CN117797057A - Composition containing hyaluronic acid and application of composition in preparation of moisturizing products - Google Patents
Composition containing hyaluronic acid and application of composition in preparation of moisturizing products Download PDFInfo
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- CN117797057A CN117797057A CN202410224586.3A CN202410224586A CN117797057A CN 117797057 A CN117797057 A CN 117797057A CN 202410224586 A CN202410224586 A CN 202410224586A CN 117797057 A CN117797057 A CN 117797057A
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- hyaluronic acid
- pleurotus citrinopileatus
- containing composition
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 111
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 111
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 111
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims description 31
- 241000392443 Pleurotus citrinopileatus Species 0.000 claims abstract description 85
- 229920001184 polypeptide Polymers 0.000 claims abstract description 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 45
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 45
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 21
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 21
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 21
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 21
- 229940106189 ceramide Drugs 0.000 claims abstract description 21
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 21
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004386 Erythritol Substances 0.000 claims abstract description 11
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 11
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 11
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 11
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 11
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 11
- 229940009714 erythritol Drugs 0.000 claims abstract description 11
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 11
- 235000019414 erythritol Nutrition 0.000 claims abstract description 11
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 11
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 11
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 11
- 229940057910 shea butter Drugs 0.000 claims abstract description 11
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 11
- 239000011734 sodium Substances 0.000 claims abstract description 11
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims abstract description 4
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims abstract description 4
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 238000002386 leaching Methods 0.000 claims description 29
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 21
- 108091005658 Basic proteases Proteins 0.000 claims description 20
- 229940106157 cellulase Drugs 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 238000010298 pulverizing process Methods 0.000 claims description 18
- 239000006228 supernatant Substances 0.000 claims description 12
- 101710166469 Endoglucanase Proteins 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 235000014121 butter Nutrition 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 229940038580 oat bran Drugs 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000013329 compounding Methods 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 108010059892 Cellulase Proteins 0.000 description 9
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 5
- 210000000245 forearm Anatomy 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a composition containing hyaluronic acid and application thereof in preparing moisturizing products, wherein the composition comprises the following components in parts by mass: 14-20 parts of hyaluronic acid, 6-11 parts of polydimethylsiloxane, 11-16 parts of oat polypeptide, 3-8 parts of erythritol, 5-10 parts of acetyl hexapeptide-8 5, 5-10 parts of sodium polyglutamate, 8-13 parts of nicotinamide, 2-7 parts of chitosan oligosaccharide, 9-14 parts of shea butter, 10-15 parts of pleurotus citrinopileatus extract, 11-16 parts of ceramide and 5-10 parts of phospholipid. The composition containing hyaluronic acid prepared by compounding and synergistic effect of the components has good moisturizing effect, and has excellent moisturizing effect when being added into various moisturizing products.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition containing hyaluronic acid and application of the composition in preparation of moisturizing products.
Background
The skin is a natural coat of human body, and is composed of three parts of outermost epidermis, dermis and innermost subcutaneous tissue, and the epidermis is divided into horny layer, transparent layer, granular layer, thorn layer and basal layer. The skin is damaged by various external stimuli and environment, so that skin epidermal cells are damaged, skin dryness and water shortage are easy to occur, and the conventional small molecular moisturizer can bring instant water supplement to the skin, but cannot achieve lasting moisturizing. Traditional cosmetics, on one hand, consider dry skin due to the lack of lipid material on the skin surface. It was demonstrated that the application of grease to the skin surface alone did not soften the skin. The skin is truly due to insufficient moisture, the stratum corneum controls the skin moisture to play a barrier role, the stratum corneum should keep certain moisture to resist the humidity change of the external environment, the moisture content of the stratum corneum at the outermost layer of the skin is required to make the skin smooth, soft and elastic, the moisture content of the stratum corneum should be about 10% under normal conditions, and if the moisture content is lower than the moisture content, the skin is in a water-deficient state, and the skin becomes dry, dark in color and even molts. By adding a moisturizing component (humectant) to the cosmetic, the skin can be effectively protected from dryness and tightness.
Hyaluronic acid, also known as hyaluronic acid, is an acidic mucopolysaccharide with excellent lubricity and moisture retention, is honored as a natural moisture retention factor, has been widely applied to cosmetics, and is also appreciated by consumers. The molecular weight distribution of hyaluronic acid is very wide, and different molecular weights have different physicochemical and biological properties. The traditional cosmetic is added with a plurality of efficacy moisturizing components, and the percutaneous absorption is not fully considered, so that the efficacy moisturizing components stay on the surface of the skin and do not enter into the stratum corneum of the skin, and the deep moisturizing capability of the skin is effectively stimulated. The skin cannot be moisturized for a long time, and the cost of the functional components of the cosmetics is wasted. The types of moisturizing agents containing hyaluronic acid in the market are various, the moisturizing effect and the moisturizing time period of various moisturizing agents are different, but the overall effect is not ideal, so that the development of the moisturizing product containing hyaluronic acid with strong efficacy and long-acting moisturizing capability is very significant.
Disclosure of Invention
The invention aims to provide a composition containing hyaluronic acid and application thereof in preparing moisturizing products, and the prepared composition containing hyaluronic acid has good moisturizing effect and excellent moisturizing effect when being added into various moisturizing products through compounding and synergistic effect of various components.
In order to achieve the above object, the present invention provides the following technical solutions:
the hyaluronic acid-containing composition comprises the following components in parts by weight: 14-20 parts of hyaluronic acid, 6-11 parts of polydimethylsiloxane, 11-16 parts of oat polypeptide, 3-8 parts of erythritol, 5-10 parts of acetyl hexapeptide-8 5, 5-10 parts of sodium polyglutamate, 8-13 parts of nicotinamide, 2-7 parts of chitosan oligosaccharide, 9-14 parts of shea butter, 10-15 parts of pleurotus citrinopileatus extract, 11-16 parts of ceramide and 5-10 parts of phospholipid.
Further, the hyaluronic acid is in a mass ratio of 1:1.3-1.5 hyaluronic acid with molecular weight of 1100kDa and hyaluronic acid with molecular weight of 400 kDa.
Further, the preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:13-15, adjusting the pH value to 9-10, adding alkaline protease and cellulase in a mass ratio of 2-3:1, stirring and extracting for 3-5h at 50-53 ℃, standing, and taking supernatant;
(2) Adding activated carbon with the supernatant mass of 8-10%, maintaining the temperature at 90-92 ℃ for 1-1.5h, standing for 1-1.5h, filtering, concentrating, and sterilizing to obtain the oat polypeptide.
Further, the total mass of the alkaline protease and the cellulase accounts for 2% -2.5% of the water mass.
Further, the preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing Pleurotus citrinopileatus powder with water at a mass ratio of 1:6-10, leaching at 85-90deg.C for 1.5-2 hr to obtain leaching solution;
(3) Adding active carbon with the mass of 5-7% of the leaching solution, preserving heat at 90-95 ℃ for 80-100min, and standing for 30-50min to obtain Pleurotus citrinopileatus extract.
Further, the concentration of the pleurotus citrinopileatus extract is 1-1.5g/mL.
Further, the powder is crushed into 800 to 1000 meshes.
Further, the preparation method of the hyaluronic acid-containing composition comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 60-65deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 70-75deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
The invention also provides application of the composition containing hyaluronic acid in preparing moisturizing products.
Further, the hyaluronic acid-containing composition is added to the moisturizing product in an amount of 20-60%.
Compared with the prior art, the invention has the advantages that: according to the invention, through the compounding of multiple components and the synergy, the moisturizing effect and the moisturizing time can be improved through the compounding of the hyaluronic acid with different molecular weights, the moisturizing effect is improved, and the oat polypeptide and the pleurotus citrinopileatus extract are added to have a remarkable promoting effect on the moisturizing effect, and the prepared hyaluronic acid-containing composition has a good moisturizing effect through the synergistic effect of multiple components and is added to various moisturizing products.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a composition containing hyaluronic acid, which comprises the following components in parts by mass: 16 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 14 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 13 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Example 2
The embodiment provides a composition containing hyaluronic acid, which comprises the following components in parts by mass: 14 parts of hyaluronic acid, 11 parts of polydimethylsiloxane, 11 parts of oat polypeptide, 8 parts of erythritol, 85 parts of acetyl hexapeptide, 10 parts of sodium polyglutamate, 8 parts of nicotinamide, 7 parts of chitosan oligosaccharide, 9 parts of shea butter, 15 parts of pleurotus citrinopileatus extract, 11 parts of ceramide and 5 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.3 Is compounded with hyaluronic acid with molecular weight of 1100kDa and hyaluronic acid with molecular weight of 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:13, adjusting the pH value to 10, adding alkaline protease and cellulase in a mass ratio of 2:1, stirring and extracting at 53 ℃ for 3 h, standing, and taking supernatant;
(2) Adding 10% of active carbon, maintaining the temperature at 90 ℃ for 1. 1 h, standing for 1.5h, filtering, concentrating, and sterilizing to obtain oat polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.5% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder with the mass ratio of 1:10 with water, and leaching for 2 hours at 90 ℃ to obtain leaching liquor;
(3) Adding 7% active carbon, maintaining at 95deg.C for 100min, and standing for 50min to obtain Pleurotus citrinopileatus extractive solution.
The concentration of the pleurotus citrinopileatus extract is 1 g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 60deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 75deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 1
The difference between this comparative example and example 1 is: the components have different parts by weight.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 8 parts of hyaluronic acid, 16 parts of polydimethylsiloxane, 5 parts of oat polypeptide, 13 parts of erythritol, 8 parts of acetyl hexapeptide-8, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 14 parts of chitosan oligosaccharide, 7 parts of shea butter, 6 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 2
The difference between this comparative example and example 1 is: the hyaluronic acid is prepared from the following components in percentage by mass: 1 with a molecular weight of 1100kDa and a molecular weight of 400 kDa.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 16 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 14 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 13 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 3
The difference between this comparative example and example 1 is: oat polypeptide is commercially available from Woltesi biotechnology limited, lanzhou.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 16 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 14 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 13 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 4
The difference between this comparative example and example 1 is: the pleurotus citrinopileatus extract is commercially available and is purchased from Gansu Probiotics and Biotechnology Co.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 16 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 14 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 13 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 5
The difference between this comparative example and example 1 is: the hyaluronic acid, oat polypeptide and pleurotus citrinopileatus extract are different in mass parts.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 26 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 9 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 8 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Comparative example 6
The difference between this comparative example and example 1 is: the hyaluronic acid, oat polypeptide and pleurotus citrinopileatus extract are different in mass parts.
The method comprises the following steps: the hyaluronic acid-containing composition comprises the following components in parts by weight: 8 parts of hyaluronic acid, 8 parts of polydimethylsiloxane, 18 parts of oat polypeptide, 6 parts of erythritol, 8 7 parts of acetyl hexapeptide, 8 parts of sodium polyglutamate, 10 parts of nicotinamide, 5 parts of chitosan oligosaccharide, 11 parts of shea butter, 17 parts of pleurotus citrinopileatus extract, 14 parts of ceramide and 8 parts of phospholipid.
The hyaluronic acid is prepared from the following components in percentage by mass: 1.4A hyaluronic acid of molecular weight 1100kDa was complexed with a hyaluronic acid of molecular weight 400 kDa.
The preparation method of the oat polypeptide comprises the following steps:
(1) Mixing oat bran and water in a mass ratio of 1:14, adjusting the pH value to 9.5, adding alkaline protease and cellulase in a mass ratio of 2.5:1, stirring and extracting for 4 hours at 52 ℃, standing, and taking supernatant;
(2) Adding 9% of active carbon, maintaining at 91 deg.C for 1.2 hr, standing for 1.2 hr, vacuum filtering, concentrating, and sterilizing to obtain herba Avenae Fatuae polypeptide.
The total mass of the alkaline protease and the cellulase accounts for 2.2% of the water mass.
The preparation method of the pleurotus citrinopileatus extract comprises the following steps:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing pleurotus citrinopileatus powder and water according to a mass ratio of 1:8, and leaching for 1.7 hours at 88 ℃ to obtain leaching liquor;
(3) Adding active carbon with the mass of 6% of the leaching solution, preserving heat for 90min at 94 ℃, and standing for 40min to obtain the pleurotus citrinopileatus extract.
The concentration of the pleurotus citrinopileatus extract is 1.3g/mL.
Superfine pulverizing to 800-1000 mesh.
The preparation method of the composition containing hyaluronic acid comprises the following steps:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 63deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 72deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
Performance testing
80 subjects aged 20-40 years were tested using the skin moisture content test probe Corneometer CM 825 from CK, germany. The compositions of examples 1-2 and comparative examples 1-6 were mixed with a water volume ratio of 1:2 to give test samples, and the inner sides of the subject's forearms were allowed to remain free of any cosmetic product 2-3 days prior to application of the test samples, with a test area of 3cm x 3 cm. Equal amounts of test samples were uniformly coated in the test area. The test sample is applied to the test area by the subject in the morning and evening daily during the test period. Before each instrument test, the inner sides of the forearms of the two hands of a subject need to be cleaned uniformly, the cleaning method is to wipe the inner sides with dry facial tissues, then sit still for 20 minutes in a room meeting the standard, water and beverage cannot be drunk, the forearms are exposed, and the test state is kept for relaxation. The test time was before use, after 8 hours of use, after 2 weeks and after 4 weeks.
TABLE 1 Performance test results
As is clear from examples 1 to 2, the hyaluronic acid-containing composition of the present invention has an excellent moisturizing effect, and as is clear from comparative examples 1 to 6, the moisturizing performance of the composition is lowered by changing the raw materials and the proportions of the components.
While the foregoing is directed to the preferred embodiments of the present invention, it will be appreciated by those skilled in the art that various modifications and adaptations can be made without departing from the principles of the present invention, and such modifications and adaptations are intended to be comprehended within the scope of the present invention.
Claims (10)
1. The hyaluronic acid-containing composition is characterized by comprising the following components in parts by mass: 14-20 parts of hyaluronic acid, 6-11 parts of polydimethylsiloxane, 11-16 parts of oat polypeptide, 3-8 parts of erythritol, 5-10 parts of acetyl hexapeptide-8 5, 5-10 parts of sodium polyglutamate, 8-13 parts of nicotinamide, 2-7 parts of chitosan oligosaccharide, 9-14 parts of shea butter, 10-15 parts of pleurotus citrinopileatus extract, 11-16 parts of ceramide and 5-10 parts of phospholipid.
2. The hyaluronic acid-containing composition of claim 1, wherein the hyaluronic acid is in a mass ratio of 1:1.3-1.5 hyaluronic acid with molecular weight of 1100kDa and hyaluronic acid with molecular weight of 400 kDa.
3. The hyaluronic acid-containing composition of claim 1, wherein the oat polypeptide is prepared by a method comprising:
(1) Mixing oat bran and water in a mass ratio of 1:13-15, adjusting the pH value to 9-10, adding alkaline protease and cellulase in a mass ratio of 2-3:1, stirring and extracting for 3-5h at 50-53 ℃, standing, and taking supernatant;
(2) Adding activated carbon with the supernatant mass of 8-10%, maintaining the temperature at 90-92 ℃ for 1-1.5h, standing for 1-1.5h, filtering, concentrating, and sterilizing to obtain the oat polypeptide.
4. The hyaluronic acid-containing composition according to claim 3, characterized in that the total mass of alkaline protease and cellulase is 2% -2.5% of the water mass.
5. The hyaluronic acid-containing composition of claim 1, wherein the pleurotus citrinopileatus extract is prepared by a method comprising:
(1) Drying Pleurotus citrinopileatus, and superfine pulverizing to obtain Pleurotus citrinopileatus powder;
(2) Mixing Pleurotus citrinopileatus powder with water at a mass ratio of 1:6-10, leaching at 85-90deg.C for 1.5-2 hr to obtain leaching solution;
(3) Adding active carbon with the mass of 5-7% of the leaching solution, preserving heat at 90-95 ℃ for 80-100min, and standing for 30-50min to obtain Pleurotus citrinopileatus extract.
6. The hyaluronic acid-containing composition according to claim 5, wherein the concentration of the pleurotus citrinopileatus extract is 1-1.5g/mL.
7. The hyaluronic acid-containing composition of claim 5, wherein the hyaluronic acid-containing composition is ultrafine pulverized to 800-1000 mesh.
8. The hyaluronic acid-containing composition of claim 1, wherein the hyaluronic acid-containing composition is prepared by a process comprising:
(1) Mixing hyaluronic acid, butter of Butyrospermum parkii, pleurotus citrinopileatus extract, ceramide and oat polypeptide, dispersing at 60-65deg.C, and cooling to 40deg.C to obtain phase A; mixing the rest components, dispersing at 70-75deg.C, and cooling to 40deg.C to obtain phase B;
(2) And mixing the uniformly dispersed phase A and phase B, uniformly dispersing, and vacuumizing and defoaming to obtain the composition containing the hyaluronic acid.
9. Use of a hyaluronic acid-containing composition according to any of claims 1-8 for the preparation of a moisturizing product.
10. The use according to claim 9, wherein the hyaluronic acid-containing composition is added to the moisturizing product in an amount of 20-60%.
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