CN117572000A - Early mutation tumor diagnosis device - Google Patents
Early mutation tumor diagnosis device Download PDFInfo
- Publication number
- CN117572000A CN117572000A CN202311573695.8A CN202311573695A CN117572000A CN 117572000 A CN117572000 A CN 117572000A CN 202311573695 A CN202311573695 A CN 202311573695A CN 117572000 A CN117572000 A CN 117572000A
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- Prior art keywords
- guide rail
- axis guide
- early stage
- base
- dyeing
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 20
- 238000003745 diagnosis Methods 0.000 title claims abstract description 16
- 230000035772 mutation Effects 0.000 title claims abstract description 7
- 238000004043 dyeing Methods 0.000 claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000007789 sealing Methods 0.000 claims abstract description 24
- 239000011521 glass Substances 0.000 claims abstract description 21
- 230000007246 mechanism Effects 0.000 claims abstract description 20
- 239000000725 suspension Substances 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 241001170716 Garra gotyla Species 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 11
- 230000009471 action Effects 0.000 description 4
- 238000002791 soaking Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 2
- 239000006059 cover glass Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000026267 regulation of growth Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention belongs to the technical field of medical equipment, and particularly relates to an early mutation tumor diagnosis device, which can realize dyeing and sealing treatment on a glass slide filled with a sample in a machine body through the matching of a dyeing mechanism and a sealing mechanism, reduce the transfer operation of different equipment and improve the operation convenience; through the setting of dyeing mechanism, can carry out the dyeing operation through moving subassembly and holder automatic control to the sample on the slide, reduce the intervention operation of manpower, utilize the slide after the oscillator soaks single solution simultaneously to carry out the operation of removing liquid, reduce the pollution mixture between the different solutions, improve the use number of times of solution and the accuracy of dyeing.
Description
Technical Field
The invention belongs to the technical field of medical equipment, and particularly relates to an early mutation tumor diagnosis device.
Background
Tumors are new forms of growth formed by the fact that a certain cell of local tissues loses normal regulation of growth of the cells at the gene level under the action of various cancerogenic factors, and the new forms of the cells are formed by clonally abnormal hyperplasia of the cells, and gradually appear by adopting different diagnosis and treatment modes along with the deep cognition of people on the tumors, wherein biopsy sampling of early tumors is one of the current diagnosis modes.
After taking a sample from a tumor biopsy of a patient, the sample is subjected to corresponding operation, such as paraffin embedding, slicing and PE dyeing operation, most of the current dyeing works are operated manually, the dyeing mode is low in efficiency, the control time is not required to be judged manually, the dyeing is easy to be incomplete, the problem of defect in color development is caused, and the sealing operation after the dyeing is finished also requires manual intervention, so that the problems of workload increase and loss are easy to occur when a large number of samples are dyed and sealed.
Disclosure of Invention
The purpose of the invention is that: it is intended to provide an early stage mutant tumor diagnosis apparatus for solving the problems mentioned in the background art.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
an early mutation tumor diagnosis device comprises a machine body and a control panel, wherein the machine body is symmetrically provided with two working cavities, and a dyeing mechanism and a sealing piece mechanism are respectively arranged in the two working cavities;
the dyeing mechanism comprises a moving assembly, a clamp holder and a plurality of liquid storage cylinders, wherein the moving assembly comprises an X-axis guide rail, a Y-axis guide rail and a Z-axis guide rail, the X-axis guide rail is connected with the rear inner wall of the corresponding working cavity, the Y-axis guide rail is connected with the X-axis guide rail, the Z-axis guide rail is connected with the Y-axis guide rail, the clamp holder is connected with the Z-axis guide rail, and the liquid storage cylinders are uniformly arranged at the bottom of the corresponding working cavity;
the sealing piece mechanism comprises a rotary table and a sealing piece assembly, the rotary table is rotationally arranged in the corresponding working cavity, the sealing piece assembly comprises a sucker group and a placer, the sucker group is arranged on the upper side of the rotary table, and the placer is arranged on the side face of the rotary table.
The holder includes base and U-shaped fastener, the base with the slider fixed connection of Z axle guide rail, U-shaped fastener with the base is connected and the opening is down, U-shaped fastener and outside slide glass place frame phase-match.
Still be equipped with the oscillator between base with U-shaped fastener, the oscillator includes cooperation pole, restorer and director, the quantity of restorer is two and symmetry locates the base front end, U-shaped fastener with two the restorer is connected, Z axle guide middle part open-ended mounting groove, the director is located middle part in the mounting groove, the cooperation pole with U-shaped fastener is connected and stretches into in the mounting groove with director assorted.
The reset device comprises two springs and a guide block, wherein the base is provided with a transverse groove matched with the reset device, the guide block is slidably arranged in the transverse groove, and the two springs are fixedly arranged at the left end and the right end of the guide block respectively and are all positioned in the transverse groove.
The guide comprises a base plate and an electric control telescopic rod, the electric control telescopic rod is embedded in the mounting groove, the thickness of the base plate is half of the depth of the mounting groove and is connected with an output shaft of the electric control telescopic rod, and the front end of the base plate is provided with a wave groove matched with the matching rod.
The upper end and the lower end of the base plate are respectively provided with a horn mouth communicated with the wave groove.
The sucker group comprises a suspension, a sucker head and a liquid injection head, the suspension is fixedly arranged at the upper end of the corresponding working cavity, the sucker head is arranged at the lower end of the suspension in a front-back symmetrical mode through a guide rail, and the liquid injection head is communicated with an external neutral resin storage and is arranged at the right side of the lower end of the suspension.
The placer comprises a placement box, a lifting cylinder and a translation guide rail, wherein the translation guide rail is fixedly arranged at the bottom in the corresponding working cavity and is positioned at the other side of the liquid injection head, the lifting cylinder is arranged on a sliding block of the translation guide rail, the placement box is connected with an output shaft of the lifting cylinder, and a plurality of placement cavities are uniformly formed in the placement box.
Compared with the prior art, the invention has at least the following advantages:
by matching the dyeing mechanism and the sealing mechanism, the slide glass filled with the sample can be dyed and sealed in one machine body, so that the transfer operation of different devices is reduced, and the operation convenience is improved; through the setting of dyeing mechanism, can carry out the dyeing operation through moving subassembly and holder automatic control to the sample on the slide, reduce the intervention operation of manpower, utilize the slide after the oscillator soaks single solution simultaneously to carry out the operation of removing liquid, reduce the pollution mixture between the different solutions, improve the use number of times of solution and the accuracy of dyeing.
Drawings
The invention may be further illustrated by means of non-limiting examples given in the accompanying drawings.
FIG. 1 is a schematic diagram of an early stage mutant tumor diagnosis apparatus according to the present invention.
Fig. 2 is a schematic view of another angle structure of the present invention.
Fig. 3 is a schematic structural view of the present invention.
Fig. 4 is a schematic structural view of the present invention.
The machine body 1, the working cavity 11, the liquid storage barrel 12, the X-axis guide rail 2, the Y-axis guide rail 21, the Z-axis guide rail 22, the turntable 3, the base 4, the U-shaped fastener 41, the matching rod 42, the mounting groove 43, the spring 51, the guide block 52, the transverse groove 53, the base plate 6, the wave groove 61, the horn mouth 62, the suspension 7, the suction disc head 71, the liquid injection head 72, the placement box 73, the lifting cylinder 74 and the translation guide rail 75.
Detailed Description
In order that those skilled in the art will better understand the present invention, the following technical scheme of the present invention will be further described with reference to the accompanying drawings and examples.
Example 1: as shown in fig. 1-4, an early stage mutation tumor diagnosis device comprises a machine body 1 and a control panel, wherein the machine body 1 is symmetrically provided with two working cavities 11, and a dyeing mechanism and a sealing mechanism are respectively arranged in the two working cavities 11;
the dyeing mechanism comprises a moving assembly, a clamp and a plurality of liquid storage cylinders 12, wherein the moving assembly comprises an X-axis guide rail 2, a Y-axis guide rail 21 and a Z-axis guide rail 22, the X-axis guide rail 2 is connected with the rear inner wall of the corresponding working cavity 11, the Y-axis guide rail 21 is connected with the X-axis guide rail 2, the Z-axis guide rail 22 is connected with the Y-axis guide rail 21, the clamp is connected with the Z-axis guide rail 22, and the liquid storage cylinders 12 are uniformly arranged at the bottom of the corresponding working cavity 11;
the sealing piece mechanism comprises a rotary table 3 and a sealing piece assembly, the rotary table 3 is rotationally arranged in the corresponding working cavity 11, the sealing piece assembly comprises a sucker group and a placer, the sucker group is arranged on the upper side of the rotary table 3, and the placer is arranged on the side face of the rotary table 3.
Before pathological sample is dyed, placing a paraffin section sample to be dyed on a glass slide, then placing the glass slide with the sample in an external placing frame, then clamping the placing frame on a clamp holder, at the moment, controlling a moving assembly by a control panel to drive the placing frame to move according to a preset moving track and sequentially pass through a plurality of liquid storage cylinders 12, and storing dyed solution in the liquid storage cylinders 12 respectively so as to carry out solution soaking dyeing treatment on the sample matched with the glass slide, wherein an X-axis track is used for controlling the left and right positions of the clamp holder, a U-axis track is used for controlling the front and back positions of the clamp holder, and a Z-axis track is used for controlling the upper and lower positions of the clamp holder, so that the position of the glass slide on the clamp holder is adjusted and soaked;
after sample dyeing is completed, the dyed glass slide can be taken out together with the placing frame, then placed into another working cavity 11, and the glass slide is sealed by a sealing mechanism to realize long-term preservation, wherein the turntable 3 is used for placing the glass slide and adjusting the position of the glass slide to perform operations such as placing, conveying, gluing, sealing and the like, the sucker group is used for adsorbing the glass slide, the cover glass and the like, and the placer is used for collecting samples with the sealing completed.
The holder includes base 4 and U-shaped fastener 41, and base 4 and Z axle guide rail 22's slider fixed connection, U-shaped fastener 41 is connected and opening downwards with base 4, and U-shaped fastener 41 and outside slide glass place the frame phase-match.
The base 4 is used for installing the U-shaped fastener 41 and matching the Z-axis guide rail 22, thereby realizing the effects of clamping the component and adjusting the orientation of the component.
The sucking disc group comprises a suspension 7, a sucking disc head 71 and a liquid injection head 72, wherein the suspension 7 is fixedly arranged at the upper end of the corresponding working cavity 11, the sucking disc head 71 is arranged at the lower end of the suspension 7 in a front-back symmetrical mode through a guide rail, and the liquid injection head 72 is communicated with an external neutral resin storage and is arranged at the right side of the lower end of the suspension 7.
The placer comprises a placement box 73, a lifting air cylinder 74 and a translation guide rail 75, wherein the translation guide rail 75 is fixedly arranged at the bottom in the corresponding working cavity 11 and positioned at the other side of the liquid injection head 72, the lifting air cylinder 74 is arranged on a sliding block of the translation guide rail 75, the placement box 73 is connected with an output shaft of the lifting air cylinder 74, and a plurality of placement cavities are uniformly formed in the placement box 73.
The suspension 7 is used for installing the suction disc head 71 and the liquid injection head 72 so as to facilitate the movement of the components during sealing and avoid the influence of the components, wherein the suction disc head 71 is matched with an external suction mechanism, so that the movement of the glass slide and the cover glass can be realized, and the transportation of the components is satisfied, and the transportation of the components by utilizing vacuum suction is a conventional prior art means, so that the description is not repeated herein, while the liquid injection head 72 is used for coating neutral resin on the glass slide ready for sealing after the glass slide is placed, then carrying out a cover plate, finally placing the glass slide into the placing box 73 to finish sealing, wherein the sample for conveying the sealing can be realized by adopting a roller or a guide rail;
the placement box 73 can realize position adjustment in the Y-axis and Z-axis directions by the cooperation of the lifting air cylinder 74 and the translation guide rail 75, so that the placement cavity of the placement box 73 is matched with the sample of the finished sealing piece, and the samples are sequentially placed.
Example 2: as shown in fig. 1-4, in a further improvement on the basis of embodiment 1, an oscillator is further provided between the base 4 and the U-shaped fastener 41, the oscillator includes a matching rod 42, two resetters and a guide, the number of the resetters is two and symmetrically provided at the front end of the base 4, the U-shaped fastener 41 is connected with the two resetters, the middle of the Z-axis guide rail 22 is provided with an opening mounting groove 43, the guide is provided in the middle of the mounting groove 43, and the matching rod 42 is connected with the U-shaped fastener 41 and extends into the mounting groove 43 to be matched with the guide.
The restorer comprises two springs 51 and a guide block 52, the base 4 is provided with a transverse groove 53 matched with the restorer, the guide block 52 is slidably arranged in the transverse groove 53, and the two springs 51 are fixedly arranged at the left end and the right end of the guide block 52 respectively and are both positioned in the transverse groove 53.
The director includes base plate 6 and automatically controlled telescopic link, and automatically controlled telescopic link inlays locates in the mounting groove 43, and the thickness of base plate 6 is half of mounting groove 43 degree of depth and with automatically controlled telescopic link's output shaft, the front end of base plate 6 is opened has with cooperation pole 42 assorted wave groove 61.
The upper and lower ends of the base plate 6 are provided with flare openings 62 communicated with the wave grooves 61.
In order to improve the use times of the dyeing solution, reduce the pollution of the dyeing solution and improve the resource utilization rate and improve the dyeing effect, when the dyeing treatment is carried out, after the glass slide is soaked in one solution, at the moment, the moving component lifts the clamp upwards to enable the placing frame containing the glass slide to leave the solution, meanwhile, the electronic control telescopic rod pushes the base plate 6 to move outwards, at the moment, the base plate 6 is overlapped with the matching rod 42, when the U-shaped fastener 41 moves upwards, the matching rod 42 slides into the horn mouth 62 of the base plate 6 and is guided into the wave groove 61, and because the U-shaped fastener 41 is connected with the base 4 through the reset device, the matching rod 42 is connected with the U-shaped fastener 41 again, when the matching rod 42 receives the blocking guide, the short-range swing action of the U-shaped fastener 41 is generated, and further up-down reciprocating swing is carried out through the Z-axis guide rail 22, so that the liquid removal after the soaking of the single solution is finished can be realized, and the influence of excessive solution on the glass slide is avoided;
when the liquid removal is completed, the electric control telescopic rod withdraws the substrate 6, and the thickness of the substrate 6 is smaller than half of the depth of the mounting groove 43, so that the matching rod 42 is separated from the action influence of the substrate 6, and the re-soaking action of the Z-axis guide rail 22 can be adapted at the moment, so that the midpoint of the spring 51 of the resetting device is matched for resetting, thereby meeting the oscillating liquid removal requirement on one hand and the stationary positioning requirement on the other hand.
The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims of this invention, which are within the skill of those skilled in the art, can be made without departing from the spirit and scope of the invention disclosed herein.
Claims (8)
1. An early stage mutation tumor diagnosis device, comprising a body and a control panel, characterized in that: the machine body is symmetrically provided with two working cavities, and the two working cavities are respectively provided with a dyeing mechanism and a sealing piece mechanism;
the dyeing mechanism comprises a moving assembly, a clamp holder and a plurality of liquid storage cylinders, wherein the moving assembly comprises an X-axis guide rail, a Y-axis guide rail and a Z-axis guide rail, the X-axis guide rail is connected with the rear inner wall of the corresponding working cavity, the Y-axis guide rail is connected with the X-axis guide rail, the Z-axis guide rail is connected with the Y-axis guide rail, the clamp holder is connected with the Z-axis guide rail, and the liquid storage cylinders are uniformly arranged at the bottom of the corresponding working cavity;
the sealing piece mechanism comprises a rotary table and a sealing piece assembly, the rotary table is rotationally arranged in the corresponding working cavity, the sealing piece assembly comprises a sucker group and a placer, the sucker group is arranged on the upper side of the rotary table, and the placer is arranged on the side face of the rotary table.
2. The early stage mutant tumor diagnosis apparatus according to claim 1, wherein: the holder includes base and U-shaped fastener, the base with the slider fixed connection of Z axle guide rail, U-shaped fastener with the base is connected and the opening is down, U-shaped fastener and outside slide glass place frame phase-match.
3. The early stage mutant tumor diagnosis apparatus according to claim 2, wherein: still be equipped with the oscillator between base with U-shaped fastener, the oscillator includes cooperation pole, restorer and director, the quantity of restorer is two and symmetry locates the base front end, U-shaped fastener with two the restorer is connected, Z axle guide middle part open-ended mounting groove, the director is located middle part in the mounting groove, the cooperation pole with U-shaped fastener is connected and stretches into in the mounting groove with director assorted.
4. The apparatus for diagnosing an early stage mutant tumor according to claim 3, wherein: the reset device comprises two springs and a guide block, wherein the base is provided with a transverse groove matched with the reset device, the guide block is slidably arranged in the transverse groove, and the two springs are fixedly arranged at the left end and the right end of the guide block respectively and are all positioned in the transverse groove.
5. The device for diagnosing an early stage mutant tumor according to claim 4, wherein: the guide comprises a base plate and an electric control telescopic rod, the electric control telescopic rod is embedded in the mounting groove, the thickness of the base plate is half of the depth of the mounting groove and is connected with an output shaft of the electric control telescopic rod, and the front end of the base plate is provided with a wave groove matched with the matching rod.
6. The early stage mutant tumor diagnosis apparatus according to claim 5, wherein: the upper end and the lower end of the base plate are respectively provided with a horn mouth communicated with the wave groove.
7. The early stage mutant tumor diagnosis apparatus according to claim 6, wherein: the sucker group comprises a suspension, a sucker head and a liquid injection head, the suspension is fixedly arranged at the upper end of the corresponding working cavity, the sucker head is arranged at the lower end of the suspension in a front-back symmetrical mode through a guide rail, and the liquid injection head is communicated with an external neutral resin storage and is arranged at the right side of the lower end of the suspension.
8. The early stage mutant tumor diagnosis apparatus according to claim 7, wherein: the placer comprises a placement box, a lifting cylinder and a translation guide rail, wherein the translation guide rail is fixedly arranged at the bottom in the corresponding working cavity and is positioned at the other side of the liquid injection head, the lifting cylinder is arranged on a sliding block of the translation guide rail, the placement box is connected with an output shaft of the lifting cylinder, and a plurality of placement cavities are uniformly formed in the placement box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311573695.8A CN117572000A (en) | 2023-11-23 | 2023-11-23 | Early mutation tumor diagnosis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311573695.8A CN117572000A (en) | 2023-11-23 | 2023-11-23 | Early mutation tumor diagnosis device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117572000A true CN117572000A (en) | 2024-02-20 |
Family
ID=89893264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311573695.8A Pending CN117572000A (en) | 2023-11-23 | 2023-11-23 | Early mutation tumor diagnosis device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117572000A (en) |
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2023
- 2023-11-23 CN CN202311573695.8A patent/CN117572000A/en active Pending
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