), and the test liquid in the test liquid storage container (10) is sent to the primary side of the filtration membrane. a fluid line (30);
a first pressure measuring means (40) for measuring the pressure in the test liquid feeding line (30);
a filtrate liquid transfer line (50) having one end connected to the first output port (22) and having the filtrate output from the filter (20);
a filtrate-sending pump (50P) connected to the filtrate-sending line (50) for sending the filtrate;
a conditioning liquid feeding means (80) for feeding the conditioning liquid to the test liquid storage container (10),
The adjusted liquid feeding means (80) supplies the adjusted liquid so that the difference between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. A testing device that delivers liquids.
[2] a filter (20);
an adjustment liquid storage container (70) in which the adjustment liquid is stored;
The test apparatus according to [1], further comprising:
[3] The first pressure measuring means (40)
a first pressure gauge (41);
a first chamber (42);
a first pressure line (43) having one end connected to the first pressure gauge (41) and the other end connected to the connection terminal of the first chamber (42);
The test liquid feed line (30) is
a first liquid sending line (31) having one end connected to the test liquid storage container (10) and the other end connected to the input port of the first chamber (42);
a second liquid feed line (32) one end of which is connected to the output port of the first chamber (42) and the other end of which is connected to the input port (21) of the filter (20); Test equipment as described.
[4] The connection terminal of the first chamber (42) is positioned vertically above the gas in the first chamber (42), and the test liquid is sent to the vertically lower portion of the first chamber (42),
The adjustment liquid delivery means (80) supplies the adjustment liquid so that the height of the liquid level (11) of the test liquid storage container (10) and the height of the liquid level (33) of the first chamber (42) are aligned. The test device according to [3], which sends a liquid.
[5] The filter (20) is installed so that the height of its central position in the vertical direction is aligned with the height of the liquid surface (33) of the first chamber (42), [3] or [4 ] test equipment described in.
[6] The adjustment liquid feeding means (80)
an adjustment liquid feed line (81) having one end connected to the adjustment liquid storage container (70) and the other end connected to the test liquid storage container (10);
a conditioning liquid feeding pump (82) installed in the conditioning liquid feeding line (81) for feeding the conditioning liquid in the conditioning liquid storage container (70) to the test liquid storage container (10) [2 ] to [5].
[7] The filter (20) further has a second output port (23) communicating with the primary side of the filtration membrane,
The test apparatus according to any one of [1] to [6], further comprising a waste liquid feeding line (90) having one end connected to the second output port (23) and through which the waste liquid is fed.
[8] a waste liquid transfer pump (90P) installed in a waste liquid transfer line (90);
a third pressure measuring means (40B) installed upstream of the waste liquid transfer pump (90P) and measuring the pressure in the waste liquid transfer line (90);
The test device according to [7], further comprising:
[9] The test device according to any one of [1] to [8], wherein the test liquid and the adjustment liquid are the same solution.
[10] A filter having a filtration membrane, an input port (21) that communicates with the primary side of the filtration membrane, and a first output port (22) that communicates with the secondary side of the filtration membrane and outputs filtrate. (20) the test device,
a test liquid storage container (10) in which the test liquid is stored;
One end is connected to the test liquid storage container (10), the other end is connected to the input port (21), and the test liquid in the test liquid storage container (10) is sent to the primary side of the filtration membrane. a fluid line (30);
a first pressure measuring means (40) for measuring the pressure in the test liquid feeding line (30);
a filtrate liquid transfer line (50) having one end connected to the first output port (22) and having the filtrate output from the filter (20);
a filtrate-sending pump (50P) connected to the filtrate-sending line (50) for sending the filtrate;
The test liquid is connected to the test liquid storage container (10) so that the difference between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. test liquid level adjustment means (100) for adjusting the position of the liquid level of the storage container (10);
A testing device comprising:
[11] The test liquid level adjustment means (100)
elevating means for adjusting the height of the liquid surface of the test liquid storage container (10) by elevating the lift platform (120) supporting the test liquid storage container (10);
The test apparatus according to [10], having pressing means for adjusting the height of the liquid surface in the liquid bag by pressing the liquid bag, which is the test liquid storage container (10).
[12] The test device according to any one of [1] to [11], wherein the filter is an ascites filter.
[13] The filter (20) has a cylindrical body,
The input port (21) is provided at one axial end of the main body,
The first output port (22) is provided on the outer periphery of the main body,
The test apparatus according to any one of [1] to [12], wherein the filter (20) is installed so that the central axis of the main body is horizontal.
and/or
a second temperature regulating device (25) for accommodating the filter (20) to be regulated and maintained at a predetermined second temperature;
The test apparatus according to any one of [1] to [13], further comprising:
[15] of [1] to [14], further comprising a second pressure measuring means (40A) installed upstream of the filtrate sending pump (50P) and measuring the pressure in the filtrate sending line (50); A testing device according to any one of the preceding claims.
[16] A filter having a filtration membrane, an input port (21) that communicates with the primary side of the filtration membrane, and a first output port (22) that communicates with the secondary side of the filtration membrane and outputs filtrate. (20) test method,
By applying a negative pressure to the filter (20) with the filtrate negative pressure means connected to the first output port (22), the test liquid is connected to the test liquid reservoir (10) at one end and A step of sucking and filtering from the test liquid storage container (10) to the filter (20) through the test liquid delivery line (30) connected to the input port (21);
measuring the pressure in the test liquid delivery line (30) with the first pressure measuring means (40);
The position of the liquid surface of the test liquid storage container (10) is adjusted so that the difference between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. an adjusting step;
test methods, including
[17] The test method according to [16], which uses the test device according to any one of [1] to [15].
本発明において、調整液送液手段は、試験液貯留容器の液面における圧力と第１圧力測定手段の測定箇所における圧力との差が一定となるように、調整液を試験液貯留容器へ送液する。このように、第１圧力測定手段で測定された圧力が一定となる（すなわち、変化しない）ことで、試験をスムーズに実行できる。 In the present invention, the adjusting liquid feeding means sends the adjusting liquid to the test liquid storage container so that the difference between the pressure at the liquid surface of the test liquid storage container and the pressure at the measurement point of the first pressure measuring means is constant. liquid. In this way, the pressure measured by the first pressure measuring means becomes constant (that is, does not change), so that the test can be performed smoothly.
以下、図面を参照して、本発明の例示的な実施形態について説明する。これらの具体的な説明は、どのように本発明を実施するかについての教示を当業者に与えるだけであり、本発明のすべての可能な形態を一々挙げるのではなく、本発明の範囲を限定するものでもないと理解すべきである。 Exemplary embodiments of the invention will now be described with reference to the drawings. These specific descriptions merely provide teachings to those skilled in the art as to how to carry out the invention, and do not single out all possible forms of the invention, but rather limit the scope of the invention. It should be understood that it is not something to do.
（第１の実施形態）
図１に示すように、本発明は、濾過器の試験装置を提供している。そのうち、濾過器２０は腹水濾過器であってもよい。
(First embodiment)
As shown in FIG. 1, the present invention provides a filter testing apparatus. Among them, the filter 20 may be an ascites filter.
濾過器２０は試験装置の一部とみなされてもよいが、試験装置は、濾過器２０を含まず、濾過器２０への試験に用いられてもよいと理解すべきである。 Although the filter 20 may be considered part of the test device, it should be understood that the test device may be used to test the filter 20 without including the filter 20 .
濾過器２０は、濾過膜と、濾過膜の一次側（例えば、中空繊維の内側）に連通する入力ポート２１と、濾過膜の二次側（例えば、中空繊維の外側）に連通して濾液が出力される第１出力ポート２２と、を有する。濾過器２０は、濾過膜の一次側に連通し、廃液が出力される第２出力ポート２３と、濾過膜の二次側に連通し、かつ本試験において封止可能な通液ポート２４と、をさらに有してもよい。濾過膜は、薄膜とは限らず、中空繊維膜などを含む濾過素子であってもよいと理解すべきである。 The filter 20 includes a filtration membrane, an input port 21 that communicates with the primary side of the filtration membrane (eg, the inside of the hollow fibers), and a secondary side of the filtration membrane (eg, the outside of the hollow fibers) that communicates with the filtrate. and a first output port 22 for output. The filter 20 has a second output port 23 that communicates with the primary side of the filtration membrane and outputs waste liquid, a liquid communication port 24 that communicates with the secondary side of the filtration membrane and can be sealed in this test, may further have It should be understood that the filtration membrane is not limited to a thin film, but may be a filtration element including hollow fiber membranes and the like.
本実施形態に係る試験装置は、試験液が貯留される試験液貯留容器１０と、一端が試験液貯留容器１０に接続され、他端が入力ポート２１に接続され、試験液貯留容器１０内の試験液が濾過膜の一次側へ送液される試験液送液ライン３０と、試験液送液ライン３０での圧力を測定する第１圧力測定手段４０と、第１出力ポート２２に一端が接続され、濾液が濾過器２０から出力される濾液送液ライン５０と、濾液送液ライン５０に接続され、特に濾液送液ライン５０に設置され、濾液を送液する濾液送液ポンプ５０Ｐと、調整液を試験液貯留容器１０へ送液する調整液送液手段８０と、を備えてもよい。 The test apparatus according to the present embodiment includes a test liquid storage container 10 in which a test liquid is stored, one end of which is connected to the test liquid storage container 10, and the other end of which is connected to an input port 21. One end is connected to a test liquid feeding line 30 through which the test liquid is fed to the primary side of the filtration membrane, a first pressure measuring means 40 for measuring the pressure in the test liquid feeding line 30, and a first output port 22. a filtrate liquid-feeding line 50 through which the filtrate is output from the filter 20; a filtrate liquid-feeding pump 50P connected to the filtrate liquid-feeding line 50 and particularly installed in the filtrate liquid-feeding line 50 for feeding the filtrate; Adjusting liquid feeding means 80 for feeding the liquid to the test liquid storage container 10 may be provided.
本実施形態に係る試験装置は、調整液が貯留される調整液貯留容器７０をさらに備えてもよい。調整液送液手段８０は、調整液貯留容器７０内の調整液を試験液貯留容器１０へ送液するためのものである。 The test apparatus according to this embodiment may further include an adjustment liquid storage container 70 in which the adjustment liquid is stored. The adjustment liquid feeding means 80 is for sending the adjustment liquid in the adjustment liquid storage container 70 to the test liquid storage container 10 .
ここで、調整液送液手段８０は、試験液貯留容器１０の液面１１の圧力と、第１圧力測定手段４０の測定箇所における圧力と、の差が一定となるように、調整液を送液する。 Here, the adjusting liquid feeding means 80 feeds the adjusting liquid so that the difference between the pressure of the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement point of the first pressure measuring means 40 is constant. liquid.
試験液が濾過器２０へと送液されるに連れて、試験液貯留容器１０の液面１１が下がることで、第１圧力測定手段４０の測定箇所における圧力が変化し続け、この変化する圧力により、試験はスムーズに実行されにくい。本発明では、調整液送液手段８０は、試験液貯留容器１０の液面１１の圧力と、第１圧力測定手段４０の測定箇所における圧力と、の差が一定となるように、調整液を試験液貯留容器１０へ送液する。このように、第１圧力測定手段４０で測定された圧力が一定となる（すなわち、変化しない）ことで、試験をスムーズに実行できる。 As the test liquid is sent to the filter 20, the liquid level 11 of the test liquid storage container 10 is lowered, and the pressure at the measurement point of the first pressure measurement means 40 continues to change. This makes it difficult for the test to run smoothly. In the present invention, the adjustment liquid feeding means 80 supplies the adjustment liquid so that the difference between the pressure of the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement point of the first pressure measurement means 40 is constant. The liquid is sent to the test liquid storage container 10 . In this way, the pressure measured by the first pressure measuring means 40 becomes constant (that is, does not change), so that the test can be performed smoothly.
調整液送液手段８０は、試験液貯留容器１０の液面１１の位置が一定となるように、調整液を送液することが好ましい。 The adjusting liquid feeding means 80 preferably feeds the adjusting liquid so that the position of the liquid surface 11 of the test liquid storage container 10 is constant.
第１圧力測定手段４０は、第１圧力計４１と、第１チャンバー４２と、一端が第１圧力計４１に接続され、他端が第１チャンバー４２の接続端子に接続される第１圧力ライン４３と、を有してもよい。 The first pressure measuring means 40 includes a first pressure gauge 41, a first chamber 42, and a first pressure line having one end connected to the first pressure gauge 41 and the other end connected to a connection terminal of the first chamber 42. 43 and .
試験液送液ライン３０は、一端が試験液貯留容器１０に接続され、他端が第１チャンバー４２の入力ポートに接続される第１送液ライン３１と、一端が第１チャンバー４２の出力ポートに接続され、他端が濾過器２０の入力ポート２１に接続される第２送液ライン３２と、を有してもよい。 The test liquid feeding line 30 has a first liquid feeding line 31 connected at one end to the test liquid storage container 10 and having the other end connected to the input port of the first chamber 42, and one end to the output port of the first chamber 42. , and the other end of which is connected to the input port 21 of the filter 20 .
第１チャンバー４２の接続端子は、第１チャンバー４２の鉛直方向上部、特に第１チャンバー４２の鉛直方向上端に位置してもよい。勿論、接続端子は、第１チャンバー４２の上部におけるいかなる他の箇所に位置してもよい。第１チャンバー４２の上部は空気などのガスを有してもよく、第１チャンバー４２の鉛直方向下部は試験液を引き込む。具体的には、第１送液ライン３１は、試験液を第１チャンバー４２の入力ポートから第１チャンバー４２へ送液する。試験液は第１チャンバー４２の出力ポートから第２送液ライン３２を介して濾過器２０に引き込まれる。 The connection terminal of the first chamber 42 may be positioned vertically above the first chamber 42 , particularly at the vertical top end of the first chamber 42 . Of course, the connection terminals may be located at any other location in the upper portion of the first chamber 42 . The upper portion of the first chamber 42 may contain gas, such as air, and the vertically lower portion of the first chamber 42 draws the test liquid. Specifically, the first liquid feed line 31 feeds the test liquid from the input port of the first chamber 42 to the first chamber 42 . The test liquid is drawn into the filter 20 from the output port of the first chamber 42 through the second liquid feed line 32 .
ここで、調整液送液手段８０は、試験液貯留容器１０の液面１１の高さと、第１チャンバー４２の液面３３の高さと、が揃うように調整液を送液することが好ましい。試験液貯留容器１０の液面１１の高さと第１チャンバー４２の液面３３の高さとは高低差を有してもよいが、高低差が存在している場合、高低差は一定となることが好ましい。 Here, it is preferable that the adjusting liquid feeding means 80 feeds the adjusting liquid so that the height of the liquid level 11 of the test liquid storage container 10 and the height of the liquid level 33 of the first chamber 42 are aligned. The height of the liquid level 11 of the test liquid storage container 10 and the height of the liquid level 33 of the first chamber 42 may have a height difference, but if there is a height difference, the height difference should be constant. is preferred.
濾過器２０は、鉛直方向における中心位置の高さが第１チャンバー４２の液面３３の高さに揃うように設置されていることが好ましい。 The filter 20 is preferably installed so that the height of the central position in the vertical direction is aligned with the height of the liquid surface 33 of the first chamber 42 .
第１チャンバー４２内に封止されたガスの圧力は液面３３における圧力とほぼ等しい（ガスにより液面３３における圧力が第１圧力計４１に伝達する）。また、液面３３の高さは濾過器２０の鉛直方向における中心位置の高さに揃う。よって、第１圧力計４１で測定された圧力は濾過膜の受けた圧力とほぼ等しいため、濾過膜の受けた圧力を容易に取得し得る。 The pressure of the gas sealed in the first chamber 42 is approximately equal to the pressure at the liquid level 33 (the gas transmits the pressure at the liquid level 33 to the first pressure gauge 41). Also, the height of the liquid surface 33 is aligned with the height of the central position of the filter 20 in the vertical direction. Therefore, since the pressure measured by the first pressure gauge 41 is substantially equal to the pressure applied to the filtration membrane, the pressure applied to the filtration membrane can be easily obtained.
本実施形態では、第１圧力測定手段４０の測定箇所は液面３３となる。空気を介さない場合には、液面３３は、第１圧力測定手段４０または第１圧力計４１が直接測定する箇所となる。 In this embodiment, the liquid surface 33 is the measurement point of the first pressure measuring means 40 . Without air, the liquid level 33 is directly measured by the first pressure measuring means 40 or the first pressure gauge 41 .
本実施形態では、第１チャンバー４２を設け、第１チャンバー４２内に封止されたガスの圧力を計測することで、第１圧力計４１は試験液と接触する必要がない。よって、試験液が第１圧力計４１を汚染することを回避できるため、第１圧力計４１は繰り返して使用されやすい。これにより、試験のコストを低減する。 In this embodiment, by providing the first chamber 42 and measuring the pressure of the gas sealed in the first chamber 42, the first pressure gauge 41 does not need to come into contact with the test liquid. Therefore, it is possible to avoid contamination of the first pressure gauge 41 with the test liquid, so that the first pressure gauge 41 is likely to be used repeatedly. This reduces the cost of testing.
調整液送液手段８０は、一端が調整液貯留容器７０に接続され、他端が試験液貯留容器１０に接続される調整液送液ライン８１と、調整液送液ライン８１に設置され、調整液貯留容器７０内の調整液を試験液貯留容器１０へ送液する調整液送液ポンプ８２と、を有してもよい。少なくとも安定した試験段階では、調整液送液ポンプ８２は作動し続けることが可能となる。これにより、試験液貯留容器１０の液面１１の位置を一定に保持する。本願に記載の送液ポンプが送液ラインに設置されることは、送液ポンプが２本の送液ラインを接続するように反映されてもよいと理解すべきである。 The adjustment liquid delivery means 80 is installed in an adjustment liquid delivery line 81 having one end connected to the adjustment liquid storage container 70 and the other end connected to the test liquid storage container 10, and the adjustment liquid delivery line 81. and a conditioned liquid feeding pump 82 for feeding the conditioned liquid in the liquid storage container 70 to the test liquid storage container 10 . At least in the stable test phase, the adjustment liquid feed pump 82 can continue to operate. As a result, the position of the liquid surface 11 of the test liquid storage container 10 is kept constant. It should be understood that the fact that the liquid-sending pump described in the present application is installed in the liquid-sending line may be reflected so that the liquid-sending pump connects two liquid-sending lines.
本実施形態に係る試験装置は、濾過器２０の第２出力ポート２３に一端が接続され、廃液が送液される廃液送液ライン９０をさらに備えてもよい。 The test apparatus according to the present embodiment may further include a waste liquid feeding line 90 having one end connected to the second output port 23 of the filter 20 and through which the waste liquid is fed.
ここで、試験液と調整液とは同一の溶液であってもよいことで、試験の実行はより簡単になる。しかし、本発明は上述の記載に限定されない。例えば、試験液と調整液は、密度が異なり、かつ互いに溶けない液体であってもよい。調整液の密度が試験液の密度よりも高い場合、濾過器２０へ送液された液体は常に試験液であり、調整液は試験液貯留容器１０の液面１１に対する調整のみに用いられる。 Here, the test liquid and the conditioning liquid may be the same solution, which makes the execution of the test simpler. However, the invention is not limited to the above description. For example, the test liquid and the adjustment liquid may be liquids that have different densities and are insoluble in each other. When the density of the adjustment liquid is higher than the density of the test liquid, the liquid sent to the filter 20 is always the test liquid, and the adjustment liquid is used only for adjusting the liquid level 11 of the test liquid storage container 10 .
濾過器２０は、円柱状の本体を有してもよく、入力ポート２１は本体の軸方向の一端に設けられ、第２出力ポート２３は本体の軸方向の他端に設けられてもよい。第１出力ポート２２と通液ポート２４は本体の外周に設けられ、本試験では本体の外周から伸びてもよい。ここで、濾過器２０はその本体の中心軸が水平となるように設置されていることが好ましい。例えば、濾過膜が中空繊維を含む場合には、濾過器２０の本体の中心軸における圧力は、濾過膜の受けた圧力を表すことができる。このような濾過器２０の設置方法により、濾過膜の受けた圧力を容易かつ正確に取得し得る。濾過器２０はほぼ垂直に（すなわちほぼ鉛直方向に沿って）設置されてもよいと理解すべきである。 The filter 20 may have a cylindrical body, the input port 21 may be provided at one axial end of the body, and the second output port 23 may be provided at the other axial end of the body. The first output port 22 and the liquid passage port 24 are provided on the outer periphery of the body and may extend from the outer periphery of the body in this test. Here, it is preferable that the filter 20 is installed so that the central axis of its body is horizontal. For example, if the filtration membrane includes hollow fibers, the pressure at the central axis of the body of filter 20 can represent the pressure experienced by the filtration membrane. With such a method of installing the filter 20, the pressure applied to the filter membrane can be obtained easily and accurately. It should be understood that filter 20 may be installed substantially vertically (ie along a substantially vertical direction).
本実施形態に係る試験装置は、試験液貯留容器１０を所定の第１温度に調節して保持するように収容する第１温度調整装置１２をさらに選択的に備えてもよい。第１温度は、例えば人体の体温３７℃である。第１温度調整装置１２は液体を収納した恒温槽であってもよく、試験液貯留容器１０はこの液体中に設置されている。 The test apparatus according to the present embodiment may further optionally include a first temperature adjustment device 12 that accommodates the test liquid storage container 10 so as to adjust and maintain the first temperature. The first temperature is, for example, the human body temperature of 37°C. The first temperature control device 12 may be a constant temperature bath containing liquid, and the test liquid storage container 10 is installed in this liquid.
本実施形態に係る試験装置は、濾過器２０を所定の第２温度に調節して保持するように収容する第２温度調整装置２５をさらに選択的に備えてもよい。第２温度は、例えば人体の体温３７℃である。第２温度調整装置２５は液体を収納した恒温槽であってもよく、濾過器２０はこの液体中に設置されている。 The test apparatus according to the present embodiment may optionally further include a second temperature control device 25 that accommodates the filter 20 so as to control and maintain the second temperature. The second temperature is, for example, the human body temperature of 37°C. The second temperature control device 25 may be a constant temperature bath containing liquid, and the filter 20 is installed in this liquid.
このように、試験液の温度を人体の体温に近くすることができることにより、本当の腹水濾過器の使用状況を模擬できる。 By making the temperature of the test liquid close to the body temperature of the human body in this way, it is possible to simulate the actual use of the ascites filter.
本実施形態に係る試験装置は、濾液送液ポンプ５０Ｐの上流側に設置され、濾液送液ライン５０での圧力を測定する第２圧力測定手段４０Ａをさらに備えてもよい。第１圧力測定手段４０と同じように、第２圧力測定手段４０Ａは、第２圧力計４１Ａと、第２チャンバー４２Ａと、第２圧力ライン４３Ａと、を有してもよい。第２圧力測定手段４０Ａが第１圧力測定手段４０と同じようであるため、第２圧力測定手段４０Ａについての詳細な説明を省略する。 The test apparatus according to the present embodiment may further include second pressure measuring means 40A that is installed upstream of the filtrate-sending pump 50P and measures the pressure in the filtrate-sending line 50 . Similar to the first pressure measuring means 40, the second pressure measuring means 40A may comprise a second pressure gauge 41A, a second chamber 42A and a second pressure line 43A. Since the second pressure measuring means 40A is similar to the first pressure measuring means 40, a detailed description of the second pressure measuring means 40A will be omitted.
試験液送液ライン３０と同じように、濾液送液ライン５０は２本の送液ラインを含んでもよく、第２チャンバー４２Ａは２本の送液ラインを接続する。濾液送液ライン５０から出力された濾液（濾過によって所望しない成分が除去された試験液）は濾液収集容器５１内に収集されて採取・計測される。 Similar to the test liquid feed line 30, the filtrate feed line 50 may include two liquid feed lines, and the second chamber 42A connects the two liquid feed lines. The filtrate (the test liquid from which unwanted components have been removed by filtration) output from the filtrate-sending line 50 is collected in the filtrate collection container 51 and is sampled and measured.
本実施形態に係る試験装置は、廃液送液ライン９０に設置され、廃液が送液される廃液送液ポンプ９０Ｐと、廃液送液ポンプ９０Ｐの上流側に設置され、廃液送液ライン９０での圧力を測定する第３圧力測定手段と、をさらに備えてもよい。 The test apparatus according to the present embodiment includes a waste liquid transfer pump 90P that is installed in the waste liquid transfer line 90 to transfer the waste liquid, and a waste liquid transfer pump 90P that is installed upstream of the waste liquid transfer pump 90P. and third pressure measuring means for measuring pressure.
第１圧力測定手段４０と同じように、第３圧力測定手段４０Ｂは、第３圧力計４１Ｂと、第３チャンバー４２Ｂと、第３圧力ライン４３Ｂと、を有してもよい。第３圧力測定手段４０Ｂが第１圧力測定手段４０と同じようであるため、第３圧力測定手段４０Ｂについての詳細な説明を省略する。 Similar to the first pressure measuring means 40, the third pressure measuring means 40B may comprise a third pressure gauge 41B, a third chamber 42B and a third pressure line 43B. Since the third pressure measuring means 40B is similar to the first pressure measuring means 40, a detailed description of the third pressure measuring means 40B will be omitted.
試験液送液ライン３０と同じように、廃液送液ライン９０は２本の送液ラインを含んでもよく、第３圧力ライン４３Ｂは２本の送液ラインを接続する。廃液送液ライン９０から出力された廃液（濾過によって除去された所望しない成分）は廃液収集容器９１内に収集可能である。 As with the test liquid feed line 30, the waste liquid feed line 90 may include two liquid feed lines, and the third pressure line 43B connects the two liquid feed lines. Waste liquid (undesired components removed by filtration) output from the waste liquid feed line 90 can be collected in a waste liquid collection container 91 .
ここで、送液ポンプ８２、５０Ｐ、９０Ｐはローラーポンプであってもよい。 Here, the liquid-sending pumps 82, 50P, and 90P may be roller pumps.
（第２の実施形態）
図２は、本発明の第２の実施形態の濾過器の試験装置を示すものである。第１の実施形態と同一のまたは類似する部材に同じ図面符号を付し、かつこれら部材についての詳細な説明を省略する。以下、第２の実施形態と第１の実施形態との違いについて説明する。
(Second embodiment)
FIG. 2 shows a filter testing apparatus according to a second embodiment of the present invention. The same or similar members as those of the first embodiment are denoted by the same reference numerals, and detailed descriptions of these members are omitted. The difference between the second embodiment and the first embodiment will be described below.
第１の実施形態では、調整液送液手段８０は、調整液貯留容器７０内の調整液を試験液貯留容器１０へ送液することにより試験液貯留容器１０の液面１１の位置を調整する。よって、調整液貯留容器７０と調整液送液手段８０とは試験液液面調整手段を構成するものと考えられる。 In the first embodiment, the adjustment liquid delivery means 80 adjusts the position of the liquid surface 11 of the test liquid storage container 10 by delivering the adjustment liquid in the adjustment liquid storage container 70 to the test liquid storage container 10. . Therefore, the adjustment liquid storage container 70 and the adjustment liquid delivery means 80 are considered to constitute the test liquid level adjustment means.
第２の実施形態では、他の方式の試験液液面調整手段を用いている。本実施形態における試験液液面調整手段は、試験液貯留容器１０に接続され、試験液貯留容器１０の液面１１における圧力と、第１圧力測定手段４０の測定箇所における圧力と，の差が一定となるように試験液貯留容器１０の液面１１の位置を調整する。特に、本実施形態における試験液液面調整手段は、試験液貯留容器１０の液面１１の位置が一定となる（高さが変化しない）ように、試験液貯留容器１０の高さ及び／又は位置及び／又は形状を調整する。 In the second embodiment, another type of test liquid level adjusting means is used. The test liquid level adjustment means in this embodiment is connected to the test liquid storage container 10, and the difference between the pressure at the liquid level 11 of the test liquid storage container 10 and the pressure at the measurement point of the first pressure measurement means 40 is The position of the liquid surface 11 of the test liquid storage container 10 is adjusted so as to be constant. In particular, the test liquid level adjusting means in this embodiment adjusts the height and/or Adjust position and/or shape.
一実施例では、図２に示すように、試験液液面調整手段１００は、固定部１１０と昇降台１２０とを備える昇降手段を有してもよい。試験液貯留容器１０は昇降手段の昇降台１２０に支持され、昇降台１２０の昇降によって試験液貯留容器１０の液面１１の高さを調整する。該昇降台は手動または電動で昇降可能である。 In one embodiment, as shown in FIG. 2, the test liquid level adjusting means 100 may have an elevating means comprising a fixed portion 110 and an elevating platform 120 . The test liquid storage container 10 is supported by an elevating table 120 of the elevating means, and the height of the liquid surface 11 of the test liquid storing container 10 is adjusted by elevating the elevating table 120 . The platform can be lifted manually or electrically.
別の実施例では、試験液液面調整手段は、試験液貯留容器１０である液袋を押圧することによって液袋内の液面の高さを調整する押圧手段を有してもよい。 In another embodiment, the test liquid level adjusting means may have pressing means for adjusting the height of the liquid level in the liquid bag by pressing the liquid bag, which is the test liquid storage container 10 .
本発明は、本発明の試験装置を使用可能な濾過器の試験方法をさらに提供する。 The present invention further provides a filter testing method that can use the testing device of the present invention.
本実施形態に係る試験方法は、第１出力ポート２２に接続される濾液陰圧手段（例えば、濾液送液ポンプ５０Ｐ）で濾過器２０に陰圧を作用させることによって、試験液を、試験液送液ライン３０を介して、試験液貯留容器１０から濾過器２０へ吸引して濾過するステップと、第１圧力測定手段４０で試験液送液ライン３０での圧力を測定するステップと、試験液貯留容器１０の液面１１における圧力と第１圧力測定手段４０の測定箇所における圧力との差が一定となるように、試験液貯留容器１０の液面１１の位置を調整するステップと、を備える。 In the test method according to the present embodiment, a negative pressure is applied to the filter 20 by a filtrate negative pressure means (e.g., filtrate feed pump 50P) connected to the first output port 22, so that the test liquid is A step of sucking from the test liquid storage container 10 to the filter 20 via the liquid feeding line 30 and filtering; a step of measuring the pressure in the test liquid feeding line 30 with the first pressure measuring means 40; and adjusting the position of the liquid surface 11 of the test liquid storage container 10 so that the difference between the pressure at the liquid surface 11 of the storage container 10 and the pressure at the measurement point of the first pressure measuring means 40 is constant. .
本実施形態に係る試験装置の各構造、ステップ及び機能についての上述の説明は、本実施形態に係る試験方法にも適用できると理解すべきである。 It should be understood that the above description of each structure, step and function of the test apparatus according to this embodiment can also be applied to the test method according to this embodiment.
上述した第１圧力測定手段４０、第２圧力測定手段４０Ａ及び第３圧力測定手段４０Ｂで測定された圧力に基づいて、濾過膜の膜間差圧（膜を渡る差圧とも称する）を計算することができる。この膜間差圧は濾過器の限外濾過性能の計算に用いられることができる。本実施形態に係る試験装置及び試験方法により、第１圧力測定手段４０による圧力の測定を安定化することで、限外濾過性能試験を容易に実行できる。 Based on the pressures measured by the first pressure measuring means 40, the second pressure measuring means 40A and the third pressure measuring means 40B described above, the transmembrane pressure (also referred to as the transmembrane pressure) is calculated. be able to. This transmembrane pressure can be used to calculate the ultrafiltration performance of the filter. By stabilizing the pressure measurement by the first pressure measuring means 40 with the testing apparatus and testing method according to the present embodiment, an ultrafiltration performance test can be easily performed.
一実施例では、
膜間差圧ＴＭＰ＝（濾過器入口側圧力＋濾過器出口側圧力）／２－濾液側圧力
である。
In one example,
Transmembrane differential pressure TMP=(filter inlet side pressure+filter outlet side pressure)/2−filtrate side pressure.
そのうち、第１圧力測定手段４０で測定された圧力を上述した濾過器入口側圧力とし、第２圧力測定手段４０Ａで測定された圧力を上述した濾液側圧力とし、第３圧力測定手段４０Ｂで測定された圧力を濾過器出口側圧力としてもよい。 Among them, the pressure measured by the first pressure measuring means 40 is taken as the filter inlet side pressure described above, the pressure measured by the second pressure measuring means 40A is taken as the filtrate side pressure mentioned above, and the pressure is measured by the third pressure measuring means 40B. The resulting pressure may be used as the filter outlet side pressure.
本発明の試験装置及び試験方法は限外濾過性能の計測のみに用いられるとは限らず、例えば、本発明の試験装置及び試験方法は濾過器２０の阻止率の計測に用いられてもよいと理解すべきである。 The test apparatus and test method of the present invention are not limited to being used only for measuring ultrafiltration performance. For example, the test apparatus and test method of the present invention may be used to measure the rejection rate of the filter 20. should understand.
上述した実施形態は例示的なものにすぎず、本発明を限定するものではないと理解すべきである。本発明の示唆に基づく均等な変更及び改良は、すべて本発明の範囲内に属する。 It should be understood that the above-described embodiments are illustrative only and are not intended to limit the invention. All equivalent modifications and improvements based on the suggestions of the present invention are within the scope of the present invention.
１０ 試験液貯留容器
１２ 第１温度調整装置
２０ 濾過器
２１ 入力ポート
２２ 第１出力ポート
２３ 第２出力ポート
２４ 通液ポート
２５ 第２温度調整装置
３０ 試験液送液ライン
３１ 第１送液ライン
３２ 第２送液ライン
４０ 第１圧力測定手段
４１ 第１圧力計
４２ 第１チャンバー
４３ 第１圧力ライン
４０Ａ 第２圧力測定手段
４１Ａ 第２圧力計
４２Ａ 第２チャンバー
４３Ａ 第２圧力ライン
４０Ｂ 第３圧力測定手段
４１Ｂ 第３圧力計
４２Ｂ 第３チャンバー
４３Ｂ 第３圧力ライン
５０ 濾液送液ライン
５０Ｐ 濾液送液ポンプ
５１ 濾液収集容器
７０ 調整液貯留容器
８０ 調整液送液手段
８１ 調整液送液ライン
８２ 調整液送液ポンプ
９０ 廃液送液ライン
９０Ｐ 廃液送液ポンプ
９１ 廃液収集容器
１００ 試験液液面調整手段
１１０ 固定部
１２０ 昇降台
10 Test liquid storage container 12 First temperature adjustment device 20 Filter 21 Input port 22 First output port 23 Second output port 24 Liquid passage port 25 Second temperature adjustment device 30 Test liquid sending line 31 First liquid sending line 32 Second liquid supply line 40 First pressure measuring means 41 First pressure gauge 42 First chamber 43 First pressure line 40A Second pressure measuring means 41A Second pressure gauge 42A Second chamber 43A Second pressure line 40B Third pressure measurement Means 41B Third pressure gauge 42B Third chamber 43B Third pressure line 50 Filtrate sending line 50P Filtrate sending pump 51 Filtrate collecting container 70 Adjusting liquid reservoir 80 Adjusting liquid sending means 81 Adjusting liquid sending line 82 Adjusting liquid sending Liquid pump 90 Waste liquid sending line 90P Waste liquid sending pump 91 Waste liquid collecting container 100 Test liquid level adjusting means 110 Fixing part 120 Elevating table
Claims (17)
試験液が貯留される試験液貯留容器（１０）と、
一端が前記試験液貯留容器（１０）に接続され、他端が前記入力ポート（２１）に接続され、前記試験液貯留容器（１０）内の試験液が前記濾過膜の一次側へ送液される試験液送液ライン（３０）と、
前記試験液送液ライン（３０）での圧力を測定する第１圧力測定手段（４０）と、
前記第１出力ポート（２２）に一端が接続され、濾液が前記濾過器（２０）から出力される濾液送液ライン（５０）と、
前記濾液送液ライン（５０）に接続され、前記濾液を送液する濾液送液ポンプ（５０Ｐ）と、
調整液を前記試験液貯留容器（１０）へ送液する調整液送液手段（８０）と、を備え、
前記調整液送液手段（８０）は、前記試験液貯留容器（１０）の液面における圧力と、前記第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように前記調整液を送液する、試験装置。 A filter ( 20) The test device,
a test liquid storage container (10) in which the test liquid is stored;
One end is connected to the test liquid storage container (10), the other end is connected to the input port (21), and the test liquid in the test liquid storage container (10) is sent to the primary side of the filtration membrane. a test liquid feed line (30),
a first pressure measuring means (40) for measuring the pressure in the test liquid feeding line (30);
a filtrate liquid transfer line (50) having one end connected to the first output port (22) and having filtrate output from the filter (20);
a filtrate-sending pump (50P) connected to the filtrate-sending line (50) for sending the filtrate;
an adjustment liquid delivery means (80) for delivering an adjustment liquid to the test liquid storage container (10);
The adjustment liquid feeding means (80) is arranged so that the difference between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. A test device for feeding the adjustment liquid.
前記調整液が貯留される調整液貯留容器（７０）と、
をさらに備える、請求項１に記載の試験装置。 the filter (20);
an adjustment liquid storage container (70) in which the adjustment liquid is stored;
The test device of claim 1, further comprising:
第１圧力計（４１）と、
第１チャンバー（４２）と、
一端が前記第１圧力計（４１）に接続され、他端が前記第１チャンバー（４２）の接続端子に接続される第１圧力ライン（４３）と、を有し、
前記試験液送液ライン（３０）は、
一端が前記試験液貯留容器（１０）に接続され、他端が前記第１チャンバー（４２）の入力ポートに接続される第１送液ライン（３１）と、
一端が前記第１チャンバー（４２）の出力ポートに接続され、他端が前記濾過器（２０）の入力ポート（２１）に接続される第２送液ライン（３２）と、を有する、請求項２に記載の試験装置。 Said first pressure measuring means (40) comprises:
a first pressure gauge (41);
a first chamber (42);
a first pressure line (43) having one end connected to the first pressure gauge (41) and the other end connected to a connection terminal of the first chamber (42);
The test liquid feeding line (30) is
a first liquid sending line (31) having one end connected to the test liquid storage container (10) and the other end connected to the input port of the first chamber (42);
and a second liquid feeding line (32) having one end connected to the output port of the first chamber (42) and the other end connected to the input port (21) of the filter (20). 2. The test device according to 2.
前記調整液送液手段（８０）は、前記試験液貯留容器（１０）の液面（１１）の高さと、前記第１チャンバー（４２）の液面（３３）の高さと、が揃うように前記調整液を送液する、請求項３に記載の試験装置。 The connection terminal of the first chamber (42) is positioned vertically above the gas in the first chamber (42), and the test liquid is sent to the vertically lower portion of the first chamber (42),
The adjustment liquid feeding means (80) is arranged so that the height of the liquid level (11) of the test liquid storage container (10) and the height of the liquid level (33) of the first chamber (42) are aligned. The test device according to claim 3, which feeds the adjustment liquid.
一端が前記調整液貯留容器（７０）に接続され、他端が前記試験液貯留容器（１０）に接続される調整液送液ライン（８１）と、
前記調整液送液ライン（８１）に設置され、前記調整液貯留容器（７０）内の調整液を前記試験液貯留容器（１０）へ送液する調整液送液ポンプ（８２）と、を有する、請求項２～５のいずれか一項に記載の試験装置。 The adjustment liquid feeding means (80)
an adjustment liquid feed line (81) having one end connected to the adjustment liquid storage container (70) and the other end connected to the test liquid storage container (10);
an adjustment liquid delivery pump (82) installed in the adjustment liquid delivery line (81) for delivering the adjustment liquid in the adjustment liquid storage container (70) to the test liquid storage container (10). , the test device according to any one of claims 2 to 5.
前記第２出力ポート（２３）に一端が接続され、廃液が送液される廃液送液ライン（９０）をさらに備える、請求項１～６のいずれか一項に記載の試験装置。 The filter (20) further has a second output port (23) communicating with the primary side of the filtration membrane,
The test apparatus according to any one of claims 1 to 6, further comprising a waste liquid feeding line (90) having one end connected to the second output port (23) and through which a waste liquid is fed.
前記廃液送液ポンプ（９０Ｐ）の上流側に設置され、前記廃液送液ライン（９０）での圧力を測定する第３圧力測定手段（４０Ｂ）と、
をさらに備える、請求項７に記載の試験装置。 a waste liquid transfer pump (90P) installed in the waste liquid transfer line (90);
a third pressure measuring means (40B) installed upstream of the waste liquid transfer pump (90P) and measuring the pressure in the waste liquid transfer line (90);
8. The testing device of claim 7, further comprising:
試験液が貯留される試験液貯留容器（１０）と、
一端が前記試験液貯留容器（１０）に接続され、他端が前記入力ポート（２１）に接続され、前記試験液貯留容器（１０）内の試験液が前記濾過膜の一次側へ送液される試験液送液ライン（３０）と、
前記試験液送液ライン（３０）での圧力を測定する第１圧力測定手段（４０）と、
前記第１出力ポート（２２）に一端が接続され、濾液が前記濾過器（２０）から出力される濾液送液ライン（５０）と、
前記濾液送液ライン（５０）に接続され、前記濾液を送液する濾液送液ポンプ（５０Ｐ）と、
前記試験液貯留容器（１０）に接続され、前記試験液貯留容器（１０）の液面における圧力と、前記第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように前記試験液貯留容器（１０）の液面の位置を調整する試験液液面調整手段（１００）と、
を備える、試験装置。 A filter ( 20) The test device,
a test liquid storage container (10) in which the test liquid is stored;
One end is connected to the test liquid storage container (10), the other end is connected to the input port (21), and the test liquid in the test liquid storage container (10) is sent to the primary side of the filtration membrane. a test liquid feed line (30),
a first pressure measuring means (40) for measuring the pressure in the test liquid feeding line (30);
a filtrate liquid transfer line (50) having one end connected to the first output port (22) and having filtrate output from the filter (20);
a filtrate-sending pump (50P) connected to the filtrate-sending line (50) for sending the filtrate;
It is connected to the test liquid storage container (10) so that the difference between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. a test liquid level adjustment means (100) for adjusting the position of the liquid level of the test liquid storage container (10);
A testing device comprising:
前記試験液貯留容器（１０）を支持する昇降台（１２０）の昇降によって前記試験液貯留容器（１０）の液面の高さを調整する昇降手段、または、
前記試験液貯留容器（１０）である液袋を押圧することによって前記液袋内の液面の高さを調整する押圧手段
を有する、請求項１０に記載の試験装置。 The test liquid level adjusting means (100)
elevating means for adjusting the height of the liquid surface of the test liquid storage container (10) by elevating the lift platform (120) supporting the test liquid storage container (10);
11. The test apparatus according to claim 10, further comprising pressing means for adjusting the height of the liquid surface in the liquid bag by pressing the liquid bag that is the test liquid storage container (10).
前記入力ポート（２１）は、前記本体の軸方向の一端に設けられ、
前記第１出力ポート（２２）は、前記本体の外周に設けられ、
前記濾過器（２０）は、前記本体の中心軸が水平となるように設置されている、請求項１～１２のいずれか一項に記載の試験装置。 The filter (20) has a cylindrical body,
The input port (21) is provided at one axial end of the main body,
The first output port (22) is provided on the outer periphery of the main body,
The test apparatus according to any one of claims 1 to 12, wherein the filter (20) is installed so that the central axis of the body is horizontal.
前記濾過器（２０）を所定の第２温度に調節して保持するように収容する第２温度調整装置（２５）
をさらに備える、請求項１～１３のいずれか一項に記載の試験装置。 and/or
a second temperature regulating device (25) accommodating the filter (20) so as to regulate and maintain the filter (20) at a second predetermined temperature;
The test device according to any one of claims 1 to 13, further comprising:
前記第１出力ポート（２２）に接続される濾液陰圧手段で前記濾過器（２０）に陰圧を作用させることによって、試験液を、一端が試験液貯留容器（１０）に接続され、他端が前記入力ポート（２１）に接続される試験液送液ライン（３０）を介して、前記試験液貯留容器（１０）から前記濾過器（２０）へ吸引して濾過するステップと、
第１圧力測定手段（４０）で前記試験液送液ライン（３０）での圧力を測定するステップと、
前記試験液貯留容器（１０）の液面における圧力と、前記第１圧力測定手段（４０）の測定箇所における圧力と、の差が一定となるように前記試験液貯留容器（１０）の液面の位置を調整するステップと、
を含む、試験方法。 A filter ( 20) test method,
By applying a negative pressure to the filter (20) with the filtrate negative pressure means connected to the first output port (22), the test liquid is connected to the test liquid storage container (10) at one end and the other to the test liquid storage container (10). a step of sucking and filtering from the test liquid storage container (10) to the filter (20) through a test liquid feeding line (30) whose end is connected to the input port (21);
measuring the pressure in the test liquid feeding line (30) with a first pressure measuring means (40);
The liquid level of the test liquid storage container (10) is adjusted so that the difference between the pressure at the liquid level of the test liquid storage container (10) and the pressure at the measurement point of the first pressure measuring means (40) is constant. adjusting the position of the
test methods, including
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| FR2901607B1 (en) * | 2006-05-29 | 2008-09-12 | Univ Aix Marseill Iii Paul Cezanne | METHOD FOR CONTROLLING OR DETERMINING THE CHARACTERISTICS OF A ULTRAFILTRATION OR MICRO-FILTRATION MEMBRANE |
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| JP2000237502A (en) | 1999-02-22 | 2000-09-05 | Mitsubishi Rayon Co Ltd | Method and device for separating water and oil |
| WO2007080260A1 (en) | 2005-12-20 | 2007-07-19 | Degremont | Method and device for testing the integrity of filtration membranes |
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