CN105361891A - Blood glucose sensor planted in live fish eye ball sclera interstitial fluid and production method of blood glucose sensor - Google Patents
Blood glucose sensor planted in live fish eye ball sclera interstitial fluid and production method of blood glucose sensor Download PDFInfo
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- CN105361891A CN105361891A CN201510680579.5A CN201510680579A CN105361891A CN 105361891 A CN105361891 A CN 105361891A CN 201510680579 A CN201510680579 A CN 201510680579A CN 105361891 A CN105361891 A CN 105361891A
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Abstract
The invention provides a blood glucose sensor planted in live fish eye ball sclera interstitial fluid and a production method of the blood glucose sensor and aims to solve the problem that a blood glucose sensor planted into a fish body is difficult to measure the blood glucose concentration in the live fish body stably and in real time in the prior art. The blood glucose sensor comprises sensor base material and a wireless transmitting device electrically connected with the sensor base material. The sensor base material comprises a working electrode and a reference electrode. One end of the working electrode is provided with a sensing cavity. An insulating layer coats a part from the other end of the working electrode to the sensing cavity. The reference electrode wraps the outer surface of the insulating layer. The reference electrode comprises a copper wire on the outer surface of the insulating layer and a silver/silver chloride paste layer covering the copper wire. A perfluorosulfonate polymer membrane covers the outer surface of the sensing cavity of the working electrode, and a glucose oxidase layer covers the outer surface of the perfluorosulfonate polymer membrane. The blood glucose sensor planted in live fish eye ball sclera interstitial fluid is high in blood glucose detection accuracy and portability and good in stability.
Description
Technical field
The present invention relates to bio electrochemistry detection technique, particularly relate to one kind and plant blood glucose sensor in live fish eyeball scleral tissue interstitial fluid and preparation method.
Background technology
Fresh and alive fish, because of its delicious flavour, is of high nutritive value, and is rich in high-quality protein, favor that electrolytes and minerals receives consumers in general.Live fish blood sugar level is the important indicator of reflection live fish stress level in transportation.The blood sugar level that real-time radio monitoring obtains live fish updates the reference frame of fresh and alive fish On Transportaion of Live technology and equipment; Meanwhile, by biosensor technique and wireless communication technique, Wicresoft plants in fish body, and Real-Time Monitoring live fish each stage difference in transportation stress blood sugar level also be optimize On Transportaion of Live flow process important information acquiring technology further.But in the direct implanted live fish body of blood glucose sensor, sensor sensing position there will be the situation of haemproteins cohesion, thus reduces or inhibit sensor sensing electric current to export.Therefore direct fish body of being implanted by sensor is difficult to stablize, measure blood sugar concentration in live fish body in real time.
Summary of the invention
The invention provides one kind and plant blood glucose sensor in live fish eyeball scleral tissue interstitial fluid and preparation method, blood glucose sensor being implanted for solving in prior art the problem that fish body is difficult to stablize, measure in real time blood sugar concentration in live fish body.
In order to solve the problem:
On the one hand, a blood glucose sensor of planting in live fish eyeball scleral tissue interstitial fluid of the present invention, comprise: sensor substrate, and the radio transmitting device being used for transmission current signal is electrically connected with described sensor substrate, wherein, described sensor substrate comprises working electrode and reference electrode, induction cavity is set in an end of described working electrode, working electrode surface between from the other end of described working electrode to induction cavity is covered with insulating barrier, is enclosed with reference electrode at insulating barrier outer surface;
Described reference electrode is around in the copper wire of insulating barrier appearance by interval spiral, and the silver covering copper wire and lay/silver chloride pulp layer is formed; Be covered with perfluorinated sulfonic acid polymeric membrane at the induction cavity outer surface of described working electrode, be covered with glucose oxidase layer at the outer surface of described perfluorinated sulfonic acid polymeric membrane.
Further, the outer surface of described reference electrode is provided with insulate heat collapsible tube.
Further, described working electrode is platinoiridita working electrode, and the insulating barrier of working electrode outer surface is polytetrafluoroethylene floor.
Further, epoxy resin layer is covered with in the induction cavity outer end of described working electrode.
Further, described radio transmitting device comprises electrochemical signals amplifier, wireless transport module and plate and carries antenna, and wherein, described electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable; Described wireless transport module is connected with electrochemical signals amplifier electric; Described plate carries antenna and is electrically connected with wireless transport module.
Further, the diameter of described epoxy resin layer is 0.175mm-0.2mm, and length is 0.3mm-0.4mm.
Further, the length of described perfluorinated sulfonic acid polymeric membrane is 1mm-1.1mm.
Further, the diameter of described epoxy resin layer is 0.175mm, and length is 0.3mm.
Further, the length of described perfluorinated sulfonic acid polymeric membrane is 1mm.
On the other hand, the preparation method of a kind of blood glucose sensor of the present invention, comprises the following steps:
Take platinumiridio material to be made into working electrode, an end of the working electrode be made is set to induction cavity, and the working electrode surface between from the other end of described working electrode to induction cavity is covered with polytetrafluoroethylene floor;
The politef layer region of above-mentioned working electrode is wound around copper wire with interval spiral way, and forms reference electrode with silver/silver chloride pulp layer covering copper silk;
Epoxy resin layer is coated in the outer end of induction cavity, 5%-6% perfluorosulfonic acid type polymer solution is coated with, air-dry rear formation perfluorinated sulfonic acid polymeric membrane to the remaining region surface of induction cavity between from the outer end of induction cavity to polytetrafluoroethylene floor;
Be immersed in by the working electrode being covered with perfluorinated sulfonic acid polymeric membrane in the phosphate buffer of the 0.1mol/L0.25-3ml containing 2.5-3mg glucoseoxidase and 5-7mg bovine serum albumin after 10-15 minute, air-dry in atmosphere, this process repeats at least twice;
Working electrode induction cavity is immersed in 25%-30% glutaraldehyde solution and soaks 5h-6h;
One electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable;
One wireless transport module is connected with above-mentioned electrochemical signals amplifier electric;
One plate is carried antenna be electrically connected with above-mentioned wireless transport module.
Can be learnt by above-mentioned: adopt in the present invention between perfluorinated sulfonic acid polymeric membrane and glucose oxidase layer and there is excellent electric conductivity, the detection efficiency of blood glucose sensor can be improved.By means of the effect of glutaraldehyde cross-linking agent, by enzyme molecule is effectively fixing and the life-span is long.In addition, perfluorinated sulfonic acid polymeric membrane is thinner, has selective penetrated property, reduces the resistance of mass transfer resistance and electrode, greatly can improve the utilization rate of working electrode.Perfluorinated sulfonic acid polymeric membrane can allow hydrion pass through after water suction simultaneously, has high differential permeability but has repulsive interaction to anion, play certain protected effect to electrode to cation.This blood glucose sensor, in reference electrode, utilizes the copper wire of winding type with sensing bioelectrical signals preferably, can be convenient to follow-up current signal transfer.
Accompanying drawing explanation
Fig. 1 is the structural representation of blood glucose sensor described in the embodiment of the present invention 1;
Fig. 2 is the structural representation of working electrode end in Fig. 1;
Fig. 3 is the structural representation of blood glucose sensor described in the embodiment of the present invention 2
Fig. 4 is the dependency figure of blood sugar concentration change and current output sensor in live fish eyeball scleral tissue interstitial fluid;
Fig. 5 is the dependency figure of fish body blood and eyeball scleral tissue interstitial fluid (ESIF) blood sugar concentration.
In figure: 1, working electrode; 2, polytetrafluoroethylene floor; 3, silver/silver chloride pulp layer; 4, copper wire; 5, electrode cable; 6, electrochemical signals amplifier; 7, wireless transport module; 8, plate carries antenna; 9, perfluorinated sulfonic acid polymeric membrane; 10, glucose oxidase layer; 11, epoxy resin layer; 12, insulate heat collapsible tube.
Detailed description of the invention
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail.Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Fig. 1 and Fig. 2 shows the blood glucose sensor that described in the embodiment of the present invention 1, a kind is planted in live fish eyeball scleral tissue interstitial fluid, comprise: sensor substrate, and the radio transmitting device being used for transmission current signal is electrically connected with described sensor substrate, wherein, described sensor substrate comprises working electrode 1 and reference electrode, induction cavity is set in an end of described working electrode, the insulating barrier that working electrode surface between from the other end of described working electrode to induction cavity covers is polytetrafluoroethylene floor 2, is enclosed with reference electrode at insulating barrier outer surface.Described reference electrode is around in the copper wire 4 of insulating barrier appearance by interval spiral, and the silver/silver chloride pulp layer 3 covering copper wire and lay is formed; Be covered with perfluorinated sulfonic acid polymeric membrane 9 at the induction cavity outer surface of described working electrode, be covered with glucose oxidase layer 10 at the outer surface of described perfluorinated sulfonic acid polymeric membrane.
Be covered with epoxy resin layer 11 in the induction cavity outer end of described working electrode, perfluorinated sulfonic acid polymeric membrane 9 is covered with to the remaining region surface of induction cavity between from the outer end of induction cavity to polytetrafluoroethylene floor.Epoxy resin layer has contamination resistance, has certain protective action to sensor.Wherein, the diameter of described epoxy resin layer can be 0.175mm-0.2mm, and length is 0.3mm-0.4mm.The length of described perfluorinated sulfonic acid polymeric membrane is 1mm-1.1mm.
Described radio transmitting device comprises electrochemical signals amplifier 6, wireless transport module 7 and plate and carries antenna 8, and wherein, described electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable 5; Described wireless transport module is connected with electrochemical signals amplifier electric; Described plate carries antenna and is electrically connected with wireless transport module.
Above-mentioned blood glucose sensor is in use implanted in live fish eyeball scleral tissue interstitial fluid by less invasive techniques, blood glucose in glucose oxidase layer on working electrode induction cavity and eyeball scleral tissue interstitial fluid sends bio electrochemistry and reacts, and the weak current that reaction produces is by spreading out of effective current information with wireless transmission method after electrochemical signals amplifier processing and amplifying.
Due to the relational expression that the graph of a relation and end that determine flake ball scleral tissue interstitial fluid blood glucose and current output sensor according to many experiments result draw.As the graph of a relation repeatedly result produced by of Fig. 4 for obtaining in an experimentation.Summing up a linear regression relation formula according to Fig. 4 is: Y=5.414+0.05962X, and wherein, correlation coefficient is R=0.994, X is concentration of glucose, and Y is current output sensor.Therefore, above-mentioned relational expression is had can to estimate concentration of glucose in flake ball scleral tissue interstitial fluid according to current output sensor.From biological angle, because in the concentration of glucose in flake ball scleral tissue interstitial fluid and fish body, concentration of glucose is closely-related, as shown in Figure 5, its relation can be expressed as Y=-0.2996+0.9439X by linear regression mode equally, wherein, correlation coefficient is R=0.961, and the sample point N=111 of test is individual, X is fish body blood sugar concentration, and Y is the blood sugar concentration in eyeball scleral tissue interstitial fluid.Therefore, above-mentioned relational expression is had just can to estimate fish body blood sugar concentration.
Adopt in the present embodiment between perfluorinated sulfonic acid polymeric membrane and glucose oxidase layer and there is the detection efficiency that excellent electric conductivity improves blood glucose sensor.By means of the effect of glutaraldehyde cross-linking agent, by enzyme molecule is effectively fixing and the life-span is long.In addition, perfluorinated sulfonic acid polymeric membrane is thinner, has selective penetrated property, reduces the resistance of mass transfer resistance and electrode, greatly can improve the utilization rate of working electrode.Perfluorinated sulfonic acid polymeric membrane can allow hydrion pass through after water suction simultaneously, has high differential permeability but has repulsive interaction to anion, play certain protected effect to electrode to cation.This blood glucose sensor, in reference electrode, utilizes the copper wire of winding type with sensing bioelectrical signals preferably, can be convenient to follow-up current signal transfer.
One kind described in the embodiment of the present invention 2 shown in Fig. 3 blood glucose sensor of planting in live fish eyeball scleral tissue interstitial fluid.The present embodiment is compared embodiment 1 difference and is: the outer surface of described reference electrode is provided with insulate heat collapsible tube 12.Insulate heat collapsible tube can prevent interstitial fluid to the erosion damage of sensor element.
A kind of preparation method of blood glucose sensor described in embodiment 4, comprises the following steps:
Take platinumiridio material to be made into working electrode, an end of the working electrode be made is set to induction cavity, and the working electrode surface between from the other end of described working electrode to induction cavity is covered with polytetrafluoroethylene floor;
The politef layer region of above-mentioned working electrode is wound around copper wire with interval spiral way, and forms reference electrode with silver/silver chloride pulp layer covering copper silk;
Epoxy resin layer is coated in the outer end of induction cavity, 5%-6% perfluorosulfonic acid type polymer solution is coated with, air-dry rear formation perfluorinated sulfonic acid polymeric membrane to the remaining region surface of induction cavity between from the outer end of induction cavity to polytetrafluoroethylene floor;
Be immersed in by the working electrode being covered with perfluorinated sulfonic acid polymeric membrane in the phosphate buffer of the 0.1mol/L0.25-3ml containing 2.5-3mg glucoseoxidase and 5-7mg bovine serum albumin after 10-15 minute, air-dry in atmosphere, this process repeats at least twice;
Working electrode induction cavity is immersed in 25%-30% glutaraldehyde solution and soaks 5h-6h;
One electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable;
One wireless transport module is connected with above-mentioned electrochemical signals amplifier electric;
One plate is carried antenna be electrically connected with above-mentioned wireless transport module.
By above-mentioned steps for the preparation of the blood glucose sensor of planting in live fish eyeball scleral tissue interstitial fluid.
In addition, those skilled in the art can understand, although embodiments more described herein to comprise in other embodiment some included feature instead of further feature, the combination of the feature of different embodiment means and to be within scope of the present invention and to form different embodiments.Such as, in the following claims, the one of any of embodiment required for protection can use with arbitrary compound mode.
The present invention will be described instead of limit the invention to it should be noted above-described embodiment, and those skilled in the art can design alternative embodiment when not departing from the scope of claims.In the claims, any reference marks between bracket should be configured to limitations on claims.Word " comprises " not to be got rid of existence and does not arrange element in the claims or step.Word "a" or "an" before being positioned at element is not got rid of and be there is multiple such element.The present invention can by means of including the hardware of some different elements and realizing by means of the computer of suitably programming.In the unit claim listing some devices, several in these devices can be carry out imbody by same hardware branch.Word first, second and third-class use do not represent any order.Can be title by these word explanations.
One of ordinary skill in the art will appreciate that: above each embodiment, only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to foregoing embodiments to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein some or all of technical characteristic; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of the claims in the present invention.
Claims (10)
1. plant the blood glucose sensor in live fish eyeball scleral tissue interstitial fluid for one kind, it is characterized in that, comprise: sensor substrate, and the radio transmitting device being used for transmission current signal is electrically connected with described sensor substrate, wherein, described sensor substrate comprises working electrode and reference electrode, induction cavity is set in an end of described working electrode, working electrode surface between from the other end of described working electrode to induction cavity is covered with insulating barrier, is enclosed with reference electrode at insulating barrier outer surface;
Described reference electrode is around in the copper wire of insulating barrier appearance by interval spiral, and the silver covering copper wire and lay/silver chloride pulp layer is formed; Be covered with perfluorinated sulfonic acid polymeric membrane at the induction cavity outer surface of described working electrode, be covered with glucose oxidase layer at the outer surface of described perfluorinated sulfonic acid polymeric membrane.
2. blood glucose sensor according to claim 1, is characterized in that, the outer surface of described reference electrode is provided with insulate heat collapsible tube.
3. blood glucose sensor according to claim 1, is characterized in that, described working electrode is platinoiridita working electrode, and the insulating barrier of working electrode outer surface is polytetrafluoroethylene floor.
4. blood glucose sensor according to claim 1, is characterized in that, is covered with epoxy resin layer in the induction cavity outer end of described working electrode.
5. blood glucose sensor according to claim 1, it is characterized in that, described radio transmitting device comprises electrochemical signals amplifier, wireless transport module and plate and carries antenna, and wherein, described electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable; Described wireless transport module is connected with electrochemical signals amplifier electric; Described plate carries antenna and is electrically connected with wireless transport module.
6. blood glucose sensor according to claim 4, is characterized in that, the diameter of described epoxy resin layer is 0.175mm-0.2mm, and length is 0.3mm-0.4mm.
7. blood glucose sensor according to claim 1, is characterized in that, the length of described perfluorinated sulfonic acid polymeric membrane is 1mm-1.1mm.
8. blood glucose sensor according to claim 6, is characterized in that, the diameter of described epoxy resin layer is 0.175mm, and length is 0.3mm.
9. blood glucose sensor according to claim 7, is characterized in that, the length of described perfluorinated sulfonic acid polymeric membrane is 1mm.
10. a preparation method for blood glucose sensor, is characterized in that, comprises the following steps:
Take platinumiridio material to be made into working electrode, an end of the working electrode be made is set to induction cavity, and the working electrode surface between from the other end of described working electrode to induction cavity is covered with polytetrafluoroethylene floor;
The politef layer region of above-mentioned working electrode is wound around copper wire with interval spiral way, and forms reference electrode with silver/silver chloride pulp layer covering copper silk;
Epoxy resin layer is coated in the outer end of induction cavity, 5%-6% perfluorosulfonic acid type polymer solution is coated with, air-dry rear formation perfluorinated sulfonic acid polymeric membrane to the remaining region surface of induction cavity between from the outer end of induction cavity to polytetrafluoroethylene floor;
Be immersed in by the working electrode being covered with perfluorinated sulfonic acid polymeric membrane in the phosphate buffer of the 0.1mol/L0.25-3ml containing 2.5-3mg glucoseoxidase and 5-7mg bovine serum albumin after 10-15 minute, air-dry in atmosphere, this process repeats at least twice;
Working electrode induction cavity is immersed in 25%-30% glutaraldehyde solution and soaks 5h-6h;
One electrochemical signals amplifier is connect with working electrode, reference electrode electrical respectively by electrode cable;
One wireless transport module is connected with above-mentioned electrochemical signals amplifier electric;
One plate is carried antenna be electrically connected with above-mentioned wireless transport module.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110101847.9A CN112932477A (en) | 2015-10-19 | 2015-10-19 | Blood glucose sensor implanted in interocular scleral interstitial fluid of live fish eyeball and preparation method thereof |
| CN201510680579.5A CN105361891A (en) | 2015-10-19 | 2015-10-19 | Blood glucose sensor planted in live fish eye ball sclera interstitial fluid and production method of blood glucose sensor |
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| CN201510680579.5A CN105361891A (en) | 2015-10-19 | 2015-10-19 | Blood glucose sensor planted in live fish eye ball sclera interstitial fluid and production method of blood glucose sensor |
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| CN201510680579.5A Pending CN105361891A (en) | 2015-10-19 | 2015-10-19 | Blood glucose sensor planted in live fish eye ball sclera interstitial fluid and production method of blood glucose sensor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106706726A (en) * | 2016-12-09 | 2017-05-24 | 中国农业大学 | Method and device for monitoring blood glucose in water-free keep-alive transportation process of aquatic products |
| CN111870238A (en) * | 2019-05-03 | 2020-11-03 | 乌宁 | Implanted biosensor and manufacturing method thereof |
| WO2022252744A1 (en) * | 2019-08-19 | 2022-12-08 | Medtrum Technologies Inc. | Analyte detection device |
| CN117969629A (en) * | 2024-04-02 | 2024-05-03 | 四川省疾病预防控制中心(四川省预防医学科学研究院四川省卫生监测检验中心) | System and method for detecting physiological index |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114767105B (en) * | 2022-06-22 | 2022-10-14 | 苏州百孝医疗科技有限公司 | Implantable electrochemical biosensor, testing method and implantable medical device |
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| US5165407A (en) * | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
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- 2015-10-19 CN CN201510680579.5A patent/CN105361891A/en active Pending
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| CN103687958A (en) * | 2011-04-18 | 2014-03-26 | 诺威奥森斯有限公司 | Biosensor |
| WO2014041190A1 (en) * | 2012-09-17 | 2014-03-20 | Brains Online Holding B.V. | Rod shaped implantable biosensor |
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| CN106706726A (en) * | 2016-12-09 | 2017-05-24 | 中国农业大学 | Method and device for monitoring blood glucose in water-free keep-alive transportation process of aquatic products |
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| CN111870238A (en) * | 2019-05-03 | 2020-11-03 | 乌宁 | Implanted biosensor and manufacturing method thereof |
| WO2022252744A1 (en) * | 2019-08-19 | 2022-12-08 | Medtrum Technologies Inc. | Analyte detection device |
| CN117969629A (en) * | 2024-04-02 | 2024-05-03 | 四川省疾病预防控制中心(四川省预防医学科学研究院四川省卫生监测检验中心) | System and method for detecting physiological index |
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Application publication date: 20160302 |