CN117959232A - Hair-blacking essence composition and preparation method and application thereof - Google Patents
Hair-blacking essence composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN117959232A CN117959232A CN202410370935.2A CN202410370935A CN117959232A CN 117959232 A CN117959232 A CN 117959232A CN 202410370935 A CN202410370935 A CN 202410370935A CN 117959232 A CN117959232 A CN 117959232A
- Authority
- CN
- China
- Prior art keywords
- hair
- parts
- extract
- blacking
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 84
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 210000004209 hair Anatomy 0.000 claims abstract description 106
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims abstract description 50
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims abstract description 25
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 25
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 25
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 25
- 239000011648 beta-carotene Substances 0.000 claims abstract description 25
- 229960002747 betacarotene Drugs 0.000 claims abstract description 25
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 25
- 239000000419 plant extract Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003906 humectant Substances 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- 230000000149 penetrating effect Effects 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 4
- 230000002335 preservative effect Effects 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims description 86
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 42
- 238000003756 stirring Methods 0.000 claims description 24
- 241001597062 Channa argus Species 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- 241001289529 Fallopia multiflora Species 0.000 claims description 19
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 18
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 18
- 230000000968 intestinal effect Effects 0.000 claims description 18
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 18
- 239000001540 sodium lactate Substances 0.000 claims description 18
- 229940005581 sodium lactate Drugs 0.000 claims description 18
- 235000011088 sodium lactate Nutrition 0.000 claims description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 18
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 17
- 229920002498 Beta-glucan Polymers 0.000 claims description 17
- 235000011187 glycerol Nutrition 0.000 claims description 17
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 15
- APZYKUZPJCQGPP-UHFFFAOYSA-N Tetrahydropiperine Chemical compound C=1C=C2OCOC2=CC=1CCCCC(=O)N1CCCCC1 APZYKUZPJCQGPP-UHFFFAOYSA-N 0.000 claims description 15
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 15
- 229960000367 inositol Drugs 0.000 claims description 15
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 15
- 239000012141 concentrate Substances 0.000 claims description 13
- 239000001771 mentha piperita Substances 0.000 claims description 12
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 10
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 10
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 10
- 240000003152 Rhus chinensis Species 0.000 claims description 8
- 235000014220 Rhus chinensis Nutrition 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 238000004090 dissolution Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 235000007215 black sesame Nutrition 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 239000000118 hair dye Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940101267 panthenol Drugs 0.000 claims description 2
- 235000020957 pantothenol Nutrition 0.000 claims description 2
- 239000011619 pantothenol Substances 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 28
- 102000003425 Tyrosinase Human genes 0.000 abstract description 16
- 108060008724 Tyrosinase Proteins 0.000 abstract description 16
- 210000003780 hair follicle Anatomy 0.000 abstract description 15
- 210000002752 melanocyte Anatomy 0.000 abstract description 15
- 230000008439 repair process Effects 0.000 abstract description 13
- 210000004761 scalp Anatomy 0.000 abstract description 11
- 230000015572 biosynthetic process Effects 0.000 abstract description 8
- 230000033228 biological regulation Effects 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 230000004913 activation Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 235000020710 ginseng extract Nutrition 0.000 description 5
- 230000036564 melanin content Effects 0.000 description 5
- 208000001382 Experimental Melanoma Diseases 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000012747 synergistic agent Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 229960004441 tyrosine Drugs 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 description 2
- 101710200814 Melanotropin alpha Proteins 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000008099 melanin synthesis Effects 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 2
- RRJOMESUBQAYOA-BZSNNMDCSA-N (2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide Chemical compound NCCCC[C@H](NC(=O)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CN=CN1 RRJOMESUBQAYOA-BZSNNMDCSA-N 0.000 description 1
- UDOOPSJCRMKSGL-ZHACJKMWSA-N (e)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one Chemical compound OC1=CC=CC=C1\C=C\C(=O)C1=CC=CC=C1 UDOOPSJCRMKSGL-ZHACJKMWSA-N 0.000 description 1
- KISUPFXQEHWGAR-RRKCRQDMSA-N 4-amino-5-bromo-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound C1=C(Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 KISUPFXQEHWGAR-RRKCRQDMSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000017701 Endocrine disease Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241000830535 Ligustrum lucidum Species 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- -1 N-acetyl-D-glucosamine amino alcohol Chemical class 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- OGAOAWXZOWXVOG-UHFFFAOYSA-L copper;2-oxopyrrolidine-1-carboxylate Chemical compound [Cu+2].[O-]C(=O)N1CCCC1=O.[O-]C(=O)N1CCCC1=O OGAOAWXZOWXVOG-UHFFFAOYSA-L 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- DOGXPDFZEQXZDS-UHFFFAOYSA-N imidazo[1,2-a]pyridine-3-carboxylic acid Chemical compound C1=CC=CN2C(C(=O)O)=CN=C21 DOGXPDFZEQXZDS-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-M oxalate(1-) Chemical compound OC(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-M 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a hair-blacking essence composition, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The hair-blacking essence composition comprises the following components in parts by weight: 6-14 parts of plant extract, 2-5 parts of humectant, 0.1-0.5 part of penetrating agent, 0.4-0.6 part of preservative and 70-90 parts of water. The hair blackening essence composition provided by the invention is also added with the synergistic components of beta-carotene and psoralen, the beta-carotene and the psoralen which are accidentally sent out and the plant extract can effectively penetrate into scalp and hair follicles through mutual renting, tyrosinase is activated, damaged melanocytes are repaired, the growth of melanocytes and the generation of melanin are promoted, regulation and repair are carried out on a melanin formation channel, the purpose of blackening hair is achieved, and the addition of the beta-carotene and the psoralen can improve the durability of blackening hair.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a hair-blacking essence composition, and a preparation method and application thereof.
Background
Hair is a part of human tissue and is an organism composed of cells. Hair cells divide from the follicle and, in multiples, new hair is pushed from the follicle to the scalp surface. One end of the hair is black, so that people are young, healthy and mental, and therefore, one end of the hair is expected to have a natural black hair.
Along with the development of society, the life rhythm is accelerated, the working and life pressures of people are also increased, the immunity is also reduced, and the hair is white and the hair is lost more and more. Excessive hair loss or whitening is closely related to hypofunction, heredity, mental stress, excessive brain use, malnutrition, etc.
The color of hair depends on the number, size, distribution of pigment particles in the hair shaft and the nature of the pigment contained. White hair is the hair that is fully or partially whitened, and white hair is produced due to reduced melanin particles in the medulla and cortex of the hair or air-filled, both congenital and acquired. The main physiological or pathological factors responsible for acquired grey hair include 4 general categories: (1) The accumulation of hydrogen peroxide causes methionine to oxidize, and as the age increases, the content of oxygen radicals in the hair increases, and when its concentration in the hair roots increases to a certain level, it causes a decrease in the activity of melanocyte tyrosinase in the hair, and the synthesis of melanin decreases, resulting in the formation of white hair. (2) lack of nutrition can also cause the hair to turn from black to white; (3) Reduced transcriptional activity of the P53 protein gene by mood transmitters; (4) Diseases, drugs and changes in body functions, which are factors that change hair from black to white, endocrine disorders such as hypophysis dysfunction and hyperthyroidism, wasting disorders such as tuberculosis, typhoid fever and pernicious anemia, autonomic nerve dysfunction and the like have also been found to be diseases associated with hair changing from black to white.
The prior hair-blackening composition has more researches, for example, china patent CN112220719B discloses a hair-blackening composition, a preparation method and application thereof, and the hair-blackening composition comprises the following components in parts by weight: 0.05-10 parts of sakura extract, 0.01-7 parts of glycyrrhetinic acid, 0.1-8 parts of ginseng extract and 0.01-5 parts of glossy privet fruit extract. The hair blackening composition can effectively penetrate into scalp and hair follicles through synergistic combination of four active ingredients, activate tyrosinase, repair damaged melanocytes, promote growth of melanocytes, mature transformation of functional melanocytes and generation of melanin, regulate and repair from a melanin formation path, and achieve the purposes of blackening hair, improving grey hair and white hair; meanwhile, the hair blackening composition can regulate and control the microecological system for scalp and hair growth and maintain the stable and healthy growth of scalp and hair, and the oxidation effect of scalp hair follicles of the composition is not ideal.
And as Chinese patent CN115998630A discloses a hair blackening essence and a preparation method thereof, the hair blackening essence can improve the white hair phenomenon of some adult men and has higher white hair to black hair efficiency. The hair blackening essence comprises a solvent and a main agent, wherein the main agent comprises, by mass, 10-20 parts of 2-hydroxy chalcone, 5-15 parts of acetyl tetrapeptide-3, 8-18 parts of imidazo [1,2-A ] pyridine-3-carboxylic acid, 6-16 parts of copper pyrrolidone carboxylate, 3-9 parts of hydrogen oxalate, 6-12 parts of hydrolyzed collagen, 1-7 parts of 2-deoxy-2-hexylglycerol, 2-8 parts of phenylacrylol, 3-13 parts of N-acetyl-D-glucosamine amino alcohol and 2-8 parts of 5-bromo-2' -deoxycytidine. The hair blackening essence can penetrate into hair follicles to clean, and each component can penetrate into hair follicles efficiently to nourish hair follicles and hair papilla, promote repair and development of melanocyte, strengthen connection of hair papilla and blood vessel, repair nutrition supply channel of hair papilla, promote synthesis and transfer efficiency of melanin, effectively repair adult male white hair, promote white hair to turn into black hair, and the composition can not activate the aminopeptidase better.
Therefore, there is a need to develop a hair-blacking essence composition which can effectively nourish hair follicles, and can effectively activate tyrosinase and promote the growth of melanocytes, and a preparation method and application thereof.
Disclosure of Invention
Based on the defects existing in the prior art, the invention aims to provide the hair blacking essence composition which has multiple plant components, high activity and small irritation, can effectively nourish hair follicles, activate tyrosinase and promote the growth of melanocytes, and a preparation method thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The hair-blacking essence composition comprises the following components in parts by weight: 6-14 parts of plant extract, 2-5 parts of humectant, 0.1-0.5 part of penetrating agent, 0.4-0.6 part of preservative and 70-90 parts of water.
Wherein,
The plant extract is selected from one or more of snakehead intestinal leaf extract, peppermint leaf extract, black sesame extract, polygonum multiflorum extract and gallnut extract;
preferably, the plant extract is selected from one or more of snakehead leaf extract, peppermint leaf extract, polygonum multiflorum extract and gallnut extract.
Still more preferably, the plant extract is a mixture of a snakehead leaf extract, a peppermint leaf extract, a polygonum multiflorum extract and a gallnut extract.
Further preferably, the plant extract is a snakehead intestinal leaf extract, a peppermint leaf extract, a polygonum multiflorum extract and a gallnut extract with a mass ratio of 4-6:0.4-0.6:1-3:1-3.
Further, the snakehead intestinal leaf extract in the plant extract is 4-6 parts by weight; for example 4 parts, 4.5 parts, 5 parts, 5.5 parts or 6 parts; and specific point values between the above point values, are limited in space and for brevity, the present invention is not intended to exhaustively enumerate the specific point values included in the range.
Further, the mint leaf extract in the plant extract is 0.4-0.6 part by weight; for example 0.4 parts, 0.5 parts or 0.6 parts; and specific point values between the above point values, are limited in space and for brevity, the present invention is not intended to exhaustively enumerate the specific point values included in the range.
Further, the polygonum multiflorum extract in the plant extract is 1-3 parts by weight; for example 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts; and specific point values between the above point values, are limited in space and for brevity, the present invention is not intended to exhaustively enumerate the specific point values included in the range.
Further, the weight of the gallnut extract in the plant extract is 1-3 parts; for example 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts; and specific point values between the above point values, are limited in space and for brevity, the present invention is not intended to exhaustively enumerate the specific point values included in the range.
Still more preferably, the plant extract is a snakehead intestinal leaf extract, a peppermint leaf extract, a polygonum multiflorum extract and a gallnut extract in a mass ratio of 5:0.5:3:1.5.
As a preferred embodiment, the plant extract comprises 10 parts by weight, specifically 5 parts of snakehead leaf extract, 0.5 part of peppermint leaf extract, 3 parts of polygonum multiflorum extract and 1.5 parts of gallnut extract.
The humectant is one or more selected from glycerol, propylene glycol, 1, 3-butanediol, sodium hyaluronate, sodium lactate, hydrolyzed collagen, beta-glucan and panthenol;
preferably, the humectant is a mixture of sodium hyaluronate, sodium lactate and beta-glucan;
Still preferably, the mass ratio of the sodium hyaluronate, the sodium lactate and the beta-glucan is 8-12:3-5:1.
Further preferably, the mass ratio of the sodium hyaluronate, the sodium lactate and the beta-glucan is 10:4:1.
As a preferred embodiment, the humectant comprises 3 parts by weight, specifically 2 parts of sodium hyaluronate, 0.8 part of sodium lactate and 0.2 part of beta-glucan.
In the implementation process, the invention discovers that the mixture of the sodium hyaluronate, the sodium lactate and the beta-glucan is used as the humectant, so that not only can the moisturizing effect of the hair-blacking essence composition be improved, but also the integrity of a fiber structure can be maintained, the living environment of skin cells can be improved, the metabolism of skin tissues can be promoted, and the effect of moisturizing the skin can be achieved.
The penetrating agent is a mixture of glycerol, tetrahydropiperine and inositol, and the mass ratio of the glycerol to the tetrahydropiperine to the inositol is 10:7:1.
As a preferred embodiment, the penetrant comprises 0.45 parts by weight, specifically 0.25 parts of glycerin, 0.175 parts of tetrahydropiperine and 0.025 parts of inositol.
In the implementation process, the invention discovers that the mixture of glycerol, tetrahydropiperine and inositol is adopted as the penetrating agent, so that each component in the hair blackening essence composition can efficiently penetrate into hair follicles, nourish the hair follicles and hair papilla, promote the repair and development of melanocytes, strengthen the connection between the hair papilla and blood vessels, repair the nutrition supply channel of the hair papilla, and promote the synthesis and transfer efficiency of melanin.
The preservative is p-hydroxyacetophenone.
The hair-blacking essence composition also comprises 0.05-0.1 part of synergist, wherein the synergist is a mixture of beta-carotene and psoralen, and the mass ratio of the beta-carotene to the psoralen is 1:1.
As a preferred embodiment, the synergistic agent comprises 0.08 parts by weight, specifically 0.04 parts of beta-carotene and 0.04 parts of psoralen.
The invention discovers that beta-carotene, psoralen and plant extracts can effectively penetrate into scalp and hair follicles through mutual renting, activate tyrosinase, repair damaged melanocytes, promote melanocyte growth and melanin generation, regulate and repair from a melanin formation path, achieve the purpose of blackening hair, and the addition of the beta-carotene and the psoralen can improve the durability of blackening hair.
As a preferred embodiment, the hair-blacking essence composition comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone, 0.04 part of beta-carotene, 0.04 part of psoralen and 86.15 parts of water.
The invention also provides a preparation method of the hair-blacking essence composition, which comprises the following steps:
Adding penetrant, humectant and water into a stirring pot, heating to 50-60 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
The invention also provides application of the hair-blacking essence composition in preparation of hair-blacking products.
The hair blackening product is hair blackening spray, hair nourishing lotion, hair blackening essence, shampoo, hair conditioner or hair dye.
Compared with the prior art, the invention has the beneficial effects that:
(1) The hair-blacking essence composition provided by the invention comprises snakehead intestine leaf extract, peppermint leaf extract, polygonum multiflorum extract and gallnut extract, wherein the plant extracts have the effect of blacking hair; in the implementation process, synergistic components of beta-carotene and psoralen are added into the hair blackening essence composition, the beta-carotene and the psoralen which are accidentally sent out and the plant extract can effectively penetrate into scalp and hair follicles through mutual renting, tyrosinase is activated, damaged melanocytes are repaired, the growth of melanocytes and the generation of melanin are promoted, regulation and repair are carried out from a melanin formation channel, the purpose of blackening hair is achieved, and the addition of the beta-carotene and the psoralen can improve the durability of blackening hair;
(2) The invention adopts the mixture of sodium hyaluronate, sodium lactate and beta-glucan as the humectant, which not only can improve the moisturizing effect of the hair-blacking essence composition, but also can maintain the integrity of fiber structure, improve the living environment of skin cells and promote the metabolism of skin tissues, thereby achieving the effect of moisturizing the skin.
(3) It is known in the art that hair blackening essence compositions accumulate on the surface of the scalp if the active ingredients thereof cannot be absorbed, which is liable to cause clogging of pores of the scalp, which brings a heavy burden to the scalp and even causes bacteria to grow; however, in the implementation process, the invention discovers that the mixture of glycerol, tetrahydropiperine and inositol is adopted as the penetrating agent, so that each component in the hair blackening essence composition can efficiently penetrate into hair follicles, nourish the hair follicles and hair papilla, promote the repair and development of melanocytes, strengthen the connection between the hair papilla and blood vessels, repair the nutrition supply channel of the hair papilla, and improve the synthesis and transfer efficiency of melanin.
(4) The hair-blacking essence composition provided by the invention has simple components, contains various natural plant components, has small irritation, can deeply nourish hair follicles, and does not generate dependence.
Detailed Description
Hereinafter, specific embodiments of the present invention will be described. However, the present invention is not limited to the above description, and various changes, modifications, and improvements may be made according to knowledge of the manufacturer without departing from the scope of the present invention.
The manufacturers and models of the components in the following examples are:
example 1 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone, 0.04 part of beta-carotene, 0.04 part of psoralen and 86.15 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 55 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Example 2 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 6 parts of snakehead intestinal leaf extract, 0.6 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 3 parts of Chinese gall extract, 3.2 parts of sodium hyaluronate, 1.2 parts of sodium lactate, 0.4 part of beta-glucan, 0.1 part of glycerin, 0.07 part of tetrahydropiperine, 0.01 part of inositol, 0.4 part of p-hydroxyacetophenone, 0.025 part of beta-carotene, 0.025 part of psoralen and 82.37 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 50 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Example 3 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 4 parts of snakehead intestinal leaf extract, 0.4 part of mint leaf extract, 1 part of polygonum multiflorum extract, 1 part of Chinese gall extract, 3 parts of sodium hyaluronate, 1.25 parts of sodium lactate, 0.25 part of beta-glucan, 0.27 part of glycerin, 0.189 part of tetrahydropiperine, 0.027 part of inositol, 0.6 part of p-hydroxyacetophenone, 0.05 part of beta-carotene, 0.05 part of psoralen and 87.914 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 60 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Example 4 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone and 86.23 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 55 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Example 5 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone, 0.08 part of beta-carotene and 86.15 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 55 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Example 6 Hair blacking essence composition and preparation method thereof
The coating comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone, 0.08 part of psoralen and 86.15 parts of water.
The preparation method comprises the following steps:
Adding the penetrating agent, the humectant and the water into a stirring pot, heating to 55 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
Comparative example 1
The difference from example 1 is that: the snakehead intestinal leaf extract and the mint leaf extract are replaced with ginseng extract, namely 5.5 parts of ginseng extract, and other components and preparation methods are the same as in example 1.
Comparative example 2
The difference from example 1 is that: the mass ratio of the beta-carotene to the psoralen was 7:1, namely, 0.07 part of the beta-carotene, 0.01 part of the psoralen, and other components and preparation methods were the same as in example 1.
Comparative example 3
The difference from example 1 is that: the mass ratio of the beta-carotene to the psoralen was 1:7, namely, 0.01 part of the beta-carotene and 0.07 part of the psoralen, and other components and preparation methods are the same as in example 1.
Effect experiment
1. Irritation detection
The hair-blacking essence compositions provided in examples 1-6 were used for the skin irritation test of human body spot patches.
Dripping hair blackening essence composition (25 μl) onto filter paper sheets attached to the spot tester, and placing into the spot tester; applying the patch test with the hair blackening essence composition dropwise onto the curved side of forearm of a subject with a non-irritating adhesive tape, and applying to skin with palm light pressure for 24 hr; after removing the spot tester for 30min, the skin reaction is observed after the indentation disappears. If the result is negative, observing again after 24h and 48h respectively after the patch test; the skin reaction evaluation criteria for the closed patch test are shown in table 1.
TABLE 1
60 Volunteers 20-50 years old with healthy skin were randomly selected, and were randomly divided into 6 groups, and scores of the closed patch test were recorded using the hair blackening essence compositions provided in examples 1-6, respectively, to obtain skin irritation test results of the human patch, and specific results are shown in Table 2 below.
TABLE 2
According to the detection results of table 1, it can be seen that the hair blackening essence compositions provided by examples 1-6 of the invention show good safety in skin irritation experiments of human body spots, and the hair blackening essence composition provided by the invention is proved to be mild and non-irritating to human skin and can be safely used.
2. Tyrosinase activation rate
0.5Mg/mL of L-tyrosine solution (the solvent is phosphate buffer) is prepared, 35mg/mL of mushroom tyrosinase solution (the solvent is phosphate buffer) is prepared, and 1mg/mL of sample solution to be tested (the hair blackening essence compositions provided in examples 1-6 and comparative examples 1-3 are respectively tested) is prepared by using propylene glycol as the solvent to serve as a comparative test group.
The 4 groups of solutions were prepared according to the following proportions:
A:0.7mL of L-tyrosine solution+0.7 mL of pure propylene glycol+0.6 mL of phosphate buffer;
b:0.7mL of pure propylene glycol+1.3 mL of phosphate buffer;
c:0.7mL of L-tyrosine solution+0.7 mL of propylene glycol solution of the sample to be tested+0.6 mL of phosphate buffer;
D:0.7mL of propylene glycol solution of the sample to be tested plus 0.6mL of phosphate buffer;
After the above 4 groups of solutions were kept at a constant temperature in a water bath of 37℃for 10 minutes, 0.3mL of tyrosinase solution was added to each solution, and after 5 minutes of reaction, the solution was quickly transferred into a cuvette, absorbance (OD) was measured at 475nm, OD was recorded, and tyrosinase activation rate=100% × ((OD 3-OD4)-(OD1-OD2))/(OD1-OD2); where (OD 1-OD2) represents the change in OD value of the reaction solution in the absence of an activator and (OD 3-OD4) represents the change in OD value of the reaction solution in the presence of an activator (hair-blacking concentrate compositions provided in examples 1 to 6, comparative examples 1 to 3), and the detection data were shown in Table 3 below.
TABLE 3 Table 3
As can be seen from the detection results of the above Table 3, the activation rate of tyrosinase of the hair blackening essence compositions provided by the embodiments 1-3 of the present invention can reach 25% at the highest; in example 4, the activating rate of tyrosinase by the obtained hair-blacking essence composition is obviously reduced by 18.7 percent; the variety of the synergists in examples 5-6, i.e., the use of beta-carotene alone or psoralen alone, affects the activation rate of the hair blackening essence composition to tyrosinase to some extent; in comparative example 1, the plant extracts of snakehead intestinal leaf extract and peppermint leaf extract are replaced by ginseng extract, so that the activation rate of tyrosinase by the hair-blacking essence composition is obviously reduced; changing the mass ratio of the synergistic agent ingredients in comparative examples 2-3 also affects the activation rate of tyrosinase by the hair blackening essence composition to some extent, but the activation rate is significantly higher than in examples 4-6.
3. Melanin content test
The density of the B16 melanoma cell suspension was adjusted to 1X 10 5 cells/mL, and 1mL of the cell suspension per well was inoculated into a 12-well plate to give a cell density of 5X 10 4 cells/well, and the cell suspension was cultured in an incubator (37 ℃ C., 5% carbon dioxide) for 24 hours. The 12-well plate was taken out, the culture medium was removed, 1mL of the culture medium containing the sample to be tested (the hair-blacking essence composition provided in examples 1 to 6 and comparative examples 1 to 3, the concentration was 1 mg/mL), 1mL of the culture medium containing no sample to be tested was added to the blank control group and the zeroing group, and after the culture was continued in the incubator for 12 hours, the culture medium was removed. 1mL of alpha-MSH solution prepared by RPMI 1640 medium is added into each hole of the experimental group and the zeroing group, 1mL of medium without alpha-MSH is added into the blank group, and the blank group is placed into an incubator for culturing for 36 hours. The wells were washed twice with 1mL of PBS, 100. Mu.L of 1N NaOH solution (prepared with PBS) containing 10% DMSO was added to each well, after 1 hour of water bath in a water bath at 80℃the cell lysates of each group in 12 well plates were transferred to 96 well plates, and the absorbance OD of each well was measured at 475nm by an ELISA reader. The formula for calculating the intracellular melanin content is as follows: melanin content = 100% × (OD 1-OD3)/(OD2-OD3), where OD 1 is the absorbance of the experimental group, OD 2 is the absorbance of the blank group, OD 3 is the absorbance of the zeroed group, and the test data are shown in table 4 below.
TABLE 4 Table 4
From the test data of table 4 above, it can be seen that the hair blacking essence compositions provided in examples 1-3 of the present invention increased the melanin content in B16 melanoma cells to 8.15% at maximum; however, in example 4, the hair-blacking essence composition obtained does not contain a synergistic agent, so that the melanin content in B16 melanoma cells is not improved as in examples 1-3, but is only 7.61%; examples 5-6, in which the variety of the potentiating agent is varied, i.e., the use of β -carotene alone or psoralen alone, affects melanin production to some extent; in comparative example 1, the plant extracts of snakehead intestinal leaf extract and peppermint leaf extract were replaced with ginseng extract, and changing the mass ratio of the synergistic agent components in comparative examples 2-3 all affected the production of melanin, so that the content of melanin in B16 melanoma cells was not improved as in examples 1-3, but was superior to examples 4-6.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (14)
1. A hair blacking essence composition, characterized in that: the coating comprises the following components in parts by weight: 6-14 parts of plant extract, 2-5 parts of humectant, 0.1-0.5 part of penetrating agent, 0.4-0.6 part of preservative and 70-90 parts of water;
The plant extract is selected from one or more of snakehead intestinal leaf extract, peppermint leaf extract, black sesame extract, polygonum multiflorum extract and gallnut extract.
2. The hair blacking concentrate composition of claim 1 wherein: the plant extract is a mixture of snakehead intestinal leaf extract, peppermint leaf extract, polygonum multiflorum extract and gallnut extract; the mass ratio is 4-6:0.4-0.6:1-3:1-3.
3. The hair blacking concentrate composition of claim 1 wherein: the plant extract is a mixture of snakehead intestinal leaf extract, peppermint leaf extract, polygonum multiflorum extract and gallnut extract; the mass ratio is 5:0.5:3:1.5.
4. The hair blacking concentrate composition of claim 1 wherein: the humectant is one or more selected from glycerol, propylene glycol, 1, 3-butanediol, sodium hyaluronate, sodium lactate, hydrolyzed collagen, beta-dextran and panthenol.
5. The hair blacking concentrate composition of claim 4 wherein: the humectant is a mixture of sodium hyaluronate, sodium lactate and beta-glucan; the mass ratio is 8-12:3-5:1.
6. The hair blacking concentrate composition of claim 5 wherein: the mass ratio of the sodium hyaluronate to the sodium lactate to the beta-glucan is 10:4:1.
7. The hair blacking concentrate composition of claim 1 wherein: the penetrating agent is a mixture of glycerol, tetrahydropiperine and inositol, and the mass ratio of the glycerol to the tetrahydropiperine to the inositol is 10:7:1.
8. The hair blacking concentrate composition of claim 1 wherein: the hair-blacking essence composition also comprises 0.05-0.1 part of synergist.
9. The hair blacking concentrate composition of claim 8 wherein: the synergist is selected from the group consisting of beta-carotene and psoralen.
10. The hair blacking concentrate composition of claim 9 wherein: the mass ratio of the beta-carotene to the psoralen is 1:1.
11. The hair blacking concentrate composition of any one of claims 1-10, wherein: the coating comprises the following components in parts by weight: 5 parts of snakehead intestinal leaf extract, 0.5 part of mint leaf extract, 3 parts of polygonum multiflorum extract, 1.5 parts of Chinese gall extract, 2 parts of sodium hyaluronate, 0.8 part of sodium lactate, 0.2 part of beta-glucan, 0.25 part of glycerin, 0.175 part of tetrahydropiperine, 0.025 part of inositol, 0.5 part of p-hydroxyacetophenone, 0.04 part of beta-carotene, 0.04 part of psoralen and 86.15 parts of water.
12. A process for preparing a hair blacking concentrate composition according to any one of claims 1 to 10, characterized in that: the method comprises the following steps:
Adding penetrant, humectant and water into a stirring pot, heating to 50-60 ℃ while stirring, cooling to below 40 ℃ after complete dissolution, adding the rest components, stirring uniformly, and standing to room temperature to obtain the hair blackening essence composition.
13. Use of the hair blacking concentrate composition according to any one of claims 1 to 10 for the preparation of hair blacking products.
14. The use according to claim 13, characterized in that: the hair blackening product is hair blackening spray, hair nourishing lotion, hair blackening essence, shampoo, hair conditioner or hair dye.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410370935.2A CN117959232B (en) | 2024-03-29 | 2024-03-29 | Hair-blacking essence composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410370935.2A CN117959232B (en) | 2024-03-29 | 2024-03-29 | Hair-blacking essence composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117959232A true CN117959232A (en) | 2024-05-03 |
| CN117959232B CN117959232B (en) | 2024-06-11 |
Family
ID=90858384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410370935.2A Active CN117959232B (en) | 2024-03-29 | 2024-03-29 | Hair-blacking essence composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117959232B (en) |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2829388A1 (en) * | 2001-09-11 | 2003-03-14 | Oreal | Use of carotenoids in cosmetic compositions e.g. for stimulating keratinocyte proliferation, inhibiting keratinocyte differentiation, promoting epidermal renewal or regeneration or promoting wound healing |
| CN104055709A (en) * | 2014-06-30 | 2014-09-24 | 南通蛇类治疗研究所 | Natural plant multiple-effect hair growing and conditioning agent |
| JP2016149999A (en) * | 2015-02-19 | 2016-08-22 | 株式会社アイビー化粧品 | Additive |
| CN106619315A (en) * | 2017-01-22 | 2017-05-10 | 张东洋 | Tuber fleeceflower serum for nourishing and darkening hair and preparation method thereof |
| CN106943492A (en) * | 2017-03-22 | 2017-07-14 | 广州国草夏方生物科技有限公司 | One kind prevents white hair blackening liquid composition and preparation method thereof |
| CN107789520A (en) * | 2017-10-30 | 2018-03-13 | 李翠香 | A kind of draft nutrition hair tonic turns black medicine in vain |
| CN108310112A (en) * | 2018-05-16 | 2018-07-24 | 深圳市自然青中医药研究有限公司 | A kind of black hair Chinese medicine composition and hair blackening liquid |
| CN110025658A (en) * | 2019-03-28 | 2019-07-19 | 广州市茗妍化妆品有限公司 | A kind of hair-loss preventing and hair-restoring liquid and preparation method thereof |
| CN110507579A (en) * | 2019-09-19 | 2019-11-29 | 成少东 | A kind of black hair Essence and preparation method |
| CN110840883A (en) * | 2019-12-20 | 2020-02-28 | 广州韩金靓化妆品有限公司 | Hair-blacking composition and application thereof |
| CN113318043A (en) * | 2021-05-21 | 2021-08-31 | 广州市涵美化妆品有限公司 | Essence with effects of fixing hair and growing hair and preparation method thereof |
| CN115475122A (en) * | 2022-09-02 | 2022-12-16 | 曼秀雷敦(中国)药业有限公司 | Hair blackening essence and preparation method thereof |
| CN115770196A (en) * | 2022-11-30 | 2023-03-10 | 广州市婷采化妆品有限公司 | Multi-effect skin care product capable of whitening and removing freckles as well as preparation method and application thereof |
| CN115998630A (en) * | 2023-02-17 | 2023-04-25 | 北京普世安生物科技有限公司 | Hair-blacking essence and preparation method thereof |
| CN116392420A (en) * | 2023-03-30 | 2023-07-07 | 北京普世安生物科技有限公司 | Hair-blacking composition and preparation method and application thereof |
| CN116785218A (en) * | 2023-06-25 | 2023-09-22 | 吉林农业大学 | Moisturizing skin composition and application thereof in cosmetics |
| CN117503673A (en) * | 2023-12-08 | 2024-02-06 | 孙永军 | Reinforced hair-loss regeneration white hair-to-black herbal shampoo and preparation method thereof |
-
2024
- 2024-03-29 CN CN202410370935.2A patent/CN117959232B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2829388A1 (en) * | 2001-09-11 | 2003-03-14 | Oreal | Use of carotenoids in cosmetic compositions e.g. for stimulating keratinocyte proliferation, inhibiting keratinocyte differentiation, promoting epidermal renewal or regeneration or promoting wound healing |
| CN104055709A (en) * | 2014-06-30 | 2014-09-24 | 南通蛇类治疗研究所 | Natural plant multiple-effect hair growing and conditioning agent |
| JP2016149999A (en) * | 2015-02-19 | 2016-08-22 | 株式会社アイビー化粧品 | Additive |
| CN106619315A (en) * | 2017-01-22 | 2017-05-10 | 张东洋 | Tuber fleeceflower serum for nourishing and darkening hair and preparation method thereof |
| CN106943492A (en) * | 2017-03-22 | 2017-07-14 | 广州国草夏方生物科技有限公司 | One kind prevents white hair blackening liquid composition and preparation method thereof |
| CN107789520A (en) * | 2017-10-30 | 2018-03-13 | 李翠香 | A kind of draft nutrition hair tonic turns black medicine in vain |
| CN108310112A (en) * | 2018-05-16 | 2018-07-24 | 深圳市自然青中医药研究有限公司 | A kind of black hair Chinese medicine composition and hair blackening liquid |
| CN110025658A (en) * | 2019-03-28 | 2019-07-19 | 广州市茗妍化妆品有限公司 | A kind of hair-loss preventing and hair-restoring liquid and preparation method thereof |
| CN110507579A (en) * | 2019-09-19 | 2019-11-29 | 成少东 | A kind of black hair Essence and preparation method |
| CN110840883A (en) * | 2019-12-20 | 2020-02-28 | 广州韩金靓化妆品有限公司 | Hair-blacking composition and application thereof |
| CN113318043A (en) * | 2021-05-21 | 2021-08-31 | 广州市涵美化妆品有限公司 | Essence with effects of fixing hair and growing hair and preparation method thereof |
| CN115475122A (en) * | 2022-09-02 | 2022-12-16 | 曼秀雷敦(中国)药业有限公司 | Hair blackening essence and preparation method thereof |
| CN115770196A (en) * | 2022-11-30 | 2023-03-10 | 广州市婷采化妆品有限公司 | Multi-effect skin care product capable of whitening and removing freckles as well as preparation method and application thereof |
| CN115998630A (en) * | 2023-02-17 | 2023-04-25 | 北京普世安生物科技有限公司 | Hair-blacking essence and preparation method thereof |
| CN116392420A (en) * | 2023-03-30 | 2023-07-07 | 北京普世安生物科技有限公司 | Hair-blacking composition and preparation method and application thereof |
| CN116785218A (en) * | 2023-06-25 | 2023-09-22 | 吉林农业大学 | Moisturizing skin composition and application thereof in cosmetics |
| CN117503673A (en) * | 2023-12-08 | 2024-02-06 | 孙永军 | Reinforced hair-loss regeneration white hair-to-black herbal shampoo and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 张何等: "《实用美容药物》", 31 August 2016, 华中科技大学出版社, pages: 33 * |
| 杜杰慧等: "《女性养颜美容》", 31 January 2001, 人民卫生出版社, pages: 95 - 96 * |
| 王绪前: "《本草心悟-五十年临证经验讲透中药》", 30 June 2022, 中国医药科技出版社, pages: 72 * |
| 袁云谢坤: "《养生四十讲》", 30 September 1986, 上海文化出版社, pages: 144 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117959232B (en) | 2024-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2203151B1 (en) | Use of melanin biosynthesis inhibitors from ginseng for skin whitening | |
| US9089504B2 (en) | Cosmetic composition containing green tea component | |
| CN112618400A (en) | Composition for improving skin color and whitening cosmetic | |
| CN105147535A (en) | Essence capable of reducing wrinkles, compacting, repairing, whitening and removing freckles and preparing method thereof | |
| CN110772444A (en) | Skin conditioner and mask for whitening and removing wrinkles and preparation method thereof | |
| CN114681358A (en) | Tyrosinase activity inhibitor and skin care product with synergistic whitening effect | |
| CN117959232B (en) | Hair-blacking essence composition and preparation method and application thereof | |
| CN113368003A (en) | Composition with overnight muscle repairing effect and preparation method and application thereof | |
| JP3435181B2 (en) | External preparation for melanin production suppression | |
| CN112315844A (en) | Composition for improving skin color and preparation method and application thereof | |
| CN112656701A (en) | Whitening and freckle-removing composition containing PDRN and application thereof | |
| KR100753437B1 (en) | Nano-liposomal particles containing red ginseng irradiated with saponin, licorice, biotin, copper peptide, cytokine and cosmetics for hair care | |
| CN114099388B (en) | Anti-wrinkle composition and preparation method and application thereof | |
| CN113940909A (en) | Composition for regulating circadian rhythm and application thereof | |
| CN111617025B (en) | Fermentation product cosmetic for whitening, removing freckles and resisting saccharification | |
| CN114303944B (en) | Callus culture medium and extract of rosa tenuifolia, preparation method and application | |
| CN113633585B (en) | External hair care composition and preparation with effects of preventing alopecia, promoting hair growth and blackening hair and preparation method thereof | |
| CN108272677A (en) | A kind of moistening and whitening facial mask and preparation method thereof containing plant extracts | |
| JPH03167113A (en) | Hair regenerating agent | |
| CN111743798A (en) | Multi-effect anti-aging skin care product and preparation method thereof | |
| CN115887281B (en) | Supermolecule composition and preparation method and application thereof | |
| CN115554380B (en) | Composition for preventing and treating alopecia by acting on hair follicle tissue and application thereof | |
| CN111840205B (en) | Multiple anti-aging composition, essence lotion and preparation method thereof | |
| CN107802594A (en) | A kind of anti-aging containing sweet osmanthus stem cell extract, net white composition and preparation method thereof | |
| CN113197788B (en) | Composition for skin whitening and skin care cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |