CN117959403A - 一种治疗奶牛子宫内膜炎的药物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗奶牛子宫内膜炎的药物及其制备方法,其包括以下重量份的组分:蒲黄炭4‑15份、五灵脂4‑15份、泽兰4‑15份、桃仁4‑15份、红花4‑15份、莪术4‑15份、甘草1‑5份、卷柏4‑15份、赤芍8‑25份、川芎4‑15份、续断4‑15份、枳壳4‑15份、阿胶6‑20份。本发明的药物组方合理,制备工艺简单,治愈率高,药物无残留,无毒副作用;本发明以活血通经、凉血散瘀、补血行气、利水止带为组方原则,能够增强机体的免疫功能,提高对细菌感染的抵抗力,有效的治疗奶牛急慢性子宫内膜炎,产后服用还能够预防奶牛子宫内膜炎的发生,同时提高受孕率和乳汁的质量。
Description
技术领域
本发明属于兽药技术领域,具体涉及一种治疗奶牛子宫内膜炎的药物及其制备方法。
背景技术
奶牛子宫内膜炎是由于母牛分娩时或产后微生物感染所引起的子宫内膜的炎症,可以发生在繁殖过程的各个环节,且发病率高,危害大,是导致小产的主要因素。奶牛子宫内膜炎是奶牛生殖系统中的常见疾病,发病率高达20%-40%,严重地影响奶牛的繁殖力和生产性能,其危害主要表现为,不仅会影响到牛只的繁殖能力,使奶牛产犊间隔延长、产奶量减少、奶牛不孕、增加治疗费用、配种费用,淘汰率增加。1)母牛子宫内膜炎可以引起繁殖障碍,产后发情延迟,70~80%的子宫内膜炎患牛会超过60天以后才发情,而且会发生屡配不孕的现象,从而增加配种次数,增加配种费用,30~40%的子宫内膜炎患牛都要进行2次以上才能怀孕妊娠。2)产犊间隔时间延长,正常情况下,母牛12~13个月就会产犊一次,如果发生子宫内膜炎,导致多次配种不孕,增加了牛只的空怀时间,增加未怀胎情况下的饲养成本增加,奶牛则会造成产奶量的巨大损失,年产差异2~3吨。3)子宫内膜炎久治不愈,就会失去经济价值,就要面临淘汰处理,每年淘汰的奶牛中大约有30%以上是因为子宫内膜炎造成的。
目前,子宫内膜炎的治疗方法有局部疗法、全身疗法和生物学疗法,治疗药物主要有抗生素、激素、防腐消毒药及中草药,这些药物对奶牛子宫内膜炎都有一定的疗效,但也有许多缺点。抗生素和激素在治疗奶牛子宫内膜炎方面发挥着巨大的作用,但随着其应用时间的延长,不但出现了毒副作用和耐药性,引起奶牛生殖内分泌功能紊乱,而且易在牛奶中残留,疗效降低,甚至造成弃奶或降低奶价出售,残留严重时还会危害人类的健康。中草药因具有抗菌、消炎,不易产生耐药性,低毒、无残留或低残留等特点,被国内外研究人员所关注。市面上治疗子宫内膜炎的中药很有限,而且传统剂型的治疗效果也不理想。
发明内容
有鉴于此,本发明的目的之一在于提出一种治疗奶牛子宫内膜炎的药物及其制备方法,其治愈率高,药物无残留,无毒副作用;对各种类型急性子宫内膜炎或慢性子宫内膜炎均有明显的预防和治疗作用,同时提高受孕率和乳汁的质量。
为实现上述目的,本发明采用以下方案:
一种治疗奶牛子宫内膜炎的药物,其特征在于,包括以下重量份的组分:蒲黄炭4-15份、五灵脂4-15份、泽兰4-15份、桃仁4-15份、红花4-15份、莪术4-15份、甘草1-5份、卷柏4-15份、赤芍8-25份、川芎4-15份、续断4-15份、枳壳4-15份、阿胶6-20份。优选的,包括以下重量份的组分:蒲黄炭6-12份、五灵脂6-12份、泽兰6-12份、桃仁6-12份、红花6-12份、莪术6-12份、甘草1-5份、卷柏6-12份、赤芍10-20份、川芎6-12份、续断6-12份、枳壳6-12份、阿胶9-15份。更优选的,包括以下重量份的药物:蒲黄炭9份、五灵脂9份、泽兰9份、桃仁9份、红花9份、莪术9份、甘草3份、卷柏9份、赤芍15份、川芎9份、续断9份、枳壳9份、阿胶12份。
进一步的,所述的治疗奶牛子宫内膜炎的药物,其特征在于:所述药物的剂型为散剂、汤剂、灌肠剂、子宫灌注剂、栓剂、泡腾片或凝胶剂。
本发明还提供了所述治疗奶牛子宫内膜炎的药物的制备方法,包括以下步骤:将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳、阿胶药材,分别粉碎成细粉,混匀,制备成散剂,分装,即得。
本发明还提供了所述治疗奶牛子宫内膜炎的药物的制备方法,包括以下步骤:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,干燥,粉碎成干膏粉,备用;
2)将阿胶粉碎成细粉,备用;
3)将上述提取干膏粉与阿胶粉碎粉混匀,用常规方法制备成颗粒剂,分装,即得。
本发明还提供了所述治疗奶牛子宫内膜炎的药物的制备方法,包括以下步骤:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,备用;
2)将阿胶加适量水加热烊化,备用;
3)将上述浓缩液与阿胶烊化液混匀,用常规方法制备成口服液或子宫灌注剂,分装,即得。
本发明还提供了所述治疗奶牛子宫内膜炎的药物的制备方法,包括以下步骤:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并回收回流液,浓缩至无醇味,继续浓缩至干,得到浸膏;粉碎,过筛,得到干燥药粉一;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,干燥;粉碎,过筛,得到干燥药粉二;
3)将阿胶粉碎成细粉,备用;
4)将干燥药粉一、干燥药粉二、阿胶粉加入到栓剂基质和表面活性剂中,充分混合,得到热混合物;将热混合物定型制成栓剂。
本发明还提供了所述治疗奶牛子宫内膜炎的药物的制备方法,包括以下步骤:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并醇提液,并加入阿胶加热烊化,浓缩至无醇味,得醇提液,药渣备用;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液和上述醇提液,减压浓缩至折合原药材浓度约2-4g/mL的浸膏;
3)将浸膏加入到栓剂基质和表面活性剂中,充分混合,得到热混合物;将热混合物定型制成栓剂;上述栓剂是由35%~45%的浸膏与3%~6%吐温80、20%~30%聚乙二醇400、30%~40%脂肪酸甘油酯组成;所述脂肪酸甘油酯包括36号混合脂肪酸甘油酯、38号混合脂肪酸甘油酯或半合成脂肪酸甘油酯中的一种或多种。
本发明另一方面还提供了所述药物在制备治疗奶牛急慢性子宫内膜炎药物中的应用。
本发明中的药物的组分说明:
蒲黄炭为蒲黄的炮制品。蒲黄取原药材,揉碎结块过筛,拣去杂质。取净蒲黄粉末,置炒药锅内,用武火炒至全部显棕褐色,存性,喷淋清水少许,灭净火星,取出,放干铁盘里,用铲搅拌散热,待烟尽后,过铁丝筛,将结块揉碎,摊晾凉,晒干,即为蒲黄炭。炒炭后,止血功能增强。蒲黄性滑,长于行血,蒲黄炭味涩,善能止血,故肿瘤患者症属瘀血停滞为主,宜生用;若以失血之症为主,则宜炒用。性味甘平,入肝、心经。功用止血、活血、利尿。用于吐血、衄血,咯血、便血、尿血、崩漏及创伤出血、脘腹疼痛、产后血阏腹痛及痛经、血淋。蒲黄生用性滑,长于行血,炒用味涩,善能止血,若以失血之症为主,则宜炒用。
五灵脂为鼯鼠科动物橙足鼯鼠和飞鼠等的干燥粪便。苦甘,温。功能主治为:生用行血止痛。治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤。炒用止血。治妇女血崩,经水过多,赤带不绝。《开宝本草》:主疗心腹冷气,小儿五疳,辟疫,治肠风,通利气脉,女子月闭。《本草衍义补遗》:能行血止血。治心腹冷气,妇人心痛,血气刺痛。《本草蒙筌》:行血宜生,止血须炒,通经闭及治经行不止;定产妇血晕,除小儿疳蛔。《纲目》:纲目》:止妇人经水过多,赤带不绝,胎前产后,血气诸痛;男女一切心腹、胁肋。少腹诸痛,疝痛,血痢、肠风腹痛。
泽兰,为唇形科植物毛叶地瓜儿苗Lycopus lucidus Turcz.vat.hirtus Regel的干燥地上部分。性味苦、辛,微温。归肝、脾经。功效活血调经,祛瘀消痈,利水消肿。用于月经不调,经闭,痛经,产后瘀血腹痛,疮痈肿毒,水肿腹水。《本草纲目》:养营气,破宿血,主妇人劳瘦,女科要药也。《本经》:乳妇内衄,中风余疾,大腹水肿,身面四肢浮肿,骨节中水,金疮,痈肿疮脓。《别录》:产后金疮内塞。
桃仁为蔷薇科植物桃Prunus persica(L.)Batsch或山桃Prunus davidiana(Carr.)Franch.的干燥成熟种子。性味苦、甘,平。归心、肝、大肠经。功效活血祛瘀,润肠通便,止咳平喘。用于经闭痛经,症瘕痞块,肺痈肠痈,跌扑损伤,肠燥便秘,咳嗽气喘。《本草纲目》:桃仁行血,宜连皮、尖生用。润燥活血,宜汤浸去皮、尖炒黄用。或麦麸同炒,或烧存性,各随本方。双仁者有毒,不可食,说见杏仁下。《本经》:瘀血血闭,症瘕邪气,杀小虫。《别录》:止咳逆上气,消心下坚硬,除卒暴击血,通月水,止心腹痛。
红花,为菊科植物红花Carthamus tinctorius L.的干燥花。性味:辛,温。入心、肝经。功能主治:活血通经,去瘀止痛。治经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤。《唐本草》:治口噤不语,血结,产后诸疾。《开宝本草》:主产后血运口噤,腹内恶血不尽、绞痛,胎死腹中,并酒煮服。亦主蛊毒下血。《纲目》:活血,润燥,止痛,散肿,通经。《本草正》:达痘疮血热难出,散斑疹血滞不消。《本草再新》:利水消肿,安生胎,堕死胎。
赤芍,为毛茛科植物芍药或川赤芍的干燥根。性味味苦,性微寒。归肝经。功效清热凉血,散瘀止痛。用于热入营血,温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癥瘕腹痛,跌扑损伤,痈肿疮疡。李东垣:赤芍药破瘀血而疗腹痛,烦热亦解。仲景方中多用之者,以其能定寒热,利小便也。贾所学:赤芍,味苦能泻,带酸入肝,专泻肝火。盖肝藏血,用此清热凉血。以其能主降,善行血滞,调女人之经,消瘀通乳;以其性禀寒,能解热烦,祛内停之湿,利水通便。较白芍味苦重,但能泻而无补。
莪术,为姜科植物莪术Curcuma aeruginosa Roxb.[C.zedoaria non Rosc.]、广西莪术Curcuma kwangsiensis S.G.Lee et C.F.Liang和温郁金Curcuma wenyujinY.H.Chen et C.Ling的根茎。味辛、苦,性温。归肝、脾经。功效行气破血,消积止痛。用于血气心痛,饮食积滞,脘腹胀痛,血滞经闭,痛经,癥瘕痞块,跌打损伤。《医学启源》:主心膈痛。《本草图经》:治积聚诸气,为最要之药。
甘草为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhizainflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根和根茎。味甘,性平。归心、肺、脾、胃经。功效补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。《药品化义》:甘草,生用凉而泻火,主散表邪,消痈肿,利咽痛,解百药毒,除胃积热,去尿管痛,此甘凉除热之力也。炙用温而补中,主脾虚滑泻,胃虚口渴,寒热咳嗽,气短困倦,劳役虚损,此甘温助脾之功也。
卷柏为卷柏科植物卷柏Selaginellatamariscina(Beauv.)Spring或垫状卷柏Selaginellapulvinata(Hook.et Grev.)Maxim.的干燥全草。味辛,性平。归肝、心经。功效卷柏活血通经;卷柏炭化瘀止血。用于经闭痛经,症瘕痞块,跌扑损伤;卷柏炭用于吐血,崩漏,便血,脱肛。《本草求真》:卷柏,其治有分生熟。生则微寒,力能破血通经,故治症瘕淋结等症;炙则辛温,能以止血,故治肠红脱肛等症。《本经》:主五脏邪气,女子阴中寒热痛、症瘕、血闭绝子,久服轻身,和颜色。《别录》:止咳逆,治脱肛,散淋结,头中风眩,瘘躄,强阴益精。
川芎为伞形科植物川芎Ligusticum chuanxiong Hort.的干燥根茎。辛,温。归肝、胆、心包经。功能与主治活血行气,祛风止痛。用于安抚神经,正头风头痛,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。《本经》:主中风入脑头痛,寒痹,筋挛缓急,金创,妇人血闭无子。《别录》:除脑中冷动,面上游风去来,目泪出,多涕唾,忽忽如醉,诸寒冷气,心腹坚痛,中恶,卒急肿痛,胁风痛,温中内寒。《药性论》:治腰脚软弱,半身不遂,主胞衣不出,治腹内冷痛。《日华子本草》:治一切风,一切气,一切劳损,一切血,补五劳,壮筋骨,调众脉,破症结宿血,养新血,长肉,鼻洪,吐血及溺血,痔瘘,脑痈发背,瘰疬瘿赘,疮疥,及排脓消瘀血。
续断为川续断科多年生草本植物川续断Dipsacus asper Wall.ex Henry的干燥根,因能“续折接骨”而得名。味苦、辛,性微温。归肝,肾经。功能主治:补肝肾、强筋骨,调血脉,止崩漏。主治腰膝酸痛,肢节痿痹;跌扑创伤、损筋折骨、胎动漏红、血崩、遗精、带下、痈疽疮肿。《本经》:主伤寒,补不足,金疮,痈疡,折跌,续筋骨,妇人乳难,久服益气力。《别录》:主崩中漏血,金疮血内漏,止痛,生肌肉,腕伤,恶血,腰痛,关节缓急。《药性论》:主绝伤,去诸温毒,能宣通经脉。《日华子本草》:助气,调血脉,补五劳七伤,破症结瘀血,消肿毒,肠风,痔瘘,乳痈,瘰疬,扑损,妇人产前后一切病,面黄虚肿,缩小便,止泄精,尿血,胎漏,子宫冷。《滇南本草》:补肝,强筋骨,走经络,止经中(筋骨)酸痛,安胎,治妇人白带,生新血,破瘀血,落死眙,止咳嗽咳血,治赤白便浊。
枳壳为芸香科植物酸橙Citrus aurantium L.及其栽培变种的干燥未成熟果实。苦、辛、酸,微寒。归脾、胃经。功效理气宽中,行滞消胀。主治用于胸胁气滞,胀满疼痛,食积不化,痰饮内停,脏器下垂。《开宝》:风痒麻痹,通利关节,劳气咳嗽,背膊闷倦,散留结胸膈痰滞,逐水,消胀满大肠风,安胃,止风痛。《本草纲目》:治里急后重。
阿胶为马科驴属动物驴的皮,经漂泡去毛后熬制而成的胶块。归肺、肝、肾经。性味甘,平。功能主治补血滋阴,润燥,止血。用于血虚萎黄,眩晕心悸,肌痿无力,心烦不眠,虚风内动,肺燥咳嗽,劳嗽咯血,吐血尿血,便血崩漏,妊娠胎漏。《神农本草经》:主心腹内崩,劳极洒洒如疟状,腰腹痛,四肢酸痛,女子下血,安胎。《名医别录》:“主丈夫小腹痛,虚劳羸瘦,阴气不足,脚酸不能久立,养肝气。《日华子》:治一切风,并鼻洪,吐血,肠风,血痢及崩中带下。《本草元命苞》:咳脓血非此不补,续气止嗽,补血安胎,止女子崩中下血,疗瘫痪。《医林纂要·药性》:补心和血,散热滋阴。
牛子宫内膜炎,多发生于难产,胎衣不下,子宫脱出,子宫复位不全,流产,产道扩伤之后,或者死胎遗留在子官内,细菌感染引起子宫内膜炎;或患有布氏杆菌病、沙门氏杆菌病以及其他侵害生殖道的传染病或其他疾病的母牛,子宫内膜原来就有慢性炎症,分娩之后由于抵抗力下降及子宫损伤,病程加剧而转为急性炎症;或在配种、人工授精、阴道检查时,消毒不严格引起感染。中兽医称根据其症状表现,可归属于崩漏、带下、不孕等范畴,其主要病机是气血瘀滞,湿热寒毒凝滞,多因母畜产后细菌、病毒的感染,或由于孕期饲养管理不善,怀孕负担过大,过度使役、分娩等因素导致气血阻滞或虚损,进而机体正气虚衰,邪毒乘虚内侵,湿浊、热毒壅积下焦,与气血相搏,致气血壅滞而发病。具体而言,脾气虚弱则水湿不运,湿热流注或侵及下焦,损及任带,再若肾气不固,封藏失职,则水湿必然从阴道分泌而出成为带下病;或因素体虚弱,湿邪、热邪、毒邪乘虚而入,致气血运行不畅,冲任受到阻滞、带脉失约;或又因情志郁结致气血瘀滞等内因。因此,治疗本病的法则主要在于化瘀止血、清解余毒,利湿止带,兼顾补肾固摄。组方依据:方中赤芍清热凉血,散瘀止痛;阿胶补血滋阴,润燥,止血;共为君药;蒲黄炭止血活血利尿,五灵脂行血止血止痛;桃仁活血祛瘀,红花活血通经,去瘀止痛;卷柏活血通经,泽兰活血调经、祛瘀消痈、利水消肿,共为臣药;川芎活血行气、祛风止痛,枳壳理气宽中、行滞消胀,莪术行气破血,消积止痛;续断补肝肾、强筋骨、调血脉、止崩漏,载药入肾和子宫,为佐使;甘草解毒,调和诸药,诸药合用,全方共奏活血通经、凉血散瘀、补血行气、利水止带之功,用于奶牛各种隐性子宫内膜炎、急慢性子宫内膜炎具有良好的效果。本发明的中药遵循君臣佐使的配制原则,经反复试验和验证最终确定了中草药的种类和最佳用量,使得其中各种中药成分之间协同增效,相互促进,达到了极好的治疗奶牛急慢性子宫内膜炎的技术效果。
本发明的有益效果在于:
1)本发明以中药治疗奶牛子宫内膜炎,可以有效减少因抗生素治疗手段带来的耐药性及抗生素残留等问题;组方合理,制备工艺简单;取材广、成本低、治愈率高;药物无残留,无毒副作用,易于奶牛吸收;本发明以活血通经、凉血散瘀、补血行气、利水止带为组方原则,能够增强机体的免疫功能,提高对细菌感染的抵抗力,有效的治疗奶牛子宫内膜炎,产后服用还能够预防奶牛子宫内膜炎的发生,同时提高受孕率和乳汁的质量。
2)本发明制成的药物用于治疗奶牛隐性子宫内膜炎和临床型子宫内膜炎,尤以发病后的早期治疗,服用效果最佳,可用于各种类型的急慢性子宫内膜炎的治疗。经临床试用、跟踪观察记录,对急性子宫内膜炎的治愈率为92%以上,有效率为100%;对慢性子宫内膜炎的治愈率为82%以上,有效率为94%以上。
具体实施方式
本发明的内容仅局限于所举实施例。根据上述发明内容对实施方案进行非本质的改进和调整,仍属于本发明的保护范围。
实施例1:治疗奶牛子宫内膜炎的散剂
处方:蒲黄炭9份、五灵脂9份、泽兰9份、桃仁9份、红花9份、莪术9份、甘草3份、卷柏9份、赤芍15份、川芎9份、续断9份、枳壳9份、阿胶12份。
制法:将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳、阿胶药材,分别粉碎成细粉,混匀,制备成散剂,分装,120g/袋,即得。
实施例2:治疗奶牛子宫内膜炎的散剂
处方:蒲黄炭4-15份、五灵脂4-15份、泽兰4-15份、桃仁4-15份、红花4-15份、莪术4-15份、甘草1-5份、卷柏4-15份、赤芍8-25份、川芎4-15份、续断4-15份、枳壳4-15份、阿胶6-20份。
制法:将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳、阿胶药材,分别粉碎成细粉,混匀,制备成散剂,分装,55g-200g/袋,即得。
实施例3:治疗奶牛子宫内膜炎的颗粒剂
处方:蒲黄炭60g、五灵脂60g、泽兰60g、桃仁60g、红花60g、莪术60g、甘草10g、卷柏60g、赤芍200g、川芎60g、续断60g、枳壳60g、阿胶150g。
制法:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加8倍的水煎煮提取3次,每次30分钟,合并煎液,减压浓缩,干燥,粉碎成干膏粉,备用;
2)将阿胶粉碎成细粉,备用;
3)将上述提取干膏粉与阿胶粉碎粉混匀,用常规方法制备成颗粒剂,分装成10袋,即得。
实施例4:治疗奶牛子宫内膜炎的颗粒剂
处方:蒲黄炭120g、五灵脂120g、泽兰120g、桃仁120g、红花120g、莪术120g、甘草50g、卷柏120g、赤芍100g、川芎120g、续断120g、枳壳120g、阿胶90g。
制法:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加15倍的水煎煮提取2次,每次60分钟,合并煎液,减压浓缩,干燥,粉碎成干膏粉,备用;
2)将阿胶粉碎成细粉,备用;
3)将上述提取干膏粉与阿胶粉碎粉混匀,用常规方法制备成颗粒剂,分装成10袋,即得。
实施例5:治疗奶牛子宫内膜炎的口服液或子宫灌注剂
处方:蒲黄炭9份、五灵脂9份、泽兰9份、桃仁9份、红花9份、莪术9份、甘草3份、卷柏9份、赤芍15份、川芎9份、续断9份、枳壳9份、阿胶12份。
制法:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加10倍的水煎煮提取3次,每次30分钟,合并煎液,减压浓缩,备用;
2)将阿胶加适量水加热烊化,备用;
3)将上述浓缩液与阿胶烊化液混匀,用常规方法制备成口服液或子宫灌注剂,分装,灭菌,每瓶装50-100ml,每袋含药材量60-120g,即得。
实施例6:治疗奶牛子宫内膜炎的栓剂
处方:蒲黄炭6-12g、五灵脂6-12g、泽兰6-12g、桃仁6-12g、红花6-12g、莪术6-12g、甘草1-5g、卷柏6-12g、赤芍10-20g、川芎6-12g、续断6-12g、枳壳6-12g、阿胶9-15g。
制法:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并醇提液,并加入阿胶加热烊化,浓缩至无醇味,得醇提液,药渣备用;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液和上述醇提液,减压浓缩至折合原药材浓度约2-4g/mL的浸膏;
3)将浸膏加入到栓剂基质和表面活性剂中,充分混合,得到热混合物;将热混合物定型制成栓剂;上述栓剂是由35%~45%的浸膏与3%~6%吐温80、20%~30%聚乙二醇400、30%~40%脂肪酸甘油酯组成;所述脂肪酸甘油酯包括36号混合脂肪酸甘油酯、38号混合脂肪酸甘油酯或半合成脂肪酸甘油酯中的一种或多种。
实施例7:治疗奶牛子宫内膜炎的栓剂
处方:蒲黄炭6-12g、五灵脂6-12g、泽兰6-12g、桃仁6-12g、红花6-12g、莪术6-12g、甘草1-5g、卷柏6-12g、赤芍10-20g、川芎6-12g、续断6-12g、枳壳6-12g、阿胶9-15g。
制法:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加12倍体积75%乙醇加热回流2次,每次回流0.5小时;合并回收回流液,浓缩至无醇味,继续浓缩至干,得到浸膏;粉碎,过筛,得到干燥药粉一;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8倍的水煎煮提取2次,每次60分钟,合并煎液,减压浓缩,干燥;粉碎,过筛,得到干燥药粉二;
3)将阿胶粉碎成细粉,备用;
4)栓剂的制备:首先按比例将聚乙二醇600、聚乙二醇6000、吐温80,在搅拌状态下水浴锅加热充分溶化后,加入上述干燥药粉一、干燥药粉二、阿胶粉,混匀后,倒入涂有石蜡油的模具内,将模具置于4℃冰箱内,20-30分钟后取出,倒出栓剂即为成品栓剂;上述栓剂是由30%~40%的中药提取物干粉与5%~10%吐温80、30%~35%聚乙二醇600(PEG600)和30%~35%聚乙二醇6000(PEG6000)组成。
实施例8:治疗奶牛子宫内膜炎的凝胶剂
处方:蒲黄炭6-12g、五灵脂6-12g、泽兰6-12g、桃仁6-12g、红花6-12g、莪术6-12g、甘草1-5g、卷柏6-12g、赤芍10-20g、川芎6-12g、续断6-12g、枳壳6-12g、阿胶9-15g。
制法:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并回收回流液,浓缩至无醇味,继续浓缩至干,得到浸膏一;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,加入阿胶烊化,得浸膏二;
3)将浸膏一、浸膏二混匀,加入凝胶赋形剂、保湿剂、促透剂、抑菌剂、酸碱调节剂按常规方法制成子宫用凝胶剂。
验证例:以下结合临床试验对本发明进一步说明。
对某地畜牧养殖区的5个奶牛厂的母奶牛进行检查,经临床检查确诊为106头确定为慢性子宫内膜炎,38为急性子宫内膜炎。按急性子宫内膜炎和慢性子宫内膜炎随机分为3组,考察本申请对急性子宫内膜炎和慢性子宫内膜炎的疗效。
治疗组1:先用生理盐水将子宫炎性渗出物及脱落黏膜冲洗干净,见回流液透明时,不再冲洗。然后本申请实施例5的子宫灌注剂50ml灌注于子宫内,隔日一次,治疗3次。每3次为一个疗程。
治疗组2:其中治疗组服用本发明实施例1的散剂,拌入饲料投喂,每日一袋,分早晚两次饭后服用,6天为1个疗程。
对照组:以常规抗菌素治疗,给病牛静脉滴注2~5g的甲硝唑,1次/d,持续治疗5d,并于子宫内灌注160万U的青霉素、100万U的链霉素及50mL的生理盐水,1次/d,持续治疗3d。
治疗疗效判定标准:
显效:子宫无脓液分泌物,而是清亮的或略带淡白色的分泌物;外阴部肿胀消失;直检子宫角的质地大小和收缩反应恢复正常;发情时的卵泡发育良好。
有效:子宫分泌物或混有脓液,或有少量异物流出;外阴部肿胀或不明显;或发情时的卵泡发育不好。即其中有一项不正常。
无效:在上述的几项中有两项不正常,而且不发情。
结果:用于治疗奶牛急性子宫内膜炎:实验组1病牛用药治愈率为92.3%,有效率为100.0%;实验组2病牛用药治愈率和有效率为100.0%;而对照组治愈率为50.0%,有效率为83.3%,可见,本发明的散剂和子宫灌注剂在口服和外用等方面都对奶牛急性子宫内膜炎具有很好的治疗作用;对照组、实验组1和实验组2的产后3个情期受孕率分别为75%、100%、100%。结果详见表1。
表1用于治疗奶牛急性子宫内膜炎试验结果表
组别 | 病例数 | 治愈数 | 有效数 | 无效数 | 治愈率 | 有效率 | 产后3个情期受孕率 |
对照组 | 12 | 6 | 4 | 2 | 50.0% | 83.3% | 75.0% |
实验组1 | 13 | 12 | 1 | 0 | 92.3% | 100.0% | 100% |
实验组2 | 13 | 13 | 0 | 0 | 100.0% | 100.0% | 100% |
用于治疗奶牛慢性子宫内膜炎:实验组1病牛用药治愈率为:82.9%,有效率为94.3%;实验组2病牛用药治愈率为86.1%,有效率为97.2%;而对照组治愈率为51.4%,有效率为82.8%,可见,本发明的颗粒剂对奶牛慢性子宫内膜炎具有很好的治疗作用,对照组、实验组1和实验组2的产后3个情期受孕率分别为71.4%、85.7%、88.9%。结果详见表2。
表2用于治疗奶牛慢性子宫内膜炎试验结果表
组别 | 病例数 | 治愈数 | 有效数 | 无效数 | 治愈率 | 有效率 | 产后3个情期受孕率 |
对照组 | 35 | 18 | 11 | 6 | 51.4% | 82.8% | 71.4% |
实验组1 | 35 | 29 | 4 | 2 | 82.9% | 94.3% | 85.7% |
实验组2 | 36 | 31 | 4 | 1 | 86.1% | 97.2% | 88.9% |
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的宗旨和范围,其均应涵盖在本发明的权利要求范围当中。
Claims (10)
1.一种治疗奶牛子宫内膜炎的药物,其特征在于,包括以下重量份的组分:蒲黄炭4-15份、五灵脂4-15份、泽兰4-15份、桃仁4-15份、红花4-15份、莪术4-15份、甘草1-5份、卷柏4-15份、赤芍8-25份、川芎4-15份、续断4-15份、枳壳4-15份、阿胶6-20份。
2.根据权利要求1所述的治疗奶牛子宫内膜炎的药物,其特征在于,包括以下重量份的组分:蒲黄炭6-12份、五灵脂6-12份、泽兰6-12份、桃仁6-12份、红花6-12份、莪术6-12份、甘草1-5份、卷柏6-12份、赤芍10-20份、川芎6-12份、续断6-12份、枳壳6-12份、阿胶9-15份。
3.根据权利要求1所述的治疗奶牛子宫内膜炎的药物,其特征在于包括以下重量份的组分:蒲黄炭9份、五灵脂9份、泽兰9份、桃仁9份、红花9份、莪术9份、甘草3份、卷柏9份、赤芍15份、川芎9份、续断9份、枳壳9份、阿胶12份。
4.根据权利要求1所述的治疗奶牛子宫内膜炎的药物,其特征在于:所述药物的剂型为散剂、汤剂、灌肠剂、子宫灌注剂、栓剂、泡腾片或凝胶剂。
5.根据权利要求4所述的治疗奶牛子宫内膜炎的药物的制备方法,其特征在于,包括以下步骤:将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳、阿胶药材,分别粉碎成细粉,混匀,制备成散剂,分装,即得。
6.根据权利要求4所述的治疗奶牛子宫内膜炎的药物的制备方法,其特征在于,包括以下步骤:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,干燥,粉碎成干膏粉,备用;
2)将阿胶粉碎成细粉,备用;
3)将上述干膏粉与阿胶粉碎粉混匀,用常规方法制备成颗粒剂,分装,即得。
7.根据权利要求4所述的治疗奶牛子宫内膜炎的药物的制备方法,其特征在于,包括以下步骤:
1)将处方量的蒲黄炭、五灵脂、泽兰、桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,备用;
2)将阿胶加适量水加热烊化,备用;
3)将上述浓缩液与阿胶烊化液混匀,用常规方法制备成口服液或子宫灌注剂,分装,即得。
8.根据权利要求4所述的治疗奶牛子宫内膜炎的药物的制备方法,其特征在于,包括以下步骤:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并回收回流液,浓缩至无醇味,继续浓缩至干,得到浸膏;粉碎,过筛,得到干燥药粉一;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液,减压浓缩,干燥;粉碎,过筛,得到干燥药粉二;
3)将阿胶粉碎成细粉,备用;
4)将干燥药粉一、干燥药粉二、阿胶粉加入到栓剂基质和表面活性剂中,充分混合,得到热混合物;将热混合物定型制成栓剂。
9.根据权利要求4所述的治疗奶牛子宫内膜炎的药物的制备方法,其特征在于,包括以下步骤:
1)将处方量的桃仁、红花、莪术、甘草、卷柏、赤芍、川芎、续断、枳壳,加6~12倍体积55-75%乙醇加热回流2~3次,每次回流0.5~1小时;合并醇提液,并加入阿胶加热烊化,浓缩至无醇味,得醇提液,药渣备用;
2)将步骤1)的药渣与处方量的蒲黄炭、五灵脂、泽兰药材,加8-15倍的水煎煮提取2-3次,每次30-60分钟,合并煎液和上述醇提液,减压浓缩至折合原药材浓度约2-4g/mL的浸膏;
3)将浸膏加入到栓剂基质和表面活性剂中,充分混合,得到热混合物;将热混合物定型制成栓剂;上述栓剂是由35%~45%的浸膏与3%~6%吐温80、20%~30%聚乙二醇400、30%~40%脂肪酸甘油酯组成;所述脂肪酸甘油酯包括36号混合脂肪酸甘油酯、38号混合脂肪酸甘油酯或半合成脂肪酸甘油酯中的一种或多种。
10.根据权利要求1-9任一所述的药物制备治疗奶牛急慢性子宫内膜炎药物中的应用。
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