CN115998630A - Hair-blacking essence and preparation method thereof - Google Patents
Hair-blacking essence and preparation method thereof Download PDFInfo
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- CN115998630A CN115998630A CN202310127437.0A CN202310127437A CN115998630A CN 115998630 A CN115998630 A CN 115998630A CN 202310127437 A CN202310127437 A CN 202310127437A CN 115998630 A CN115998630 A CN 115998630A
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- 238000002360 preparation method Methods 0.000 title abstract description 14
- 210000004209 hair Anatomy 0.000 claims abstract description 149
- 239000002904 solvent Substances 0.000 claims abstract description 75
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 66
- RRJOMESUBQAYOA-BZSNNMDCSA-N (2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide Chemical compound NCCCC[C@H](NC(=O)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CN=CN1 RRJOMESUBQAYOA-BZSNNMDCSA-N 0.000 claims abstract description 38
- UDOOPSJCRMKSGL-ZHACJKMWSA-N (e)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one Chemical compound OC1=CC=CC=C1\C=C\C(=O)C1=CC=CC=C1 UDOOPSJCRMKSGL-ZHACJKMWSA-N 0.000 claims abstract description 35
- KISUPFXQEHWGAR-RRKCRQDMSA-N 4-amino-5-bromo-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound C1=C(Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 KISUPFXQEHWGAR-RRKCRQDMSA-N 0.000 claims abstract description 35
- 102000008186 Collagen Human genes 0.000 claims abstract description 35
- 108010035532 Collagen Proteins 0.000 claims abstract description 35
- 229920001436 collagen Polymers 0.000 claims abstract description 35
- OGAOAWXZOWXVOG-UHFFFAOYSA-L copper;2-oxopyrrolidine-1-carboxylate Chemical compound [Cu+2].[O-]C(=O)N1CCCC1=O.[O-]C(=O)N1CCCC1=O OGAOAWXZOWXVOG-UHFFFAOYSA-L 0.000 claims abstract description 35
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims abstract description 34
- -1 N-acetyl-D-glucosamine amino alcohol Chemical class 0.000 claims abstract description 34
- 229950006780 n-acetylglucosamine Drugs 0.000 claims abstract description 34
- DOGXPDFZEQXZDS-UHFFFAOYSA-N imidazo[1,2-a]pyridine-3-carboxylic acid Chemical compound C1=CC=CN2C(C(=O)O)=CN=C21 DOGXPDFZEQXZDS-UHFFFAOYSA-N 0.000 claims abstract description 29
- MUBZPKHOEPUJKR-UHFFFAOYSA-M oxalate(1-) Chemical compound OC(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-M 0.000 claims abstract description 12
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 23
- 229940014041 hyaluronate Drugs 0.000 claims description 23
- UJRAXLUXHBUNDO-UHFFFAOYSA-M sodium;hydron;oxalate Chemical compound [Na+].OC(=O)C([O-])=O UJRAXLUXHBUNDO-UHFFFAOYSA-M 0.000 claims description 21
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 18
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 17
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 17
- 229940041616 menthol Drugs 0.000 claims description 17
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 9
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 8
- 239000011591 potassium Substances 0.000 claims description 8
- 229910052700 potassium Inorganic materials 0.000 claims description 8
- JMTCDHVHZSGGJA-UHFFFAOYSA-M potassium hydrogenoxalate Chemical group [K+].OC(=O)C([O-])=O JMTCDHVHZSGGJA-UHFFFAOYSA-M 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- AJGPQPPJQDDCDA-UHFFFAOYSA-N azanium;hydron;oxalate Chemical compound N.OC(=O)C(O)=O AJGPQPPJQDDCDA-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000001968 nicotinic acid Nutrition 0.000 claims description 3
- 239000011664 nicotinic acid Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 38
- 210000003780 hair follicle Anatomy 0.000 abstract description 25
- 210000004204 blood vessel Anatomy 0.000 abstract description 16
- 210000002752 melanocyte Anatomy 0.000 abstract description 13
- 230000008439 repair process Effects 0.000 abstract description 13
- 238000011161 development Methods 0.000 abstract description 8
- 235000016709 nutrition Nutrition 0.000 abstract description 8
- 230000035764 nutrition Effects 0.000 abstract description 8
- 230000015572 biosynthetic process Effects 0.000 abstract description 6
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 238000012546 transfer Methods 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 93
- 239000000686 essence Substances 0.000 description 59
- 230000000052 comparative effect Effects 0.000 description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- 239000000243 solution Substances 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 15
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- 210000004761 scalp Anatomy 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
- 230000003340 mental effect Effects 0.000 description 6
- 230000019612 pigmentation Effects 0.000 description 5
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 230000003779 hair growth Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 208000030172 endocrine system disease Diseases 0.000 description 3
- 230000008099 melanin synthesis Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 102000016359 Fibronectins Human genes 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical class OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000009583 hair follicle growth Effects 0.000 description 2
- 210000002432 hair matrix stem cell Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000014993 Pituitary disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- PUTWALAGSAIJLE-UHFFFAOYSA-L calcium 2-hydroxy-2-oxoacetate Chemical compound C(C(=O)[O-])(=O)[O-].C(C(=O)O)(=O)O.[Ca+2] PUTWALAGSAIJLE-UHFFFAOYSA-L 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Cosmetics (AREA)
Abstract
The application relates to the technical field of hair care, and particularly discloses a hair-blacking essence and a preparation method thereof, which can improve the white hair phenomenon of some adult men and have higher white hair-to-black hair efficiency. The hair-blacking essence comprises a solvent and a main agent, wherein the main agent comprises, by mass, 10-20 parts of 2-hydroxy chalcone, 5-15 parts of acetyl tetrapeptide-3, 8-18 parts of imidazo [1,2-A ] pyridine-3-formic acid, 6-16 parts of copper pyrrolidone carboxylate, 3-9 parts of hydrogen oxalate, 6-12 parts of hydrolyzed collagen, 1-7 parts of 2-deoxy-2-hexylglycerol, 2-8 parts of phenylacrylol, 3-13 parts of N-acetyl-D-glucosamine amino alcohol and 2-8 parts of 5-bromo-2' -deoxycytidine. The hair blackening essence can penetrate into hair follicles to clean, and each component can penetrate into hair follicles efficiently to nourish hair follicles and hair papilla, promote repair and development of melanocyte, strengthen connection of hair papilla and blood vessel, repair nutrition supply channel of hair papilla, promote synthesis and transfer efficiency of melanin, effectively repair adult male white hair, and promote white hair to turn black hair.
Description
Technical Field
The application relates to the technical field of hair care, in particular to hair-blacking essence and a preparation method thereof.
Background
Under normal conditions, the hair papilla of human hair has rich blood vessels, so that sufficient nutrition is provided for the hair papilla and the hair bulb part, and melanin particles can be smoothly synthesized. Various bad stimulations can cause angiogenesis spasm for supplying hair nutrition, and can cause dysfunction of melanin secretion of melanocytes of hair papilla and hair bulb, and influence formation and transportation of melanin granules. White hair occurs when melanin particles are formed in the papilla and the bulb, or, although formed, cannot be transported into the hair due to a factor, and the melanin particles in the medulla and cortex of the hair are reduced and disappeared. For example, in adult men, some endocrinopathies, such as pituitary or thyroid disorders, can affect the ability of melanocytes to produce pigment particles, resulting in gradual whitening of the hair. Some adult men, in a short period of time, have a large amount of hair whitened, and are associated with severe mental trauma or mental overfatigue such as excessive anxiety, sadness, etc. The existing essence for treating adult male white hair has an unsatisfactory effect in improving white hair and blackening hair.
Disclosure of Invention
In order to improve the white hair phenomenon of some adult men, the application provides a hair-blacking essence capable of effectively improving the white hair of the adult men to blacken hair and a preparation method thereof.
In a first aspect, the present application proposes a hair blackening essence, and adopts the following technical scheme.
The hair blackening essence comprises a solvent and a main agent, wherein the main agent comprises, by mass, 10-20 parts of 2-hydroxy chalcone, 5-15 parts of acetyl tetrapeptide-3, 8-18 parts of imidazole [1,2-A ] pyridine-3-formic acid, 6-16 parts of copper pyrrolidone carboxylate, 3-9 parts of hydrogen oxalate, 6-12 parts of hydrolyzed collagen, 1-7 parts of 2-deoxy-2-hexylglycerol, 2-8 parts of phenylacrylol, 3-13 parts of N-acetyl-D-glucosamine amino alcohol and 2-8 parts of 5-bromo-2' -deoxycytidine.
By adopting the technical scheme, the 2-hydroxy chalcone has the function of promoting hair follicle penetration, is beneficial to cleaning hair follicles and promotes other components to permeate into the hair follicles. Acetyl tetrapeptide-3 can directly act on tissues near hair follicles to repair melanocytes of the hair follicles rapidly to form extracellular matrix proteins and fibronectin, so that the root is firm, and the connection between hair papilla and blood vessels is enhanced. The imidazole [1,2-A ] pyridine-3-formic acid can promote the development of hair papilla and further strengthen the connection between the hair papilla and blood vessels. Copper pyrrolidone carboxylate can relax blood vessel and further strengthen the connection between hair papilla and blood vessel. The hydrogen oxalate salt can accelerate the absorption of acetyl tetrapeptide-3 in hair follicles and enhance the efficacy. The hydrolyzed collagen can regulate pigment secretion, reduce melanin pigmentation on skin, and increase melanin pigmentation on hair. 2-deoxy-2-hexylglycerol can promote activity of tyrosinase and promote melanin synthesis efficiency. During the synthesis of melanin, tyrosinase catalyzes the formation of dopa from tyrosine, and dopa is oxidized to dopa quinone, which in turn generates melanin under the catalysis of various enzymes and structural proteins. The phenylacrylic alcohol can promote the efficiency of the generated melanin to permeate into the hair papilla. N-acetyl-D-glucosamine amino alcohol can regulate water-oil balance in hair follicle, and provide good environment for hair follicle growth. The 5-bromo-2' -deoxycytidine can promote hair growth, promote growth of hair matrix stem cells, and promote melanin to be fused into hair growth. The above components are matched together to promote the white hair of adult men to turn into black hair.
As an improvement of the hair-blacking essence, the main agent comprises, by mass, 14-16 parts of 2-hydroxy chalcone, 9-11 parts of acetyl tetrapeptide-3, 12-14 parts of imidazo [1,2-A ] pyridine-3-formic acid, 10-12 parts of copper pyrrolidone carboxylate, 5-7 parts of hydrogen oxalate, 8-10 parts of hydrolyzed collagen, 3-5 parts of 2-deoxy-2-hexylglycerol, 4-6 parts of phenylacrylol, 7-9 parts of N-acetyl-D-glucosamine amino alcohol and 4-6 parts of 5-bromo-2' -deoxycytidine.
By adopting the technical scheme, the components complement each other to form a relatively coordinated and unified hair-blacking essence system, and the white hair of an adult man can be better promoted to be changed into black hair.
As an improvement of the hair-blacking essence, the main agent comprises 15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-carboxylic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of hydrogen oxalate salt, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine according to mass.
By adopting the technical scheme, the effects of promoting the white hair of the adult men to turn into black hair reach the best within a certain range under the complementary action of the components.
As an improvement of the hair-blacking essence, the hydrogen oxalate is potassium hydrogen oxalate, sodium hydrogen oxalate or ammonium hydrogen oxalate.
By adopting the technical scheme, the potassium hydrogen oxalate, the sodium hydrogen oxalate or the ammonium hydrogen oxalate can all play roles in accelerating the absorption of acetyl tetrapeptide-3 in hair follicles and improving the effect in an essence system.
As an improvement of the hair-blacking essence, the main agent also comprises 4-10 parts of hyaluronate.
By adopting the technical scheme, the hyaluronate can repair damaged melanocytes, promote the development of the melanocytes and promote the white hair of men to turn black hair.
As an improvement of the hair-blacking essence, the main agent comprises 7 parts of hyaluronate.
By adopting the technical scheme, the hyaluronate and other components reach better proportion, and the effect is obvious.
As an improvement of the hair blacking essence, the hyaluronate is sodium hyaluronate, potassium hyaluronate or calcium hyaluronate.
By adopting the technical scheme, sodium hyaluronate, potassium hyaluronate or calcium hyaluronate can be matched with other components to repair damaged melanocytes, promote development of melanocytes and promote white hair of men to turn black hair.
As an improvement of the hair-blacking essence, the main agent also comprises 5-15 parts of menthol lactate.
By adopting the technical scheme, the menthol lactate can further relax blood vessels, promote the combination of the blood vessels and the hair papilla, and promote the nutrition supply efficiency to the hair papilla.
As an improvement of the hair-blacking essence, the main agent comprises 10 parts of menthol lactate.
By adopting the technical scheme, menthol lactate is matched with other components in the hair blacking essence, so that the effect of turning white hair into black hair of men is improved.
In a second aspect, the present application further provides a preparation method of the hair blackening essence, and the following technical scheme is adopted.
The preparation method of the hair blackening essence comprises the steps of taking 10-20 parts of 2-hydroxy chalcone, 5-15 parts of acetyl tetrapeptide-3, 8-18 parts of imidazo [1,2-A ] pyridine-3-formic acid, 6-16 parts of copper pyrrolidone carboxylate, 3-9 parts of hydrogen oxalate, 6-12 parts of hydrolyzed collagen, 1-7 parts of 2-deoxidizing-2-hexylglycerol, 2-8 parts of phenylacrylol, 3-13 parts of N-acetyl-D-glucosamine amino alcohol and 2-8 parts of 5-bromo-2' -deoxycytidine as main agents by mass, adding into a solvent, and uniformly mixing to obtain the hair blackening essence; the mass percentage of the main agent and the solvent is (15-20%): (80-85%).
By adopting the technical scheme and adopting reasonable proportion, the hair-blacking essence capable of effectively improving white hair of adult men to blacken hair is obtained, and the preparation method is simple. The use method of the prepared hair-blacking essence can be as follows: after the scalp is dry or washed, the scalp is semi-dried, the essence is uniformly coated on the scalp, and the scalp is gently massaged and absorbed. The solvent can be a mixed solution of water and ethanol, and the mass ratio of the water to the ethanol can be (2-4): 1, the solvent may be pure water.
In summary, the hair-blacking essence and the preparation method thereof have the following beneficial effects:
the hair blackening essence can penetrate into hair follicles to clean, and each component of the hair blackening essence can penetrate into hair follicles efficiently to nourish hair follicles and hair papilla, promote repair and development of melanocyte, strengthen connection of hair papilla and blood vessel, repair nutrition supply channels of hair papilla, promote synthesis and transfer efficiency of melanin, effectively repair white hair generated gradually by serious mental wounds or mental overfatigue of adult men due to endocrine diseases or excessive anxiety, sadness and the like, and promote white hair to turn into black hair.
Detailed Description
Some examples of hair-blacking essence and preparation method thereof of the present application are described in detail below.
Example 1
The preparation method of the hair blackening essence comprises the steps of taking 10 parts by mass of 2-hydroxy chalcone, 15 parts by mass of acetyl tetrapeptide-3, 8 parts by mass of imidazo [1,2-A ] pyridine-3-carboxylic acid, 16 parts by mass of copper pyrrolidone carboxylate, 3 parts by mass of potassium hydrogen oxalate, 12 parts by mass of hydrolyzed collagen, 1 part by mass of 2-deoxy-2-hexylglycerol, 8 parts by mass of phenylacrylol, 3 parts by mass of N-acetyl-D-glucosamine amino alcohol and 8 parts by mass of 5-bromo-2' -deoxycytidine as main agents, and adding into a solvent to be uniformly mixed to obtain the hair blackening essence. The mass percentage of the main agent and the solvent is 15 percent: 85%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 2
The preparation method of the hair blackening essence comprises the steps of taking 20 parts of 2-hydroxy chalcone, 5 parts of acetyl tetrapeptide-3, 18 parts of imidazo [1,2-A ] pyridine-3-carboxylic acid, 6 parts of copper pyrrolidone carboxylate, 9 parts of sodium hydrogen oxalate, 6 parts of hydrolyzed collagen, 7 parts of 2-deoxy-2-hexylglycerol, 2 parts of phenylacrylol, 13 parts of N-acetyl-D-glucosamine amino alcohol and 2 parts of 5-bromo-2' -deoxycytidine as main agents by mass, adding into a solvent, and uniformly mixing to obtain the hair blackening essence. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 3
The preparation method of the hair blackening essence comprises the steps of taking 14 parts by mass of 2-hydroxy chalcone, 11 parts by mass of acetyl tetrapeptide-3, 12 parts by mass of imidazo [1,2-A ] pyridine-3-carboxylic acid, 12 parts by mass of copper pyrrolidone carboxylate, 5 parts by mass of potassium hydrogen oxalate, 10 parts by mass of hydrolyzed collagen, 3 parts by mass of 2-deoxy-2-hexylglycerol, 6 parts by mass of phenylacrylol, 7 parts by mass of N-acetyl-D-glucosamine amino alcohol and 6 parts by mass of 5-bromo-2' -deoxycytidine as main agents, and adding into a solvent to be uniformly mixed to obtain the hair blackening essence. The mass percentage of the main agent and the solvent is 15 percent: 85%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 4
16 parts of 2-hydroxy chalcone, 9 parts of acetyl tetrapeptide-3, 14 parts of imidazo [1,2-A ] pyridine-3-formic acid, 10 parts of copper pyrrolidone carboxylate, 7 parts of sodium hydrogen oxalate, 8 parts of hydrolyzed collagen, 5 parts of 2-deoxy-2-hexylglycerol, 4 parts of phenylacrylol, 6 parts of N-acetyl-D-glucosamine amino alcohol and 4 parts of 5-bromo-2' -deoxycytidine are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 5
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 6
This example is an addition of 4 parts sodium hyaluronate as compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 4 parts of sodium hyaluronate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 7
This example is an addition of 7 parts potassium hyaluronate as compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of potassium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 7 parts of potassium hyaluronate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 8
This example is an addition of 10 parts of calcium hyaluronate as compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of calcium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 10 parts of calcium hyaluronate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 9
This example is an addition of 5 parts menthol lactate compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 5 parts of menthol lactate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 10
This example is an addition of 10 parts menthol lactate compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 10 parts of menthol lactate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 11
This example is an addition of 15 parts menthol lactate compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine and 15 parts of menthol lactate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Example 12
This example is an addition of 7 parts potassium hyaluronate and 10 parts menthol lactate as compared to example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of potassium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol, 5 parts of 5-bromo-2' -deoxycytidine, 7 parts of potassium hyaluronate and 10 parts of menthol lactate are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 1
In this comparative example, no 2-hydroxy chalcone was added as compared with example 5, as follows.
The preparation method of the hair blackening essence comprises the steps of taking 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine as main agents by mass, adding the main agents into a solvent, and uniformly mixing to obtain the hair blackening essence. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 2
In this comparative example, no acetyltetrapeptide-3 was added as compared with example 5, as follows.
15 parts of 2-hydroxy chalcone, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxidizing-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 3
In this comparative example, no imidazo [1,2-A ] pyridine-3-carboxylic acid was added as compared to example 5, as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blacking essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 4
In this comparative example, copper pyrrolidone carboxylate was not added, as follows, in particular, in comparison with example 5.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxidizing-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 5
In this comparative example, sodium hydrogen oxalate was not added, as compared with example 5, concretely as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 6
In this comparative example, compared with example 5, no hydrolyzed collagen was added, as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 7
In this comparative example, as compared with example 5, 2-deoxy-2-hexylglycerol was not added, as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 5 parts of phenylacrylol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blacking essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 8
In this comparative example, no phenylacrylol was added as compared with example 5, specifically as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 8 parts of N-acetyl-D-glucosamine amino alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents by mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 9
In this comparative example, in contrast to example 5, no N-acetyl-D-glucosamine amino alcohol was added, as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxy-2-hexylglycerol, 5 parts of benzyl alcohol and 5 parts of 5-bromo-2' -deoxycytidine are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Comparative example 10
In this comparative example, in contrast to example 5, 5-bromo-2' -deoxycytidine was not added, as follows.
15 parts of 2-hydroxy chalcone, 10 parts of acetyl tetrapeptide-3, 13 parts of imidazo [1,2-A ] pyridine-3-formic acid, 11 parts of copper pyrrolidone carboxylate, 6 parts of sodium hydrogen oxalate, 9 parts of hydrolyzed collagen, 4 parts of 2-deoxidizing-2-hexyl glycerol, 5 parts of phenylacrylol and 8 parts of N-acetyl-D-glucosamine amino alcohol are taken as main agents according to mass, and added into a solvent to be uniformly mixed, so that the hair blackening essence is obtained. The mass percentage of the main agent and the solvent is 20 percent: 80%. The solvent is water: ethanol = 3:1 ethanol solution.
Test example 1
The essences prepared in examples 1 to 12 and comparative examples 1 to 10 were uniformly applied to the scalp of white hair patients aged 38 to 55 years old, one type of the essence was used for each patient, and the application was carried out once daily by gently massaging and absorbing, 10g was applied each time, and the application was continued for 30 days. During the test, 22 white hair men aged 38-55 were scored first and then after the essential oils of each example or comparative example were used. The scoring rule is that the full hair is 0 score, half of the black hair is 50 score, and half of the white hair is 100 score.
The test results are shown in Table 1 below.
Table 1 comparison of the effects of the essential oils prepared in each example and comparative example
As can be seen from table 1 above, the essential oils prepared in examples 1 to 12 have better effects and significantly improved blackening ratio than those prepared in comparative examples 1 to 10 in the experiments of turning white hair into black hair for men. Wherein the effects of examples 3-5 are slightly better than those of examples 1-2, especially the use effect of example 5 is better. Compared with the example 5, the examples 6-8 are added with hyaluronate, and the hyaluronate can repair damaged melanocytes, promote the development of the melanocytes, promote the white hair of men to turn into black hair, and promote the conversion rate of turning into black hair. Compared with the embodiment 5, the embodiment 9-11 has the advantages that the menthol lactate is added to the raw materials, the menthol lactate can further relax blood vessels, promote the combination of blood vessels and hair papilla, improve the nutrition supply efficiency to the hair papilla, and improve the conversion rate of white hair to black hair. Example 12 the conversion of white to black hair was further improved by increasing the potassium hyaluronate and menthol lactate as compared to example 5.
Compared with the example 5, the comparative example 1 is not added with 2-hydroxy chalcone, and the 2-hydroxy chalcone has the effect of promoting hair follicle penetration, is beneficial to cleaning hair follicle and promoting other components to penetrate into the hair follicle, so the efficiency of penetrating the essential oil prepared in the comparative example 1 into the hair follicle is reduced, the conversion rate of white hair to black hair is greatly affected, and the conversion rate is obviously reduced.
Comparative example 2 compared with example 5, no acetyl tetrapeptide-3 was added, and acetyl tetrapeptide-3 was able to act directly on the tissue near the hair follicle, rapidly repairing the melanocytes of the hair follicle, forming extracellular matrix proteins and fibronectin, securing the root and strengthening the connection of the papilla with the blood vessel. Therefore, the amount of melanin formation excited by the essential oil prepared in comparative example 2 was significantly reduced, and thus the conversion rate of white hair into black hair was also significantly reduced.
Comparative example 3 in comparison with example 5, imidazole [1,2-a ] pyridine-3-carboxylic acid was not added, and imidazole [1,2-a ] pyridine-3-carboxylic acid was able to promote development of hair papilla, further enhancing connection of hair papilla and blood vessel. The essential oil prepared in comparative example 3 was reduced in nutrient supply to the restoration hair papilla, and the conversion rate of white hair to black hair was also significantly reduced for men.
Comparative example 4 in comparison with example 5, no copper pyrrolidone carboxylate was added, and copper pyrrolidone carboxylate was able to relax blood vessels, further enhancing the connection of hair papilla and blood vessels. The essential oil prepared in comparative example 4 also had an effect on enhancing the nutrition supply to the hair papilla, and its conversion rate from white to black was also decreased for men.
Comparative example 5 in comparison with example 5, sodium hydrogen oxalate was not added, and the hydrogen oxalate was able to accelerate the absorption and increase the efficacy of acetyl tetrapeptide-3 in hair follicles. The essential oil prepared in comparative example 5 was reduced in the efficacy of absorption and the conversion rate of white hair to black hair for men was also reduced.
Comparative example 6 compared with example 5, no hydrolyzed collagen was added, and hydrolyzed collagen was able to regulate pigment secretion, reduce melanin pigmentation in the skin, and increase melanin pigmentation in the hair, so the essential oil prepared in comparative example 6 affected melanin pigmentation in the hair, and thus its conversion rate to white hair of men was also decreased.
Comparative example 7 compared with example 5, 2-deoxy-2-hexylglycerol was not added, and 2-deoxy-2-hexylglycerol can enhance the activity of tyrosinase and enhance the efficiency of melanin synthesis. The essential oil prepared in comparative example 7 had a lower level of activity for enhancing tyrosinase, and had a reduced conversion rate for turning white hair into black hair in men.
Comparative example 8 compared to example 5, no phenylacrylol was added, which can enhance the efficiency of penetration of the produced melanin into the hair papilla. The essential oil prepared in comparative example 8 also had a reduced conversion rate for white to black men.
Comparative example 9 in comparison with example 5, no N-acetyl-D-glucosamine amino alcohol was added, which could regulate the water-oil balance in hair follicles, providing a good environment for hair follicle growth. The essential oil prepared in comparative example 9 showed a significant decrease in the conversion rate of white hair to black hair for men.
Comparative example 10 compared with example 5, 5-bromo-2 '-deoxycytidine was not added, and 5-bromo-2' -deoxycytidine was able to promote hair growth, promote growth of hair matrix stem cells, and promote melanin incorporation into the progress of hair growth. The essential oil prepared in comparative example 10 showed a significant decrease in the conversion rate of white hair to black hair for men.
Experimental example 1 shows that 2-hydroxy chalcone, acetyl tetrapeptide-3, imidazo [1,2-A ] pyridine-3-carboxylic acid, copper pyrrolidone carboxylate, hydrogen oxalate, hydrolyzed collagen, 2-deoxy-2-hexylglycerol, phenylacrylol, N-acetyl-D-glucosamine amino alcohol and 5-bromo-2' -deoxycytidine added in examples 1 to 12 are combined together to promote the conversion of white hair of adult men into black hair.
The use method of the hair blackening essence can be as follows: after the scalp is dry or washed, the scalp is semi-dried, the essence is uniformly coated on the scalp, and the scalp is gently massaged and absorbed. The hair blackening essence can penetrate into hair follicles to clean, and each component of the hair blackening essence can penetrate into hair follicles efficiently to nourish hair follicles and hair papilla, promote repair and development of melanocyte, strengthen connection of hair papilla and blood vessel, repair nutrition supply channels of hair papilla, promote synthesis and transfer efficiency of melanin, effectively repair white hair generated gradually by serious mental wounds or mental overfatigue of adult men due to endocrine diseases or excessive anxiety, sadness and the like, and promote white hair to turn into black hair.
The above-mentioned embodiments are only preferred embodiments of the present application, and the protection scope of the present application is not limited to the above-mentioned embodiments, and all technical solutions belonging to the concept of the present application belong to the protection scope of the present application. It should be noted that modifications and adaptations to those skilled in the art without departing from the principles of the present application are intended to be within the scope of the present application.
Claims (10)
1. The hair blackening essence is characterized by comprising a solvent and a main agent, wherein the main agent comprises, by mass, 10-20 parts of 2-hydroxy chalcone, 5-15 parts of acetyl tetrapeptide-3, 8-18 parts of imidazole [1,2-A ] pyridine-3-formic acid, 6-16 parts of copper pyrrolidone carboxylate, 3-9 parts of hydrogen oxalate, 6-12 parts of hydrolyzed collagen, 1-7 parts of 2-deoxy-2-hexylglycerol, 2-8 parts of phenylacrylol, 3-13 parts of N-acetyl-D-glucosamine amino alcohol and 2-8 parts of 5-bromo-2' -deoxycytidine.
2. The hair blacking essence according to claim 1, wherein the main agent comprises, by mass, 14 to 16 parts of 2-hydroxy-chalcone, 9 to 11 parts of acetyl tetrapeptide-3, 12 to 14 parts of imidazo [1,2-a ] pyridine-3-carboxylic acid, 10 to 12 parts of copper pyrrolidone carboxylate, 5 to 7 parts of hydrogen oxalate, 8 to 10 parts of hydrolyzed collagen, 3 to 5 parts of 2-deoxy-2-hexylglycerol, 4 to 6 parts of phenylacrylol, 7 to 9 parts of N-acetyl-D-glucosamine amino alcohol, and 4 to 6 parts of 5-bromo-2' -deoxycytidine.
3. The hair-blacking essence according to claim 2, characterized in that the main agent comprises 15 parts by mass of 2-hydroxy-chalcone, 10 parts by mass of acetyl tetrapeptide-3, 13 parts by mass of imidazo [1,2-a ] pyridine-3-carboxylic acid, 11 parts by mass of copper pyrrolidone carboxylate, 6 parts by mass of hydrogen oxalate, 9 parts by mass of hydrolyzed collagen, 4 parts by mass of 2-deoxy-2-hexylglycerol, 5 parts by mass of phenylacrylol, 8 parts by mass of N-acetyl-D-glucosamine amino alcohol and 5 parts by mass of 5-bromo-2' -deoxycytidine.
4. The hair blacking essence according to any one of claims 1 to 3, wherein the hydrogen oxalate is potassium hydrogen oxalate, sodium hydrogen oxalate or ammonium hydrogen oxalate.
5. The hair blacking essence according to any one of claims 1 to 3, wherein the main agent further comprises 4 to 10 parts of hyaluronate.
6. The hair blacking concentrate of claim 5 wherein the base comprises 7 parts hyaluronate.
7. The hair blacking concentrate of claim 5 wherein the hyaluronate is sodium hyaluronate, potassium hyaluronate, or calcium hyaluronate.
8. The hair blacking essence according to any one of claims 1 to 3, wherein the main agent further comprises 5 to 15 parts of menthol lactate.
9. The hair blacking concentrate of claim 8 wherein the base agent includes 10 parts menthol lactate.
10. A method for preparing the hair-blacking essence according to any one of claims 1 to 9, characterized in that 10 to 20 parts by mass of 2-hydroxy chalcone, 5 to 15 parts by mass of acetyl tetrapeptide-3, 8 to 18 parts by mass of imidazole [1,2-a ] pyridine-3-carboxylic acid, 6 to 16 parts by mass of copper pyrrolidone carboxylate, 3 to 9 parts by mass of hydrogen oxalate, 6 to 12 parts by mass of hydrolyzed collagen, 1 to 7 parts by mass of 2-deoxy-2-hexylglycerol, 2 to 8 parts by mass of phenylacrylol, 3 to 13 parts by mass of N-acetyl-D-glucosamine amino alcohol and 2 to 8 parts by mass of 5-bromo-2' -deoxycytidine are taken as main agents, and added into a solvent to be uniformly mixed, so as to obtain the hair-blacking essence; the mass percentage of the main agent and the solvent is (15-20%): (80-85%).
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| CN112263520A (en) * | 2020-10-30 | 2021-01-26 | 花安堂生物科技集团有限公司 | Hair-blacking composition, hair-blacking essence and application of hair-blacking essence |
| CN112245368A (en) * | 2020-11-25 | 2021-01-22 | 广州美茵生物科技有限公司 | Cassia seed extract hair-blacking composition and essence and preparation method thereof |
| CN114712299A (en) * | 2022-04-11 | 2022-07-08 | 广州禾力生物科技有限公司 | White hair-to-black hair essence and application thereof |
| CN115475122A (en) * | 2022-09-02 | 2022-12-16 | 曼秀雷敦(中国)药业有限公司 | Hair blackening essence and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117959232A (en) * | 2024-03-29 | 2024-05-03 | 珠海博御中医药研究有限公司 | Hair-blacking essence composition and preparation method and application thereof |
| CN117959232B (en) * | 2024-03-29 | 2024-06-11 | 珠海博御中医药研究有限公司 | Hair-blacking essence composition and preparation method and application thereof |
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|---|---|
| CN115998630B (en) | 2023-06-06 |
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Denomination of invention: A black hair essence and its preparation method Effective date of registration: 20231205 Granted publication date: 20230606 Pledgee: Bank of Beijing Co.,Ltd. Economic and Technological Development Zone Branch Pledgor: BEIJING PUSHIAN BIOTECHNOLOGY CO.,LTD. Registration number: Y2023110000511 |