CN117598917A - 一种复合型类胡萝卜素及其制备方法与应用 - Google Patents
一种复合型类胡萝卜素及其制备方法与应用 Download PDFInfo
- Publication number
- CN117598917A CN117598917A CN202311582998.6A CN202311582998A CN117598917A CN 117598917 A CN117598917 A CN 117598917A CN 202311582998 A CN202311582998 A CN 202311582998A CN 117598917 A CN117598917 A CN 117598917A
- Authority
- CN
- China
- Prior art keywords
- carotenoid
- stirring
- core material
- composite
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000021466 carotenoid Nutrition 0.000 title claims abstract description 59
- 150000001747 carotenoids Chemical class 0.000 title claims abstract description 58
- 239000002131 composite material Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 108010010803 Gelatin Proteins 0.000 claims abstract description 31
- 229920000159 gelatin Polymers 0.000 claims abstract description 31
- 239000008273 gelatin Substances 0.000 claims abstract description 31
- 235000019322 gelatine Nutrition 0.000 claims abstract description 31
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 31
- 239000011162 core material Substances 0.000 claims abstract description 29
- 238000003756 stirring Methods 0.000 claims abstract description 27
- 241000220479 Acacia Species 0.000 claims abstract description 26
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims abstract description 26
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 26
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 238000001035 drying Methods 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 9
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 9
- 239000003381 stabilizer Substances 0.000 claims abstract description 9
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 9
- 239000008158 vegetable oil Substances 0.000 claims abstract description 9
- 238000005406 washing Methods 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 25
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 16
- 235000010413 sodium alginate Nutrition 0.000 claims description 16
- 229940005550 sodium alginate Drugs 0.000 claims description 16
- 239000000661 sodium alginate Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 9
- 235000005487 catechin Nutrition 0.000 claims description 9
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 9
- 229950001002 cianidanol Drugs 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- 235000020235 chia seed Nutrition 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims description 6
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 5
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 5
- 235000013793 astaxanthin Nutrition 0.000 claims description 5
- 239000001168 astaxanthin Substances 0.000 claims description 5
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 5
- 229940022405 astaxanthin Drugs 0.000 claims description 5
- 235000013734 beta-carotene Nutrition 0.000 claims description 5
- 239000011648 beta-carotene Substances 0.000 claims description 5
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 5
- 229960002747 betacarotene Drugs 0.000 claims description 5
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 5
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 5
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 4
- FLISWPFVWWWNNP-BQYQJAHWSA-N dihydro-3-(1-octenyl)-2,5-furandione Chemical compound CCCCCC\C=C\C1CC(=O)OC1=O FLISWPFVWWWNNP-BQYQJAHWSA-N 0.000 claims description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 4
- 230000003647 oxidation Effects 0.000 claims description 4
- 238000007254 oxidation reaction Methods 0.000 claims description 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 4
- 239000003086 colorant Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims description 2
- 235000019489 Almond oil Nutrition 0.000 claims description 2
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 claims description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 2
- 235000019498 Walnut oil Nutrition 0.000 claims description 2
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 claims description 2
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 claims description 2
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 claims description 2
- 239000008168 almond oil Substances 0.000 claims description 2
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- SJWWTRQNNRNTPU-ABBNZJFMSA-N fucoxanthin Chemical compound C[C@@]1(O)C[C@@H](OC(=O)C)CC(C)(C)C1=C=C\C(C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)C(=O)C[C@]1(C(C[C@H](O)C2)(C)C)[C@]2(C)O1 SJWWTRQNNRNTPU-ABBNZJFMSA-N 0.000 claims description 2
- AQLRNQCFQNNMJA-UHFFFAOYSA-N fucoxanthin Natural products CC(=O)OC1CC(C)(C)C(=C=CC(=CC=CC(=CC=CC=C(/C)C=CC=C(/C)C(=O)CC23OC2(C)CC(O)CC3(C)C)C)CO)C(C)(O)C1 AQLRNQCFQNNMJA-UHFFFAOYSA-N 0.000 claims description 2
- 235000008777 kaempferol Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 235000012680 lutein Nutrition 0.000 claims description 2
- 239000001656 lutein Substances 0.000 claims description 2
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 2
- 229960005375 lutein Drugs 0.000 claims description 2
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 235000005875 quercetin Nutrition 0.000 claims description 2
- 229960001285 quercetin Drugs 0.000 claims description 2
- 239000008170 walnut oil Substances 0.000 claims description 2
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 2
- 235000010930 zeaxanthin Nutrition 0.000 claims description 2
- 239000001775 zeaxanthin Substances 0.000 claims description 2
- 229940043269 zeaxanthin Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009471 action Effects 0.000 abstract description 5
- 230000001804 emulsifying effect Effects 0.000 abstract description 5
- 239000003094 microcapsule Substances 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 235000010489 acacia gum Nutrition 0.000 abstract description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 235000013361 beverage Nutrition 0.000 description 6
- 230000008569 process Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 244000000626 Daucus carota Species 0.000 description 2
- 235000002767 Daucus carota Nutrition 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical group CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000287502 Phoenicopteriformes Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- -1 carotenoid compound Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明公开了一种复合型类胡萝卜素及其制备方法与应用，属于类胡萝卜素技术领域，制备方法包括如下步骤：将植物油、类胡萝卜素和多酚稳定剂混合，超声分散后得到芯材，将明胶溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，用高速分散机乳化，调节pH值为弱酸性，搅拌，降温至15‑20℃，加入交联剂，调节pH值为弱碱性，搅拌，搅拌结束后，经过过滤、水洗、干燥，即可。该复合型类胡萝卜素以明胶和阿拉伯胶为壁材，在溶液中形成凝聚物，然后经过交联剂交联固化，形成微囊，对内部芯材可以实现缓慢释放，不仅可以对芯材中的成分进行有效地保护，而且可以实现有效成分的缓慢释放，延长作用时间。
Description
技术领域
本发明属于类胡萝卜素技术领域，具体涉及一种复合型类胡萝卜素及其制备方法与应用。
背景技术
类胡萝卜素是一类具有多种生物活性的天然色素，主要存在于动物、高等植物、真菌、藻类的黄色、橙红色或红色的色素之中。从微生物，动物，植物等中已经鉴定出超过750种类胡萝卜素。例如，西红柿，胡萝卜，火烈鸟和龙虾的颜色是由类胡萝卜素颜料着色的。类胡萝卜素在自然界中的生理作用是多种多样的，并且在光合作用，光保护和抗氧化作用中的辅助采光作用中起着重要作用。此外，类胡萝卜素是人类和其他动物的人体所需的营养素是维生素A的前体，近年来在癌症和心脏疾病的也有报道预防作用。
类胡萝卜素通常具有式C40H56的基本骨架，该骨架由连接在一起的八个异戊二烯单元组成。构成类胡萝卜素化学结构的高度不饱和长烃链降低了它的水溶性和生物利用度，还增加了它们对光、pH、氧和高温的敏感性，限制了它们的工业适用性。
发明内容
本发明的目的在于提供一种复合型类胡萝卜素及其制备方法与应用，以解决类胡萝卜对温度、光照敏感性较强，限制其工业适应性的问题。
本发明的目的可以通过以下技术方案实现：
一种复合型类胡萝卜素的制备方法，包括如下步骤：
将植物油、类胡萝卜素和多酚稳定剂混合，超声分散后得到芯材，将明胶溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，用高速分散机乳化，调节pH值为弱酸性，搅拌10min-20min，降温至15-20℃，加入交联剂，调节pH值为弱碱性，搅拌30min-40min，搅拌结束后，经过过滤、水洗、干燥，得到一种复合型类胡萝卜素。
进一步地，芯材中植物油、类胡萝卜素和多酚稳定剂的用量比为70-75：20：0.5-1；明胶和阿拉伯胶的质量比为1：1；明胶溶液和阿拉伯胶溶液的质量分数为1％；明胶和阿拉伯胶的总用量和芯材的质量比为1：1.5-1.7；交联剂的添加量为明胶和阿拉伯胶的总用量的1％。耐热性更好，间接影响抗氧化效果。
进一步地，所述类胡萝卜素包括为β-胡萝卜素、叶黄素、玉米黄质、岩藻黄素和虾青素中两种或两种以上按照任意比例混合。
进一步地，所述植物油包括奇亚籽油、核桃油、杏仁油和玉米油。
进一步地，所述交联剂通过如下步骤制备：
将氧化海藻酸钠和水混合，调节pH值为9，在35℃下分批加入经过无水乙醇稀释的辛烯基琥珀酸酐，加完后，维持反应体系的温度为9，搅拌反应3h，反应结束后，调节pH值为7，用无水乙醇水溶液洗涤，干燥后得到交联剂。
进一步地，所述氧化海藻酸钠通过如下步骤制备：
将海藻酸钠分散在无水乙醇中，搅拌分散得到分散液，加入高碘酸钠水溶液，避光搅拌反应4h，反应结束后加入乙二醇中止反应，将得到的反应液与无水乙醇混合，析出沉淀后，经过过滤干燥，得到氧化海藻酸钠。氧化海藻酸钠的氧化度为80％。
进一步地，所述多酚稳定剂为儿茶素、山柰酚和槲皮素中的一种。
一种复合型类胡萝卜素，由上述制备方法制备而成。
一种复合型类胡萝卜素应用于食品、化妆品中，作为营养增补剂和着色剂使用。
本发明的有益效果：
本发明提供了一种复合型类胡萝卜素，以明胶和阿拉伯胶为壁材，在溶液中形成凝聚物，然后经过交联剂交联固化，形成微囊，对内部芯材可以实现缓慢释放，不仅可以对芯材中的成分进行有效地保护，而且可以实现有效成分的缓慢释放，延长作用时间。
本发明提供的复合型类胡萝卜素中含有植物油、类胡萝卜素和多酚稳定剂，类胡萝卜素长期处于高温条件下，其清除自由基的能力会下降，在高温下容易加速芯材的氧化变质，本发明中的加工过程温度低，能减少在加工过程中有效成分的损失，配合多酚稳定剂能更好的发挥清除自由基的作用，此外，植物油可以根据需要选择，不能可以提高芯材中各物质的混合效果，而且在成分上选择性多，可以满足不同领域的需求。
本发明中在选择交联剂的过程中选择自制的交联剂，相对于常规的甲醛作为交联剂的能形成复杂的交联网络，具有更好的耐热性，并且，相对于甲醛更加安全，不用考虑残留、安全性等问题；更为突出的是，交联剂在使用前经过了辛烯基琥珀酸酐的修饰，提高了交联剂的两亲性，对于芯材的载量也具有一定的提升，能满足高载量的需求。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例1
本实施例提供一种交联剂，通过如下步骤制备：
将5g海藻酸钠分散在25mL无水乙醇中，搅拌分散得到分散液，加入高碘酸钠水溶液，避光搅拌反应4h，反应结束后加入乙二醇中止反应，将得到的反应液与无水乙醇混合，析出沉淀后，经过过滤干燥，得到氧化海藻酸钠。控制氧化海藻酸钠的氧化度为80％；海藻酸钠：Mn＝357475，Mn/Mw＝1.392，食品级。
将2g氧化海藻酸钠和10mL水混合，调节pH值为9，在35℃下分批加入经过1mL无水乙醇稀释的0.2g辛烯基琥珀酸酐，加完后，维持反应体系的温度为9，搅拌反应3h，反应结束后，调节pH值为7，用无水乙醇水溶液洗涤，干燥后得到交联剂。
实施例2
本实施例提供一种复合型类胡萝卜素的制备方法，包括如下步骤：
将奇亚籽油、类胡萝卜素和儿茶素混合，超声分散后得到芯材，将明胶(A型明胶)溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，用高速分散机乳化，调节pH值为弱酸性(pH值为5)，搅拌10min，降温至15℃，加入按照实施例1中的方法制备的交联剂，调节pH值为弱碱性(pH值为9)，搅拌30min，搅拌结束后，经过过滤、水洗、干燥，得到一种复合型类胡萝卜素。类胡萝卜素为β-胡萝卜素和虾青素等质量混合而成；
芯材中奇亚籽油、类胡萝卜素和儿茶素的用量比为70：20：0.5；明胶和阿拉伯胶的质量比为1：1；明胶溶液和阿拉伯胶溶液的质量分数为1％；明胶和阿拉伯胶的总用量和芯材的质量比为1：1.5；交联剂的添加量为明胶和阿拉伯胶的总用量的1％。
实施例3
本实施例提供一种复合型类胡萝卜素的制备方法，包括如下步骤：
将奇亚籽油、类胡萝卜素和儿茶素混合，超声分散后得到芯材，将明胶(A型明胶)溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，用高速分散机乳化，调节pH值为弱酸性(pH值为5)，搅拌10min，降温至15℃，加入实施例1中的方法制备的交联剂，调节pH值为弱碱性(pH值为9)，搅拌40min，搅拌结束后，经过过滤、水洗、干燥，得到一种复合型类胡萝卜素。类胡萝卜素为β-胡萝卜素和虾青素等质量混合而成；
芯材中奇亚籽油、类胡萝卜素和儿茶素的用量比为75：20：1；明胶和阿拉伯胶的质量比为1：1；明胶溶液和阿拉伯胶溶液的质量分数为1％；明胶和阿拉伯胶的总用量和芯材的质量比为1：1.6；交联剂的添加量为明胶和阿拉伯胶的总用量的1％。
实施例4
本实施例提供一种复合型类胡萝卜素的制备方法，包括如下步骤：
将奇亚籽油、类胡萝卜素和儿茶素混合，超声分散后得到芯材，将明胶(A型明胶)溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，用高速分散机乳化，调节pH值为弱酸性(pH值为5)，搅拌20min，降温至20℃，加入实施例1中的方法制备的交联剂，调节pH值为弱碱性(pH值为9)，搅拌40min，搅拌结束后，经过过滤、水洗、干燥，得到一种复合型类胡萝卜素。类胡萝卜素为β-胡萝卜素和虾青素等质量混合而成；
芯材中奇亚籽油、类胡萝卜素和儿茶素的用量比为75：20：1；明胶和阿拉伯胶的质量比为1：1；明胶溶液和阿拉伯胶溶液的质量分数为1％；明胶和阿拉伯胶的总用量和芯材的质量比为1：1.7；交联剂的添加量为明胶和阿拉伯胶的总用量的1％。
对比例1
本对比例与实施例4相比，交联剂换成2％的甲醛其余原料及制备过程保持不变。
对比例2
本对比例与实施例4相比，交联剂换成实施例1中的氧化海藻酸钠其余原料及制备过程保持不变。
对比例3
对比例与对比例2相比，不添加儿茶素余原料及制备过程保持不变。
将装有300mL、2％的微胶囊悬浮液的烧杯在20℃条件下放置20min，然后放置在80℃水浴中，在200rpm下搅拌，每隔20min取出一个过滤，收集过滤后的溶液，测定溶液吸光度值变化。
表1
从测试结果可知，本发明中的微囊结构能更好地储存以及缓释类胡萝卜素，在高温条件下，能对其内部包埋的类胡萝卜复合物更好地保护。
以质量分数100％计，饮料中含有白砂糖20％、柠檬酸0.5％、甜橙香料0.15％，在饮料中添加0.5％的实施例4的复合型类胡萝卜素，余量为水。将饮料置于50℃，光照条件下放置1年，观察沉淀和浊度。采用浊度计测定饮料的浊度，浊度单位NTU，测定角度90°±2.5°，测定波长860nm±10nm，测试结果如下表2；
表2
由表2可以看出，本发明制备的复合型类胡萝卜素具有良好的缓释效果，可以延长饮料的货架期，提高饮料的稳定性。
需要说明的是，在本文中，诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来，而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素，而且还包括没有明确列出的其他要素，或者是还包括为这种过程、方法、物品或者设备所固有的要素。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (9)
1.一种复合型类胡萝卜素的制备方法，其特征在于，包括如下步骤：
将植物油、类胡萝卜素和多酚稳定剂混合，超声分散后得到芯材，将明胶溶液和阿拉伯胶溶液混合，然后加入混合好的芯材，在温度为40℃条件下，搅拌分散，调节pH值为弱酸性，搅拌10min-20min，降温至15-20℃，加入交联剂，调节pH值为弱碱性，搅拌30min-40min，搅拌结束后，经过过滤、水洗、干燥，得到一种复合型类胡萝卜素。
2.根据权利要求1所述的一种复合型类胡萝卜素的制备方法，其特征在于，芯材中植物油、类胡萝卜素和多酚稳定剂的用量比为70-75：20：0.5-1；明胶和阿拉伯胶的质量比为1：1；明胶溶液和阿拉伯胶溶液的质量分数为1％；明胶和阿拉伯胶的总用量和芯材的质量比为1：1.5-1.7；交联剂的添加量为明胶和阿拉伯胶的总用量的1％。
3.根据权利要求1所述的一种复合型类胡萝卜素的制备方法，其特征在于，所述类胡萝卜素包括为β-胡萝卜素、叶黄素、玉米黄质、岩藻黄素和虾青素中两种或两种以上按照任意比例混合。
4.根据权利要求1所述的一种复合型类胡萝卜素的制备方法，其特征在于，所述植物油包括奇亚籽油、核桃油、杏仁油和玉米油。
5.根据权利要求1所述的一种复合型类胡萝卜素的制备方法，其特征在于，所述交联剂通过如下步骤制备：
将氧化海藻酸钠和水混合，调节pH值为9，在35℃下分批加入经过无水乙醇稀释的辛烯基琥珀酸酐，加完后，维持反应体系的温度为9，搅拌反应3h，反应结束后，调节pH值为7，用无水乙醇水溶液洗涤，干燥后得到交联剂。
6.根据权利要求5所述的一种复合型类胡萝卜素的制备方法，其特征在于，所述氧化海藻酸钠通过如下步骤制备：
将海藻酸钠分散在无水乙醇中，搅拌分散得到分散液，加入高碘酸钠水溶液，避光搅拌反应4h，反应结束后加入乙二醇中止反应，将得到的反应液与无水乙醇混合，析出沉淀后，经过过滤干燥，得到氧化海藻酸钠；氧化海藻酸钠的氧化度为80％。
7.根据权利要求1所述的一种复合型类胡萝卜素的制备方法，其特征在于，所述多酚稳定剂为儿茶素、山柰酚和槲皮素中的一种。
8.一种复合型类胡萝卜素，由权利要求1-7任意一项所述的制备方法制备而成。
9.一种根据权利要求8所述的复合型类胡萝卜素应用于食品、化妆品中，作为营养增补剂和着色剂使用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311582998.6A CN117598917A (zh) | 2023-11-24 | 2023-11-24 | 一种复合型类胡萝卜素及其制备方法与应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311582998.6A CN117598917A (zh) | 2023-11-24 | 2023-11-24 | 一种复合型类胡萝卜素及其制备方法与应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117598917A true CN117598917A (zh) | 2024-02-27 |
Family
ID=89949230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311582998.6A Pending CN117598917A (zh) | 2023-11-24 | 2023-11-24 | 一种复合型类胡萝卜素及其制备方法与应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117598917A (zh) |
-
2023
- 2023-11-24 CN CN202311582998.6A patent/CN117598917A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20090119976A (ko) | 개질 아카시아 검을 함유하는 카로테노이드 조성물 | |
| US11723879B2 (en) | Lycopene micro-capsule powder and preparation method thereof | |
| CN106283722A (zh) | 一种用天然染料对壳聚糖纤维织物染色的方法 | |
| CN100526408C (zh) | 一种低氯漂白紫胶的制备方法 | |
| CN101797063B (zh) | 紫红薯饮料的制备方法 | |
| DE60130183T2 (de) | Anthocyaninfarbmittel und verfahren zu dessen herstellung aus organischem material | |
| CN117598917A (zh) | 一种复合型类胡萝卜素及其制备方法与应用 | |
| CN111034902B (zh) | 一种高稳定性的色素衍生物及其制备方法 | |
| CN111955729A (zh) | 一种光稳定透明水分散β-胡萝卜素的制备方法 | |
| CN1070214C (zh) | 水溶性红曲红色素和黄色素的制备 | |
| JP6756721B2 (ja) | ヘリアンサス属植物種子抽出物及びその製造方法 | |
| EP2545787A1 (de) | Anthocyanhaltige Zusammensetzung | |
| CN110934253B (zh) | 纳米级透明水分散姜黄素的制备方法 | |
| CN114304635A (zh) | 一种含有花青素的组合物、食品及制备方法和应用 | |
| Rosalina et al. | The potential of anthocyanin from red banana peel as natural dye in smart packaging development | |
| KR101795692B1 (ko) | 황반색소 밀도유지용 복합제제의 제조방법 | |
| CN105557996A (zh) | 一种柑橘光亮保鲜剂及其制备方法 | |
| CN107114786B (zh) | 一种提升黑莓花青素稳定性的方法 | |
| CN109006261A (zh) | 一种提高紫甘蓝花青素含量的方法 | |
| Alouk et al. | Encapsulation of natural pigments by double emulsion: A review | |
| CN111441179A (zh) | 一种用于纺织产品功能增强的染料配方及生产工艺 | |
| RU2702598C1 (ru) | Способ получения антоцианового красителя из ягодного сырья | |
| JP2506102B2 (ja) | アントシアニン系色素の安定化法 | |
| CN106578138B (zh) | 富有机硒食用油及其制备方法 | |
| Selvamuthukumaran | A Short Glimpse of Synthetic and Natural Anthocyanins Obtained from Various Subtropical Fruits |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |