CN211339513U - Novel cell counting and identifying equipment - Google Patents
Novel cell counting and identifying equipment Download PDFInfo
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- CN211339513U CN211339513U CN201921542389.7U CN201921542389U CN211339513U CN 211339513 U CN211339513 U CN 211339513U CN 201921542389 U CN201921542389 U CN 201921542389U CN 211339513 U CN211339513 U CN 211339513U
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Abstract
The utility model discloses a novel cell counting and identifying device, which comprises a capillary tube, a containing cavity, a joint, a probe, a connecting tube and a top cover, wherein the side parts of the capillary tube and the containing cavity are connected and are jointly inserted into the end part of the joint; after the solution enters the bypass connecting channel through the capillary tube, the solution generates an electric signal after contacting with the detection end of the probe, then enters the central connecting channel and finally flows into the accommodating cavity. Compared with the prior art, the utility model discloses technical scheme has advantages such as compact structure, the simple and easy and cost of operation is lower, can effectively improve solution particle detection convenience and detect the precision and reduce use cost.
Description
Technical Field
The utility model relates to a cell detection technology field, in particular to novel cell count and identification equipment.
Background
The requirements of modern high-precision machinery on a dust-free environment, PM2.5 detection in air and the technical field of biomedicine on cell research and the like all put forward more urgent demands on the particle number and state research in the micro field, particularly, the counting technology of the micro particles is particularly important, and the methods applied to counting the micro particles in the prior art comprise a blood cell counting method, a light scattering particle counter, a Coulter principle and the like.
The blood counting method is based on a blood counting chamber for counting, the blood counting chamber can be used for carrying out microscopic counting on red blood cells and white blood cells in a human body and is also commonly used for calculating the quantity of microorganisms such as bacteria, fungi, yeasts and the like, so the method is a common biological tool.
The light scattering particle counter focuses light from the light source into the measuring cavity of the sensor, and a vacuum device is arranged at the outlet of the sensor, so that air is pumped away after passing through the sensor, and when each particle in the air rapidly passes through the measuring cavity, the incident light is scattered once, so that an optical pulse signal is formed. The scattered light is focused on the photoelectric detector by the following condenser lens, then the light is converted into a voltage signal, finally the microprocessor connects the counter to a control data collection system through an interface, finally the data is displayed through a counting system, and finally the counting work of a large number of electric pulses is completed.
However, the prior art blood cell counting method requires manual operation, so the counting operation process is complicated, and in order to improve the counting precision, on one hand, multiple and repeated operations are required, and on the other hand, the blood cell counting method also requires professional personnel to perform so as to ensure the final counting accuracy, so the blood cell counting method takes a long time. The counting method of the light scattering particle counter has low calculation result accuracy, and the detection result of the method is more biased to detection of one order of magnitude, so that the design and manufacture of a single peripheral device are required, and the overall cost is relatively high.
Therefore, under the condition of ensuring certain cell counting precision, the method has important significance for improving the convenience of cell counting equipment operation and simplifying the equipment to the maximum extent.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a compact structure, simple and easy and lower novel cell count of cost and identification equipment of operation, aim at improving solution particle detection convenience and detect the precision and reduce use cost.
In order to achieve the purpose, the utility model provides a novel cell counting and identifying device, which comprises a capillary tube, a containing cavity, a joint, a probe, a connecting pipe and a top cover, wherein the side parts of the capillary tube and the containing cavity are connected with each other and are jointly inserted into the end part of the joint; after the solution enters the bypass connecting channel through the capillary tube, the solution generates an electric signal after contacting with the detection end of the probe, then enters the central connecting channel and finally flows into the accommodating cavity.
Preferably, the detection device comprises a first I-V converter and a second I-V converter electrically connected with the probe, the first I-V converter and the second I-V converter are respectively connected in parallel with a resistor and grounded, the first I-V converter is further connected with the anode of a differential amplifier, the second I-V converter is connected with the cathode of the differential amplifier, the detection device further comprises an envelope detector, a first amplifier, a high-pass filter, a second amplifier, a low-pass filter, a third amplifier and a signal acquisition and display which are sequentially connected, and the differential amplifier is further connected with one end of the envelope detector.
Preferably, the detection end of the probe is provided with a step groove, and the surface of the step groove is provided with a plating electrode which is opposite to the outlet end of the bypass connecting channel and is contacted with the circulated solution.
Preferably, the capillary and the side part of the containing cavity are connected through a connecting block, and the top part of the connecting block, the upper part of the capillary and the upper part of the containing cavity form a groove and can be abutted against the inside of the joint.
Preferably, the bottom end of the connecting pipe is connected with the top end of the connector in a threaded fit manner, and the top end of the connecting pipe is connected with the top cover in a threaded fit manner.
Preferably, the accommodating cavity is made of a soft material.
Preferably, the top end of the probe is provided with a positioning block which is embedded, positioned and installed with the joint.
The utility model discloses technical scheme prior art has following advantage relatively:
the utility model discloses technical scheme produces through holding the chamber and warp and produce the negative pressure to center interface channel and bypass interface channel to make the solution that has the particle flow through capillary, bypass interface channel and center interface channel, and finally detected and produce the signal of telecommunication by the electrode that plates of probe, thereby can realize convenient tally function through the detection device who links to each other with the probe.
The utility model discloses technical scheme uses the signal of telecommunication to count, and the counting process can conveniently go on through solution flow process, and the operation process is simple and easy more and the testing result is reliable. Furthermore the utility model discloses technical scheme's novel cell count and identification facilities overall structure are compact and conveniently carry, can conveniently dismantle the replacement through the bottom structure, make detection cost and whole manufacturing cost reduce and have bigger range of application.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic perspective view of the novel cell counting and identification device of the present invention;
FIG. 2 is an exploded view of the novel cell counting and identification device of the present invention;
FIG. 3 is a sectional view of the internal structure of the novel cell counting and identification device of the present invention;
fig. 4 is a schematic diagram of the internal circuit structure of the detection device of the present invention.
The reference numbers illustrate:
the objects, features and advantages of the present invention will be further described with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
It should be noted that, if directional indications (such as upper, lower, left, right, front and rear … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.
The utility model provides a novel cell count and identification equipment.
Referring to fig. 1 to 3, the novel cell counting and identification device according to an embodiment of the present invention includes a capillary 7, a receiving chamber 5, a connector 3, a probe 4, a connecting tube 2, and a top cap 1, wherein the capillary 7 and the receiving chamber 5 are connected laterally and can be inserted together into the end of the connector 3. Specifically, the end position of the joint 3 of the present embodiment is provided with a groove to be connected with the capillary 7 and the accommodating cavity 5 in a matching manner, and a central connecting channel 31 is axially arranged in the center of the joint 3 and extends from the top end to the bottom end of the joint and into the accommodating cavity 5, a bypass connecting channel 32 is further arranged in the joint 3, wherein the upper part of the bypass connecting channel 32 is communicated with the central connecting channel 31, the bottom end of the bypass connecting channel 32 extends to the bottom end of the joint 3, and in addition, the bottom end of the bypass connecting channel 32 is communicated with the center of the capillary 7. The top end of the probe 4 of the present embodiment is matched with the top of the connector 3 for positioning and installation, while the lower structure of the probe 4 extends into the central connecting channel 31, and the plated electrode 41 at the bottom of the probe 4 is opposite to the bypass connecting channel 32, so that the probe can be used for detecting the solution and generating an electric signal. The inside equipment fixing cavity 21 that is equipped with of connecting pipe 2 that links to each other with connecting 3 top to install detection device and probe 4 electricity in the equipment fixing cavity 21 and be connected, consequently can be used for the function of detected signal and through the inside circuit realization count of detection device with probe 4 cooperation work, and the top of connecting pipe 2 still links to each other with top cap 1.
Wherein the detection device of the embodiment comprises a first I-V converter 8 and a second I-V converter 9 which are electrically connected with the probe 4, the first I-V converter 8 and the second I-V converter 9 are respectively connected with a resistor in parallel, one end of the first I-V converter is grounded, the first I-V converter 8 is also connected with the anode of a differential amplifier 10, the second I-V converter 9 is connected with the cathode of the differential amplifier 10, the differential amplifier 10 is also connected with one end of an envelope detector 11, the other end of the envelope detector 11 is connected with one end of a first amplifier 12, the other end of the first amplifier 12 is connected with one end of a high-pass filter 13, the other end of the high-pass filter 13 is connected with one end of a second amplifier 14, the other end of the second amplifier 14 is connected with one end of a low-pass filter 15, the other end of the low-, the other end of the third amplifier 16 is connected with one end of a signal acquisition and display device 17.
When the novel cell counting and identifying device of the embodiment is used for detecting particles in a solution, the accommodating cavity 5 is pressed, so that negative pressure is generated in the central connecting channel 31 and the bypass connecting channel 32, the solution can be upwards adsorbed by the capillary 7 connected with the bypass connecting channel 32, the solution can sequentially pass through the capillary 7, the bypass connecting channel 32 and the central connecting channel 31, the outlet end of the bypass connecting channel 32 of the embodiment is connected with the middle part of the central connecting channel 31, and the outlet end of the bypass connecting channel 32 is opposite to the plating electrode 41 of the probe 4, so that the particles of the solution can be contacted with the plating electrode 41 of the probe 4 when entering the central connecting channel 31 from the bypass connecting channel 32, the probe 4 generates a pulse signal, the pulse signal is detected by the detecting device, and finally the quantity of the particles contained in the solution can be conveniently detected and the counting effect can be achieved, and the detected solution will enter the receiving chamber 5 through the central connecting channel 31. After the detection is finished, the accommodating cavity 5 and the capillary tube 7 can be conveniently replaced by pulling the end part of the joint 3 downwards together with the accommodating cavity 5 and the capillary tube 7.
Wherein, the capillary 7 of this embodiment with hold 5 lateral parts of chamber and pass through connecting block 6 and link to each other to the top of connecting block 6 and capillary 7 with hold between the 5 upper portions of chamber form the recess can with connect 3 inner structure offseting location, thereby can realize capillary 7 and hold chamber 5 and conveniently install in connecting 3 inside and fix a position, prevent that the chamber 5 and capillary 7 that hold of testing process from deviating from the joint downwards.
Preferably, the bottom end of the connection pipe 2 of the present embodiment is connected to the end of the connector 3 by screw-fitting, and the top end of the connection pipe 2 is connected to the top cover 1 by screw-fitting, so that different detection devices can be quickly installed and replaced between the upper portion of the connection pipe 2 and the top cover 1 and between the lower portion of the connection pipe 2 and the connector 3.
In addition, the chamber 5 material that holds of this embodiment is made for soft materials, because the novel cell count and identification equipment at this embodiment detect the in-process, need extrude holding chamber 5, consequently through will holding the material of chamber 5 and inject soft materials in order to conveniently extrude holding chamber 5 and produce negative pressure state and can further improve and hold the sealing performance between chamber 5 and the joint 3. In addition the utility model discloses an in other embodiments, it can also be provided with to set up to evacuation structure to hold 5 bottoms in chamber, also be provided with sealed pull mechanism just holding the chamber bottom, also can realize producing negative pressure power to center connecting channel 31, bypass connecting channel 32 and capillary 7 like this to drive solution loops through capillary 7, bypass connecting channel 32 and center connecting channel 31 and finally makes the inside particle of solution detected.
In addition, the top end of the probe 4 of the embodiment is provided with a positioning block 42 to be embedded, positioned and installed with the joint 3, so that the installation position of the probe 4 can be limited, and the plated electrode 41 of the probe 4 is ensured to be opposite to the bypass connecting channel 32.
The above only is the preferred embodiment of the present invention, not so limiting the patent scope of the present invention, all under the concept of the present invention, the equivalent structure transformation made by the contents of the specification and the drawings is utilized, or the direct/indirect application is included in other related technical fields in the patent protection scope of the present invention.
Claims (7)
1. A novel cell counting and identifying device is characterized by comprising a capillary tube, an accommodating cavity, a joint, a probe, a connecting pipe and a top cover, wherein the side parts of the capillary tube and the accommodating cavity are connected and are jointly inserted into the end part of the joint; after the solution enters the bypass connecting channel through the capillary tube, the solution generates an electric signal after contacting with the detection end of the probe, then enters the central connecting channel and finally flows into the accommodating cavity.
2. The novel cell counting and identification device of claim 1, wherein the detection device comprises a first I-V converter and a second I-V converter electrically connected to the probe, the first I-V converter and the second I-V converter are respectively connected in parallel with a resistor and grounded, the first I-V converter is further connected to the positive pole of the differential amplifier, the second I-V converter is connected to the negative pole of the differential amplifier, the detection device further comprises an envelope detector, a first amplifier, a high-pass filter, a second amplifier, a low-pass filter, a third amplifier and a signal acquisition and display, which are connected in sequence, and the differential amplifier is further connected to one end of the envelope detector.
3. The novel cell counting and identification device as claimed in claim 1, wherein the detection end of the probe is provided with a step groove, and the surface of the step groove is provided with a plated electrode which is opposite to the outlet end of the bypass connecting channel and is contacted with the circulating solution.
4. The novel cell counting and identification device of claim 1, wherein the capillary and the side of the receiving chamber are connected by a connecting block, and the top of the connecting block forms a groove with the upper part of the capillary and the upper part of the receiving chamber and can be positioned against the inside of the connector.
5. The novel cell counting and identification device of claim 1 wherein said bottom end of said connecting tube is threadably engaged with said top end of said connector and said top end of said connecting tube is threadably engaged with said top cap.
6. The novel cell counting and identification device of claim 1 wherein the containment chamber is made of a soft material.
7. The novel cell counting and identification device as claimed in claim 1, wherein the probe has a positioning block at its top end for mounting with the connector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921542389.7U CN211339513U (en) | 2019-09-17 | 2019-09-17 | Novel cell counting and identifying equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921542389.7U CN211339513U (en) | 2019-09-17 | 2019-09-17 | Novel cell counting and identifying equipment |
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| Publication Number | Publication Date |
|---|---|
| CN211339513U true CN211339513U (en) | 2020-08-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921542389.7U Expired - Fee Related CN211339513U (en) | 2019-09-17 | 2019-09-17 | Novel cell counting and identifying equipment |
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| CN (1) | CN211339513U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110628593A (en) * | 2019-09-17 | 2019-12-31 | 广东工业大学 | Novel cell counting and identifying equipment |
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2019
- 2019-09-17 CN CN201921542389.7U patent/CN211339513U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110628593A (en) * | 2019-09-17 | 2019-12-31 | 广东工业大学 | Novel cell counting and identifying equipment |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200825 Termination date: 20210917 |