TW202321213A - Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式 - Google Patents

Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式 Download PDF

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TW202321213A
TW202321213A TW111126873A TW111126873A TW202321213A TW 202321213 A TW202321213 A TW 202321213A TW 111126873 A TW111126873 A TW 111126873A TW 111126873 A TW111126873 A TW 111126873A TW 202321213 A TW202321213 A TW 202321213A
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compound
ser
leu
glu
solvate
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TW111126873A
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天 吳
佩若瑄 阿賈瓦
安德列斯 Ｒ 羅勒里
賢秀 朴
麥可 Ｊ 佛朗
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美商安進公司
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW111126873A 2021-07-21 2022-07-18 Ｋｉｆ１８ａ抑制劑化合物之鹽和固態形式 TW202321213A (zh)

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US202163224208P 2021-07-21 2021-07-21
US63/224,208 2021-07-21

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US (1) US20240327384A1 (https=)
EP (1) EP4373818A1 (https=)
JP (1) JP2024526882A (https=)
KR (1) KR20240051338A (https=)
CN (1) CN117940416A (https=)
AR (1) AR126537A1 (https=)
AU (1) AU2022313961A1 (https=)
CA (1) CA3226614A1 (https=)
IL (1) IL310234A (https=)
MX (1) MX2024000990A (https=)
TW (1) TW202321213A (https=)
UY (1) UY39866A (https=)
WO (1) WO2023004075A1 (https=)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
IL310863A (en) 2021-08-26 2024-04-01 Volastra Therapeutics Inc Spiro indoline inhibitors of kif18a
EP4509505A4 (en) * 2022-04-15 2026-04-15 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company KIF18A INHIBITOR AND ITS USAGE
TW202416973A (zh) 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
CN116535400B (zh) * 2023-04-26 2024-08-16 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用
WO2025077882A1 (zh) * 2023-10-13 2025-04-17 武汉人福创新药物研发中心有限公司 Kif18a抑制剂化合物的盐、晶型及其制备方法和用途
WO2025185704A1 (zh) * 2024-03-07 2025-09-12 长春金赛药业有限责任公司 一种kif18a抑制剂的晶型及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8576985B2 (en) 2009-09-01 2013-11-05 Aptuit (West Lafayette) Llc Methods for indexing solid forms of compounds
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
MX2022012992A (es) * 2020-04-14 2022-11-08 Amgen Inc Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas.

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WO2023004075A1 (en) 2023-01-26
CA3226614A1 (en) 2023-01-26
US20240327384A1 (en) 2024-10-03
JP2024526882A (ja) 2024-07-19
IL310234A (en) 2024-03-01
AR126537A1 (es) 2023-10-18
AU2022313961A1 (en) 2024-02-08
EP4373818A1 (en) 2024-05-29
KR20240051338A (ko) 2024-04-19
UY39866A (es) 2023-01-31
CN117940416A (zh) 2024-04-26
MX2024000990A (es) 2024-02-12

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