CN117940416A - Kif18a抑制剂化合物的盐和固态形式 - Google Patents

Kif18a抑制剂化合物的盐和固态形式 Download PDF

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Publication number
CN117940416A
CN117940416A CN202280060739.4A CN202280060739A CN117940416A CN 117940416 A CN117940416 A CN 117940416A CN 202280060739 A CN202280060739 A CN 202280060739A CN 117940416 A CN117940416 A CN 117940416A
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compound
solvate
crystalline
cancer
crystalline compound
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CN202280060739.4A
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English (en)
Chinese (zh)
Inventor
T·吴
P·阿加瓦尔
A·R·罗特利
H·帕克
M·J·弗罗恩
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Amgen Inc
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Amgen Inc
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202280060739.4A 2021-07-21 2022-07-21 Kif18a抑制剂化合物的盐和固态形式 Pending CN117940416A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163224208P 2021-07-21 2021-07-21
US63/224,208 2021-07-21
PCT/US2022/037928 WO2023004075A1 (en) 2021-07-21 2022-07-21 Salts and solid state forms of a kif18a inhibitor compound

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CN117940416A true CN117940416A (zh) 2024-04-26

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US (1) US20240327384A1 (https=)
EP (1) EP4373818A1 (https=)
JP (1) JP2024526882A (https=)
KR (1) KR20240051338A (https=)
CN (1) CN117940416A (https=)
AR (1) AR126537A1 (https=)
AU (1) AU2022313961A1 (https=)
CA (1) CA3226614A1 (https=)
IL (1) IL310234A (https=)
MX (1) MX2024000990A (https=)
TW (1) TW202321213A (https=)
UY (1) UY39866A (https=)
WO (1) WO2023004075A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
IL310863A (en) 2021-08-26 2024-04-01 Volastra Therapeutics Inc Spiro indoline inhibitors of kif18a
EP4509505A4 (en) * 2022-04-15 2026-04-15 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company KIF18A INHIBITOR AND ITS USAGE
TW202416973A (zh) 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
CN116535400B (zh) * 2023-04-26 2024-08-16 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用
WO2025077882A1 (zh) * 2023-10-13 2025-04-17 武汉人福创新药物研发中心有限公司 Kif18a抑制剂化合物的盐、晶型及其制备方法和用途
WO2025185704A1 (zh) * 2024-03-07 2025-09-12 长春金赛药业有限责任公司 一种kif18a抑制剂的晶型及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8576985B2 (en) 2009-09-01 2013-11-05 Aptuit (West Lafayette) Llc Methods for indexing solid forms of compounds
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
MX2022012992A (es) * 2020-04-14 2022-11-08 Amgen Inc Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas.

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WO2023004075A1 (en) 2023-01-26
CA3226614A1 (en) 2023-01-26
US20240327384A1 (en) 2024-10-03
JP2024526882A (ja) 2024-07-19
IL310234A (en) 2024-03-01
AR126537A1 (es) 2023-10-18
AU2022313961A1 (en) 2024-02-08
TW202321213A (zh) 2023-06-01
EP4373818A1 (en) 2024-05-29
KR20240051338A (ko) 2024-04-19
UY39866A (es) 2023-01-31
MX2024000990A (es) 2024-02-12

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