CN117717509A - Soothing and whitening composition for washing face and preparation method thereof - Google Patents
Soothing and whitening composition for washing face and preparation method thereof Download PDFInfo
- Publication number
- CN117717509A CN117717509A CN202311645309.1A CN202311645309A CN117717509A CN 117717509 A CN117717509 A CN 117717509A CN 202311645309 A CN202311645309 A CN 202311645309A CN 117717509 A CN117717509 A CN 117717509A
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- Prior art keywords
- extract
- white
- soothing
- whitening composition
- washing
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Abstract
The invention discloses a soothing and whitening composition for washing face and a preparation method thereof. According to the method, the tea bran extract and the bighead atractylodes rhizome extract are used as the surfactant, the raw materials of the facial cleanser are reduced to stimulate the skin, the chamomile, the white paeony root and the white muscardine silkworm are used as the auxiliary materials to calm and relieve the skin, and the problems of red blood streaks, redness and the like are solved, the white poria, the Japanese ampelopsis root, the white rose and the calendula are used as the auxiliary materials to achieve the anti-melanin deposition whitening effect, and volatile oil components unstable under normal temperature conditions in the extract are removed in the preparation process, so that the stability of the extract is improved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a soothing and whitening composition for washing faces and a preparation method thereof.
Background
Skin problems such as acne, red blood streak, skin sensitivity and the like of facial skin are caused by factors such as pore blockage caused by unclean puberty, excessive horny layer thinning caused by excessive cleaning or skin hydration caused by excessive skin care. The face washing product is used as a rinsing product for cleaning facial skin, the safety and the relieving effect of the face washing product are widely paid attention to by consumers with skin problems, and a plurality of irritant chemical synthetic substances such as cyclic alcohol amide, amine oxide, stabilizing agents, preservatives, essence and the like are added to the raw materials for preparing the face washing product in the market at present, so that the face washing product containing safer and healthier plants or plant extracts is favored by consumers compared with the face washing product containing unsafe and sensitized chemical synthetic substances. The prior art of adding plants or plant extracts to a facial wash product currently has the following problems:
(1) A whitening and face washing soap (CN 201811093824.2) comprises 13-29 parts of azalea acid, 14-22 parts of arbutin, 6-10 parts of grape seed powder, 2-6 parts of jasmine essential oil, 5-9 parts of aloe extract, 1-3 parts of narcissus essential oil, 4-8 parts of gardenia pollen, 9-15 parts of pearl powder, 14-20 parts of sodium sulfate, 3-7 parts of sodium cocoyl glutamate and 5-11 parts of medicinal frosted particles, wherein the medicinal frosted particles contain salicylic acid particle components, and salicylic acid is acidic and can stimulate skin and aggravate skin problems of consumers;
(2) A whitening facial cleanser containing Notoginseng radix comprises surfactant 80-100 parts, foaming agent 3-8 parts, glycerol 3-5 parts, water 30-50 parts, caprylic/capric triglyceride 5-10 parts, stearyl alcohol 3-5 parts, soybean protein 1-3 parts, notoginseng radix extract 20-30 parts, aloe 3-8 parts, granati 2-3 parts and seaweed powder 3-5 parts, and stearyl alcohol as emulsion stabilizer is added to stimulate eyes and skin.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a soothing and whitening composition for washing faces, and aims to overcome the defects that skin problems are aggravated due to irritation of components of facial cleanser and the whitening effect of a washing product is poor. The preparation method of the soothing and whitening composition for washing the face aims to solve the problems that part of volatile oil in an extract obtained by the existing preparation method is unstable under the normal temperature condition and reacts with other substances to form impurities, and the effective active ingredients are denatured and reduced due to high-temperature concentration.
In order to achieve the above purpose, the invention provides a method for preparing a soothing and whitening composition for washing faces, which at least comprises the following raw materials: tea bran extract, white atractylodes rhizome extract, silkworm extract, white peony root extract, white poria extract, japanese ampelopsis extract, white rose extract, chamomile extract and calendula extract.
Preferably, in the above technical solution, at least the following raw materials are included: 35-60% of tea bran extract, 1-10% of bighead atractylodes rhizome extract, 1-15% of silkworm larva extract, 1-15% of white paeony root extract, 1-15% of white poria extract, 1-10% of Japanese ampelopsis extract, 1-10% of white rose extract, 5-15% of chamomile extract, 1-12% of calendula extract and the balance of thickening agent.
Preferably, in the above technical solution, at least the following raw materials are included: 36-45% of tea bran extract, 3-6% of bighead atractylodes rhizome extract, 6-12% of silkworm larva extract, 3-9% of white paeony root extract, 4-8% of white poria extract, 4-8% of Japanese ampelopsis extract, 6-9% of white rose extract, 8-12.5% of chamomile extract, 5-12% of calendula extract and the balance of thickening agent.
Preferably, in the above technical solution, at least the following raw materials are included: 38% of tea bran extract, 3% of bighead atractylodes rhizome extract, 12% of silkworm larva extract, 9% of white paeony root extract, 5% of white poria extract, 5% of Japanese ampelopsis extract, 6% of white rose extract, 12% of chamomile extract, 8% of calendula extract and 2% of seaweed powder.
Preferably, in the above technical solution, at least the following raw materials are included: 38% of tea bran extract, 5% of bighead atractylodes rhizome extract, 8% of silkworm extract, 3% of white paeony root extract, 7.5% of white poria extract, 7.5% of Japanese ampelopsis extract, 9% of white rose extract, 8% of chamomile extract, 12% of calendula extract and 2% of thickening agent.
Preferably, in the above technical scheme, the thickener is one or more of agar, seaweed powder and gelatin.
A method for preparing a soothing and whitening composition for washing the face, which comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein the ultrasonic extraction method comprises the following specific steps:
(1) Grinding: crushing and grinding the plant extraction part to obtain plant powder with preset particle size;
(2) Extracting: adding ethanol into the plant powder for ultrasonic extraction to obtain crude extract;
(3) Purifying: filtering the crude extract, removing volatile oil, and concentrating to obtain extract;
the hot reflux extraction method comprises the following specific steps:
(1) Extracting: extracting plant petals by heating with ethanol, and setting reflux temperature and reflux time to obtain condensate;
(2) Purifying: filtering the condensate, removing volatile oil, concentrating to obtain extract;
wherein, tea bran, white atractylodes rhizome, silkworm larva, white peony root, white poria and Japanese ampelopsis are extracted by an ultrasonic extraction method to obtain corresponding extracts, white rose, chamomile and calendula are extracted by a thermal reflux extraction method to obtain corresponding extracts, and the extracts are mixed according to a preset percentage to obtain the soothing and whitening composition.
Preferably, in the above technical solution, the ethanol concentration is 70-90%, and the plant powder: ethanol is 1:15-20, and the plant petals: ethanol is 1:20-25.
Preferably, in the above technical scheme, the volatile oil removal is to heat condensate or crude extract to 20-30deg.C under vacuum degree of-0.1 MPa for 10-20min, and remove volatile oil component unstable at normal temperature.
Preferably, in the above technical scheme, the concentration is performed under normal temperature, and the air flow speed of the crude extract or condensate is 40-60m/s.
The raw materials used in the present invention are all commercially available.
Tea bran: and large-area tea-oil trees are planted in Guangxi province, a large amount of tea bran is produced by squeezing tea-oil, and the raw materials are convenient and cheap. The tea bran contains rich protein and tea saponin, which is also called tea saponin, is a natural nonionic surfactant containing structural sugar and structural acid, and has good functions of emulsification, dispersion, wetting, foaming, foam stabilization, decontamination and the like. By utilizing the functions of the tea saponin in the tea bran extract and using the tea bran extract as a surfactant, the defect that the existing face washing product uses sodium stearate as the surfactant to destroy the weak acidic environment of human skin is overcome, the weak acidic environment of the skin is not destroyed while the cleaning effect is maintained, and the sensitivity of the skin of a user is reduced.
White atractylodes rhizome: the white atractylodes rhizome belongs to the asteraceae plant, the chemical components of the white atractylodes rhizome comprise white atractylodes rhizome volatile oil, white atractylodes rhizome polysaccharide, white atractylodes rhizome lactone I, white atractylodes rhizome lactone II, white atractylodes rhizome lactone III, biwhite atractylodes rhizome lactone, vitamin A, sesquiterpene glycoside and the like, but the volatile oil of the white atractylodes rhizome is unstable and is easy to deteriorate due to the fact that the volatile oil of the white atractylodes rhizome is easily oxidized into lactone compounds under the condition of illumination or ultraviolet rays, the volatile oil of the white atractylodes rhizome is removed in the extraction process so as to overcome the defects of difficult preservation, deterioration of finished products and the like of the white atractylodes rhizome extract, and the vitamin A and the white atractylodes rhizome polysaccharide have the effects of promoting the aged stratum corneum cells to soften and fall off, and protecting and repairing skin. The Atractylodis rhizoma extract has no sensitization substances.
Bombyx Batryticatus: refers to a dry body which is lethal to the infection of the silkworm larvae of 4-5 years old with beauveria bassiana. The silkworm extract contains small molecular polypeptide with molecular mass of 1.2KD, the small molecular polypeptide is arranged between amino acid and protein, and the small molecular polypeptide is externally coated to penetrate through stratum corneum into stratum spinosum and stratum basale, so that new keratinocytes are formed by regulating cell proliferation and differentiation, the epidermis is promoted to update, and the moisturizing capability of skin is improved, so that the facial skin is fine and smooth and has luster.
White peony root: white peony root is a common traditional Chinese medicine taking the root as a medicine, has the effects of nourishing blood, regulating menstruation, astringing yin, stopping sweat, softening liver, relieving pain, suppressing liver yang, relieving spasm, easing pain and the like, contains a large amount of active ingredients, and has the main ingredients of white peony root glycoside, total paeoniflorin, triterpenoid saponin and the like, and the white peony root extract has the effects of calming epidermal nerves, relieving skin tension and relieving and improving skin allergy.
Poria cocos: is saprophytic fungus parasitized under pine root, has sweet, light and mild taste, and has the functions of promoting diuresis, removing dampness, invigorating spleen, regulating stomach, calming heart and tranquillizing. The white poria extract comprises pachyman, daucosterol, beta-sitosterol, octacosane, palmitic acid, p-hydroxy benzoic acid, behenic acid, syringic acid, emodin, aloe-emodin, chrysophanol and the like, and polysaccharide molecules contain a plurality of hydrogen bonds, wherein the hydrogen bonds can be combined with free water to form bonding water with weak volatility, the bonding water of a cuticle is enhanced, and active free water volatilization is reduced, so that the effects of moisturizing and preserving moisture are achieved. The chrysophanol improves SOD activity and the daucosterol reacts with oxygen ion free radicals through an electron transfer way, and a large amount of oxygen ion free radicals generated by skin promotion through irradiation of ultraviolet rays with medium and long wavelengths are removed, so that cell membranes of skin cells are prevented from being damaged by peroxidized lipid, and the anti-aging purpose is achieved.
Ampelopsis japonica: radix Ampelopsis, also called radix Ampelopsis and caulis et folium fici Pumilae, is a plant of Ampelopsis of Vitaceae, has effects of clearing heat, resolving carbuncle, resolving hard mass, healing sore, promoting granulation, etc., and the radix Ampelopsis extract contains gallic acid, beta-sitosterol, protocatechuic acid, gentisic acid, resveratrol, emodin, lupeol, daucosterol, etc. Beta-sitosterol improves SOD activity and glucoraphanin reacts with oxygen ion free radicals through an electron transfer way to eliminate oxygen ion free radicals in skin, reduce amino acid oxidation dopa and reduce melanin formation of black cells, thereby realizing whitening.
White rose: the white rose extract contains nerol, geraniol, neral, geranial, beta-large Ma Xitong, beta-damascenone, beta-ionone and vitamin C, and the white rose has strong capability of eliminating superoxide anions, thereby reducing melanin deposition, aging resistance, reducing fine wrinkles, acne marks and the like, contains a large amount of volatile oil and aromatic substances, has rich amino acid and vitamin, has the effects of whitening, removing wrinkles and recovering skin elasticity, and can make skin have luster and antioxidant function.
Chamomile flower: the chamomile extract is used for reducing the damage of sebaceous membranes, maintaining the stability of skin barriers, reducing telangiectasis and solving the problems of redness of skin and uneven skin color adjustment.
Calendula officinalis: calendula, also called calendula, is a plant of the genus calendula of the family Compositae, the calendula extract comprises lutein, carotene, polysaccharides, saponins, terpenes, vitamin C, alkaloids and other components, the calendula extract has strong inhibition effect on the activity of the aminopeptidase, and the calendula extract cooperates with antioxidant components of chinaroot greenbrier rhizome, japanese ampelopsis and white rose to jointly reduce pigmentation.
Compared with the prior art, the invention has the following beneficial effects:
(1) The soothing and whitening composition for washing the face has the advantages that through the coordination and synergy of the active ingredients in the extract, tea bran and bighead atractylodes rhizome are used as main cleaning and decontamination raw materials, the bighead atractylodes rhizome extract softens the horny layer, the aged horny layer is promoted to fall off, and the effects of emulsification, dispersion, wetting, foaming, foam stabilization, decontamination and the like of the tea bran extract are cooperated, so that dead skin is cleaned and removed together, and acnes or acnes caused by horny layer accumulation and pore blockage are reduced; the chamomile, the white paeony root and the white muscardine silkworm are used as auxiliary materials for moisturizing, stabilizing and relieving, the white paeony root extract relieves the tension of skin, relieves pain, and cooperates with the chamomile extract and the white muscardine silkworm extract to jointly relieve telangiectasis, simultaneously improves the moisturizing capability of skin and maintains the stable skin barrier; the whitening raw materials of the chinaroot greenbrier rhizome, the Japanese ampelopsis root, the white rose and the calendula are supplemented, the calendula extract inhibits the activity of the aminopeptidase, reduces the conversion of the aminoplast into dopa by the aminoplast, cooperates with the strong antioxidation effect of the chinaroot greenbrier rhizome extract, the Japanese ampelopsis root extract and the white rose extract, reduces the number of oxygen ion free radicals in skin, reduces the melanin and lipid injury formed by oxidation of the aminoplast and cell membranes by the oxygen ion free radicals, further reduces the melanin deposition caused by acne marks or photo aging, and achieves the effects of whitening and resisting aging to a certain extent.
(2) The raw material pure natural plant extract and the zero chemical component of the soothing and whitening composition for washing the face are added, the components are mild and non-irritating, the cleaning effect is good, and the composition has a certain whitening effect after long-term use.
(3) According to the preparation method of the soothing and whitening composition for washing the face, volatile oil which is unstable under the normal temperature condition in the plant extract is removed in a low-temperature mode, so that the stability of the plant extract is improved under the condition that the components such as polysaccharide, polypeptide and protein of the extract are not damaged; the ethanol extract is removed by adopting a blowing method, so that the denaturation risk of each component of the plant extract is reduced.
Drawings
FIG. 1 is a plot of the foaming force determination lines of the present invention for various surfactants.
Detailed Description
The following detailed description of the present invention is made in connection with specific examples, but it should be understood that the scope of the invention is not limited by the specific examples.
Example 1
A soothing and whitening composition for washing face comprises the following raw materials: 38% of tea bran extract, 3% of bighead atractylodes rhizome extract, 12% of silkworm larva extract, 9% of white paeony root extract, 5% of white poria extract, 5% of Japanese ampelopsis extract, 6% of white rose extract, 12% of chamomile extract, 8% of calendula extract and 2% of seaweed powder.
A preparation method of a soothing and whitening composition for face washing comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis are extracted by the ultrasonic extraction method, and the preparation method comprises the following specific steps of:
(1) Grinding: pulverizing and grinding the plant extraction part to obtain plant powder with particle size of 40-50 meshes;
(2) Extracting: adding 90% ethanol into the plant powder for ultrasonic extraction to obtain crude extract, wherein the plant powder is prepared from the following raw materials: ethanol is 1:15;
(3) Purifying: filtering the crude extract, heating the crude extract to 30 ℃ under the vacuum degree of-0.1 MPa, heating for 10min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 60m/s to the crude extract under the normal temperature condition for 20min;
the hot reflux extraction method is used for extracting the white rose, the chamomile and the calendula and comprises the following specific steps:
(1) Extracting: extracting plant petals by heating with 90% ethanol, and setting reflux temperature and reflux time to obtain condensate, wherein the plant petals: ethanol is 1:20;
(2) Purifying: filtering the condensate, heating the condensate to 30 ℃ under the vacuum degree of-0.1 MPa, heating for 10min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 40m/s to the condensate for 20min under the normal temperature condition;
mixing the extract with seaweed powder according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 1.
The application method of the composition comprises uniformly applying on face, slightly rubbing for 3-6min to generate fine foam, and washing the foam with clear water.
The soothing and whitening composition is applied to the preparation of soothing and whitening face washing products, such as: facial wash, facial soap, facial cleanser, cleaning mud, etc.
Example 2
A soothing and whitening composition for washing face comprises the following raw materials: 38% of tea bran extract, 5% of bighead atractylodes rhizome extract, 8% of silkworm extract, 3% of white paeony root extract, 7.5% of white poria extract, 7.5% of Japanese ampelopsis extract, 9% of white rose extract, 8% of chamomile extract, 12% of calendula extract and 2% of seaweed powder.
A preparation method of a soothing and whitening composition for face washing comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis are extracted by the ultrasonic extraction method, and the preparation method comprises the following specific steps of:
(1) Grinding: pulverizing and grinding the plant extraction part to obtain plant powder with particle size of 40-50 meshes;
(2) Extracting: adding 85% ethanol into the plant powder for ultrasonic extraction to obtain a crude extract, wherein the plant powder is prepared from the following components: ethanol is 1:18;
(3) Purifying: filtering the crude extract, heating the crude extract to 28 ℃ under the vacuum degree of-0.1 MPa, heating for 15min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 50m/s to the crude extract under the normal temperature condition for 25min;
the hot reflux extraction method is used for extracting the white rose, the chamomile and the calendula and comprises the following specific steps:
(1) Extracting: extracting plant petals by heating with 85% ethanol, and setting reflux temperature and reflux time to obtain condensate, wherein the plant petals: ethanol is 1:23;
(2) Purifying: filtering the condensate, heating the condensate to 28 ℃ under the vacuum degree of-0.1 MPa, heating for 15min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 50m/s to the condensate for 25min under the normal temperature condition;
mixing the extract with seaweed powder according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 2.
The application method of the composition comprises uniformly applying on face, slightly rubbing for 3-6min to generate fine foam, and washing the foam with clear water.
The soothing and whitening composition is applied to the preparation of soothing and whitening face washing products, such as: facial wash, facial soap, facial cleanser, cleaning mud, etc.
Example 3
A soothing and whitening composition for washing face at least comprises the following raw materials: 56% of tea bran extract, 3% of bighead atractylodes rhizome extract, 6% of silkworm larva extract, 6% of white paeony root extract, 4% of white poria extract, 4% of Japanese ampelopsis extract, 6% of white rose extract, 8% of chamomile extract, 5% of calendula extract and 2% of agar.
A preparation method of a soothing and whitening composition for face washing comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis are extracted by the ultrasonic extraction method, and the preparation method comprises the following specific steps of:
(1) Grinding: pulverizing and grinding the plant extraction part to obtain plant powder with particle size of 40-50 meshes;
(2) Extracting: adding 70% ethanol into the plant powder for ultrasonic extraction to obtain crude extract, wherein the plant powder is prepared from the following raw materials: ethanol is 1:20;
(3) Purifying: filtering the crude extract, heating the crude extract to 23 ℃ under the vacuum degree of-0.1 MPa, heating for 20min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 40m/s to the crude extract under the normal temperature condition for 30min;
the hot reflux extraction method is used for extracting the white rose, the chamomile and the calendula and comprises the following specific steps:
(1) Extracting: extracting plant petals with 70% ethanol under heating, and setting reflux temperature and reflux time to obtain condensate, wherein the plant petals: ethanol is 1:25;
(2) Purifying: filtering the condensate, heating the condensate to 23 ℃ under the vacuum degree of-0.1 MPa, heating for 20min to remove volatile oil which is unstable under the normal temperature condition in the extract, and concentrating to obtain the extract, wherein the concentration is to apply air flow speed of 40m/s to the condensate for 30min under the normal temperature condition;
mixing the extract with agar according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 3.
The application method of the composition comprises uniformly applying on face, slightly rubbing for 3-6min to generate fine foam, and washing the foam with clear water.
The soothing and whitening composition is applied to the preparation of soothing and whitening face washing products, such as: facial wash, facial soap, facial cleanser, cleaning mud, etc.
Comparative example 1
Substantially the same as in example 2, the difference is that the whitening raw material and the preparation method of the soothing and whitening composition are different.
A soothing and whitening composition for washing face comprises the following raw materials: 47% of tea bran extract, 5% of bighead atractylodes rhizome extract, 8% of silkworm extract, 3% of white paeony root extract, 7.5% of white poria extract, 7.5% of Japanese ampelopsis extract, 8% of chamomile extract, 12% of nicotinamide and 2% of seaweed powder.
A preparation method of a soothing and whitening composition for face washing comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis are extracted by the ultrasonic extraction method, and the preparation method comprises the following specific steps of:
(1) Grinding: pulverizing and grinding the plant extraction part to obtain plant powder with particle size of 40-50 meshes;
(2) Extracting: adding 85% ethanol into the plant powder for ultrasonic extraction to obtain a crude extract, wherein the plant powder is prepared from the following components: ethanol is 1:18;
(3) Purifying: filtering and concentrating the crude extract to obtain an extract, wherein the concentration is to apply air flow speed of 50m/s to the crude extract for 25min under normal temperature;
the hot reflux extraction method is used for extracting the white rose, the chamomile and the calendula and comprises the following specific steps:
(1) Extracting: extracting plant petals by heating with 85% ethanol, and setting reflux temperature and reflux time to obtain condensate, wherein the plant petals: ethanol is 1:23;
(2) Purifying: filtering the condensate, concentrating to obtain an extract, wherein the concentration is to apply air flow speed of 50m/s to the condensate for 25min under normal temperature;
mixing the above extract with seaweed powder at 70-80deg.C and stirring speed of 1500rpm for 10min to obtain a soothing and whitening composition, designated as product 4.
Comparative example 2
Substantially the same as comparative example 1, except that the cleaning raw materials in the soothing and whitening composition are different.
A soothing and whitening composition for washing face at least comprises the following raw materials: 33% of surfactant, 5% of foaming agent, 3% of white atractylodes rhizome extract, 12% of silkworm extract, 9% of white paeony root extract, 5% of white poria extract, 5% of Japanese ampelopsis extract, 5% of white rose extract, 12% of chamomile extract, 4% of calendula extract and 2% of seaweed powder, and uniformly mixing the above compositions to obtain a product 4.
The surfactant is a mixture of laureth potassium phosphate, ammonium dodecyl sulfate and cocoyl glucoside mixed in a ratio of 5:3:1.
Mixing the extract with seaweed powder according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 5.
Comparative example 3
Substantially the same as in example 2, the difference is that calendula and ampelopsis are less in whitening raw materials. A soothing and whitening composition for washing face comprises the following raw materials: 45% of tea bran extract, 5% of bighead atractylodes rhizome extract, 8% of silkworm larva extract, 11% of white paeony root extract, 11% of white poria extract, 10% of white rose extract, 8% of chamomile extract and 2% of seaweed powder.
Mixing the extract with seaweed powder according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 6.
Comparative example 4
Substantially the same as in example 2, the difference is that white atractylodes rhizome, japanese ampelopsis root, white poria and white rose are used. A soothing and whitening composition for washing face comprises the following raw materials: 48% of tea bran extract, 12.5% of silkworm extract, 11% of white peony root extract, 12.5% of chamomile extract, 12% of calendula extract and 4% of seaweed powder.
Mixing the extract with seaweed powder according to the weight percentage of the soothing and whitening composition to obtain the soothing and whitening composition, which is named as a product 7.
Comparative example 5
Substantially the same as in example 1, except that the raw materials of chamomile and white peony root were less relaxed. A soothing and whitening composition for washing face comprises the following raw materials: 50% of tea bran extract, 12% of bighead atractylodes rhizome extract, 12% of silkworm extract, 5% of white poria extract, 5% of Japanese ampelopsis extract, 6% of white rose extract, 8% of calendula extract and 2% of seaweed powder.
A preparation method of a soothing and whitening composition for face washing comprises an ultrasonic extraction method and a thermal reflux extraction method, wherein tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis are extracted by the ultrasonic extraction method, and the preparation method comprises the following specific steps of:
(1) Grinding: pulverizing and grinding the plant extraction part to obtain plant powder with particle size of 40-50 meshes;
(2) Extracting: adding 85% ethanol into the plant powder for ultrasonic extraction to obtain a crude extract, wherein the plant powder is prepared from the following components: ethanol is 1:18;
(3) Purifying: filtering and concentrating the crude extract to obtain an extract, wherein the concentration is to apply air flow speed of 50m/s to the crude extract for 25min under normal temperature;
the hot reflux extraction method is used for extracting the white rose, the chamomile and the calendula and comprises the following specific steps:
(1) Extracting: extracting plant petals by heating with 85% ethanol, and setting reflux temperature and reflux time to obtain condensate, wherein the plant petals: ethanol is 1:23;
(2) Purifying: filtering the condensate, concentrating to obtain an extract, wherein the concentration is to apply air flow speed of 50m/s to the condensate for 25min under normal temperature;
mixing the above extract with seaweed powder at 70-80deg.C and stirring speed of 1500rpm, and collecting the above composition, designated product 8.
1. Performance testing and related testing
Cleaning performance: the cleansing effect of the facial cleanser reduces the adhesion of grease, dust and the like on the skin surface through the properties of wetting, penetrating, emulsifying, dispersing, solubilizing and the like of the surfactant, and then the grease, dust and the like are washed away with water, while foam is an important measure of detergency, and the tea bran extract is combined with common surfactants such as: the cleaning ability test of coco glucoside, disodium laureth sulfosuccinate, potassium laureth phosphate and octyl glucoside is shown in fig. 1, and the test method is referred to GB/T7462-1994, and the standard test temperature is changed to 32±2 ℃ considering that the consumer product is used at normal temperature.
As a result, as shown in fig. 1, the foaming of cocoyl glucoside was optimal, the foam stabilizing effect of the tea bran extract was optimal, and of these surfactants, the foaming stabilizing effect was the best, and the foam was an important measure of detergency, indicating that the cleaning effect of the tea bran extract was better, and the tea bran extract was suitable as a surfactant for a facial cleanser.
Stability test: the cold resistance and heat resistance stability of the products 1-8 obtained by production are tested, and the results are shown in table 1, and the test method refers to the heat resistance and cold resistance test in GB/T29680-2013.
TABLE 1 Heat and Cold resistance test Condition Table
The results are shown in Table 1, and the volatile oil is not removed during extraction, so that the volatile oil is subjected to oxidative discoloration to cause the obtained composition to be easy to discolor, even form resin-like substances, and the obtained composition is thickened.
2. Skin soothing test of the composition
The experimental animals are SPF-class rats, the weight is 180-220g, the rats are provided by Hunan Szechwan laboratory animal Limited, the rats are divided into blank groups (6), model groups (12), product 1 groups (12), product 2 groups (12), product 3 groups (12) and product 4 groups (12), the lower abdomen hair of the rats is removed, 6 model groups and rats of each product group are respectively taken, the lower abdomen of the rats is shaved Mao Oushi at 8 early and 10 late, and then the rats are subjected to full-coverage wet dressing treatment by using the same product mask after being cut into pieces with 5% salicylic acid, and the skin overhydration model is obtained by continuous treatment for 21 d. The following 3 signs indicate successful molding: (1) the skin of the molding part is obviously reddened, and the reddened area is accompanied with a large number of red blood filaments; (2) local tissue eruption at the molding part; (3) the molding part is seriously dried until peeling or serious oil discharge occurs. Taking 6 model groups and rats of each product group respectively, injecting propionibacterium acnes bacterial liquid compound smearing oil substances into the lower abdomen shaving area of the rats, namely injecting 30-50 mu L of propionibacterium acnes bacterial liquid in logarithmic phase into the lower abdomen shaving area of the rats, determining the bacterial liquid concentration to be 1X 108CFU/mL by a No. 0.5 Mitsubishi turbidimeter core or absorbance to be 0.08-0.13 at 635nm wavelength, and coating coal tar or oleic acid to be 0.2-0.5mL for 21 days continuously to induce the rats to form the acne model with granulomatous inflammation. The following 4 signs indicate successful molding: (1) papules or pustules can be seen on the skin at the molding site; (2) local tissue thickening and hardening; (3) the hair follicle orifice is provided with black angle plugs to form blackheads or acnes; (4) the opening of the follicular orifice is enlarged and the area of the hair follicle and the diameter of the sebaceous gland are increased. After the molding rats were successfully manufactured, each administration group was applied to the lower abdomen shaving area of the rats 1 time per night, and after the respective products were gently rubbed out of the foam for 3-6min, the foam was rinsed with clear water, and the empty groups and the model groups were rinsed with normal clear water, and the results are shown in the following table 2.
Skin problems caused by overhydration of rat skin, the appearance criteria formed are as follows:
(1) level 0: the skin is smooth and moist, and has no eruption and desquamation;
(2) stage I: slightly reddening or a small amount of red blood streaks, slightly peeling or a small amount of oil;
(3) stage II: obviously reddening with more red blood streaks and no eruption, and drying until a large amount of peeling or oil is discharged;
(4) III grade: obviously reddening is accompanied by a large amount of red blood filaments, uneven skin eruption, and the skin is dried until the skin is severely peeled or severely oiled.
The appearance criteria for skin problems due to acne in rat skin are as follows:
(1) level 0: skin pores are not seen by the naked eye, and blackheads, acnes, papules and pustules are avoided;
(2) stage I: less than 10 macroscopic pores, a small amount of blackheads or acnes and more papules or pustules of 1-3;
(3) stage II: 10-20 macroscopic pores, more blackheads or acnes, and 4-6 papules or pustules;
(4) III grade: at least 20 macroscopic pores are seen, and a large number of blackheads or comedones, and at least 7 papules or pustules are present.
TABLE 2 change in skin appearance index in shaved area of lower abdomen of rat
As shown in table 2, the effect of improving the problems of skin excessive hydration and acne was more remarkable when the product 1 obtained in example 1 of the present invention was applied to hydration model rats and acne model rats, because the product 1 did not contain a irritating ingredient such as nicotinamide, surfactant or foaming agent, etc., and the component ingredient ratio also affected the soothing effect. By comparing product 1 with product 2, it is demonstrated that product 1 component has better effect on soothing and improving skin problems. Product 2 and product 7 show that the bighead atractylodes rhizome can soften the cuticle to promote the absorption of components and promote the improvement of skin problems more quickly.
3. Test for Effect on inhibition of melanogenesis
Adding 1mL of L-dopa with the concentration of 30mmol/L into 0.1mg/mL of phosphate buffer solution to obtain the product, adding the products respectively, placing the products in a water bath with the temperature of 26 ℃ to react for 15min, adding tyrosinase solution to make the total reaction volume be 10mL, preserving heat for 15min at the temperature of 26 ℃, and finally measuring the OD value at 475nm of a spectrophotometer, wherein the calculation formula is as follows: tyrosinase activity inhibition (%) = (control group-sample)/control group, wherein the control group is total tyrosinase activity of the control group to which no sample was added, and the sample is tyrosinase activity remaining after inhibition by the addition of the sample, and the results are shown in table 3.
TABLE 3 tyrosinase activity inhibition rates of the products
| Inhibition ratio (%) | |
| Product 1 | 74.1 |
| Product 2 | 75.9 |
| Product 3 | 72.5 |
| Product 4 | 62.9 |
| Product 5 | 70.8 |
| Product 6 | 52.4 |
| Product 7 | 64.7 |
| Product 8 | 71.5 |
The higher the inhibition ratio, the higher the ability to inhibit the formation of melanin, which is known to be. As shown in table 3, the pharmaceutical composition and the composition ratio of the raw materials of the invention all contain, and the inhibition rate is high and the effect is best; the pharmaceutical composition partially containing the raw materials of the invention has low phase inhibition rate and poor effect. The inhibition rate of the product 2 is obviously reduced when the product 6 is compared with the product 6, and the inhibition rate is obviously reduced when the product 2 is compared with the product 4, wherein the product 4 is prepared by replacing white rose with nicotinamide, and the synergistic effect of the extracts of white rose, calendula, white poria, ampelopsis and the like is shown to be better than that of the extracts of the nicotinamide, the white poria, the ampelopsis and the like.
4. In vitro test antioxidant test (DPPH free radical scavenging test)
Test principle: DPPH is a 1, 1-diphenyl-2-picrylhydrazyl radical. Due to the presence of multiple electron-withdrawing-NO in the molecule 2 And pi of benzene ring, helium free radical exists stably. As DPPH radicals are scavenged, the absorbance a at 519mm of their absorption maximum wavelength decreases.
The test method comprises the following steps: adding 4mL DPPH test and sample solution into a 10mL cuvette, adding absolute ethanol to scale, mixing, and immediately adding 1mL cuvetteAbsorbance A measured at 519mm wavelength i Further preserving at room temperature for 30min under dark condition to measure absorbance A j The control experiment is that only DPPH ethanol solution is added, and the absorbance value is A c The calculation formula of the free radical clearance is as follows: clearance (%) = [ 1- (a) i -A j )〕/A c *100%. The results are shown in Table 4.
TABLE 4 DPPH radical scavenging effect of the products
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The DPPH free radical scavenging effect test is an important test mode for detecting the components in vitro to resist oxidation and scavenge free radicals, wherein the antioxidation components in the components can be combined with oxygen ion free radicals, so that the number of free oxygen ion free radicals is reduced, and the oxygen ion free radicals oxidize the tyrosine to form dopa or destroy cell membranes to cause cell aging and decay. From the results shown in Table 4, it is clear that the clearance rate of product 7 is the lowest due to lack of Atractylodis rhizoma to promote component absorption and antioxidation of radix Ampelopsis, poria, and flos Rosae Rugosae.
5. Effect of clinical test
Collection of 80 15-55 year old volunteers with acne problems and 40 15-55 year old volunteers with excessive hydration problems as subjects, 160 subjects with acne problems were randomized into 8 groups, 80 subjects with excessive hydration problems were randomized into 8 groups, and sensitization test was performed behind the ears of all subjects without sensitization.
The test method comprises the following steps: the test time is from 1 day of 22 years 9 months 1 to 31 days of 23 years 3 months. The method for testing the melanin content, the whiteness and the moisture content of the face of the subject, comprises the steps of: the method comprises the steps of coating corresponding products to be tested on the whole face of a subject every night for 3-6min, lightly kneading, foaming, flushing, coating water emulsion, continuously using for 6 months, photographing and recording the face of the subject when the conditions of use are fed back in the initial period of 10 months and the initial period of 1 month, giving a new test tool, photographing and recording the face of the subject at the end of the 6-month test, and detecting the melanin content, whiteness and moisture content of the face of the subject. The subjects were kept free of other skin care products and skin treatment drugs as much as possible during the test, and the subjects were tested for facial changes after 180 days of use, and the test results are shown in table 5, wherein the skin conditions were as follows:
(1) the obvious improvement is as follows: the acne condition is obviously reduced, pores are reduced, the number of large pores is obviously reduced, the areas of skin reddening and red blood streaks are greatly reduced, and the phenomena of water deficiency and peeling are obviously improved;
(2) the method is greatly improved: the acne condition is greatly relieved, the number of large pores is reduced more, and the areas of skin redness and red blood streaks are obviously reduced;
(3) slight improvement: the acne is relieved, the number of large pores is slightly reduced, and the areas of skin redness and red blood wires are slightly reduced;
(4) has no effect: the acne condition is not changed obviously, the problem of large pores is not improved, and the skin redness or red blood streak is not improved.
Table 5 clinical test effect of each product
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (10)
1. A soothing and whitening composition for washing the face, which is characterized by at least comprising the following raw materials: tea bran extract, white atractylodes rhizome extract, silkworm extract, white peony root extract, white poria extract, japanese ampelopsis extract, white rose extract, chamomile extract and calendula extract.
2. The soothing and whitening composition for washing the face according to claim 1, which comprises at least the following raw materials: 35-60% of tea bran extract, 1-10% of bighead atractylodes rhizome extract, 1-15% of silkworm larva extract, 1-15% of white paeony root extract, 1-15% of white poria extract, 1-10% of Japanese ampelopsis extract, 1-10% of white rose extract, 5-15% of chamomile extract, 1-12% of calendula extract and the balance of thickening agent.
3. The soothing and whitening composition for washing the face according to claim 2, comprising at least the following raw materials: 36-45% of tea bran extract, 3-6% of bighead atractylodes rhizome extract, 6-12% of silkworm larva extract, 3-9% of white paeony root extract, 4-8% of white poria extract, 4-8% of Japanese ampelopsis extract, 6-9% of white rose extract, 8-12.5% of chamomile extract, 5-12% of calendula extract and the balance of thickening agent.
4. A soothing and whitening composition for washing the face according to claim 3, characterized in that it comprises at least the following raw materials: 38% of tea bran extract, 3% of bighead atractylodes rhizome extract, 12% of silkworm larva extract, 9% of white paeony root extract, 5% of white poria extract, 5% of Japanese ampelopsis extract, 6% of white rose extract, 12% of chamomile extract, 8% of calendula extract and 2% of seaweed powder.
5. A soothing and whitening composition for washing the face according to claim 3, characterized in that it comprises at least the following raw materials: 38% of tea bran extract, 5% of bighead atractylodes rhizome extract, 8% of silkworm extract, 3% of white paeony root extract, 7.5% of white poria extract, 7.5% of Japanese ampelopsis extract, 9% of white rose extract, 8% of chamomile extract, 12% of calendula extract and 2% of thickening agent.
6. The soothing and whitening composition for washing the face according to any one of claims 2 to 5, wherein the thickener is one or more of agar, seaweed powder and gelatin.
7. A preparation method of a soothing and whitening composition for face washing is characterized by comprising an ultrasonic extraction method and a thermal reflux extraction method, wherein the ultrasonic extraction method is used for preparing tea bran, bighead atractylodes rhizome, silkworm larva, white paeony root, white poria and Japanese ampelopsis, and the preparation method comprises the following specific steps of:
(1) Grinding: crushing and grinding the plant extraction part to obtain plant powder with preset particle size;
(2) Extracting: adding ethanol into the plant powder for ultrasonic extraction to obtain crude extract;
(3) Purifying: filtering the crude extract, removing volatile oil, and concentrating to obtain extract;
the specific steps of extracting the white rose, the chamomile and the calendula by the hot reflux extraction method are as follows:
(1) Extracting: extracting plant petals by heating with ethanol, and setting reflux temperature and reflux time to obtain condensate;
(2) Purifying: filtering the condensate, removing volatile oil, concentrating to obtain extract;
mixing the extract with a thickener according to a preset percentage to obtain the soothing and whitening composition, wherein the thickener is one or more of agar, seaweed powder and gelatin.
8. The method for preparing a soothing and whitening composition for washing the face according to claim 7, wherein the concentration of ethanol is 70-90%, plant powder: ethanol is 1:15-20, plant petals: ethanol is 1:20-25.
9. The method for preparing a soothing and whitening composition for washing the face according to claim 7, wherein the volatile oil removal is to heat the condensate or the crude extract to 20-30 ℃ under the vacuum degree of-0.1 MPa for 10-20min, so as to remove volatile oil components which are unstable under the normal temperature condition in the extract.
10. The method for preparing a soothing and whitening composition for washing the face according to claim 7, wherein the concentration is performed by applying an air flow rate of 40-60m/s to the crude extract or condensate at normal temperature for a treatment time of 20-30min.
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