CN117715633A - 用于治疗covid-19、自身免疫性疾病或细胞因子风暴反应的利多卡因或阿替卡因 - Google Patents

用于治疗covid-19、自身免疫性疾病或细胞因子风暴反应的利多卡因或阿替卡因 Download PDF

Info

Publication number
CN117715633A
CN117715633A CN202280046171.0A CN202280046171A CN117715633A CN 117715633 A CN117715633 A CN 117715633A CN 202280046171 A CN202280046171 A CN 202280046171A CN 117715633 A CN117715633 A CN 117715633A
Authority
CN
China
Prior art keywords
salt
lidocaine
treatment
pharmaceutical formulation
covd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280046171.0A
Other languages
English (en)
Chinese (zh)
Inventor
C·J·奥斯特伍德
R·C·J·甘海
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wilson Medical Clinical Foundation
Original Assignee
Wilson Medical Clinical Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilson Medical Clinical Foundation filed Critical Wilson Medical Clinical Foundation
Publication of CN117715633A publication Critical patent/CN117715633A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202280046171.0A 2021-06-03 2022-06-01 用于治疗covid-19、自身免疫性疾病或细胞因子风暴反应的利多卡因或阿替卡因 Pending CN117715633A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2107966.0A GB2607584B (en) 2021-06-03 2021-06-03 Composition and method of treatment
GB2107966.0 2021-06-03
PCT/IB2022/055134 WO2022254363A1 (en) 2021-06-03 2022-06-01 Lidocaine or articaine for treating covid-19, autoimmune disease or cytokine storm response

Publications (1)

Publication Number Publication Date
CN117715633A true CN117715633A (zh) 2024-03-15

Family

ID=76838703

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280046171.0A Pending CN117715633A (zh) 2021-06-03 2022-06-01 用于治疗covid-19、自身免疫性疾病或细胞因子风暴反应的利多卡因或阿替卡因

Country Status (6)

Country Link
US (1) US20240269109A1 (cg-RX-API-DMAC7.html)
EP (1) EP4346791A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024520767A (cg-RX-API-DMAC7.html)
CN (1) CN117715633A (cg-RX-API-DMAC7.html)
GB (1) GB2607584B (cg-RX-API-DMAC7.html)
WO (1) WO2022254363A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2639834A (en) * 2024-03-22 2025-10-08 Remicine Ip B V Composition and method of treatment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008550A1 (en) * 1992-10-09 1994-04-28 The Procter & Gamble Company Anaesthetic compositions
JP5111117B2 (ja) * 2005-12-22 2012-12-26 興和株式会社 ステロイドの経時的安定性が改善された外用製剤
TWI464148B (zh) * 2006-03-16 2014-12-11 Evotec Us Inc 作為p2x7調節劑之雙環雜芳基化合物與其用途
TWI395593B (zh) * 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
CN103142643B (zh) * 2013-03-22 2014-07-02 新疆医科大学第一附属医院 Alha心脏停搏液及其制备方法
CN104127397B (zh) * 2014-08-19 2016-04-27 董颖颖 一种治疗急慢性过敏性及充血性皮肤病的药物及方法
CN106692120A (zh) * 2016-12-15 2017-05-24 刘力 利多卡因的药物组合物及其用途
CN111150738A (zh) * 2020-02-06 2020-05-15 西安交通大学医学院第二附属医院 一种治疗皮肤病的外用药物
CA3178140A1 (en) * 2020-03-31 2021-10-07 Nomoreitis B.V. Treatment of hyperinflammatory syndrome
RU2742505C1 (ru) * 2020-10-01 2021-02-08 Общество с ограниченной ответственностью "Институт термологии" Аэрозоль для инвазивной механической вентиляции легких при covid-19

Also Published As

Publication number Publication date
GB2607584A (en) 2022-12-14
EP4346791A1 (en) 2024-04-10
GB202107966D0 (en) 2021-07-21
US20240269109A1 (en) 2024-08-15
JP2024520767A (ja) 2024-05-24
GB2607584B (en) 2024-07-17
WO2022254363A1 (en) 2022-12-08

Similar Documents

Publication Publication Date Title
ES2660116T3 (es) Dispositivos mucoadhesivos resistentes al uso inadecuado para la administración de buprenorfina
ES2904570T3 (es) Formulación de DHE intranasal para el tratamiento del dolor de cabeza
US20160166543A1 (en) Stable combination oral liquid formulation of melatonin and an antihistaminic agent
JP2013541583A (ja) 組み合わせ組成物
US11471483B2 (en) Iron carbohydrate complex for treatment of restless leg syndrome (RLS)
JPH0635382B2 (ja) 抗不安薬としてのフルオキセチンの使用法
ES2383433T3 (es) Formulación farmacéutica de apomorfina para administración bucal
CN117715633A (zh) 用于治疗covid-19、自身免疫性疾病或细胞因子风暴反应的利多卡因或阿替卡因
RU2015134148A (ru) Галеновая форма для введения активного действующего вещества
ES2738652T3 (es) Composiciones de midazolam para administración bucal en el tratamiento de convulsiones para obtener comienzo de acción rápido
BR112020018362A2 (pt) Composição de glp-1 para tratar obesidade e controle de peso
US20140147519A1 (en) Migraine Treatment
ES2894330T3 (es) Acido acetilsalicílico para uso en el tratamiento de la influenza de moderada a grave
JPH0826997A (ja) バスピロン:睡眠誘起性無呼吸症剤
CN103501609A (zh) 用于偏头痛的治疗
AU2013384129B2 (en) Oral suspension for treating eosinophilic esophagitis
CN107519176A (zh) 防治运动病、梅尼埃病的药物及莫扎伐普坦的医药用途
JP5823131B2 (ja) 防風通聖散含有組成物
BRPI0616144A2 (pt) composiÇço terapÊutica, uso de uma composiÇço terapÊutica,composiÇço farmacÊutica, e, uma primeira composiÇço terapÊutica compreendendo um composto s-nitrosotiol e uma segunda composiÇço terapÊutica compreendendo um segundo composto que nço o composto s-nitrosotiol
CN116171151A (zh) 用于治疗病毒感染的pde3抑制剂
ES2938574T3 (es) Péptido para la prevención o el tratamiento de la COVID-19
CN103830217B (zh) 丙酮酸钠在制备缓解高氯性酸中毒药物中的应用
ES2355680T3 (es) Reducción del sobrepeso o de la obesidad.
ES2395370B1 (es) Uso de un agonista del receptor obrb para el tratamiento de traumatismos del sistema nervioso central y/o del dolor neuropático.
BR102021017964A2 (pt) Solubilização de ativos farmacêuticos utilizando plasmas eutéticos

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination